PT1404811E - O monóxido de carbono melhora os resultados nos transplantes de tecidos e de orgãos e suprime a apoptose - Google Patents
O monóxido de carbono melhora os resultados nos transplantes de tecidos e de orgãos e suprime a apoptose Download PDFInfo
- Publication number
- PT1404811E PT1404811E PT02747932T PT02747932T PT1404811E PT 1404811 E PT1404811 E PT 1404811E PT 02747932 T PT02747932 T PT 02747932T PT 02747932 T PT02747932 T PT 02747932T PT 1404811 E PT1404811 E PT 1404811E
- Authority
- PT
- Portugal
- Prior art keywords
- carbon monoxide
- tissue
- organ transplants
- suppresses apoptosis
- improves outcomes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Physiology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30028901P | 2001-06-21 | 2001-06-21 | |
US33434001P | 2001-11-29 | 2001-11-29 | |
US33797401P | 2001-12-07 | 2001-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1404811E true PT1404811E (pt) | 2009-01-22 |
Family
ID=27404726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02747932T PT1404811E (pt) | 2001-06-21 | 2002-06-21 | O monóxido de carbono melhora os resultados nos transplantes de tecidos e de orgãos e suprime a apoptose |
Country Status (26)
Country | Link |
---|---|
US (2) | US7238469B2 (pt) |
EP (2) | EP1404811B1 (pt) |
JP (1) | JP4521183B2 (pt) |
KR (1) | KR20040032115A (pt) |
CN (1) | CN100502650C (pt) |
AT (1) | ATE413883T1 (pt) |
AU (2) | AU2002318377B2 (pt) |
BG (1) | BG108492A (pt) |
BR (1) | BR0210599A (pt) |
CA (1) | CA2451266A1 (pt) |
CY (1) | CY1108798T1 (pt) |
CZ (1) | CZ20033448A3 (pt) |
DE (1) | DE60229848D1 (pt) |
DK (1) | DK1404811T3 (pt) |
ES (1) | ES2316583T3 (pt) |
HK (1) | HK1067380A1 (pt) |
HU (1) | HUP0400371A3 (pt) |
MX (1) | MXPA03012031A (pt) |
NO (1) | NO20035637L (pt) |
NZ (1) | NZ562962A (pt) |
PL (1) | PL367544A1 (pt) |
PT (1) | PT1404811E (pt) |
SG (1) | SG147305A1 (pt) |
SI (1) | SI1404811T1 (pt) |
SK (1) | SK15942003A3 (pt) |
WO (1) | WO2003000114A2 (pt) |
Families Citing this family (40)
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US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
HUP0400371A3 (en) * | 2001-06-21 | 2010-06-28 | Beth Israel Hospital | Use of carbon monoxide for preparation of pharmaceutical composition available for improving survival or function of organ following transplantation |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7011854B2 (en) * | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
WO2003072024A2 (en) | 2002-02-13 | 2003-09-04 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating vascular disease |
AU2003216368B2 (en) | 2002-04-15 | 2007-08-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating ileus |
RS91104A (en) * | 2002-04-15 | 2007-02-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Methods of treating necrotizing enterocolitis |
AU2003226366A1 (en) | 2002-04-15 | 2003-11-03 | Beth Israel Deaconess Medical Center | Use of heme oxygenase-1 and products of heme degradation |
CN1668314B (zh) | 2002-05-17 | 2011-01-12 | 耶鲁大学 | 治疗肝炎的方法 |
PL374375A1 (en) * | 2002-06-05 | 2005-10-17 | Yale University | Methods of treating angiogenesis, tumor growth, and metastasis |
RS110504A (en) * | 2002-06-21 | 2007-02-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
CN1719975A (zh) * | 2002-11-07 | 2006-01-11 | 联邦高等教育系统匹兹堡大学 | 出血性休克的治疗 |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
WO2005041655A1 (en) * | 2003-10-22 | 2005-05-12 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
EP1552840A1 (en) * | 2004-01-07 | 2005-07-13 | Aga Ab | Use of a xenon/carbon monoxide mixture for the protection of cells |
US20060234915A1 (en) * | 2005-03-07 | 2006-10-19 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (CO) and nitric oxide (NO) to tissue using heme proteins as carriers |
EP1937059A2 (en) | 2005-07-27 | 2008-07-02 | University Of North Carolina At Charlotte | Composition and method for the restoration and preservation of transplant organs procured from dcd donors |
US20070207993A1 (en) * | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
US8887721B2 (en) | 2006-11-07 | 2014-11-18 | The General Hospital Corporation | Attenuation of vasoactive oxygen carrier-induced vasoconstriction |
SG176149A1 (en) | 2009-05-27 | 2011-12-29 | Ikaria Holdings Inc | Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery |
JP2011010865A (ja) | 2009-06-30 | 2011-01-20 | Ikaria Holdings Inc | 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法 |
EP2663193B1 (en) | 2011-01-14 | 2019-05-08 | Children's Hospital Los Angeles | Solution of carbon monoxide for treatment of disease, including sickle cell disease |
US8927750B2 (en) | 2011-02-04 | 2015-01-06 | Universitaet Zu Koeln | Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules |
JP2014510731A (ja) | 2011-03-16 | 2014-05-01 | メイヨー ファンデーション フォー メディカル エデュケーション アンド リサーチ | 赤血球製剤および血小板製剤の有効貯蔵を延ばすための方法および材料 |
ES2656237T3 (es) | 2011-04-19 | 2018-02-26 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono y usos de las mismas |
EP3391891A3 (en) * | 2011-06-10 | 2019-01-02 | VERO Biotech LLC | Pressurized vessel of nitric oxide (no) |
EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
WO2013022946A1 (en) | 2011-08-09 | 2013-02-14 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating dna damage |
ES2981406T3 (es) | 2013-03-15 | 2024-10-08 | Mallinckrodt Pharmaceuticals Ireland Ltd | Administración y monitorización de óxido nítrico en fluidos ex vivo |
US9629358B2 (en) | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
CN105288599A (zh) * | 2015-10-22 | 2016-02-03 | 徐州医学院 | 血红素氧化酶-2在制备抑制器官移植免疫排斥制剂中的应用 |
JP7249331B2 (ja) * | 2017-08-25 | 2023-03-30 | マリンクロット ホスピタル プロダクツ アイピー アンリミテッド カンパニー | 器官の生存率を改善する方法 |
EP3524290A1 (en) | 2018-02-09 | 2019-08-14 | Julius-Maximilians-Universitaet Wuerzburg | Method and system for monitoring carbon monoxide (co) administration to ex-vivo fluids |
CN116076484A (zh) * | 2022-11-30 | 2023-05-09 | 武汉大学 | 一种修复肾脏损伤的低温携氧机械灌注液及其应用 |
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HUP0400371A3 (en) * | 2001-06-21 | 2010-06-28 | Beth Israel Hospital | Use of carbon monoxide for preparation of pharmaceutical composition available for improving survival or function of organ following transplantation |
US7011854B2 (en) * | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
WO2003072024A2 (en) * | 2002-02-13 | 2003-09-04 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating vascular disease |
RS91104A (en) * | 2002-04-15 | 2007-02-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Methods of treating necrotizing enterocolitis |
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-
2002
- 2002-06-21 HU HU0400371A patent/HUP0400371A3/hu unknown
- 2002-06-21 NZ NZ562962A patent/NZ562962A/en not_active IP Right Cessation
- 2002-06-21 AU AU2002318377A patent/AU2002318377B2/en not_active Ceased
- 2002-06-21 DE DE60229848T patent/DE60229848D1/de not_active Expired - Lifetime
- 2002-06-21 MX MXPA03012031A patent/MXPA03012031A/es active IP Right Grant
- 2002-06-21 US US10/177,930 patent/US7238469B2/en not_active Expired - Lifetime
- 2002-06-21 EP EP02747932A patent/EP1404811B1/en not_active Revoked
- 2002-06-21 DK DK02747932T patent/DK1404811T3/da active
- 2002-06-21 CN CNB028163443A patent/CN100502650C/zh not_active Expired - Fee Related
- 2002-06-21 CZ CZ20033448A patent/CZ20033448A3/cs unknown
- 2002-06-21 SK SK1594-2003A patent/SK15942003A3/sk not_active Application Discontinuation
- 2002-06-21 SI SI200230772T patent/SI1404811T1/sl unknown
- 2002-06-21 JP JP2003506568A patent/JP4521183B2/ja not_active Expired - Fee Related
- 2002-06-21 SG SG200601852-7A patent/SG147305A1/en unknown
- 2002-06-21 EP EP08168801A patent/EP2033514A3/en not_active Withdrawn
- 2002-06-21 ES ES02747932T patent/ES2316583T3/es not_active Expired - Lifetime
- 2002-06-21 WO PCT/US2002/019687 patent/WO2003000114A2/en active Application Filing
- 2002-06-21 PL PL02367544A patent/PL367544A1/xx unknown
- 2002-06-21 KR KR10-2003-7016702A patent/KR20040032115A/ko active IP Right Grant
- 2002-06-21 AT AT02747932T patent/ATE413883T1/de not_active IP Right Cessation
- 2002-06-21 CA CA002451266A patent/CA2451266A1/en not_active Abandoned
- 2002-06-21 BR BR0210599-3A patent/BR0210599A/pt not_active IP Right Cessation
- 2002-06-21 PT PT02747932T patent/PT1404811E/pt unknown
-
2003
- 2003-12-17 NO NO20035637A patent/NO20035637L/no not_active Application Discontinuation
- 2003-12-22 BG BG108492A patent/BG108492A/xx unknown
-
2004
- 2004-09-10 HK HK04107560.1A patent/HK1067380A1/xx not_active IP Right Cessation
-
2006
- 2006-04-10 US US11/401,722 patent/US20070202083A1/en not_active Abandoned
-
2008
- 2008-09-18 AU AU2008221551A patent/AU2008221551A1/en not_active Ceased
-
2009
- 2009-02-09 CY CY20091100145T patent/CY1108798T1/el unknown
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