PT1824479E - Derivados de fenilpiperazina com uma combinação de agonismo de receptor de dopamina d2 parcial e inibição da reabsorção de serotonina - Google Patents
Derivados de fenilpiperazina com uma combinação de agonismo de receptor de dopamina d2 parcial e inibição da reabsorção de serotonina Download PDFInfo
- Publication number
- PT1824479E PT1824479E PT05816322T PT05816322T PT1824479E PT 1824479 E PT1824479 E PT 1824479E PT 05816322 T PT05816322 T PT 05816322T PT 05816322 T PT05816322 T PT 05816322T PT 1824479 E PT1824479 E PT 1824479E
- Authority
- PT
- Portugal
- Prior art keywords
- serotonin reuptake
- combination
- reuptake inhibition
- phenylpiperazine derivatives
- receptor agonism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63407404P | 2004-12-08 | 2004-12-08 | |
| EP04106394 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1824479E true PT1824479E (pt) | 2009-01-30 |
Family
ID=35744728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05850037T PT1827427E (pt) | 2004-12-08 | 2005-12-06 | Compostos, composição farmacêutica, método de preparar uma composição, e, uso de um composto |
| PT05816322T PT1824479E (pt) | 2004-12-08 | 2005-12-06 | Derivados de fenilpiperazina com uma combinação de agonismo de receptor de dopamina d2 parcial e inibição da reabsorção de serotonina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05850037T PT1827427E (pt) | 2004-12-08 | 2005-12-06 | Compostos, composição farmacêutica, método de preparar uma composição, e, uso de um composto |
Country Status (18)
| Country | Link |
|---|---|
| EP (4) | EP1824479B1 (ja) |
| JP (4) | JP2008523031A (ja) |
| KR (4) | KR20070085975A (ja) |
| AT (2) | ATE413173T1 (ja) |
| AU (4) | AU2005313311A1 (ja) |
| BR (1) | BRPI0518613A2 (ja) |
| CA (4) | CA2587559A1 (ja) |
| DE (2) | DE602005010902D1 (ja) |
| DK (2) | DK1824479T3 (ja) |
| ES (2) | ES2311245T3 (ja) |
| HR (2) | HRP20080538T3 (ja) |
| IL (4) | IL183063A0 (ja) |
| NO (4) | NO20072974L (ja) |
| PL (2) | PL1824479T3 (ja) |
| PT (2) | PT1827427E (ja) |
| RU (4) | RU2007125658A (ja) |
| SI (2) | SI1824479T1 (ja) |
| WO (4) | WO2006061379A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009525304A (ja) * | 2006-01-30 | 2009-07-09 | シュペーデル・エクスペリメンタ・アーゲー | α，β−不飽和化合物からのアルコールの立体選択的製造方法 |
| US8063062B2 (en) | 2006-12-20 | 2011-11-22 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition |
| US8138174B2 (en) | 2007-01-10 | 2012-03-20 | Solvay Pharmaceuticals B.V. | Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition |
| JP2010515704A (ja) * | 2007-01-10 | 2010-05-13 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | カンナビノイド−ｃｂ１拮抗作用とセロトニン再摂取阻害の組み合わせを示す化合物 |
| RS52518B (en) * | 2007-04-23 | 2013-04-30 | Janssen Pharmaceutica N.V. | 4-ALCOXYPYRIDASINE DERIVATIVES AS A FAST DISSOCATING DOPAMINE 2 RECEPTOR ANTAGONISTS |
| EP2148879B1 (en) * | 2007-04-23 | 2012-11-28 | Janssen Pharmaceutica, N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| EP2148872A1 (en) * | 2007-04-23 | 2010-02-03 | Janssen Pharmaceutica, N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
| CN103360342B (zh) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用 |
| CN103570698B (zh) * | 2012-08-01 | 2016-08-03 | 江苏恩华药业股份有限公司 | 用于制备维拉佐酮的化合物及其中间体和应用 |
| ITMI20130392A1 (it) * | 2013-03-15 | 2014-09-16 | Dipharma Francis Srl | Sintesi di un inibitore della ricaptazione della serotonina |
| WO2014203217A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| WO2014207648A1 (en) | 2013-06-24 | 2014-12-31 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
| EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| JP2002510675A (ja) * | 1998-04-08 | 2002-04-09 | アメリカン・ホーム・プロダクツ・コーポレイション | うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン（５−ｈｔ１ａ受容体活性薬） |
| NZ508506A (en) * | 1998-06-19 | 2004-01-30 | H | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| SI1212320T1 (en) * | 1999-08-23 | 2005-10-31 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| DE60311000T2 (de) * | 2002-12-10 | 2007-10-04 | Merck Patent Gmbh | Indolderivate und deren verwendung als 5-ht liganden |
-
2005
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 CA CA002587559A patent/CA2587559A1/en not_active Abandoned
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
- 2005-12-06 EP EP05816322A patent/EP1824479B1/en active Active
- 2005-12-06 CA CA002587357A patent/CA2587357A1/en not_active Abandoned
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Application Discontinuation
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Application Discontinuation
- 2005-12-06 EP EP05816324A patent/EP1824480A1/en not_active Withdrawn
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Application Discontinuation
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Application Discontinuation
- 2005-12-06 CA CA002587381A patent/CA2587381A1/en not_active Abandoned
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 SI SI200530566T patent/SI1824479T1/sl unknown
- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 DK DK05850037T patent/DK1827427T3/da active
- 2005-12-06 AU AU2005313312A patent/AU2005313312A1/en not_active Abandoned
- 2005-12-06 PT PT05850037T patent/PT1827427E/pt unknown
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 ES ES05850037T patent/ES2311245T3/es active Active
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/en active Application Filing
- 2005-12-06 RU RU2007125661/04A patent/RU2007125661A/ru not_active Application Discontinuation
- 2005-12-06 EP EP05850037A patent/EP1827427B1/en active Active
- 2005-12-06 AT AT05850037T patent/ATE401883T1/de not_active IP Right Cessation
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/en active Application Filing
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 PT PT05816322T patent/PT1824479E/pt unknown
- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/en active IP Right Grant
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 CA CA002587202A patent/CA2587202A1/en not_active Abandoned
- 2005-12-06 BR BRPI0518613-7A patent/BRPI0518613A2/pt not_active IP Right Cessation
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/en active Application Filing
- 2005-12-06 EP EP05813645A patent/EP1827426A1/en not_active Withdrawn
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 PL PL05850037T patent/PL1827427T3/pl unknown
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es active Active
-
2007
- 2007-05-08 IL IL183063A patent/IL183063A0/en unknown
- 2007-05-08 IL IL183061A patent/IL183061A0/en unknown
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
- 2007-05-08 IL IL183064A patent/IL183064A0/en unknown
- 2007-06-11 NO NO20072974A patent/NO20072974L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072981A patent/NO20072981L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation
-
2008
- 2008-10-22 HR HR20080538T patent/HRP20080538T3/xx unknown
-
2009
- 2009-01-13 HR HR20090015T patent/HRP20090015T3/xx unknown
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