PT2247585E - Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação - Google Patents
Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação Download PDFInfo
- Publication number
- PT2247585E PT2247585E PT97177729T PT09717772T PT2247585E PT 2247585 E PT2247585 E PT 2247585E PT 97177729 T PT97177729 T PT 97177729T PT 09717772 T PT09717772 T PT 09717772T PT 2247585 E PT2247585 E PT 2247585E
- Authority
- PT
- Portugal
- Prior art keywords
- ylidene
- indol
- carboxamide
- diethylamino
- pyrrole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08004143A EP2098521A1 (en) | 2008-03-06 | 2008-03-06 | Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2247585E true PT2247585E (pt) | 2014-07-17 |
Family
ID=39590734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97177729T PT2247585E (pt) | 2008-03-06 | 2009-03-05 | Formas cristalinas de n-[2-(dietilamino)etil]-5-[(5-fluoro- 1,2-dihidro-2-oxo-3h-indol-3-ilideno)metil]-2,4-dimetil-1hpirrol- 3-carboxamida e métodos para a respetiva preparação |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110034703A1 (pt) |
EP (3) | EP2098521A1 (pt) |
JP (1) | JP2011513349A (pt) |
KR (1) | KR101604501B1 (pt) |
CN (1) | CN101965342B (pt) |
AU (1) | AU2009221458A1 (pt) |
CA (1) | CA2714441A1 (pt) |
EA (1) | EA020067B1 (pt) |
ES (1) | ES2478821T3 (pt) |
IL (1) | IL207984A (pt) |
PL (1) | PL2247585T3 (pt) |
PT (1) | PT2247585E (pt) |
SI (1) | SI2247585T1 (pt) |
WO (1) | WO2009109388A1 (pt) |
ZA (1) | ZA201005796B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2699305A1 (en) * | 2007-11-21 | 2009-05-28 | Teva Pharmaceutical Industries Ltd. | Polymorphs of sunitinib base and processes for preparation thereof |
WO2009128083A1 (en) * | 2008-04-16 | 2009-10-22 | Natco Pharma Limited | Novel polymorphic forms of sunitinib base |
AR072117A1 (es) | 2008-06-13 | 2010-08-04 | Medichem Sa | Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende. |
EP2318393A1 (en) * | 2008-08-25 | 2011-05-11 | Generics [UK] Limited | Novel polymorphs of sunitinib and processes for their preparation |
AU2009286520A1 (en) * | 2008-08-25 | 2010-03-04 | Generics [Uk] Limited | Crystalline form of sunitinib and processes for its preparation |
WO2011092664A1 (en) | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | Crystalline forms of l-malic acid salt of sunitinib |
WO2011100325A2 (en) | 2010-02-09 | 2011-08-18 | Sicor Inc. | Polymorphs of sunitinib salts |
JP2017512748A (ja) * | 2012-06-25 | 2017-05-25 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | スニチニブを含んでいる眼科用局所医薬組成物 |
CN103833733B (zh) * | 2012-11-21 | 2017-08-25 | 广东东阳光药业有限公司 | 一种替尼类药物新晶型 |
EP3039424B1 (en) | 2013-08-28 | 2020-07-29 | Crown Bioscience, Inc. (Taicang) | Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same |
RU2567535C1 (ru) * | 2014-10-01 | 2015-11-10 | Олег Ростиславович Михайлов | КРИСТАЛЛИЧЕСКАЯ ε-МОДИФИКАЦИЯ N-[2-(ДИЭТИЛАМИНО)ЭТИЛ]-5-[(Z)-(5-ФТОР-1,2-ДИГИДРО-2-ОКСО-3Н-ИНДОЛ-3-ИЛИДЕН)МЕТИЛ]-2,4-ДИМЕТИЛ-1Н-ПИРРОЛ-3-КАРБОКСАМИД МАЛАТА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ |
CN106884206A (zh) * | 2017-03-17 | 2017-06-23 | 青岛大学 | 一种有机非线性光学晶体用籽晶的生长方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60029138T2 (de) | 1999-12-22 | 2007-06-06 | Sugen, Inc., San Francisco | Verwendung von Indolinonverbindungen zur Herstellung von Pharmazeutika für die Modulation der Funktion c-kit Proteintyrosinkinase |
ATE369359T1 (de) | 2000-02-15 | 2007-08-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
TR201900509T4 (tr) * | 2001-08-15 | 2019-02-21 | Pharmacia & Upjohn Co Llc | Bir ilaç olarak kullanılmaya yönelik n-[2-(dietilamino)etil]-5-[(5-floro-1,2-dihidro-2-okso-3h-indol-3-iliden)metil]-2,4-dimetil-1h-pirol-3-karboksamidin l-malik asit tuzunu içeren bir kristal. |
TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
PL372302A1 (en) * | 2002-02-15 | 2005-07-11 | Pharmacia & Upjohn Company | Process for preparing indolinone derivatives |
-
2008
- 2008-03-06 EP EP08004143A patent/EP2098521A1/en not_active Withdrawn
-
2009
- 2009-03-05 EP EP13158832.9A patent/EP2604603A1/en not_active Withdrawn
- 2009-03-05 PL PL09717772T patent/PL2247585T3/pl unknown
- 2009-03-05 KR KR1020107019864A patent/KR101604501B1/ko active IP Right Grant
- 2009-03-05 WO PCT/EP2009/001568 patent/WO2009109388A1/en active Application Filing
- 2009-03-05 PT PT97177729T patent/PT2247585E/pt unknown
- 2009-03-05 CN CN200980107316.8A patent/CN101965342B/zh not_active Expired - Fee Related
- 2009-03-05 AU AU2009221458A patent/AU2009221458A1/en not_active Abandoned
- 2009-03-05 JP JP2010549060A patent/JP2011513349A/ja active Pending
- 2009-03-05 CA CA2714441A patent/CA2714441A1/en not_active Abandoned
- 2009-03-05 ES ES09717772.9T patent/ES2478821T3/es active Active
- 2009-03-05 EP EP09717772.9A patent/EP2247585B1/en active Active
- 2009-03-05 US US12/918,612 patent/US20110034703A1/en not_active Abandoned
- 2009-03-05 EA EA201001243A patent/EA020067B1/ru not_active IP Right Cessation
- 2009-03-05 SI SI200930926T patent/SI2247585T1/sl unknown
-
2010
- 2010-08-13 ZA ZA2010/05796A patent/ZA201005796B/en unknown
- 2010-09-05 IL IL207984A patent/IL207984A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2011513349A (ja) | 2011-04-28 |
EP2247585A1 (en) | 2010-11-10 |
SI2247585T1 (sl) | 2014-08-29 |
EA201001243A1 (ru) | 2011-04-29 |
IL207984A0 (en) | 2010-12-30 |
US20110034703A1 (en) | 2011-02-10 |
EP2098521A1 (en) | 2009-09-09 |
KR101604501B1 (ko) | 2016-03-17 |
WO2009109388A1 (en) | 2009-09-11 |
CA2714441A1 (en) | 2009-09-11 |
CN101965342B (zh) | 2014-07-30 |
ES2478821T3 (es) | 2014-07-23 |
EA020067B1 (ru) | 2014-08-29 |
WO2009109388A8 (en) | 2010-10-07 |
CN101965342A (zh) | 2011-02-02 |
EP2604603A1 (en) | 2013-06-19 |
AU2009221458A1 (en) | 2009-09-11 |
IL207984A (en) | 2016-07-31 |
EP2247585B1 (en) | 2014-04-30 |
KR20100125300A (ko) | 2010-11-30 |
ZA201005796B (en) | 2011-04-28 |
PL2247585T3 (pl) | 2014-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL207984A (en) | Crystalline forms of n - [2 - (diethylamino) ethyl] 5 - [(5-fluoro-1,2-dihydro-2-oxo-h3-indole-3-ylidene) methyl] -4,2-dimethyl-h1- Pyrol-3-carboxamide and methods for their preparation | |
PT3168218T (pt) | Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento | |
EP2219671A4 (en) | USE OF TAM RECEPTOR INHIBITORS AS TAM IMMUNOSTIMULATORS AND ACTIVATORS AS IMMUNOSUPPRESSANTS | |
ZA201001860B (en) | Pyridazinone derivatives and use thereof as p2z7 receptor inhibitors | |
EP2347336A4 (en) | METHOD AND SYSTEM FOR SECURE USE OF SERVICES BY UNSECURED STORAGE SUPPLIERS | |
ZA200902638B (en) | Imidazolone and imidazolidinone derivatives as 11B-HSD1 inhibitors for diabetes | |
DK2349137T3 (da) | Enhed til brug sammen med en stomipose | |
EP1971296A4 (en) | POSTERIOR DYNAMIC STABILIZATION OF THE VERTEBRAL COLUMN | |
ZA201000326B (en) | Methods for modulating gpr119 g protein-coupled receptor and selected compounds | |
EP2328934A4 (en) | T cell Receptor Antibodies and Method of Use | |
EP2133331A4 (en) | FIVE-GLASS HETEROCYCLIC DERIVATIVE AND ITS USE IN MEDICAL PURPOSES | |
DK2358669T3 (da) | Alpha-keto-persyrer og fremgangsmåder til fremstilling og anvendelse heraf | |
IL225167A (en) | Annotations (para-methoxy) phenyl-sulfonamide, n- (isobutyl), n - [(r2) - hydroxy- (r3) - benzyl-profile] | |
HRP20190181T1 (hr) | Farmaceutski dozni oblik za trenutno oslobađanje jednog derivata indolinona | |
WO2010010454A3 (en) | Crystalline forms of a 3-pyrrole substituted 2-indolinone malate salt | |
EP2257316A4 (en) | CONTRAST AGENTS, METHODS FOR PREPARING CONTRAST AGENTS, AND IMAGING METHODS | |
IL210141A0 (en) | Pharmaceutical composition comprising n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1 h-pyrrole-3-carboxamide | |
HK1150737A1 (en) | Member for dynamic stabilisation of vertebrae | |
IL209815A0 (en) | Solid forms of (1r,2s,3r)-1-(2-(isoxazol-3-yl)-1h-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use | |
EP2470503A4 (en) | METHOD OF SYNTHESIZING AN ALKYL-CARBAZOLE AND ITS DERIVATIVES | |
EA201001125A1 (ru) | Фармацевтические композиции, включающие n-[2-(диэтиламино)этил]-5-[(5-фтор-1,2-дигидро-2-оксо-3н-индол-3-илиден)метил]-2,4-диметил-1н-пиррол-3-карбоксамид | |
IL209591A0 (en) | Diazepan and piperazine derivatives modulators of chemokine receptors | |
EP2278963A4 (en) | TAXOL DERIVATIVES AND CLOSELY RELATED COMPOUNDS | |
ZA201008139B (en) | Means for fixing of screening media,and use of such means | |
EP2482659A4 (en) | HEXAHYDROCYCLOPENTA [F] INDAZOLE 5-YLE ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS |