ATE413883T1 - Kohlenmonoxid verbessert die ergebnisse bei gewebe- und organtransplantationen und unterdrückt apoptose - Google Patents

Kohlenmonoxid verbessert die ergebnisse bei gewebe- und organtransplantationen und unterdrückt apoptose

Info

Publication number
ATE413883T1
ATE413883T1 AT02747932T AT02747932T ATE413883T1 AT E413883 T1 ATE413883 T1 AT E413883T1 AT 02747932 T AT02747932 T AT 02747932T AT 02747932 T AT02747932 T AT 02747932T AT E413883 T1 ATE413883 T1 AT E413883T1
Authority
AT
Austria
Prior art keywords
carbon monoxide
tissue
suppresses apoptosis
organ transplantations
improves results
Prior art date
Application number
AT02747932T
Other languages
English (en)
Inventor
Fritz Bach
Edda Tobiasch
Miguel Soares
Leo OTTERBEIN
Jeanne GOSE
Original Assignee
Beth Israel Hospital
Univ Yale
Jeanne GOSE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27404726&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE413883(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beth Israel Hospital, Univ Yale, Jeanne GOSE filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of ATE413883T1 publication Critical patent/ATE413883T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02747932T 2001-06-21 2002-06-21 Kohlenmonoxid verbessert die ergebnisse bei gewebe- und organtransplantationen und unterdrückt apoptose ATE413883T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30028901P 2001-06-21 2001-06-21
US33434001P 2001-11-29 2001-11-29
US33797401P 2001-12-07 2001-12-07

Publications (1)

Publication Number Publication Date
ATE413883T1 true ATE413883T1 (de) 2008-11-15

Family

ID=27404726

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02747932T ATE413883T1 (de) 2001-06-21 2002-06-21 Kohlenmonoxid verbessert die ergebnisse bei gewebe- und organtransplantationen und unterdrückt apoptose

Country Status (25)

Country Link
US (2) US7238469B2 (de)
EP (2) EP1404811B1 (de)
JP (1) JP4521183B2 (de)
KR (1) KR20040032115A (de)
CN (1) CN100502650C (de)
AT (1) ATE413883T1 (de)
AU (2) AU2002318377B2 (de)
BG (1) BG108492A (de)
BR (1) BR0210599A (de)
CA (1) CA2451266A1 (de)
CY (1) CY1108798T1 (de)
CZ (1) CZ20033448A3 (de)
DE (1) DE60229848D1 (de)
DK (1) DK1404811T3 (de)
ES (1) ES2316583T3 (de)
HU (1) HUP0400371A3 (de)
MX (1) MXPA03012031A (de)
NO (1) NO20035637L (de)
NZ (1) NZ562962A (de)
PL (1) PL367544A1 (de)
PT (1) PT1404811E (de)
SG (1) SG147305A1 (de)
SI (1) SI1404811T1 (de)
SK (1) SK15942003A3 (de)
WO (1) WO2003000114A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8128963B2 (en) * 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
US7678390B2 (en) 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
ES2316583T3 (es) * 2001-06-21 2009-04-16 Beth Israel Deaconess Medical Center, Inc. El monoxido de carbono mejora los resultados de trasplantes de tejidos y organos y suprime la adoptosis.
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1476168A2 (de) 2002-02-04 2004-11-17 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Verwendung von co-freisetzenden molekülen zur behandlung von entzündlichen krankheiten
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EA200401070A1 (ru) 2002-02-13 2005-02-24 Бет Изрейэл Диконисс Медикал Сентер, Инк. Способы лечения сосудистых заболеваний
EA200401365A1 (ru) 2002-04-15 2005-04-28 Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Способы лечения илеуса
EP1499186A4 (de) * 2002-04-15 2009-10-28 Beth Israel Hospital Verwendung von häm-oxygenase-1 und häm-abbauprodukte
JP4585765B2 (ja) 2002-04-15 2010-11-24 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 壊死性腸炎の治療方法
ES2372273T3 (es) 2002-05-17 2012-01-17 Yale University Métodos de tratamiento de la hepatitis.
AU2003248621A1 (en) * 2002-06-05 2003-12-22 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating angiogenesis, tumor growth, and metastasis
AU2003279236B8 (en) * 2002-06-21 2009-02-19 Beth Israel Deaconess Medical Center, Inc. Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
PL377733A1 (pl) * 2002-11-07 2006-02-06 University Of Pittsburgh Of The Commonwealth System Of Higher Education Leczenie wstrząsu krwotocznego
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
CN1901795B (zh) * 2003-10-22 2014-03-26 弗雷德哈钦森癌症研究中心 用于在细胞，组织，器官，和有机体中诱导停滞的方法，组合物和装置
EP1552840A1 (de) * 2004-01-07 2005-07-13 Aga Ab Mischung aus Xenon und Kohlenmonoxyd zum Schutz von Zellen
EP1863503B1 (de) * 2005-03-07 2019-05-22 Sangart, Inc. Zusammensetzung zur abgabe von kohlenmonoxid (co) und stickoxid (no) an gewebe unter verwendung von heme-proteinen als träger
WO2007014380A2 (en) * 2005-07-27 2007-02-01 University Of North Carolina At Charlotte Composition and method for the restoration and preservation of transplant organs procured from dcd donors
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
WO2007073225A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda. Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
EP2514473A1 (de) 2006-11-07 2012-10-24 The General Hospital Corporation Vorrichtung zur Zuführung von Stickoxid
BRPI0924534B1 (pt) 2009-05-27 2022-09-27 Mallinckrodt Hospital Products IP Limited Dispositivo de contenção de droga indexado
CA3130908A1 (en) 2009-06-30 2010-12-30 Mallinckrodt Hospital Products IP Limited Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
EP2663193B1 (de) 2011-01-14 2019-05-08 Children's Hospital Los Angeles Lösung aus kohlenmonoxid zur behandlung von krankheiten einschliesslich sichelzellanämie
US8927750B2 (en) 2011-02-04 2015-01-06 Universitaet Zu Koeln Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules
CA2830420A1 (en) 2011-03-16 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
WO2012145520A2 (en) 2011-04-19 2012-10-26 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
AU2012267620B2 (en) * 2011-06-10 2016-07-07 VERO Biotech LLC. Pressurized Vessel of Nitric Oxide (NO)
WO2013013179A1 (en) 2011-07-21 2013-01-24 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
JP2014525399A (ja) 2011-08-09 2014-09-29 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド Ｄｎａ損傷を処置する方法
US9629358B2 (en) 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
ES2981406T3 (es) 2013-03-15 2024-10-08 Mallinckrodt Pharmaceuticals Ireland Ltd Administración y monitorización de óxido nítrico en fluidos ex vivo
TW201618795A (zh) * 2014-04-15 2016-06-01 波泰里斯股份有限公司 用以改良器官功能及延長器官移植物壽命之系統及方法
EP4512819A3 (de) 2015-08-12 2025-08-06 The General Hospital Corporation Zusammensetzungen und verfahren zur förderung der hypoxie oder der hypoxiereaktion zur behandlung und prävention von mitochondriendysfunktion und oxidativen stresserkrankungen
CN105288599A (zh) * 2015-10-22 2016-02-03 徐州医学院 血红素氧化酶-2在制备抑制器官移植免疫排斥制剂中的应用
JP7249331B2 (ja) * 2017-08-25 2023-03-30 マリンクロット ホスピタル プロダクツ アイピー アンリミテッド カンパニー 器官の生存率を改善する方法
EP3524290A1 (de) 2018-02-09 2019-08-14 Julius-Maximilians-Universitaet Wuerzburg Verfahren und system zur überwachung der kohlenmonoxid(co)-verabreichung an ex-vivo-flüssigkeiten
CN116076484A (zh) * 2022-11-30 2023-05-09 武汉大学 一种修复肾脏损伤的低温携氧机械灌注液及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053590A (en) 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
US4264739A (en) * 1979-01-05 1981-04-28 Merck & Co., Inc. Sparger for cell culture system
JPS5679957A (en) 1979-12-05 1981-06-30 Sogo Seibutsu Igaku Kenkyusho:Kk Erucinia enterocolitica polysaccharide sensitizing blood cell and method of detecting erucinia enterocolitica polysaccharide antibody using this
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US5084380A (en) 1985-01-29 1992-01-28 Applied Biotechnology Monoclonal antibodies reactive with activated and oncogenic ras p21 proteins
CN85202057U (zh) * 1985-05-31 1986-09-10 南京低压阀门厂 电热丝预热凹槽式燃油系统
US5449665A (en) 1985-09-24 1995-09-12 Item Development Aktiebolag Continuous intravenous infusion of adenosine to human patients undergoing percutaneous transluminal angioplasty
DE3739650C1 (de) 1987-11-23 1989-05-24 Immuno Ag Fermenter zum Zuechten von Zellkulturen
DE3928144A1 (de) * 1989-08-25 1991-02-28 Hoechst Ag Zyklische pyridin-2,4- und -2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
US5180366A (en) 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
US5792325A (en) 1990-11-15 1998-08-11 Richardson, Jr.; William H. Electric arc material processing system
US5396882A (en) 1992-03-11 1995-03-14 The General Hospital Corporation Generation of nitric oxide from air for medical uses
US5570683A (en) 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
US5293875A (en) 1992-06-16 1994-03-15 Natus Medical Incorporated In-vivo measurement of end-tidal carbon monoxide concentration apparatus and methods
AU673057B2 (en) * 1993-02-22 1996-10-24 Abraxis Bioscience, Llc Methods for (in vivo) delivery of biologics and compositionsuseful therefor
AU6523194A (en) * 1993-03-26 1994-10-24 Biorelease Technologies, Inc. Compositions including heme-containing proteins and methods relating thereto
US5763431A (en) 1993-08-20 1998-06-09 Jackson; Meyer B. Method for regulating neuropeptide hormone secretion
DE4421433C1 (de) 1994-06-18 1995-06-08 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Wirkstoffen, die Kohlenmonoxid-Quellen darstellen, Verfahren zu seiner Herstellung und seine Verwendung
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
US6066333A (en) 1994-09-22 2000-05-23 William Harvey Research Limited Pharmaceutical control of inflammation
US5664563A (en) 1994-12-09 1997-09-09 Cardiopulmonary Corporation Pneumatic system
US5914316A (en) 1994-12-16 1999-06-22 Washington University Method of inhibiting intimal hyperplasia
US6063407A (en) 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5712293A (en) 1995-06-07 1998-01-27 Sepracor, Inc. Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride
FR2735382B1 (fr) * 1995-06-15 1997-07-25 Air Liquide Installation de production de monoxyde de carbone incorporant une unite de separation cryogenique
DE69632402T2 (de) 1995-06-30 2005-05-19 Zymogenetics, Inc., Seattle 4-(2-(n-(-2-carboxamidoindole)aminiethyl)-benzensulfonamide oder sulfonylharnstoffe als pdgf antagoniste
ES2267141T3 (es) 1996-04-05 2007-03-01 The General Hospital Corporation Tratamiento de una hemoglobinopatia.
US6069132A (en) 1996-08-14 2000-05-30 Revanker; Ganapathi R. Phosphazole compounds
ATE253372T1 (de) 1996-08-27 2003-11-15 Messer Griesheim Gmbh Wasserstoffhaltiges medikament
US6316403B1 (en) 1996-09-27 2001-11-13 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
US6315995B1 (en) 1996-09-27 2001-11-13 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
DE69737562T2 (de) * 1996-09-27 2007-12-27 The Trustees Of Columbia University In The City Of New York Behandlung einer ischämischen störung und zur verbesserung des infarktergebnis
US8128963B2 (en) * 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
US5869538A (en) * 1996-11-26 1999-02-09 Research Foundation Of State University Of New York Method for enhancing transport of gases to tissues
FR2757259B1 (fr) * 1996-12-18 1999-03-05 Valeo Thermique Moteur Sa Ailette metallique perfectionnee pour echangeur de chaleur, notamment pour vehicule automobile
US5912019A (en) * 1997-02-07 1999-06-15 Musc Foundation For Research Development Compounds for reducing ischemia/reperfusion injury
BR9908811A (pt) 1998-03-16 2000-12-05 Celgene Corp Composto, composição farmacêutica e seu uso no tratamento de mamìferos
US6203991B1 (en) 1998-08-21 2001-03-20 The Regents Of The University Of Michigan Inhibition of smooth muscle cell migration by heme oxygenase I
US20050250688A1 (en) 1999-04-01 2005-11-10 The Trustees Of Columbia University In The City Of New York Methods for treating an ischemic disorder and improving stroke outcome
US7678390B2 (en) * 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6558825B1 (en) * 2000-05-12 2003-05-06 Reveo, Inc. Fuel containment and recycling system
FR2812197B1 (fr) 2000-07-27 2003-01-03 Air Liquide Sante Int Utilisation de co dans le traitement de l'inflammation des voies aeriennes superieures ou des bronches
FR2816212A1 (fr) 2000-11-03 2002-05-10 Air Liquide Sante Int Utilisation de monoxyde de carbone (co) dans le traitement des inflammations du systeme cardiovasculaire
IL157580A0 (en) 2001-03-20 2004-03-28 Glaxo Group Ltd Inhalation drug combination
EP1381354A2 (de) 2001-03-30 2004-01-21 Sangstat Medical Corporation Kohlenmonoxid erzeugende verbindungen zur behandlung von gefäss-, entzündlichen und immunerkrankungen
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
EP1395241B9 (de) 2001-05-25 2005-06-15 Medtronic, Inc. Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln
ES2316583T3 (es) 2001-06-21 2009-04-16 Beth Israel Deaconess Medical Center, Inc. El monoxido de carbono mejora los resultados de trasplantes de tejidos y organos y suprime la adoptosis.
EP1476168A2 (de) 2002-02-04 2004-11-17 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Verwendung von co-freisetzenden molekülen zur behandlung von entzündlichen krankheiten
EA200401070A1 (ru) * 2002-02-13 2005-02-24 Бет Изрейэл Диконисс Медикал Сентер, Инк. Способы лечения сосудистых заболеваний
JP4585765B2 (ja) * 2002-04-15 2010-11-24 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 壊死性腸炎の治療方法
EA200401365A1 (ru) * 2002-04-15 2005-04-28 Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Способы лечения илеуса
EP1499186A4 (de) * 2002-04-15 2009-10-28 Beth Israel Hospital Verwendung von häm-oxygenase-1 und häm-abbauprodukte
ES2372273T3 (es) * 2002-05-17 2012-01-17 Yale University Métodos de tratamiento de la hepatitis.
AU2003248621A1 (en) * 2002-06-05 2003-12-22 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods of treating angiogenesis, tumor growth, and metastasis
AU2003279236B8 (en) * 2002-06-21 2009-02-19 Beth Israel Deaconess Medical Center, Inc. Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
PL377733A1 (pl) * 2002-11-07 2006-02-06 University Of Pittsburgh Of The Commonwealth System Of Higher Education Leczenie wstrząsu krwotocznego
WO2005077005A2 (en) * 2004-02-04 2005-08-25 The General Hospital Corporation Enhancing the effectiveness of an inhaled therapeutic gas

Also Published As

Publication number Publication date
US20070202083A1 (en) 2007-08-30
KR20040032115A (ko) 2004-04-14
SI1404811T1 (sl) 2009-04-30
PL367544A1 (en) 2005-02-21
WO2003000114A3 (en) 2003-04-10
WO2003000114A2 (en) 2003-01-03
CA2451266A1 (en) 2003-01-03
JP2005500875A (ja) 2005-01-13
NO20035637D0 (no) 2003-12-17
DK1404811T3 (da) 2009-03-02
WO2003000114A9 (en) 2004-05-21
CY1108798T1 (el) 2014-04-09
BG108492A (bg) 2005-02-28
HUP0400371A2 (hu) 2004-08-30
US20030039638A1 (en) 2003-02-27
PT1404811E (pt) 2009-01-22
HUP0400371A3 (en) 2010-06-28
EP1404811B1 (de) 2008-11-12
US7238469B2 (en) 2007-07-03
AU2008221551A1 (en) 2008-10-09
MXPA03012031A (es) 2005-07-01
SK15942003A3 (sk) 2004-08-03
EP2033514A2 (de) 2009-03-11
CN100502650C (zh) 2009-06-24
DE60229848D1 (de) 2008-12-24
NO20035637L (no) 2004-02-17
EP2033514A3 (de) 2009-04-29
ES2316583T3 (es) 2009-04-16
BR0210599A (pt) 2004-07-20
CN1545548A (zh) 2004-11-10
CZ20033448A3 (cs) 2004-05-12
HK1067380A1 (en) 2005-04-08
SG147305A1 (en) 2008-11-28
JP4521183B2 (ja) 2010-08-11
EP1404811A4 (de) 2006-08-09
AU2002318377B2 (en) 2008-06-19
EP1404811A2 (de) 2004-04-07
NZ562962A (en) 2009-08-28

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