PT1326633E - Composição compreendendo micropartículas imunogénicas - Google Patents

Composição compreendendo micropartículas imunogénicas Download PDF

Info

Publication number
PT1326633E
PT1326633E PT01966829T PT01966829T PT1326633E PT 1326633 E PT1326633 E PT 1326633E PT 01966829 T PT01966829 T PT 01966829T PT 01966829 T PT01966829 T PT 01966829T PT 1326633 E PT1326633 E PT 1326633E
Authority
PT
Portugal
Prior art keywords
microparticles
composition
immunogenic microparticles
provides
immunogenic
Prior art date
Application number
PT01966829T
Other languages
English (en)
Inventor
Magdalena Plebanski
Original Assignee
Austin Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR4888A external-priority patent/AUPR488801A0/en
Priority claimed from AUPR4962A external-priority patent/AUPR496201A0/en
Application filed by Austin Research Inst filed Critical Austin Research Inst
Publication of PT1326633E publication Critical patent/PT1326633E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
PT01966829T 2000-09-14 2001-09-14 Composição compreendendo micropartículas imunogénicas PT1326633E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPR0117A AUPR011700A0 (en) 2000-09-14 2000-09-14 Composition comprising immunogenic virus sized particles (VSP)
AUPR4888A AUPR488801A0 (en) 2001-05-10 2001-05-10 Composition comprising immunogenic virus sized particles (vsp)
AUPR4962A AUPR496201A0 (en) 2001-05-14 2001-05-14 Composition comprising immunogenic virus sized particles (VSP)

Publications (1)

Publication Number Publication Date
PT1326633E true PT1326633E (pt) 2011-06-29

Family

ID=27158243

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01966829T PT1326633E (pt) 2000-09-14 2001-09-14 Composição compreendendo micropartículas imunogénicas

Country Status (15)

Country Link
US (3) US20040014708A1 (pt)
EP (1) EP1326633B1 (pt)
JP (1) JP5198712B2 (pt)
KR (1) KR20030055262A (pt)
CN (1) CN100446811C (pt)
AT (1) ATE501726T1 (pt)
AU (1) AUPR011700A0 (pt)
CA (1) CA2422575C (pt)
DE (1) DE60144240D1 (pt)
DK (1) DK1326633T3 (pt)
ES (1) ES2363735T3 (pt)
IL (1) IL154913A0 (pt)
NZ (2) NZ535851A (pt)
PT (1) PT1326633E (pt)
WO (1) WO2002022164A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
FR2844514B1 (fr) * 2002-09-16 2007-10-19 Neovacs Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation
ATE481476T1 (de) * 2003-05-08 2010-10-15 Life Technologies Corp Erzeugung und isolierung antigenspezifischer t- zellen
WO2005053740A1 (ja) * 2003-12-02 2005-06-16 Bio Matrix Research Inc. 免疫増強剤およびこれを用いた強化抗原
WO2006012695A1 (en) * 2004-08-04 2006-02-09 Panvax Limited An immunogenic composition
EP1932538A4 (en) * 2005-08-25 2009-10-21 Taiho Pharmaceutical Co Ltd BIODEGRADABLE NANOTEHICLES WITH IMMOBILIZED OR CAPACITATED T-CELL-RECOGNIZABLE EPITOPEPEPID
WO2008150276A2 (en) * 2006-09-26 2008-12-11 The Board Of Regents Of The University Of Texas System Virus coated nanoparticles and uses thereof
US9764012B2 (en) 2009-04-01 2017-09-19 University Of Miami Vaccine compositions and methods of use thereof
EP2432893B1 (en) * 2009-05-19 2019-05-01 University Of Miami Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity of biologics and drugs
JP2013500329A (ja) * 2009-07-29 2013-01-07 ヘルムート アダム レフム ベルン ポリマー粒子およびその使用
US9724405B2 (en) 2010-11-05 2017-08-08 Novavax, Inc. Rabies glycoprotein virus-like particles (VLPS)
US20120189700A1 (en) * 2011-01-19 2012-07-26 Zoraida Aguilar Nanoparticle Based Immunological Stimulation
ES2685333T3 (es) * 2011-06-02 2018-10-08 The Regents Of The University Of California Nanopartículas encapsuladas en membrana y método de utilización
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
WO2015021390A2 (en) 2013-08-08 2015-02-12 The Regents Of The University Of California Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis
CN106163504B (zh) 2014-03-20 2021-02-09 加利福尼亚大学董事会 水凝胶毒素-吸收或结合纳米颗粒
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11512289B2 (en) 2015-02-18 2022-11-29 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
JP6803339B2 (ja) 2015-04-21 2020-12-23 エンリヴェックス セラピューティクス リミテッド 治療用のプールされた血液アポトーシス細胞調製物及びそれらの使用
US10610493B2 (en) 2015-04-29 2020-04-07 The Regents Of The University Of California Detoxification using nanoparticles
CN109069539A (zh) 2016-02-18 2018-12-21 恩立夫克治疗有限责任公司 用于癌症治疗的联合免疫疗法和细胞因子控制疗法
CN109200271B (zh) * 2018-11-14 2021-01-29 江南大学 一种蛋白质及其在调控巨噬细胞免疫功能方面的应用
EP3986447A4 (en) * 2019-06-18 2023-08-16 Citranvi Biosciences, LLC RATIONALLY MANIPULATED CARRIER PROTEINS FOR VACCINES
WO2020257315A1 (en) * 2019-06-18 2020-12-24 Citranvi Biosciences, Llc Multiple antigen protein displayed adjuvant systems
CN110339350A (zh) * 2019-07-25 2019-10-18 广州中科蓝华生物科技有限公司 一种抗肿瘤的联合用药物组合物及其应用
JP2023536269A (ja) * 2020-07-31 2023-08-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ワクチン組成物及びその使用方法
WO2024097307A1 (en) * 2022-11-01 2024-05-10 Lupagen, Inc. Devices and methods for extracorporeal cell treatment

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4035316A (en) * 1975-11-24 1977-07-12 California Institute Of Technology Cell specific, variable density, polymer microspheres
US4170685A (en) * 1976-03-29 1979-10-09 California Institute Of Technology Polyvinyl pyridine microspheres
US4157323A (en) * 1976-06-09 1979-06-05 California Institute Of Technology Metal containing polymeric functional microspheres
US4247434A (en) * 1978-12-29 1981-01-27 Lovelace Alan M Administrator Process for preparation of large-particle-size monodisperse
US4438239A (en) * 1981-03-30 1984-03-20 California Institute Of Technology Microsphere coated substrate containing reactive aldehyde groups
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4828984A (en) * 1986-04-11 1989-05-09 Flow Cytometry Standards Corporation Composition, synthesis and use of simulated cells
US6338853B1 (en) 1987-04-23 2002-01-15 Jean-Claude Bystryn Anti-cancer vaccine
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
GB2237510B (en) 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5443832A (en) * 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
US5219577A (en) * 1990-06-22 1993-06-15 The Regents Of The University Of California Biologically active composition having a nanocrystalline core
US5178882A (en) * 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
US5334394A (en) * 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
US6129916A (en) * 1991-04-19 2000-10-10 Tanox, Inc. Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates
FR2695563B1 (fr) * 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US5928647A (en) * 1993-01-11 1999-07-27 Dana-Farber Cancer Institute Inducing cytotoxic T lymphocyte responses
US6153201A (en) * 1993-03-09 2000-11-28 University Of Rochester Oral immunization with papillomavirus virus-like particles
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
EP1181937A3 (en) * 1994-08-09 2004-02-04 Cytrx Corporation Novel vaccine adjuvant and vaccine
AUPM873294A0 (en) * 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
WO1996014855A1 (en) 1994-11-15 1996-05-23 Agracetus, Inc. Method for inducing humoral and cellular immune responses utilizing intracellular delivery of peptide-coated microparticles
WO1996020698A2 (en) 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same
WO1997003702A1 (en) * 1995-07-21 1997-02-06 Brown University Research Foundation A method for gene therapy using nucleic acid loaded polymeric microparticles
AU726518C (en) * 1996-07-10 2002-01-03 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Compositions suitable for delivery of genes to epithelial cells
US5789261A (en) * 1996-10-30 1998-08-04 Temple University Of The Commonwealth System Of Higher Education Solid phase immunoassay
EP0991403B1 (en) 1997-01-30 2003-04-02 Chiron Corporation Use of microparticles with adsorbed antigen to stimulate immune responses
ES2248914T3 (es) 1997-08-29 2006-03-16 Corixa Corporation Agentes bioactivos encapsulados de liberacion rapida que permiten inducir o potenciar una respuesta inmunitaria y metodos para utilizar los mismos.
US6001333A (en) 1997-09-12 1999-12-14 See; Jackie R. Methods of preparing micro encapsulated agents for use in the detection of tumors by CT imaging
CA2318493A1 (en) 1998-01-16 1999-07-22 The Johns Hopkins University Oral delivery of nucleic acid vaccines by particulate complexes
SE9800615D0 (sv) 1998-02-27 1998-02-27 Ingvar Sjoeholm Mucosal microparticle conjugate vaccine
GB9817052D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
ATE452651T1 (de) 1998-09-01 2010-01-15 Merrion Res Iii Ltd Orale impfstoff-zusammensetzung
CA2361421A1 (en) * 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
CN100425287C (zh) 1999-02-09 2008-10-15 理化学研究所 肿瘤疫苗
AU3730600A (en) * 1999-03-18 2000-10-04 Xiaojiang Chen Compositions preparations and uses of human papillomavirus l1 protein
US6287588B1 (en) 1999-04-29 2001-09-11 Macromed, Inc. Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
AU4373499A (en) 1999-06-02 2000-12-28 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers
EP1118331A1 (en) 2000-01-21 2001-07-25 I.D.M. Immuno-Designed Molecules Method for enhancing the presentation of exogenous antigen by human antigen-presenting cells and opsonized micro particle complexes for applying this method
DE60121925T2 (de) 2000-03-22 2007-03-01 The Secretary Of State For Defence, Salisbury Arzneimittel zur verabreichung an schleimhäute
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
FR2859909B1 (fr) 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
US20070275007A1 (en) 2003-11-05 2007-11-29 The Government Of The United States Of America, Represented By The Secretary Of Health And Human S Carbohydrate Antigen-Nanoparticle Conjugates and Uses Thereof as Antimetastatic Agents in Treating Cancer
CA2548992A1 (en) 2003-12-11 2005-08-11 Vaxdesign Corporation Immunotherapy compositions, method of making and method of use thereof
ES2564241T3 (es) 2005-12-02 2016-03-21 Glaxosmithkline Biologicals Sa Nanopartículas para su uso en composiciones inmunogénicas
US8021689B2 (en) 2006-02-21 2011-09-20 Ecole Polytechnique Federale de Lausanne (“EPFL”) Nanoparticles for immunotherapy
AU2007221154A1 (en) 2006-02-24 2007-09-07 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
CN101472598A (zh) 2006-06-20 2009-07-01 Cmp医疗有限公司 包含壳多糖微粒的组合物及其医药用途
US8333972B2 (en) 2006-08-16 2012-12-18 Temple University Unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions
US20090202651A1 (en) 2006-08-28 2009-08-13 Moody Michael A Antigen specific fluorescent nanoparticles
AT504160A1 (de) 2006-09-11 2008-03-15 Ralf Dr Kircheis Verwendung einer mehrkomponenten-tumorvakzine
WO2008118861A2 (en) 2007-03-23 2008-10-02 The University Of North Carolina At Chapel Hill Discrete size and shape specific organic nanoparticles designed to elicit an immune response
AU2008314647B2 (en) 2007-10-12 2013-03-21 Massachusetts Institute Of Technology Vaccine nanotechnology
US9107858B2 (en) 2007-12-05 2015-08-18 Wisconsin Alumni Research Foundation Dendritic cell targeting compositions and uses thereof
CA2716622A1 (en) 2008-02-26 2009-09-03 The Regents Of The University Of California Glycopeptides and methods of making and using them
EP2389193A4 (en) 2009-01-20 2012-08-08 Univ Northwestern COMPOSITION AND METHOD FOR CREATING AN ANTIGEN-SPECIFIC TOLERANCE

Also Published As

Publication number Publication date
US20040014708A1 (en) 2004-01-22
DK1326633T3 (da) 2011-07-04
KR20030055262A (ko) 2003-07-02
US20120082725A1 (en) 2012-04-05
NZ535851A (en) 2006-04-28
IL154913A0 (en) 2003-10-31
AUPR011700A0 (en) 2000-10-05
JP2004507566A (ja) 2004-03-11
ES2363735T3 (es) 2011-08-12
US8846026B2 (en) 2014-09-30
EP1326633A4 (en) 2006-05-24
CN1630531A (zh) 2005-06-22
JP5198712B2 (ja) 2013-05-15
CN100446811C (zh) 2008-12-31
DE60144240D1 (de) 2011-04-28
NZ524843A (en) 2004-11-26
US20100136043A1 (en) 2010-06-03
CA2422575A1 (en) 2002-03-21
CA2422575C (en) 2015-04-28
EP1326633B1 (en) 2011-03-16
EP1326633A1 (en) 2003-07-16
ATE501726T1 (de) 2011-04-15
WO2002022164A1 (en) 2002-03-21
US8287877B2 (en) 2012-10-16

Similar Documents

Publication Publication Date Title
IL154913A0 (en) Composition comprising immunogenic microparticles
WO2005037190A3 (en) Multiplex vaccines
MXPA05013973A (es) Metodos para producir, mejorar y sustentar respuestas inmunes contra epitopes restringidos mhc clase i, para propositos profilacticos o terapeuticos.
IS4518A (is) Nýtt lyfjaform fyrir bóluefni
WO2004030608A3 (en) Nanoemulsion vaccines
WO2004032829A3 (en) Immunostimulatory compositions and methods of stimulating an immune response
SG170127A1 (en) Vaccine compositions comprising a saponin adjuvant
EP1594536A4 (en) ADJUVANT INFLUENZA VACCINE
MY125202A (en) Vaccine
IL150602A (en) Proteosome influenza vaccine, method for preparing such and use thereof
HK1044484A1 (en) Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide.
GB2434367A (en) Improved vaccines
WO2001097841A3 (en) Qs-21 and il-12 as an adjuvant combination
DE60136563D1 (de) Salmonella vakzine
WO2005000884A8 (en) Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
AU2001284354A1 (en) Immunological adjuvant compounds, compositions, and methods of use thereof
WO2002034287A3 (en) Therapeutic vaccine formulations containing chitosan
WO2005012538A3 (en) Accelerated vaccination
WO2004058188A3 (en) Vaccine compositions and methods
AU6761301A (en) Adjuvant composition comprising fha protein or fragment of fha protein in free form
AU2002342949A1 (en) Vaccine composition comprising at least two valences, one with enhanced adjuvant and not the other
HUP0401182A3 (en) Vaccine composition comprising at least two valences, one enhanced with adjuvant and not the other
WO2002032455A3 (en) Vaccine
IL193391A0 (en) Influenza antigens, vaccine compositions, and related methods