PT1831202E - Derivados de pirrolidínio como receptores muscarínicos m3 - Google Patents
Derivados de pirrolidínio como receptores muscarínicos m3 Download PDFInfo
- Publication number
- PT1831202E PT1831202E PT05850334T PT05850334T PT1831202E PT 1831202 E PT1831202 E PT 1831202E PT 05850334 T PT05850334 T PT 05850334T PT 05850334 T PT05850334 T PT 05850334T PT 1831202 E PT1831202 E PT 1831202E
- Authority
- PT
- Portugal
- Prior art keywords
- hydroxy
- methyl
- acetoxy
- vvo
- pyrrolidinium
- Prior art date
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- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title description 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 104
- 150000003839 salts Chemical class 0.000 claims abstract description 29
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
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- 239000001301 oxygen Chemical group 0.000 claims description 12
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- 238000002360 preparation method Methods 0.000 claims description 12
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- 125000005842 heteroatom Chemical group 0.000 claims description 11
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Classifications
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
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- Immunology (AREA)
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- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428416.2A GB0428416D0 (en) | 2004-12-24 | 2004-12-24 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1831202E true PT1831202E (pt) | 2012-04-11 |
Family
ID=34130966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05850334T PT1831202E (pt) | 2004-12-24 | 2005-12-22 | Derivados de pirrolidínio como receptores muscarínicos m3 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8383625B2 (ja) |
| EP (1) | EP1831202B1 (ja) |
| JP (1) | JP2008525358A (ja) |
| KR (1) | KR101256242B1 (ja) |
| CN (1) | CN101087777B (ja) |
| AT (1) | ATE541839T1 (ja) |
| AU (1) | AU2005318423B2 (ja) |
| BR (1) | BRPI0519208A2 (ja) |
| CA (1) | CA2589744C (ja) |
| ES (1) | ES2377486T3 (ja) |
| GB (1) | GB0428416D0 (ja) |
| MX (1) | MX2007007720A (ja) |
| PL (1) | PL1831202T3 (ja) |
| PT (1) | PT1831202E (ja) |
| RU (1) | RU2412183C2 (ja) |
| WO (1) | WO2006066928A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| WO2007059021A1 (en) * | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| CA2675942C (en) | 2007-02-23 | 2016-04-12 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2009035542A2 (en) | 2007-09-07 | 2009-03-19 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
| EP2222637A1 (en) | 2007-12-14 | 2010-09-01 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| KR20150095888A (ko) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | 오토탁신 억제제 |
| KR102050299B1 (ko) | 2013-03-15 | 2019-11-29 | 보도르 라보래토리즈, 인크. | 다한증 치료용 항콜린성 글리코피롤레이트 에스테르 |
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| EP3134398A1 (en) | 2014-04-24 | 2017-03-01 | Novartis Ag | Autotaxin inhibitors |
| PL3325487T3 (pl) | 2015-07-21 | 2021-12-13 | Bodor Laboratories, Inc. | Preparat miękkich analogów przeciwcholinergicznych |
| TWI719046B (zh) | 2016-07-21 | 2021-02-21 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0937041T3 (da) | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
| EP1302458A4 (en) | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | ESTERDERIVATE |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
| PE20050231A1 (es) | 2003-06-24 | 2005-05-20 | Novartis Ag | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 |
| GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| DK2227234T3 (da) * | 2007-10-15 | 2014-08-11 | Can Fite Biopharma Ltd | Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderaf |
-
2004
- 2004-12-24 GB GBGB0428416.2A patent/GB0428416D0/en not_active Ceased
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2005
- 2005-12-22 ES ES05850334T patent/ES2377486T3/es active Active
- 2005-12-22 BR BRPI0519208-0A patent/BRPI0519208A2/pt not_active IP Right Cessation
- 2005-12-22 RU RU2007128080/04A patent/RU2412183C2/ru not_active IP Right Cessation
- 2005-12-22 EP EP05850334A patent/EP1831202B1/en not_active Not-in-force
- 2005-12-22 MX MX2007007720A patent/MX2007007720A/es active IP Right Grant
- 2005-12-22 AU AU2005318423A patent/AU2005318423B2/en not_active Ceased
- 2005-12-22 WO PCT/EP2005/013896 patent/WO2006066928A1/en active Application Filing
- 2005-12-22 CN CN2005800447368A patent/CN101087777B/zh not_active Expired - Fee Related
- 2005-12-22 KR KR1020077014263A patent/KR101256242B1/ko not_active IP Right Cessation
- 2005-12-22 PT PT05850334T patent/PT1831202E/pt unknown
- 2005-12-22 AT AT05850334T patent/ATE541839T1/de active
- 2005-12-22 CA CA2589744A patent/CA2589744C/en not_active Expired - Fee Related
- 2005-12-22 JP JP2007547367A patent/JP2008525358A/ja active Pending
- 2005-12-22 US US11/721,058 patent/US8383625B2/en not_active Expired - Fee Related
- 2005-12-22 PL PL05850334T patent/PL1831202T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0428416D0 (en) | 2005-02-02 |
| ES2377486T3 (es) | 2012-03-28 |
| BRPI0519208A2 (pt) | 2008-12-30 |
| MX2007007720A (es) | 2007-08-14 |
| US20090291960A1 (en) | 2009-11-26 |
| PL1831202T3 (pl) | 2012-06-29 |
| RU2007128080A (ru) | 2009-01-27 |
| AU2005318423B2 (en) | 2009-12-03 |
| CN101087777A (zh) | 2007-12-12 |
| CA2589744A1 (en) | 2006-06-29 |
| ATE541839T1 (de) | 2012-02-15 |
| EP1831202B1 (en) | 2012-01-18 |
| KR101256242B1 (ko) | 2013-04-17 |
| AU2005318423A1 (en) | 2006-06-29 |
| CA2589744C (en) | 2012-08-28 |
| JP2008525358A (ja) | 2008-07-17 |
| KR20070088730A (ko) | 2007-08-29 |
| CN101087777B (zh) | 2010-12-08 |
| WO2006066928A1 (en) | 2006-06-29 |
| US8383625B2 (en) | 2013-02-26 |
| EP1831202A1 (en) | 2007-09-12 |
| RU2412183C2 (ru) | 2011-02-20 |
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