PT1466617E - Utilização de uma composição farmacêutica contendo o factor de crescimento epidérmico (egf) para prevenção da amputação do pé diabético - Google Patents

Utilização de uma composição farmacêutica contendo o factor de crescimento epidérmico (egf) para prevenção da amputação do pé diabético Download PDF

Info

Publication number
PT1466617E
PT1466617E PT27964915T PT02796491T PT1466617E PT 1466617 E PT1466617 E PT 1466617E PT 27964915 T PT27964915 T PT 27964915T PT 02796491 T PT02796491 T PT 02796491T PT 1466617 E PT1466617 E PT 1466617E
Authority
PT
Portugal
Prior art keywords
egf
pharmaceutical composition
growth factor
composition containing
epidermal growth
Prior art date
Application number
PT27964915T
Other languages
English (en)
Inventor
Jorge Berlanga Acosta
Fernandez Montequin I Jos
Calixto Valdes Perez
Neobalis Franco Perez
Ingrid Rojas Constantin
Hector Santana Milian
Larissa Chacon Corvea
Gerardo E Guillen Nieto
Luis Herrera Martinez
Leonardo Canan-Haden Frias
Haydee Geronimo Perez
Jorge Sotolongo Pena
Original Assignee
Jorge Berlanga Acosta
Fernandez Montequin I Jos
Calixto Valdes Perez
Neobalis Franco Perez
Ingrid Rojas Constantin
Hector Santana Milian
Larissa Chacon Corvea
Gerardo E Guillen Nieto
Luis Herrera Martinez
Leonardo Canan-Haden Frias
Haydee Geronimo Perez
Jorge Sotolongo Pena
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40239814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1466617(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jorge Berlanga Acosta, Fernandez Montequin I Jos, Calixto Valdes Perez, Neobalis Franco Perez, Ingrid Rojas Constantin, Hector Santana Milian, Larissa Chacon Corvea, Gerardo E Guillen Nieto, Luis Herrera Martinez, Leonardo Canan-Haden Frias, Haydee Geronimo Perez, Jorge Sotolongo Pena, Ct Ingenieria Genetica Biotech filed Critical Jorge Berlanga Acosta
Publication of PT1466617E publication Critical patent/PT1466617E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT27964915T 2001-12-20 2002-12-04 Utilização de uma composição farmacêutica contendo o factor de crescimento epidérmico (egf) para prevenção da amputação do pé diabético PT1466617E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20010308A CU23043A1 (es) 2001-12-20 2001-12-20 Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.

Publications (1)

Publication Number Publication Date
PT1466617E true PT1466617E (pt) 2009-05-20

Family

ID=40239814

Family Applications (1)

Application Number Title Priority Date Filing Date
PT27964915T PT1466617E (pt) 2001-12-20 2002-12-04 Utilização de uma composição farmacêutica contendo o factor de crescimento epidérmico (egf) para prevenção da amputação do pé diabético

Country Status (22)

Country Link
US (2) US7465704B2 (pt)
EP (1) EP1466617B1 (pt)
JP (1) JP4808378B2 (pt)
KR (1) KR100795654B1 (pt)
CN (1) CN1306954C (pt)
AR (1) AR037824A1 (pt)
AT (1) ATE422897T1 (pt)
AU (1) AU2002361923B2 (pt)
BR (1) BRPI0215214B8 (pt)
CA (1) CA2470971C (pt)
CU (1) CU23043A1 (pt)
DE (1) DE60231248D1 (pt)
DK (1) DK1466617T3 (pt)
ES (1) ES2322568T3 (pt)
HK (1) HK1077740A1 (pt)
MX (1) MXPA04005831A (pt)
MY (1) MY139214A (pt)
PT (1) PT1466617E (pt)
RU (1) RU2289424C2 (pt)
SI (1) SI1466617T1 (pt)
UA (1) UA80813C2 (pt)
WO (1) WO2003053458A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1077740A1 (en) 2001-12-20 2006-02-24 Ct Ingenieria Genetica Biotech Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation
CU23529A1 (es) * 2005-03-02 2010-06-17 Ct Ingenieria Genetica Biotech Combinación de egf/ghrp-6 para la neuroregeneración del sistema nervioso central posterior al dano autoinmune
CU23411B6 (es) * 2005-12-29 2009-09-08 Ct Ingenieria Genetica Biotech Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético
CU23388B6 (es) * 2006-01-31 2009-07-16 Ct Ingenieria Genetica Biotech Composición farmacéutica de microesferas para prevenir la amputación del pie diabético
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CU23526B6 (es) * 2006-10-03 2010-05-19 Ct Ingenieria Genetica Biotech Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética
US8211947B2 (en) * 2008-01-28 2012-07-03 Guillermo Selman-Housein Sosa Composition and method for treating and preventing musculoskeletal and connective tissue disorders
ES2340902B1 (es) 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
CN101496486B (zh) * 2009-03-13 2011-02-16 新疆巴音郭楞蒙古自治州农业科学研究所 一种蘑菇栽培方法
ES2357601B1 (es) 2011-01-26 2012-03-21 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento de preparación de derivados de glicosaminoglicanos donadores de óxido n�?trico y su uso en tratamiento de úlceras crónicas.
ES2468740B1 (es) 2012-11-13 2015-04-01 Consejo Superior De Investigaciones Científicas (Csic) Apósito para cicatrización de heridas comprometidas
US9387151B2 (en) 2013-08-20 2016-07-12 Anutra Medical, Inc. Syringe fill system and method
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
CN104173366A (zh) * 2014-09-14 2014-12-03 陈钏黄 一种三磷酸腺苷二钠在制备治疗糖尿病足药物中的应用
MX2016016339A (es) * 2016-12-09 2018-06-08 Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A S De C V Composicion coadyuvante de un factor de crecimiento y un neuropeptido para acelerar la cicatrizacion de heridas y la repitelizacion de organos.
WO2019006127A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE RENAL CELL
EP3644965A4 (en) * 2017-06-28 2021-05-05 Rutgers, The State University of New Jersey ORGANOIDS DERIVED FROM A SINGLE BRAIN CELL
CU20190022A7 (es) * 2019-03-18 2020-10-20 Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma Composición farmacéutica para el tratamiento de la úlcera del pie diabético
KR102581240B1 (ko) 2020-09-21 2023-09-22 고려대학교 산학협력단 유전자의 특이적 메틸화를 이용하여 당뇨족부궤양 재발 또는 예후를 예측하는 방법
WO2022060178A1 (ko) 2020-09-21 2022-03-24 고려대학교 산학협력단 유전자의 특이적 메틸화를 이용하여 당뇨족부궤양 재발 또는 예후를 예측하는 방법
KR20230146379A (ko) 2022-04-12 2023-10-19 고려대학교 산학협력단 마이크로바이옴을 이용하여 당뇨족부궤양 예후를 예측하는 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
NZ226171A (en) 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US5034375A (en) * 1988-08-10 1991-07-23 Institute Of Molecular Biology, Inc. Process of wound healing using PDGF and EGF
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
AU633078B2 (en) 1989-04-04 1993-01-21 Alcon Laboratories, Inc. The use of liposomes for the delivery of therapeutic agents to wounds, cuts and abrasions
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
JPH04501123A (ja) 1989-08-01 1992-02-27 ザ　ユニヴァーシティ　オブ　ミシガン 脱水／水補給リポソームに被嚢されたペプチド／タンパク質の局所送達
AU629316B2 (en) 1990-04-11 1992-10-01 Flora Inc. Periodontal disease treatment system
WO1992009301A1 (en) * 1990-11-27 1992-06-11 The American National Red Cross Tissue sealant and growth factor containing compositions that promote accelerated wound healing
CN1160582A (zh) * 1996-12-27 1997-10-01 暨南大学生物工程研究所 含有细胞生长因子的皮肤外用组合物
AU2001279073B2 (en) * 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
HK1077740A1 (en) 2001-12-20 2006-02-24 Ct Ingenieria Genetica Biotech Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation
WO2003075949A1 (en) 2002-03-12 2003-09-18 Bio-Click Technologies Ltd. Method and composition for treating skin wounds with epidermal growth factor
CN1720989A (zh) 2004-07-15 2006-01-18 深圳市清华源兴生物医药科技有限公司 一种表皮生长因子缓释微球及其制备方法与应用

Also Published As

Publication number Publication date
SI1466617T1 (sl) 2009-08-31
MY139214A (en) 2009-08-28
CA2470971A1 (en) 2003-07-03
CN1306954C (zh) 2007-03-28
BR0215214A (pt) 2004-12-07
EP1466617B1 (en) 2009-02-18
RU2004122091A (ru) 2005-04-10
HK1077740A1 (en) 2006-02-24
KR20040094669A (ko) 2004-11-10
AR037824A1 (es) 2004-12-09
BRPI0215214B8 (pt) 2021-05-25
ES2322568T3 (es) 2009-06-23
AU2002361923A1 (en) 2003-07-09
MXPA04005831A (es) 2004-09-13
US20050107294A1 (en) 2005-05-19
JP2005516024A (ja) 2005-06-02
WO2003053458A1 (es) 2003-07-03
CN1620308A (zh) 2005-05-25
ATE422897T1 (de) 2009-03-15
JP4808378B2 (ja) 2011-11-02
UA80813C2 (en) 2007-11-12
EP1466617A1 (en) 2004-10-13
DK1466617T3 (da) 2009-06-15
CU23043A1 (es) 2005-05-20
US20080312139A1 (en) 2008-12-18
CA2470971C (en) 2011-02-01
US7465704B2 (en) 2008-12-16
BRPI0215214B1 (pt) 2017-05-30
AU2002361923B2 (en) 2006-02-02
RU2289424C2 (ru) 2006-12-20
DE60231248D1 (de) 2009-04-02
KR100795654B1 (ko) 2008-01-21
US7799760B2 (en) 2010-09-21

Similar Documents

Publication Publication Date Title
PT1466617E (pt) Utilização de uma composição farmacêutica contendo o factor de crescimento epidérmico (egf) para prevenção da amputação do pé diabético
EP1610725A4 (en) ENOVOVASCULAR PROSTHESIS WITH A LAYER OF BIOLOGICAL TISSUE
ZA200806112B (en) Use of a topical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention
AU2001287144A1 (en) Fixation band for affixing a prosthetic heart valve to tissue
AU2002323044A1 (en) Delivering material to a patient
AU2001271778A1 (en) Prosthetic foot
AU2002249111A1 (en) Process for the preparation of a medical implant
EP1147747A3 (en) Dental capsule for placement of ultra-high viscosity dental composite material
AU2002320358A1 (en) Rotary osteotome for dental implant
AU2001246883A1 (en) Stabilized pharmaceutical compositions containing calcium channel blockers
AU2001231042A1 (en) Optical measurements of bone composition
IL137430A0 (en) A series of new illuminating devices for medical use
AU2002223908A1 (en) Use of insulin containing composition for wound treatment
AU2002330095A1 (en) Flavonoids for treatment of diabetes
HK1064953A1 (en) Compositions for nasal administration of insulin
AU2002346143A1 (en) Compositions for nasal administration of insulin
GB9926736D0 (en) Compositions expressing a pressure of carbon dioxide for improved healing of wounds
EP1248844B8 (en) Analogs of human basic fibroblast growth factor
AU2001258550A1 (en) Insulin formulation for inhalation
EP1372616A4 (en) STABLE PHARMACEUTICAL COMPOSITION BASED ON PRAVASTATIN
AU2001294861A1 (en) Resorbable prosthesis for medical treatment
AU2002231927A1 (en) Use of rhein for preparing a medicine for treating a high level of il-1
AU2003226276A1 (en) Oxygen enriched implant for orthopedic wounds
PT1970071E (pt) Uso de uma composição tópica com factor de crescimento epidérmico (egf) para a prevenção da amputação do pé diabético
AU2002333193A1 (en) A pharmaceutical composition for dermal application