PT1377574E - 6-fenilbenzonaftiridinas - Google Patents

6-fenilbenzonaftiridinas

Info

Publication number
PT1377574E
PT1377574E PT02722110T PT02722110T PT1377574E PT 1377574 E PT1377574 E PT 1377574E PT 02722110 T PT02722110 T PT 02722110T PT 02722110 T PT02722110 T PT 02722110T PT 1377574 E PT1377574 E PT 1377574E
Authority
PT
Portugal
Prior art keywords
phenylbenzone
pyridines
pde3
inhibitors
compounds
Prior art date
Application number
PT02722110T
Other languages
English (en)
Portuguese (pt)
Inventor
Pedro Da Silva Alves Moreira
Karl Zech
Rolf Beume
Gerhard Grundler
Dieter Flockerzi
Beate Schmidt
Armin Hatzelmann
Daniela Bundschuh
Kley Hans-Peter
Nave Ruediger
Reutter Felix
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of PT1377574E publication Critical patent/PT1377574E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Electroluminescent Light Sources (AREA)
PT02722110T 2001-02-21 2002-02-21 6-fenilbenzonaftiridinas PT1377574E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01104086 2001-02-21
PCT/EP2002/001819 WO2002066476A1 (en) 2001-02-21 2002-02-21 6-phenylbenzonaphthyridines

Publications (1)

Publication Number Publication Date
PT1377574E true PT1377574E (pt) 2005-05-31

Family

ID=8176545

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02722110T PT1377574E (pt) 2001-02-21 2002-02-21 6-fenilbenzonaftiridinas

Country Status (12)

Country Link
US (1) US6936622B2 (https=)
EP (1) EP1377574B1 (https=)
JP (1) JP4248245B2 (https=)
AT (1) ATE287403T1 (https=)
AU (1) AU2002253045B2 (https=)
CA (1) CA2438717C (https=)
DE (1) DE60202669T2 (https=)
DK (1) DK1377574T3 (https=)
ES (1) ES2236504T3 (https=)
PT (1) PT1377574E (https=)
SI (1) SI1377574T1 (https=)
WO (1) WO2002066476A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1581533A2 (en) * 2002-08-17 2005-10-05 ALTANA Pharma AG Novel benzonaphthyridines
AU2003253408A1 (en) * 2002-08-17 2004-03-11 Nycomed Gmbh Novel phenanthridines
ES2281658T3 (es) 2002-08-29 2007-10-01 Nycomed Gmbh 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
DE60313331T2 (de) * 2002-09-04 2008-01-03 Nycomed Gmbh Neue benzonaphthyridine
AU2005212857B2 (en) * 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CN104803974A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ ファルマ アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−6−フェニルフェナントリジン及びpde4インヒビターとしてのそれらの使用
CA2559200A1 (en) 2004-03-17 2005-09-29 Altana Pharma Ag Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
WO2018069210A1 (en) 2016-10-10 2018-04-19 Takeda Gmbh Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE03829B1 (et) 1996-11-11 2002-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim
JP2001514640A (ja) * 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
CA2291153A1 (en) 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
DK1075477T3 (da) * 1998-05-05 2003-06-30 Altana Pharma Ag Nye benzonaphthyridin-N-oxider
AU5970199A (en) * 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
CA2438717A1 (en) 2002-08-29
US20040097537A1 (en) 2004-05-20
SI1377574T1 (https=) 2005-08-31
EP1377574A1 (en) 2004-01-07
JP4248245B2 (ja) 2009-04-02
EP1377574B1 (en) 2005-01-19
AU2002253045B2 (en) 2007-07-12
DE60202669D1 (de) 2005-02-24
DE60202669T2 (de) 2005-09-15
ATE287403T1 (de) 2005-02-15
CA2438717C (en) 2011-08-30
WO2002066476A9 (en) 2003-10-30
JP2004526712A (ja) 2004-09-02
US6936622B2 (en) 2005-08-30
DK1377574T3 (da) 2005-04-25
WO2002066476A1 (en) 2002-08-29
ES2236504T3 (es) 2005-07-16

Similar Documents

Publication Publication Date Title
DK1070056T3 (da) Phthalazinon-PDE III/IV-inhibitorer
EA200301100A1 (ru) Новые фталазиноны
DE60310576D1 (en) 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
WO2004018431A3 (en) Novel phenanthridines
DE60311662D1 (en) 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
PL372926A1 (en) Piperidine-pyridazones and phthalazones as pde4 inhibitors
YU72002A (sh) Benzoilpirazoli i njihova primena u ulozi herbicida
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
CY1106247T1 (el) Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
ATE355284T1 (de) Inhibitoren von serinproteasen
MXPA03006224A (es) Inhibidores de cruzipaina y otras proteasas de cisteina.
GB0114185D0 (en) Compounds
DE60105418D1 (de) Serinprotease-inhibitoren
PT1086096E (pt) Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
SE0103710D0 (sv) Compounds
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
EA200600607A1 (ru) Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
SE9903290D0 (sv) Novel compounds
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
MXPA06000372A (es) Compuestos de silicio y su uso.
EA200600608A1 (ru) Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
ATE269313T1 (de) Tryptase-inhibitoren
DE60011300D1 (de) Inhibitoren der tryptase