DE60229848D1 - - und organtransplantationen und unterdrückt apoptose - Google Patents
- und organtransplantationen und unterdrückt apoptoseInfo
- Publication number
- DE60229848D1 DE60229848D1 DE60229848T DE60229848T DE60229848D1 DE 60229848 D1 DE60229848 D1 DE 60229848D1 DE 60229848 T DE60229848 T DE 60229848T DE 60229848 T DE60229848 T DE 60229848T DE 60229848 D1 DE60229848 D1 DE 60229848D1
- Authority
- DE
- Germany
- Prior art keywords
- organtransplantations
- methods
- cells
- function
- suppressing apoptosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30028901P | 2001-06-21 | 2001-06-21 | |
US33434001P | 2001-11-29 | 2001-11-29 | |
US33797401P | 2001-12-07 | 2001-12-07 | |
PCT/US2002/019687 WO2003000114A2 (en) | 2001-06-21 | 2002-06-21 | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60229848D1 true DE60229848D1 (de) | 2008-12-24 |
Family
ID=27404726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60229848T Expired - Lifetime DE60229848D1 (de) | 2001-06-21 | 2002-06-21 | - und organtransplantationen und unterdrückt apoptose |
Country Status (26)
Country | Link |
---|---|
US (2) | US7238469B2 (de) |
EP (2) | EP1404811B1 (de) |
JP (1) | JP4521183B2 (de) |
KR (1) | KR20040032115A (de) |
CN (1) | CN100502650C (de) |
AT (1) | ATE413883T1 (de) |
AU (2) | AU2002318377B2 (de) |
BG (1) | BG108492A (de) |
BR (1) | BR0210599A (de) |
CA (1) | CA2451266A1 (de) |
CY (1) | CY1108798T1 (de) |
CZ (1) | CZ20033448A3 (de) |
DE (1) | DE60229848D1 (de) |
DK (1) | DK1404811T3 (de) |
ES (1) | ES2316583T3 (de) |
HK (1) | HK1067380A1 (de) |
HU (1) | HUP0400371A3 (de) |
MX (1) | MXPA03012031A (de) |
NO (1) | NO20035637L (de) |
NZ (1) | NZ562962A (de) |
PL (1) | PL367544A1 (de) |
PT (1) | PT1404811E (de) |
SG (1) | SG147305A1 (de) |
SI (1) | SI1404811T1 (de) |
SK (1) | SK15942003A3 (de) |
WO (1) | WO2003000114A2 (de) |
Families Citing this family (40)
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---|---|---|---|---|
US8128963B2 (en) | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
PT1404811E (pt) | 2001-06-21 | 2009-01-22 | Beth Israel Hospital | O monóxido de carbono melhora os resultados nos transplantes de tecidos e de orgãos e suprime a apoptose |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
CN1646140A (zh) * | 2002-02-04 | 2005-07-27 | 阿尔法玛药品研发有限公司 | 可释放co的化合物在用于治疗炎症药物的制备中的应用 |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
CN100393323C (zh) | 2002-02-13 | 2008-06-11 | 贝思·伊斯雷尔·迪科尼斯医药中心 | 治疗血管疾病的方法 |
CN100496509C (zh) | 2002-04-15 | 2009-06-10 | 联邦高等教育系统匹兹堡大学 | 一氧化碳产品及其对于肠梗阻的用途 |
CN1652802A (zh) | 2002-04-15 | 2005-08-10 | 联邦高等教育系统匹兹堡大学 | 治疗坏死性小肠结肠炎的方法 |
CA2482260A1 (en) | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center Inc. | Use of heme oxygenase-1 and products of heme degradation |
CA2485465A1 (en) * | 2002-05-17 | 2003-11-27 | Yale University | Methods of treating hepatitis |
EP1509237A4 (de) * | 2002-06-05 | 2006-07-12 | Univ Yale | Verfahren zur behandlung von angiogenese, tumorwachstum und metastasen |
MXPA04012863A (es) * | 2002-06-21 | 2005-03-31 | Univ Pittsburgh | Uso farmaceutico de oxido nitrico, heme oxigenasa-1 y productos de degradacion de heme. |
AU2003283982A1 (en) * | 2002-11-07 | 2004-06-03 | University Of Pittsburgh Of The Commonwealth System Of High Education | Treatment for hemorrhagic shock |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
AU2004283729A1 (en) * | 2003-10-22 | 2005-05-06 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells |
EP1552840A1 (de) * | 2004-01-07 | 2005-07-13 | Aga Ab | Mischung aus Xenon und Kohlenmonoxyd zum Schutz von Zellen |
WO2006096774A2 (en) * | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
WO2007014380A2 (en) | 2005-07-27 | 2007-02-01 | University Of North Carolina At Charlotte | Composition and method for the restoration and preservation of transplant organs procured from dcd donors |
US20070207993A1 (en) * | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
WO2007073226A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda | Method for treating a mammal by administration of a compound having the ability to release co |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
EP2099463B1 (de) | 2006-11-07 | 2014-07-16 | The General Hospital Corporation | Minderung von vasoaktiver sauerstoffträger-induzierter gefässverengung |
WO2010138114A1 (en) | 2009-05-27 | 2010-12-02 | Ikaria Holdings, Inc. | Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery |
AU2009202685B1 (en) | 2009-06-30 | 2010-08-19 | Ino Therapeutics Llc | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
CA2824056C (en) * | 2011-01-14 | 2019-01-08 | Children's Hospital Los Angeles | Solution of carbon monoxide for treatment of disease, including sickle cell disease |
US8927750B2 (en) | 2011-02-04 | 2015-01-06 | Universitaet Zu Koeln | Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules |
AU2012228972A1 (en) | 2011-03-16 | 2013-10-24 | Dynasil Biomedical Corporation | Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
EP2717683A4 (de) * | 2011-06-10 | 2015-05-06 | Geno Llc | Stickoxiddruckbehälter |
EP2734235B1 (de) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Kohlenmonoxidfreisetzende rutheniummoleküle und ihre verwendungen |
US9987302B2 (en) | 2011-08-09 | 2018-06-05 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating DNA damage |
US10667510B2 (en) | 2013-03-15 | 2020-06-02 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
US9629358B2 (en) | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
CN105288599A (zh) * | 2015-10-22 | 2016-02-03 | 徐州医学院 | 血红素氧化酶-2在制备抑制器官移植免疫排斥制剂中的应用 |
CA3073399A1 (en) * | 2017-08-25 | 2019-02-28 | Mallinckrodt Hospital Products IP Limited | Methods to improve organ viability |
EP3524290A1 (de) | 2018-02-09 | 2019-08-14 | Julius-Maximilians-Universitaet Wuerzburg | Verfahren und system zur überwachung der kohlenmonoxid(co)-verabreichung an ex-vivo-flüssigkeiten |
CN116076484A (zh) * | 2022-11-30 | 2023-05-09 | 武汉大学 | 一种修复肾脏损伤的低温携氧机械灌注液及其应用 |
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US4053590A (en) * | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
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JPS5679957A (en) | 1979-12-05 | 1981-06-30 | Sogo Seibutsu Igaku Kenkyusho:Kk | Erucinia enterocolitica polysaccharide sensitizing blood cell and method of detecting erucinia enterocolitica polysaccharide antibody using this |
US5240912A (en) * | 1983-05-09 | 1993-08-31 | Todaro George J | Transforming growth factor (TGF) peptides |
US5084380A (en) * | 1985-01-29 | 1992-01-28 | Applied Biotechnology | Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins |
US5449665A (en) * | 1985-09-24 | 1995-09-12 | Item Development Aktiebolag | Continuous intravenous infusion of adenosine to human patients undergoing percutaneous transluminal angioplasty |
DE3739650C1 (de) * | 1987-11-23 | 1989-05-24 | Immuno Ag | Fermenter zum Zuechten von Zellkulturen |
US5180366A (en) * | 1990-10-10 | 1993-01-19 | Woods W T | Apparatus and method for angioplasty and for preventing re-stenosis |
US5792325A (en) * | 1990-11-15 | 1998-08-11 | Richardson, Jr.; William H. | Electric arc material processing system |
US5396882A (en) | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
US5570683A (en) | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
US5293875A (en) * | 1992-06-16 | 1994-03-15 | Natus Medical Incorporated | In-vivo measurement of end-tidal carbon monoxide concentration apparatus and methods |
CN1245156C (zh) * | 1993-02-22 | 2006-03-15 | 美国生物科学有限公司 | 用于体内传送生物制品的方法及用于该方法的组合物 |
EP0804244A1 (de) | 1993-03-26 | 1997-11-05 | Biorelease Technologies, Inc. | Häm-proteine enthaltende zusammensetzungen und dazu gehörende methoden |
US5763431A (en) * | 1993-08-20 | 1998-06-09 | Jackson; Meyer B. | Method for regulating neuropeptide hormone secretion |
DE4421433C1 (de) | 1994-06-18 | 1995-06-08 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Wirkstoffen, die Kohlenmonoxid-Quellen darstellen, Verfahren zu seiner Herstellung und seine Verwendung |
US5476764A (en) * | 1994-09-16 | 1995-12-19 | The Regents Of The University Of California | Method using CO for extending the useful shelf-life of refrigerated red blood cells |
US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
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US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US6315995B1 (en) | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
US5869538A (en) * | 1996-11-26 | 1999-02-09 | Research Foundation Of State University Of New York | Method for enhancing transport of gases to tissues |
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US6203991B1 (en) * | 1998-08-21 | 2001-03-20 | The Regents Of The University Of Michigan | Inhibition of smooth muscle cell migration by heme oxygenase I |
US20050250688A1 (en) * | 1999-04-01 | 2005-11-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
US7632803B2 (en) * | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
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FR2812197B1 (fr) | 2000-07-27 | 2003-01-03 | Air Liquide Sante Int | Utilisation de co dans le traitement de l'inflammation des voies aeriennes superieures ou des bronches |
FR2816212A1 (fr) | 2000-11-03 | 2002-05-10 | Air Liquide Sante Int | Utilisation de monoxyde de carbone (co) dans le traitement des inflammations du systeme cardiovasculaire |
BR0208012A (pt) * | 2001-03-20 | 2004-03-02 | Glaxo Group Ltd | Usos de pelo menos duas drogas e um propelente hfa e de pelo menos uma composição farmaceêutica, e, inalador acondicionado para tratar asma |
WO2002078684A2 (en) | 2001-03-30 | 2002-10-10 | Sangstat Medical Corporation | Carbon monoxide generating compounds for treatment of vascular, inflammatory and immune disorders |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
EP1395241B9 (de) * | 2001-05-25 | 2005-06-15 | Medtronic, Inc. | Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln |
PT1404811E (pt) * | 2001-06-21 | 2009-01-22 | Beth Israel Hospital | O monóxido de carbono melhora os resultados nos transplantes de tecidos e de orgãos e suprime a apoptose |
CN1646140A (zh) * | 2002-02-04 | 2005-07-27 | 阿尔法玛药品研发有限公司 | 可释放co的化合物在用于治疗炎症药物的制备中的应用 |
CN100393323C (zh) * | 2002-02-13 | 2008-06-11 | 贝思·伊斯雷尔·迪科尼斯医药中心 | 治疗血管疾病的方法 |
CN1652802A (zh) * | 2002-04-15 | 2005-08-10 | 联邦高等教育系统匹兹堡大学 | 治疗坏死性小肠结肠炎的方法 |
CN100496509C (zh) * | 2002-04-15 | 2009-06-10 | 联邦高等教育系统匹兹堡大学 | 一氧化碳产品及其对于肠梗阻的用途 |
CA2482260A1 (en) * | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center Inc. | Use of heme oxygenase-1 and products of heme degradation |
CA2485465A1 (en) * | 2002-05-17 | 2003-11-27 | Yale University | Methods of treating hepatitis |
EP1509237A4 (de) * | 2002-06-05 | 2006-07-12 | Univ Yale | Verfahren zur behandlung von angiogenese, tumorwachstum und metastasen |
MXPA04012863A (es) * | 2002-06-21 | 2005-03-31 | Univ Pittsburgh | Uso farmaceutico de oxido nitrico, heme oxigenasa-1 y productos de degradacion de heme. |
AU2003283982A1 (en) * | 2002-11-07 | 2004-06-03 | University Of Pittsburgh Of The Commonwealth System Of High Education | Treatment for hemorrhagic shock |
US20050255178A1 (en) * | 2004-02-04 | 2005-11-17 | Bloch Kenneth D | Enhancing the effectiveness of an inhaled therapeutic gas |
-
2002
- 2002-06-21 PT PT02747932T patent/PT1404811E/pt unknown
- 2002-06-21 DE DE60229848T patent/DE60229848D1/de not_active Expired - Lifetime
- 2002-06-21 PL PL02367544A patent/PL367544A1/xx unknown
- 2002-06-21 ES ES02747932T patent/ES2316583T3/es not_active Expired - Lifetime
- 2002-06-21 CA CA002451266A patent/CA2451266A1/en not_active Abandoned
- 2002-06-21 US US10/177,930 patent/US7238469B2/en not_active Expired - Lifetime
- 2002-06-21 MX MXPA03012031A patent/MXPA03012031A/es active IP Right Grant
- 2002-06-21 CN CNB028163443A patent/CN100502650C/zh not_active Expired - Fee Related
- 2002-06-21 SG SG200601852-7A patent/SG147305A1/en unknown
- 2002-06-21 EP EP02747932A patent/EP1404811B1/de not_active Revoked
- 2002-06-21 CZ CZ20033448A patent/CZ20033448A3/cs unknown
- 2002-06-21 JP JP2003506568A patent/JP4521183B2/ja not_active Expired - Fee Related
- 2002-06-21 EP EP08168801A patent/EP2033514A3/de not_active Withdrawn
- 2002-06-21 AU AU2002318377A patent/AU2002318377B2/en not_active Ceased
- 2002-06-21 KR KR10-2003-7016702A patent/KR20040032115A/ko active IP Right Grant
- 2002-06-21 DK DK02747932T patent/DK1404811T3/da active
- 2002-06-21 HU HU0400371A patent/HUP0400371A3/hu unknown
- 2002-06-21 NZ NZ562962A patent/NZ562962A/en not_active IP Right Cessation
- 2002-06-21 AT AT02747932T patent/ATE413883T1/de not_active IP Right Cessation
- 2002-06-21 WO PCT/US2002/019687 patent/WO2003000114A2/en active Application Filing
- 2002-06-21 BR BR0210599-3A patent/BR0210599A/pt not_active IP Right Cessation
- 2002-06-21 SI SI200230772T patent/SI1404811T1/sl unknown
- 2002-06-21 SK SK1594-2003A patent/SK15942003A3/sk not_active Application Discontinuation
-
2003
- 2003-12-17 NO NO20035637A patent/NO20035637L/no not_active Application Discontinuation
- 2003-12-22 BG BG108492A patent/BG108492A/xx unknown
-
2004
- 2004-09-10 HK HK04107560.1A patent/HK1067380A1/xx not_active IP Right Cessation
-
2006
- 2006-04-10 US US11/401,722 patent/US20070202083A1/en not_active Abandoned
-
2008
- 2008-09-18 AU AU2008221551A patent/AU2008221551A1/en not_active Ceased
-
2009
- 2009-02-09 CY CY20091100145T patent/CY1108798T1/el unknown
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