PT1471871E - Tratamento de disfunção neurológica compreendendo sulfamatos de frutopiranose e eritropoietina - Google Patents
Tratamento de disfunção neurológica compreendendo sulfamatos de frutopiranose e eritropoietina Download PDFInfo
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- PT1471871E PT1471871E PT02724904T PT02724904T PT1471871E PT 1471871 E PT1471871 E PT 1471871E PT 02724904 T PT02724904 T PT 02724904T PT 02724904 T PT02724904 T PT 02724904T PT 1471871 E PT1471871 E PT 1471871E
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Landscapes
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| US7674776B2 (en) | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| KR100896971B1 (ko) * | 2001-02-02 | 2009-05-14 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 프락토피라노오스 설파메이트 및 에리트로포이에틴을포함하는 신경계 기능장애 치료법 |
| US20030060423A1 (en) * | 2001-08-30 | 2003-03-27 | Plata-Salaman Carlos R. | Co-therapy for the treatment of dementia and associated behavioral manifestations comprising anticonvulsant derivatives and acetylcholinesterase inhibitors |
| JP2005534650A (ja) * | 2002-06-11 | 2005-11-17 | ザ バーナム インスティテュート | エリスロポイエチンおよびインスリン様増殖因子の神経保護的相乗作用 |
| US20030235576A1 (en) * | 2002-06-15 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New drug combinations for the treatment of ischaemic conditions |
| DE10226814A1 (de) * | 2002-06-15 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände |
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| US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| AT500929B1 (de) | 2004-11-09 | 2007-03-15 | Medizinische Uni Wien Muw | Pharmazeutische zubereitung die erythropoietin enthält |
| WO2007020922A1 (ja) * | 2005-08-17 | 2007-02-22 | Chugai Seiyaku Kabushiki Kaisha | 脳疾患の治療剤および予防剤 |
| US8124095B2 (en) * | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
| US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| WO2008022349A2 (en) * | 2006-08-18 | 2008-02-21 | Armagen Technologies, Inc. | Agents for blood-brain barrier delivery |
| WO2008088820A2 (en) * | 2007-01-16 | 2008-07-24 | The Johns Hopkins University | Glutamate receptor antagonists and methods of use |
| US20090011040A1 (en) * | 2007-05-02 | 2009-01-08 | Naash Muna I | Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases |
| RU2335296C1 (ru) * | 2007-06-26 | 2008-10-10 | Сергей Марович Дудкин | Фармацевтическая композиция для профилактики и лечения неврологических заболеваний |
| CA2694762A1 (en) | 2007-07-27 | 2009-02-05 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
| CA2724841A1 (en) * | 2008-05-22 | 2009-11-26 | Edison Pharmaceuticals, Inc. | Treatment of mitochondrial diseases with an erythropoietin mimetic |
| US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
| US20090304789A1 (en) | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| EP2408474B1 (en) | 2009-03-18 | 2019-06-26 | Armagen, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| HUE044865T2 (hu) | 2009-10-09 | 2019-11-28 | Armagen Inc | Eljárások és készítmények a központi idegrendszerben iduronát-2-szulfatáz-aktivitás növelésére |
| ES2983576T3 (es) | 2011-12-02 | 2024-10-23 | Armagen Inc | Métodos y composiciones para aumentar la actividad arilsulfatasa en el SNC |
| US9457008B2 (en) | 2012-03-23 | 2016-10-04 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Joint product comprising synephrine and topiramate |
| CN102579367B (zh) | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| CN103316026B (zh) | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
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| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| DK173067B1 (da) | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
| US5242942A (en) | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US6153407A (en) | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| JPH09501418A (ja) | 1993-07-19 | 1997-02-10 | アムジエン・インコーポレーテツド | エアゾル化タンパク質の安定化 |
| US5571787A (en) | 1993-07-30 | 1996-11-05 | Myelos Corporation | Prosaposin as a neurotrophic factor |
| US5700909A (en) | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| ZA946122B (en) | 1993-08-17 | 1995-03-20 | Amgen Inc | Erythropoietin analogs |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| DE69434652T2 (de) * | 1993-12-23 | 2007-03-01 | Ortho-Mcneil Pharmaceutical, Inc. | Antikonvulsive pseudofructopyranose sulfamate |
| IL116085A (en) | 1994-12-16 | 1999-12-31 | Ortho Pharma Corp | Spray dried erythropoietin |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5753694A (en) | 1996-06-28 | 1998-05-19 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating amyotrophic lateral sclerosis (ALS) |
| WO1998000124A1 (en) | 1996-06-28 | 1998-01-08 | Ortho Pharmaceutical Corporation | Use of topiramate or derivatives thereof for the manufacture of a medicament for the treatment of postischemic neurodegeneration |
| DE69736780T2 (de) | 1996-08-02 | 2007-09-06 | Ortho-Mcneil Pharmaceutical, Inc. | Polypeptide mit einzelnem kovalent gebundenen n-terminalen wasserlöslichen polymer |
| ATE341625T1 (de) | 1997-07-23 | 2006-10-15 | Roche Diagnostics Gmbh | Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren |
| PT902085E (pt) | 1997-09-01 | 2004-02-27 | Aventis Pharma Gmbh | Eritropoietina humana recombinante com perfil de glicosilacao vantajoso |
| US6165783A (en) | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
| AU759467B2 (en) * | 1998-04-02 | 2003-04-17 | Avicena Group, Inc. | Compositions containing a combination of a creatine compound and a second agent |
| AU775422B2 (en) | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
| JP2003521471A (ja) * | 1999-04-08 | 2003-07-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 慢性神経変性疾患を処置することに有用な抗痙攣薬誘導体 |
| PL352223A1 (en) * | 1999-04-13 | 2003-08-11 | Kenneth S Warren Inst | Modulation of excitable tissue function by peripherally administered erythropoietin |
| CA2270795A1 (en) * | 1999-05-05 | 2000-11-05 | Gestilab Inc. | Neuroprotective compositions and uses thereof |
| KR100896971B1 (ko) * | 2001-02-02 | 2009-05-14 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 프락토피라노오스 설파메이트 및 에리트로포이에틴을포함하는 신경계 기능장애 치료법 |
-
2002
- 2002-01-24 KR KR1020037010232A patent/KR100896971B1/ko not_active Expired - Fee Related
- 2002-01-24 JP JP2002563882A patent/JP2005501801A/ja not_active Ceased
- 2002-01-24 RU RU2003124059/14A patent/RU2317086C2/ru not_active IP Right Cessation
- 2002-01-24 DK DK02724904T patent/DK1471871T3/da active
- 2002-01-24 US US10/056,828 patent/US6908902B2/en not_active Expired - Lifetime
- 2002-01-24 CA CA002437333A patent/CA2437333A1/en not_active Abandoned
- 2002-01-24 ES ES02724904T patent/ES2284858T3/es not_active Expired - Lifetime
- 2002-01-24 WO PCT/US2002/003096 patent/WO2002064085A2/en not_active Ceased
- 2002-01-24 AT AT02724904T patent/ATE361089T1/de active
- 2002-01-24 NZ NZ548578A patent/NZ548578A/en not_active IP Right Cessation
- 2002-01-24 PT PT02724904T patent/PT1471871E/pt unknown
- 2002-01-24 DE DE60219961T patent/DE60219961T8/de active Active
- 2002-01-24 EP EP02724904A patent/EP1471871B1/en not_active Expired - Lifetime
- 2002-01-24 MX MXPA03006952A patent/MXPA03006952A/es active IP Right Grant
-
2003
- 2003-08-01 NO NO20033440A patent/NO20033440L/no not_active Application Discontinuation
- 2003-09-01 ZA ZA2003/06818A patent/ZA200306818B/en unknown
-
2005
- 2005-01-31 US US11/047,420 patent/US20050261182A1/en not_active Abandoned
-
2007
- 2007-07-13 CY CY20071100943T patent/CY1106733T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002064085A3 (en) | 2004-09-10 |
| DE60219961T2 (de) | 2008-01-17 |
| CA2437333A1 (en) | 2002-08-22 |
| KR100896971B1 (ko) | 2009-05-14 |
| CY1106733T1 (el) | 2012-05-23 |
| KR20040011458A (ko) | 2004-02-05 |
| JP2005501801A (ja) | 2005-01-20 |
| RU2003124059A (ru) | 2005-01-27 |
| ZA200306818B (en) | 2005-02-23 |
| DE60219961T8 (de) | 2008-04-17 |
| EP1471871B1 (en) | 2007-05-02 |
| NZ548578A (en) | 2008-03-28 |
| EP1471871A4 (en) | 2005-11-09 |
| US6908902B2 (en) | 2005-06-21 |
| DE60219961D1 (de) | 2007-06-14 |
| ES2284858T3 (es) | 2007-11-16 |
| RU2317086C2 (ru) | 2008-02-20 |
| ATE361089T1 (de) | 2007-05-15 |
| NO20033440L (no) | 2003-09-29 |
| MXPA03006952A (es) | 2004-10-15 |
| EP1471871A2 (en) | 2004-11-03 |
| DK1471871T3 (da) | 2007-09-17 |
| US20020169109A1 (en) | 2002-11-14 |
| WO2002064085A2 (en) | 2002-08-22 |
| NO20033440D0 (no) | 2003-08-01 |
| US20050261182A1 (en) | 2005-11-24 |
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