PT2132216E - Análogos inovadores de nucleósidos para o tratamento de infecções virais - Google Patents

Análogos inovadores de nucleósidos para o tratamento de infecções virais Download PDF

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Publication number
PT2132216E
PT2132216E PT08708805T PT08708805T PT2132216E PT 2132216 E PT2132216 E PT 2132216E PT 08708805 T PT08708805 T PT 08708805T PT 08708805 T PT08708805 T PT 08708805T PT 2132216 E PT2132216 E PT 2132216E
Authority
PT
Portugal
Prior art keywords
virus
compound
quot
ethynyl
compounds
Prior art date
Application number
PT08708805T
Other languages
English (en)
Portuguese (pt)
Inventor
Zheng Yin
Jeyaraj Duraiswamy
Yen Liang Chen
Original Assignee
Novartis Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39462074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2132216(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma Ag filed Critical Novartis Pharma Ag
Publication of PT2132216E publication Critical patent/PT2132216E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT08708805T 2007-02-09 2008-02-07 Análogos inovadores de nucleósidos para o tratamento de infecções virais PT2132216E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07102027 2007-02-09
EP08150003 2008-01-02

Publications (1)

Publication Number Publication Date
PT2132216E true PT2132216E (pt) 2012-02-20

Family

ID=39462074

Family Applications (1)

Application Number Title Priority Date Filing Date
PT08708805T PT2132216E (pt) 2007-02-09 2008-02-07 Análogos inovadores de nucleósidos para o tratamento de infecções virais

Country Status (18)

Country Link
US (1) US8278282B2 (https=)
EP (1) EP2132216B1 (https=)
JP (1) JP2010518047A (https=)
KR (1) KR20090109102A (https=)
CN (1) CN101600726B (https=)
AR (1) AR065249A1 (https=)
AT (1) ATE533774T1 (https=)
AU (1) AU2008212752A1 (https=)
BR (1) BRPI0807222A2 (https=)
CA (1) CA2675462A1 (https=)
CL (1) CL2008000409A1 (https=)
EA (1) EA200901080A1 (https=)
ES (1) ES2381093T3 (https=)
MX (1) MX2009008495A (https=)
PE (1) PE20090070A1 (https=)
PT (1) PT2132216E (https=)
TW (1) TW200838550A (https=)
WO (1) WO2008095993A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015643A1 (en) * 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
CN102526087B (zh) * 2010-12-30 2014-09-03 南开大学 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用
CN105669783B (zh) * 2014-12-03 2019-11-12 广东东阳光药业有限公司 一种制备呋喃糖的方法
EA201890454A1 (ru) 2015-08-06 2018-07-31 Чимерикс, Инк. Пирролопиримидиновые нуклеозиды и их аналоги, которые можно использовать в качестве противовирусных средств
CN108289931B (zh) 2015-09-23 2022-10-11 默沙东公司 4’-取代的核苷逆转录酶抑制剂及其制备
EA201892448A1 (ru) * 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
TW201815821A (zh) * 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
AU2017311566A1 (en) * 2016-08-12 2019-02-21 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
US11718534B2 (en) 2019-04-23 2023-08-08 Elementis Specialties, Inc. Slurry compositions containing mixed branched alkyl organoclay compositions
MX2024007822A (es) * 2021-12-22 2024-07-04 Cj Cheiljedang Corp Composicion antiviral que comprende analogos nucleosidicos derivados de acido nucleico y sal farmaceuticamente aceptable de los mismos.
WO2024012568A1 (en) * 2022-07-15 2024-01-18 Sunshine Lake Pharma Co., Ltd. A key intermediate for preparing glucopyranosyl derivatives and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057425A2 (en) * 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2003051352A1 (en) * 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
JP2005527499A (ja) * 2002-02-13 2005-09-15 メルク エンド カムパニー インコーポレーテッド ヌクレオシド化合物を用いてオルトポックスウイルスの複製を阻害する方法
AU2003232071A1 (en) * 2002-05-06 2003-11-17 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
AU2003279797B2 (en) * 2002-09-30 2009-10-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
US20040259934A1 (en) * 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
JP2007509939A (ja) * 2003-10-27 2007-04-19 ジェネラブズ テクノロジーズ インコーポレーティッド ウイルス感染を治療するためのヌクレオシド化合物

Also Published As

Publication number Publication date
CN101600726B (zh) 2013-03-27
US8278282B2 (en) 2012-10-02
ATE533774T1 (de) 2011-12-15
AR065249A1 (es) 2009-05-27
CA2675462A1 (en) 2008-08-14
US20100227833A1 (en) 2010-09-09
WO2008095993A1 (en) 2008-08-14
AU2008212752A1 (en) 2008-08-14
JP2010518047A (ja) 2010-05-27
CL2008000409A1 (es) 2008-08-29
ES2381093T3 (es) 2012-05-23
KR20090109102A (ko) 2009-10-19
MX2009008495A (es) 2009-08-20
BRPI0807222A2 (pt) 2014-04-29
EA200901080A1 (ru) 2010-02-26
EP2132216B1 (en) 2011-11-16
TW200838550A (en) 2008-10-01
PE20090070A1 (es) 2009-03-19
EP2132216A1 (en) 2009-12-16
CN101600726A (zh) 2009-12-09

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