PT1382693E - Metodos e composicoes para a deteccao de estados patologicos - Google Patents
Metodos e composicoes para a deteccao de estados patologicosInfo
- Publication number
- PT1382693E PT1382693E PT03017827T PT03017827T PT1382693E PT 1382693 E PT1382693 E PT 1382693E PT 03017827 T PT03017827 T PT 03017827T PT 03017827 T PT03017827 T PT 03017827T PT 1382693 E PT1382693 E PT 1382693E
- Authority
- PT
- Portugal
- Prior art keywords
- nucleic acid
- disease
- characteristic
- blood cells
- library
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001575 pathological effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 210000000601 blood cell Anatomy 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004075 alteration Effects 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9911563A FR2798673B1 (fr) | 1999-09-16 | 1999-09-16 | Methodes et compositions pour la detection d'evenements pathologiques |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1382693E true PT1382693E (pt) | 2006-07-31 |
Family
ID=9549896
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03017827T PT1382693E (pt) | 1999-09-16 | 2000-09-05 | Metodos e composicoes para a deteccao de estados patologicos |
PT00962576T PT1198595E (pt) | 1999-09-16 | 2000-09-05 | Metodos e composicoes para a deteccao de estados patologicos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00962576T PT1198595E (pt) | 1999-09-16 | 2000-09-05 | Metodos e composicoes para a deteccao de estados patologicos |
Country Status (14)
Country | Link |
---|---|
US (2) | US6372432B1 (pt) |
EP (2) | EP1382693B1 (pt) |
JP (1) | JP2003515317A (pt) |
AT (2) | ATE319860T1 (pt) |
AU (1) | AU774263B2 (pt) |
CA (1) | CA2383880C (pt) |
CY (1) | CY1105322T1 (pt) |
DE (2) | DE60006392T2 (pt) |
DK (2) | DK1382693T3 (pt) |
ES (2) | ES2209984T3 (pt) |
FR (1) | FR2798673B1 (pt) |
IL (2) | IL148613A0 (pt) |
PT (2) | PT1382693E (pt) |
WO (1) | WO2001020027A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
WO1994003624A1 (en) * | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
US20030165931A1 (en) * | 1998-03-11 | 2003-09-04 | Bruno Tocque | Qualitative differential screening |
US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
FR2798392B1 (fr) * | 1999-09-13 | 2005-07-15 | Exonhit Therapeutics Sa | Marqueurs genetiques de la toxicite, preparation et utilisations |
FR2798673B1 (fr) * | 1999-09-16 | 2004-05-28 | Exonhit Therapeutics Sa | Methodes et compositions pour la detection d'evenements pathologiques |
US7361488B2 (en) * | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
EP1329506A1 (en) * | 2002-01-18 | 2003-07-23 | Cypro S.A. | Method to quantify in vivo RNA levels |
JP2006501449A (ja) | 2002-09-27 | 2006-01-12 | ザ ジェネラル ホスピタル コーポレーション | 細胞分離のためのマイクロ流体デバイスおよびその使用 |
EP1636379A2 (en) * | 2003-06-26 | 2006-03-22 | Exonhit Therapeutics S.A. | Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis |
WO2005017186A2 (en) * | 2003-08-08 | 2005-02-24 | Thomas Jefferson University | Method for rapid identification of alternative splicing |
EP1776449A4 (en) * | 2004-03-03 | 2009-08-12 | Gen Hospital Corp | MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT |
US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US20070026415A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026414A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059680A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for cell enrichment |
US20070026416A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059774A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
US20070059719A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Business methods for prenatal Diagnosis |
US20070059683A1 (en) * | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
US20070059718A1 (en) * | 2005-09-15 | 2007-03-15 | Mehmet Toner | Systems and methods for enrichment of analytes |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US20080124721A1 (en) * | 2006-06-14 | 2008-05-29 | Martin Fuchs | Analysis of rare cell-enriched samples |
US9946887B2 (en) | 2012-06-04 | 2018-04-17 | Nokia Technologies Oy | Method and apparatus for determining privacy policy based on data and associated values |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4888278A (en) * | 1985-10-22 | 1989-12-19 | University Of Massachusetts Medical Center | In-situ hybridization to detect nucleic acid sequences in morphologically intact cells |
US5985549A (en) * | 1985-10-22 | 1999-11-16 | University Of Massachusetts | Non-isotopic in-situ hybridization method for detection of nucleic acids |
US5057410A (en) * | 1988-08-05 | 1991-10-15 | Cetus Corporation | Chimeric messenger RNA detection methods |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6309822B1 (en) * | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
US5215882A (en) * | 1989-11-30 | 1993-06-01 | Ortho Diagnostic Systems, Inc. | Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
US5521297A (en) * | 1993-06-04 | 1996-05-28 | Salk Institute Biotechnology/Industrial Associates | Nucleic acids encoding human metabotropic glutamate receptors |
US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
US5484702A (en) * | 1994-01-27 | 1996-01-16 | Research Foundation Of The State University Of New York At Buffalo | Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones |
US5679541A (en) * | 1994-02-14 | 1997-10-21 | California Institute Of Technology | Programmed cell death antagonist protein |
PH31414A (en) * | 1994-02-24 | 1998-10-29 | Boehringer Ingelheim Int | Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples. |
JP4014234B2 (ja) * | 1994-05-27 | 2007-11-28 | テキサス インスツルメンツ インコーポレイテツド | 半導体デバイス中に線間容量の低減化された相互接続線を作製する方法 |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6974666B1 (en) * | 1994-10-21 | 2005-12-13 | Appymetric, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US5830645A (en) * | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5767258A (en) * | 1995-05-12 | 1998-06-16 | The Johns Hopkins University School Of Medicine | Cell cycle regulatory gene |
US5922535A (en) * | 1995-11-07 | 1999-07-13 | Huo; Li | Identifying sequence differences in nucleic acid populations |
US6268170B1 (en) * | 1995-11-14 | 2001-07-31 | Northwestern University | α-Tocopherol transport protein: compositions and methods |
EP0880598A4 (en) * | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
EP0791660A1 (en) * | 1996-02-22 | 1997-08-27 | Smithkline Beecham Corporation | A novel diagnostic marker for splicing variants of genes associated with neurological function |
US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
FR2775984B1 (fr) * | 1998-03-11 | 2006-09-15 | Bioscreen Therapeutics Sa | Criblage differentiel qualitatif |
US20030165931A1 (en) * | 1998-03-11 | 2003-09-04 | Bruno Tocque | Qualitative differential screening |
CA2255774C (en) * | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
US6475789B1 (en) * | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
GB2321642B8 (en) * | 1996-10-01 | 2006-08-22 | Geron Corp | Human telomerase reverse transcriptase promoter |
US5858671A (en) * | 1996-11-01 | 1999-01-12 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
ATE234674T1 (de) * | 1996-11-14 | 2003-04-15 | Affymetrix Inc | Chemische amplifizierung zur synthese von musterordnungen |
US6060240A (en) * | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
US6303301B1 (en) * | 1997-01-13 | 2001-10-16 | Affymetrix, Inc. | Expression monitoring for gene function identification |
AU762888B2 (en) * | 1997-02-12 | 2003-07-10 | Us Genomics | Methods and products for analyzing polymers |
US6951924B2 (en) * | 1997-03-14 | 2005-10-04 | Human Genome Sciences, Inc. | Antibodies against secreted protein HTEBYII |
US6368799B1 (en) * | 1997-06-13 | 2002-04-09 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
CA2225187A1 (en) * | 1997-07-14 | 1999-01-14 | Universite D'ottawa/ University Of Ottawa | Xaf genes and polypeptides: methods and reagents for modulating apoptosis |
US6849400B1 (en) * | 1997-07-23 | 2005-02-01 | Gen-Probe Incorporated | Methods for detecting and measuring spliced nucleic acids |
IL121806A0 (en) * | 1997-09-21 | 1998-02-22 | Compugen Ltd | Method and apparatus for MRNA assembly |
JPH11262621A (ja) * | 1998-03-17 | 1999-09-28 | Ebara Corp | 除湿空調装置 |
US6699659B2 (en) * | 1998-06-01 | 2004-03-02 | Affymetrix, Inc. | Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions |
US6168920B1 (en) * | 1998-08-10 | 2001-01-02 | Incyte Genomics, Inc. | Extracellular adhesive proteins |
US6160105A (en) * | 1998-10-13 | 2000-12-12 | Incyte Pharmaceuticals, Inc. | Monitoring toxicological responses |
US6368794B1 (en) * | 1999-01-15 | 2002-04-09 | Incyte Genomics, Inc. | Detection of altered expression of genes regulating cell proliferation |
FR2798392B1 (fr) * | 1999-09-13 | 2005-07-15 | Exonhit Therapeutics Sa | Marqueurs genetiques de la toxicite, preparation et utilisations |
FR2798673B1 (fr) * | 1999-09-16 | 2004-05-28 | Exonhit Therapeutics Sa | Methodes et compositions pour la detection d'evenements pathologiques |
US6713257B2 (en) * | 2000-08-25 | 2004-03-30 | Rosetta Inpharmatics Llc | Gene discovery using microarrays |
EP1654371A4 (en) * | 2001-06-21 | 2010-02-10 | Verenium Corp | METHOD FOR PRODUCING PURE ENANTIOMERIC PURELY COMPOUNDS AND SELECTION OF ENANTIOSELECTIVE ENZYMES |
WO2005047521A2 (en) * | 2003-11-10 | 2005-05-26 | Investigen, Inc. | Methods of preparing nucleic acid for detection |
-
1999
- 1999-09-16 FR FR9911563A patent/FR2798673B1/fr not_active Expired - Fee Related
- 1999-12-08 US US09/456,461 patent/US6372432B1/en not_active Expired - Lifetime
-
2000
- 2000-09-05 DE DE60006392T patent/DE60006392T2/de not_active Expired - Lifetime
- 2000-09-05 DE DE60026624T patent/DE60026624T2/de not_active Expired - Lifetime
- 2000-09-05 IL IL14861300A patent/IL148613A0/xx not_active IP Right Cessation
- 2000-09-05 ES ES00962576T patent/ES2209984T3/es not_active Expired - Lifetime
- 2000-09-05 AU AU74252/00A patent/AU774263B2/en not_active Ceased
- 2000-09-05 PT PT03017827T patent/PT1382693E/pt unknown
- 2000-09-05 WO PCT/FR2000/002439 patent/WO2001020027A1/fr active Application Filing
- 2000-09-05 EP EP03017827A patent/EP1382693B1/fr not_active Expired - Lifetime
- 2000-09-05 AT AT03017827T patent/ATE319860T1/de active
- 2000-09-05 DK DK03017827T patent/DK1382693T3/da active
- 2000-09-05 DK DK00962576T patent/DK1198595T3/da active
- 2000-09-05 PT PT00962576T patent/PT1198595E/pt unknown
- 2000-09-05 AT AT00962576T patent/ATE253647T1/de active
- 2000-09-05 EP EP00962576A patent/EP1198595B1/fr not_active Expired - Lifetime
- 2000-09-05 CA CA2383880A patent/CA2383880C/fr not_active Expired - Fee Related
- 2000-09-05 JP JP2001523798A patent/JP2003515317A/ja active Pending
- 2000-09-05 ES ES03017827T patent/ES2256629T3/es not_active Expired - Lifetime
-
2006
- 2006-03-24 CY CY20061100417T patent/CY1105322T1/el unknown
-
2007
- 2007-11-01 IL IL187097A patent/IL187097A/en not_active IP Right Cessation
-
2009
- 2009-06-29 US US12/494,039 patent/US20090264301A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1198595B1 (fr) | 2003-11-05 |
US6372432B1 (en) | 2002-04-16 |
CA2383880C (fr) | 2012-08-28 |
EP1198595A1 (fr) | 2002-04-24 |
FR2798673B1 (fr) | 2004-05-28 |
JP2003515317A (ja) | 2003-05-07 |
ES2209984T3 (es) | 2004-07-01 |
EP1382693B1 (fr) | 2006-03-08 |
DK1198595T3 (da) | 2004-03-15 |
DE60006392T2 (de) | 2004-09-02 |
EP1382693A1 (fr) | 2004-01-21 |
ATE253647T1 (de) | 2003-11-15 |
IL187097A (en) | 2010-04-15 |
US20090264301A1 (en) | 2009-10-22 |
ATE319860T1 (de) | 2006-03-15 |
DE60006392D1 (de) | 2003-12-11 |
AU7425200A (en) | 2001-04-17 |
DE60026624D1 (de) | 2006-05-04 |
DK1382693T3 (da) | 2006-07-17 |
ES2256629T3 (es) | 2006-07-16 |
CY1105322T1 (el) | 2010-03-03 |
AU774263B2 (en) | 2004-06-24 |
DE60026624T2 (de) | 2006-12-21 |
PT1198595E (pt) | 2004-03-31 |
WO2001020027A1 (fr) | 2001-03-22 |
CA2383880A1 (fr) | 2001-03-22 |
FR2798673A1 (fr) | 2001-03-23 |
IL148613A0 (en) | 2002-09-12 |
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