PT2247585E - Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação - Google Patents

Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação Download PDF

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Publication number
PT2247585E
PT2247585E PT97177729T PT09717772T PT2247585E PT 2247585 E PT2247585 E PT 2247585E PT 97177729 T PT97177729 T PT 97177729T PT 09717772 T PT09717772 T PT 09717772T PT 2247585 E PT2247585 E PT 2247585E
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PT
Portugal
Prior art keywords
ylidene
indol
carboxamide
diethylamino
pyrrole
Prior art date
Application number
PT97177729T
Other languages
English (en)
Inventor
Hans-Günter Striegel
Nesrin Mohamad
Roland Boese
Rüdiger Latz
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of PT2247585E publication Critical patent/PT2247585E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
PT97177729T 2008-03-06 2009-03-05 Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação PT2247585E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08004143A EP2098521A1 (en) 2008-03-06 2008-03-06 Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation

Publications (1)

Publication Number Publication Date
PT2247585E true PT2247585E (pt) 2014-07-17

Family

ID=39590734

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97177729T PT2247585E (pt) 2008-03-06 2009-03-05 Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação

Country Status (15)

Country Link
US (1) US20110034703A1 (pt)
EP (3) EP2098521A1 (pt)
JP (1) JP2011513349A (pt)
KR (1) KR101604501B1 (pt)
CN (1) CN101965342B (pt)
AU (1) AU2009221458A1 (pt)
CA (1) CA2714441A1 (pt)
EA (1) EA020067B1 (pt)
ES (1) ES2478821T3 (pt)
IL (1) IL207984A (pt)
PL (1) PL2247585T3 (pt)
PT (1) PT2247585E (pt)
SI (1) SI2247585T1 (pt)
WO (1) WO2009109388A1 (pt)
ZA (1) ZA201005796B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2699306A1 (en) * 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof
US8466190B2 (en) 2008-04-16 2013-06-18 Natco Pharma Limited Polymorphic forms of Sunitinib base
SI2313371T1 (sl) 2008-06-13 2013-02-28 Medichem, S.A. Postopek za pripravo soli 3-pirol substituirane 2-indolinonske jabolčne kisline
JP2012500837A (ja) * 2008-08-25 2012-01-12 ジェネリクス・（ユーケー）・リミテッド 新規な結晶型およびその調製方法
JP2012500838A (ja) * 2008-08-25 2012-01-12 ジェネリクス・（ユーケー）・リミテッド スニチニブの新規な多形およびその調製方法
WO2011092664A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited Crystalline forms of l-malic acid salt of sunitinib
WO2011100325A2 (en) 2010-02-09 2011-08-18 Sicor Inc. Polymorphs of sunitinib salts
US20150174096A1 (en) * 2012-06-12 2015-06-25 Bayer Healthcare Llc Topical ophthalmological pharmaceutical composition containing sunitinib
CN103833733B (zh) * 2012-11-21 2017-08-25 广东东阳光药业有限公司 一种替尼类药物新晶型
DK3039424T3 (da) 2013-08-28 2020-08-31 Crown Bioscience Inc Taicang Genekspressionssignaturer, der er prædiktive for et individs respons på en multikinaseinhibitor, og fremgangsmåder til anvendelse af disse
RU2567535C1 (ru) * 2014-10-01 2015-11-10 Олег Ростиславович Михайлов КРИСТАЛЛИЧЕСКАЯ ε-МОДИФИКАЦИЯ N-[2-(ДИЭТИЛАМИНО)ЭТИЛ]-5-[(Z)-(5-ФТОР-1,2-ДИГИДРО-2-ОКСО-3Н-ИНДОЛ-3-ИЛИДЕН)МЕТИЛ]-2,4-ДИМЕТИЛ-1Н-ПИРРОЛ-3-КАРБОКСАМИД МАЛАТА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ
CN106884206A (zh) * 2017-03-17 2017-06-23 青岛大学 一种有机非线性光学晶体用籽晶的生长方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02006263A (es) 1999-12-22 2004-02-26 Sugen Inc Metodos de modulacion de la funcion de la cinasa de tirosina c-kit de la proteina con compuestos de indolinona.
BRPI0108394B8 (pt) * 2000-02-15 2021-05-25 Upjohn Co inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
DK3168218T3 (en) * 2001-08-15 2019-01-14 Pharmacia & Upjohn Co Llc Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
EP1476443A2 (en) * 2002-02-15 2004-11-17 PHARMACIA & UPJOHN COMPANY Process for preparing indolinone derivatives

Also Published As

Publication number Publication date
WO2009109388A8 (en) 2010-10-07
EP2247585A1 (en) 2010-11-10
SI2247585T1 (sl) 2014-08-29
KR20100125300A (ko) 2010-11-30
CN101965342B (zh) 2014-07-30
KR101604501B1 (ko) 2016-03-17
IL207984A0 (en) 2010-12-30
WO2009109388A1 (en) 2009-09-11
EP2604603A1 (en) 2013-06-19
EP2098521A1 (en) 2009-09-09
AU2009221458A1 (en) 2009-09-11
EP2247585B1 (en) 2014-04-30
ES2478821T3 (es) 2014-07-23
CA2714441A1 (en) 2009-09-11
EA020067B1 (ru) 2014-08-29
US20110034703A1 (en) 2011-02-10
EA201001243A1 (ru) 2011-04-29
PL2247585T3 (pl) 2014-09-30
JP2011513349A (ja) 2011-04-28
CN101965342A (zh) 2011-02-02
ZA201005796B (en) 2011-04-28
IL207984A (en) 2016-07-31

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