PT1711470E - Derivados de malonamida que bloqueiam a actividade de gama-secretase - Google Patents
Derivados de malonamida que bloqueiam a actividade de gama-secretase Download PDFInfo
- Publication number
- PT1711470E PT1711470E PT04764665T PT04764665T PT1711470E PT 1711470 E PT1711470 E PT 1711470E PT 04764665 T PT04764665 T PT 04764665T PT 04764665 T PT04764665 T PT 04764665T PT 1711470 E PT1711470 E PT 1711470E
- Authority
- PT
- Portugal
- Prior art keywords
- activtiy
- secretase
- gamma
- malonamide derivatives
- blocking
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03019683 | 2003-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1711470E true PT1711470E (pt) | 2009-05-21 |
Family
ID=34224068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04764665T PT1711470E (pt) | 2003-09-09 | 2004-08-31 | Derivados de malonamida que bloqueiam a actividade de gama-secretase |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7160875B2 (pt) |
| EP (1) | EP1711470B1 (pt) |
| JP (2) | JP4571639B2 (pt) |
| KR (3) | KR20070087233A (pt) |
| CN (1) | CN100593539C (pt) |
| AR (1) | AR045609A1 (pt) |
| AT (1) | ATE428698T1 (pt) |
| AU (1) | AU2004270361B2 (pt) |
| BR (1) | BRPI0413533A (pt) |
| CA (1) | CA2537440C (pt) |
| CO (1) | CO5660268A2 (pt) |
| CR (1) | CR8264A (pt) |
| CY (1) | CY1109225T1 (pt) |
| DE (1) | DE602004020680D1 (pt) |
| DK (1) | DK1711470T3 (pt) |
| EA (1) | EA009940B1 (pt) |
| EC (1) | ECSP066414A (pt) |
| ES (1) | ES2322652T3 (pt) |
| HK (1) | HK1099014A1 (pt) |
| HR (1) | HRP20090266T1 (pt) |
| IL (1) | IL173905A (pt) |
| MA (1) | MA28034A1 (pt) |
| MX (1) | MXPA06002562A (pt) |
| MY (1) | MY141308A (pt) |
| NO (1) | NO20061047L (pt) |
| NZ (1) | NZ545538A (pt) |
| PL (1) | PL1711470T3 (pt) |
| PT (1) | PT1711470E (pt) |
| RS (1) | RS20060146A (pt) |
| SI (1) | SI1711470T1 (pt) |
| TN (1) | TNSN06077A1 (pt) |
| TW (1) | TW200519092A (pt) |
| UA (1) | UA83501C2 (pt) |
| WO (1) | WO2005023772A1 (pt) |
| ZA (1) | ZA200601989B (pt) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2311795T3 (es) * | 2003-02-04 | 2009-02-16 | F. Hoffmann-La Roche Ag | Derivados de malonamida como inhibidores de gamma-secretasa. |
| BRPI0413533A (pt) * | 2003-09-09 | 2006-10-10 | Hoffmann La Roche | derivados de malonamida que bloqueiam a atividade de gama-secretase |
| PT1673347E (pt) * | 2003-10-06 | 2015-11-02 | Hoffmann La Roche | Derivados de dibenzo-azepina e benzo-diazepina substituídos, úteis como inibidores de secretase gama |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| BRPI0709773B8 (pt) | 2006-03-27 | 2021-05-25 | Hoffmann La Roche | derivados de malonamida, processo de produção do mesmo, medicamento, e seus usos como inibidores de gama-secretase no tratamento do mal de alzheimer |
| WO2008034735A2 (en) * | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| BRPI0807341A2 (pt) | 2007-02-02 | 2014-05-20 | Hoffmann La Roche | Derivados de 6-oxo-6,7-di-hidro-5h-dibenzo[b,d]azepin-7-ila |
| ATE506343T1 (de) * | 2007-03-15 | 2011-05-15 | Hoffmann La Roche | Malonamide als orexin-antagonisten |
| US7579464B2 (en) | 2007-05-25 | 2009-08-25 | Hoffmann-La Roche Inc. | Process for preparation of enantiomerically pure compounds |
| US8741889B2 (en) | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| CA2710913A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Use of a gamma-secretase inhibitor for treating cancer |
| US8309299B2 (en) | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| WO2012040444A2 (en) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Treatment of patients with incipient alzheimer's disease |
| KR101330184B1 (ko) | 2010-10-15 | 2013-11-15 | 성균관대학교산학협력단 | 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물 |
| WO2012050370A2 (ko) * | 2010-10-15 | 2012-04-19 | 성균관대학교산학협력단 | 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물 |
| US20120114638A1 (en) | 2010-11-08 | 2012-05-10 | John Boylan | Combination therapy |
| US20120184529A1 (en) | 2011-01-14 | 2012-07-19 | Demario Mark D | Combination therapy |
| US20120225860A1 (en) | 2011-03-02 | 2012-09-06 | John Frederick Boylan | Method for administration of a gamma secretase inhibitor |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| EP2897942B1 (en) | 2012-09-21 | 2016-08-31 | Bristol-Myers Squibb Company | Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch inhibitors |
| US9249157B2 (en) | 2012-09-21 | 2016-02-02 | Bristol-Myers Squibb Company | Tricyclic heterocycle compounds |
| EP2897946B1 (en) | 2012-09-21 | 2016-11-16 | Bristol-Myers Squibb Company | N-substituted bis(fluoroalkkyl)-1,4-benzodiazepinone compounds as notch inhibitors |
| JP2015531792A (ja) | 2012-09-21 | 2015-11-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | １，４−ベンゾジアゼピノン化合物のプロドラッグ |
| EP2897944B1 (en) | 2012-09-21 | 2016-10-26 | Bristol-Myers Squibb Company | Substituted 1,5-benzodiazepinone compounds |
| US9133139B2 (en) | 2012-09-21 | 2015-09-15 | Bristol-Myers Squibb Company | Fluoroalkyl-1,4-benzodiazepinone compounds |
| TWI614238B (zh) | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| WO2014047374A1 (en) | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds |
| EP2897938B1 (en) | 2012-09-21 | 2017-03-15 | Bristol-Myers Squibb Company | Fluoroalkyl dibenzodiazepinone compounds |
| WO2014165718A1 (en) | 2013-04-04 | 2014-10-09 | Bristol-Myers Squibb Company | Combination therapy for the treatment of proliferative diseases |
| EP2932966A1 (en) | 2014-04-16 | 2015-10-21 | Novartis AG | Gamma secretase inhibitors for treating respiratory diseases |
| JP6535822B2 (ja) * | 2015-10-30 | 2019-06-26 | インセプション ３， インコーポレイテッド | 耳の疾患および障害の処置におけるジベンゾアゼピン化合物およびその使用 |
| RU2757276C2 (ru) * | 2016-12-16 | 2021-10-12 | Пайплайн Терапьютикс, Инк. | Способы лечения кохлеарной синаптопатии |
| WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| WO2018201051A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| WO2019034532A1 (en) * | 2017-08-15 | 2019-02-21 | Bayer Aktiengesellschaft | 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides |
| BR112020024351A2 (pt) | 2018-06-01 | 2021-02-23 | Novartis Ag | moléculas de ligação contra bcma e usos das mesmas |
| WO2020261093A1 (en) | 2019-06-24 | 2020-12-30 | Novartis Ag | Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen |
| AU2022339008A1 (en) * | 2021-08-31 | 2024-03-14 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001257006A1 (en) * | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
| GB0012671D0 (en) * | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| ES2311795T3 (es) * | 2003-02-04 | 2009-02-16 | F. Hoffmann-La Roche Ag | Derivados de malonamida como inhibidores de gamma-secretasa. |
| BRPI0413533A (pt) * | 2003-09-09 | 2006-10-10 | Hoffmann La Roche | derivados de malonamida que bloqueiam a atividade de gama-secretase |
-
2004
- 2004-08-31 BR BRPI0413533-4A patent/BRPI0413533A/pt not_active Application Discontinuation
- 2004-08-31 PL PL04764665T patent/PL1711470T3/pl unknown
- 2004-08-31 SI SI200431116T patent/SI1711470T1/sl unknown
- 2004-08-31 KR KR1020077017458A patent/KR20070087233A/ko not_active Application Discontinuation
- 2004-08-31 JP JP2006525701A patent/JP4571639B2/ja active Active
- 2004-08-31 KR KR1020067004763A patent/KR100834177B1/ko active IP Right Grant
- 2004-08-31 ES ES04764665T patent/ES2322652T3/es active Active
- 2004-08-31 AT AT04764665T patent/ATE428698T1/de active
- 2004-08-31 DK DK04764665T patent/DK1711470T3/da active
- 2004-08-31 UA UAA200602854A patent/UA83501C2/uk unknown
- 2004-08-31 KR KR1020077017457A patent/KR100838852B1/ko active IP Right Grant
- 2004-08-31 EA EA200600503A patent/EA009940B1/ru not_active IP Right Cessation
- 2004-08-31 DE DE602004020680T patent/DE602004020680D1/de active Active
- 2004-08-31 AU AU2004270361A patent/AU2004270361B2/en not_active Ceased
- 2004-08-31 NZ NZ545538A patent/NZ545538A/en not_active IP Right Cessation
- 2004-08-31 CA CA2537440A patent/CA2537440C/en not_active Expired - Fee Related
- 2004-08-31 PT PT04764665T patent/PT1711470E/pt unknown
- 2004-08-31 WO PCT/EP2004/009700 patent/WO2005023772A1/en active Application Filing
- 2004-08-31 CN CN200480032641A patent/CN100593539C/zh active Active
- 2004-08-31 RS YUP-2006/0146A patent/RS20060146A/sr unknown
- 2004-08-31 EP EP04764665A patent/EP1711470B1/en active Active
- 2004-08-31 MX MXPA06002562A patent/MXPA06002562A/es active IP Right Grant
- 2004-09-02 US US10/933,177 patent/US7160875B2/en active Active
- 2004-09-06 MY MYPI20043603A patent/MY141308A/en unknown
- 2004-09-06 TW TW093126876A patent/TW200519092A/zh unknown
- 2004-09-08 AR ARP040103214A patent/AR045609A1/es not_active Application Discontinuation
-
2006
- 2006-02-23 IL IL173905A patent/IL173905A/en active IP Right Grant
- 2006-02-23 CO CO06018272A patent/CO5660268A2/es not_active Application Discontinuation
- 2006-03-01 CR CR8264A patent/CR8264A/es not_active Application Discontinuation
- 2006-03-03 NO NO20061047A patent/NO20061047L/no not_active Application Discontinuation
- 2006-03-07 TN TNP2006000077A patent/TNSN06077A1/fr unknown
- 2006-03-07 EC EC2006006414A patent/ECSP066414A/es unknown
- 2006-03-08 ZA ZA200601989A patent/ZA200601989B/en unknown
- 2006-03-10 MA MA28867A patent/MA28034A1/fr unknown
-
2007
- 2007-05-21 HK HK07105326.7A patent/HK1099014A1/xx not_active IP Right Cessation
-
2009
- 2009-05-12 HR HR20090266T patent/HRP20090266T1/xx unknown
- 2009-07-10 CY CY20091100729T patent/CY1109225T1/el unknown
-
2010
- 2010-06-18 JP JP2010138970A patent/JP2010229153A/ja active Pending
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