DE60026624D1 - Verfahren und Zusammensetzungen für die Detektion pathologischer Ereignisse - Google Patents

Verfahren und Zusammensetzungen für die Detektion pathologischer Ereignisse

Info

Publication number
DE60026624D1
DE60026624D1 DE60026624T DE60026624T DE60026624D1 DE 60026624 D1 DE60026624 D1 DE 60026624D1 DE 60026624 T DE60026624 T DE 60026624T DE 60026624 T DE60026624 T DE 60026624T DE 60026624 D1 DE60026624 D1 DE 60026624D1
Authority
DE
Germany
Prior art keywords
nucleic acid
disease
characteristic
blood cells
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026624T
Other languages
English (en)
Other versions
DE60026624T2 (de
Inventor
Bruno Tocque
Laurent Bracco
Fabien Schweighoffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ExonHit Therapeutics SA
Original Assignee
ExonHit Therapeutics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ExonHit Therapeutics SA filed Critical ExonHit Therapeutics SA
Application granted granted Critical
Publication of DE60026624D1 publication Critical patent/DE60026624D1/de
Publication of DE60026624T2 publication Critical patent/DE60026624T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
DE60026624T 1999-09-16 2000-09-05 Verfahren und Zusammensetzungen für die Detektion pathologischer Ereignisse Expired - Lifetime DE60026624T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911563 1999-09-16
FR9911563A FR2798673B1 (fr) 1999-09-16 1999-09-16 Methodes et compositions pour la detection d'evenements pathologiques

Publications (2)

Publication Number Publication Date
DE60026624D1 true DE60026624D1 (de) 2006-05-04
DE60026624T2 DE60026624T2 (de) 2006-12-21

Family

ID=9549896

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60026624T Expired - Lifetime DE60026624T2 (de) 1999-09-16 2000-09-05 Verfahren und Zusammensetzungen für die Detektion pathologischer Ereignisse
DE60006392T Expired - Lifetime DE60006392T2 (de) 1999-09-16 2000-09-05 Verfahren und zusammensetzung zur detektion pathogener zustände

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60006392T Expired - Lifetime DE60006392T2 (de) 1999-09-16 2000-09-05 Verfahren und zusammensetzung zur detektion pathogener zustände

Country Status (14)

Country Link
US (2) US6372432B1 (de)
EP (2) EP1382693B1 (de)
JP (1) JP2003515317A (de)
AT (2) ATE319860T1 (de)
AU (1) AU774263B2 (de)
CA (1) CA2383880C (de)
CY (1) CY1105322T1 (de)
DE (2) DE60026624T2 (de)
DK (2) DK1382693T3 (de)
ES (2) ES2209984T3 (de)
FR (1) FR2798673B1 (de)
IL (2) IL148613A0 (de)
PT (2) PT1198595E (de)
WO (1) WO2001020027A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US20030165931A1 (en) * 1998-03-11 2003-09-04 Bruno Tocque Qualitative differential screening
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
FR2798392B1 (fr) * 1999-09-13 2005-07-15 Exonhit Therapeutics Sa Marqueurs genetiques de la toxicite, preparation et utilisations
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1329506A1 (de) * 2002-01-18 2003-07-23 Cypro S.A. Verfahren zur Quantifizierung vom RNA Niveau in vivo
WO2004029221A2 (en) * 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
WO2004113571A2 (en) * 2003-06-26 2004-12-29 Exonhit Therapeutics Sa Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis
AU2004265635A1 (en) * 2003-08-08 2005-02-24 Thomas Jefferson University Method for rapid identification of alternative splicing
CA2557819A1 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US9946887B2 (en) 2012-06-04 2018-04-17 Nokia Technologies Oy Method and apparatus for determining privacy policy based on data and associated values

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US5985549A (en) * 1985-10-22 1999-11-16 University Of Massachusetts Non-isotopic in-situ hybridization method for detection of nucleic acids
US5057410A (en) * 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5215882A (en) * 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5674682A (en) * 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
US5521297A (en) * 1993-06-04 1996-05-28 Salk Institute Biotechnology/Industrial Associates Nucleic acids encoding human metabotropic glutamate receptors
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5484702A (en) * 1994-01-27 1996-01-16 Research Foundation Of The State University Of New York At Buffalo Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones
US5679541A (en) * 1994-02-14 1997-10-21 California Institute Of Technology Programmed cell death antagonist protein
PH31414A (en) * 1994-02-24 1998-10-29 Boehringer Ingelheim Int Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples.
DE69535718T2 (de) * 1994-05-27 2009-03-19 Texas Instruments Inc., Dallas Verbindungsverfahren mit Benutzung eines porösen Isolators zur Reduzierung der Kapazitäten zwischen Leiterbahnen
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5767258A (en) * 1995-05-12 1998-06-16 The Johns Hopkins University School Of Medicine Cell cycle regulatory gene
US5922535A (en) * 1995-11-07 1999-07-13 Huo; Li Identifying sequence differences in nucleic acid populations
US6268170B1 (en) * 1995-11-14 2001-07-31 Northwestern University α-Tocopherol transport protein: compositions and methods
EP0880598A4 (de) * 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
EP0791660A1 (de) * 1996-02-22 1997-08-27 Smithkline Beecham Corporation Neuer diagnostischer Marker für Spleissvarianten von Genen, verbunden mit neurologischen Funktionen
US20030165931A1 (en) * 1998-03-11 2003-09-04 Bruno Tocque Qualitative differential screening
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
FR2775984B1 (fr) * 1998-03-11 2006-09-15 Bioscreen Therapeutics Sa Criblage differentiel qualitatif
EP2369007B1 (de) * 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Erkennung von Nukleinsäuresequenz-Unterschieden mittels der gleichzeitigen Ligaseerkennungs- und Polymerasekettenreaktion
US6475789B1 (en) * 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
DE69739497D1 (de) * 1996-10-01 2009-08-27 Geron Corp Menschlische Telomerase katalytische Untereinheit
US5858671A (en) * 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
WO1998020967A1 (en) * 1996-11-14 1998-05-22 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6303301B1 (en) * 1997-01-13 2001-10-16 Affymetrix, Inc. Expression monitoring for gene function identification
JP3935509B2 (ja) * 1997-02-12 2007-06-27 ワイ． チャン，ユージーン ポリマー分析のための方法および製品
US6951924B2 (en) * 1997-03-14 2005-10-04 Human Genome Sciences, Inc. Antibodies against secreted protein HTEBYII
US6368799B1 (en) * 1997-06-13 2002-04-09 Affymetrix, Inc. Method to detect gene polymorphisms and monitor allelic expression employing a probe array
CA2225187A1 (en) * 1997-07-14 1999-01-14 Universite D'ottawa/ University Of Ottawa Xaf genes and polypeptides: methods and reagents for modulating apoptosis
US6849400B1 (en) * 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
IL121806A0 (en) * 1997-09-21 1998-02-22 Compugen Ltd Method and apparatus for MRNA assembly
JPH11262621A (ja) * 1998-03-17 1999-09-28 Ebara Corp 除湿空調装置
US6699659B2 (en) * 1998-06-01 2004-03-02 Affymetrix, Inc. Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions
US6168920B1 (en) * 1998-08-10 2001-01-02 Incyte Genomics, Inc. Extracellular adhesive proteins
US6160105A (en) * 1998-10-13 2000-12-12 Incyte Pharmaceuticals, Inc. Monitoring toxicological responses
US6368794B1 (en) * 1999-01-15 2002-04-09 Incyte Genomics, Inc. Detection of altered expression of genes regulating cell proliferation
FR2798392B1 (fr) * 1999-09-13 2005-07-15 Exonhit Therapeutics Sa Marqueurs genetiques de la toxicite, preparation et utilisations
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US6713257B2 (en) * 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7981844B2 (en) * 2001-06-21 2011-07-19 Verenium Corporation Methods for the manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes
WO2005047521A2 (en) * 2003-11-10 2005-05-26 Investigen, Inc. Methods of preparing nucleic acid for detection

Also Published As

Publication number Publication date
US6372432B1 (en) 2002-04-16
CA2383880A1 (fr) 2001-03-22
US20090264301A1 (en) 2009-10-22
PT1198595E (pt) 2004-03-31
AU774263B2 (en) 2004-06-24
FR2798673B1 (fr) 2004-05-28
DE60006392D1 (de) 2003-12-11
CA2383880C (fr) 2012-08-28
PT1382693E (pt) 2006-07-31
EP1198595A1 (de) 2002-04-24
CY1105322T1 (el) 2010-03-03
DE60026624T2 (de) 2006-12-21
WO2001020027A1 (fr) 2001-03-22
ES2209984T3 (es) 2004-07-01
IL187097A (en) 2010-04-15
DE60006392T2 (de) 2004-09-02
FR2798673A1 (fr) 2001-03-23
EP1382693B1 (de) 2006-03-08
AU7425200A (en) 2001-04-17
EP1198595B1 (de) 2003-11-05
IL148613A0 (en) 2002-09-12
JP2003515317A (ja) 2003-05-07
DK1382693T3 (da) 2006-07-17
ATE319860T1 (de) 2006-03-15
ATE253647T1 (de) 2003-11-15
DK1198595T3 (da) 2004-03-15
ES2256629T3 (es) 2006-07-16
EP1382693A1 (de) 2004-01-21

Similar Documents

Publication Publication Date Title
DE60026624D1 (de) Verfahren und Zusammensetzungen für die Detektion pathologischer Ereignisse
Sadeh et al. ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin
Podzimek et al. Salivary markers for periodontal and general diseases
GB2374929A (en) Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
Kahn et al. Gene expression profiling in an in vitro model of angiogenesis
US6127119A (en) Nucleic acid ligands of tissue target
ATE384137T1 (de) Identifizierung genetischer marker des biologischen alters und des metabolismus
JP2018057379A (ja) 多器官連関システムを基盤とした予測装置、及び予測プログラム
WO2002074911A3 (en) Identification of gene expression alterations underlying the aging process in mammals
Strehlow et al. A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma
Xu et al. Novel non-invasive diagnosis of bladder cancer in urine based on multifunctional nanoparticles
Niemitz Ras pathway activation in breast cancer
WO2001038577A3 (en) Human transcriptomes
DE69913533D1 (de) Reagentien für cyp2d fluoreszenztest
CN108424960A (zh) 一种LncRNA作为深静脉血栓形成诊断标志物的应用
Niemitz ADAM10 and Alzheimer's disease
CN107475379A (zh) 一种用于肿瘤诊断与预后检测的分子标志物及其检测引物和试剂盒
CN108384849A (zh) 血清中circ_0005396作为深静脉血栓形成诊断标志物的应用
CN108384848A (zh) 血清中circ_0021132作为深静脉血栓形成诊断标志物的应用
ATE478147T1 (de) Aus einem neuroblastom isolierte nukleinsäuren
JP2857630B2 (ja) Ｃ末端アミド化酵素の活性測定方法
JP2001029099A (ja) 皮膚におけるトランスグルタミナーゼ活性の評価
Kantor et al. A Bioinformatics-Based Bottom-up Network Reconstruction Approach to Detect Stem Cell-Related Blood Biomarkers of Cardiovascular Damage and Repair
Vogan Genetics of immune cell levels

Legal Events

Date Code Title Description
8364 No opposition during term of opposition