WO2002034287A3 - Therapeutic vaccine formulations containing chitosan - Google Patents

Therapeutic vaccine formulations containing chitosan Download PDF

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Publication number
WO2002034287A3
WO2002034287A3 PCT/DK2001/000705 DK0100705W WO0234287A3 WO 2002034287 A3 WO2002034287 A3 WO 2002034287A3 DK 0100705 W DK0100705 W DK 0100705W WO 0234287 A3 WO0234287 A3 WO 0234287A3
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WO
WIPO (PCT)
Prior art keywords
containing chitosan
formulations containing
vaccine formulations
therapeutic vaccine
formulation
Prior art date
Application number
PCT/DK2001/000705
Other languages
French (fr)
Other versions
WO2002034287A2 (en
Inventor
Anne Mette Beier
Anand Gautam
Soeren Mouritsen
Original Assignee
Pharmexa As
Anne Mette Beier
Anand Gautam
Soeren Mouritsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa As, Anne Mette Beier, Anand Gautam, Soeren Mouritsen filed Critical Pharmexa As
Priority to AU2002210407A priority Critical patent/AU2002210407A1/en
Publication of WO2002034287A2 publication Critical patent/WO2002034287A2/en
Publication of WO2002034287A3 publication Critical patent/WO2002034287A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001157—Telomerase or TERT [telomerase reverse transcriptase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A61K39/001117—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR] or CD30
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/001116—Receptors for cytokines
    • A61K39/001119—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001124—CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011—Cancer antigens
    • A61K39/001196—Fusion proteins originating from gene translocation in cancer cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a novel method and formulation for the induction of immune responses against polypeptide antigens. In particular, the invention provides a method and formulation for induction of cytotoxic T cell responses against a polypeptide antigen of choice. The formulations are characterized by containing chitosan in admixture with the polyptide antigen, preferably in the form of microparticles that may be cross-linked.
PCT/DK2001/000705 2000-10-27 2001-10-26 Therapeutic vaccine formulations containing chitosan WO2002034287A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002210407A AU2002210407A1 (en) 2000-10-27 2001-10-26 Therapeutic vaccine formulations containing chitosan

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200001606 2000-10-27
DKPA200001606 2000-10-27
US24516600P 2000-11-03 2000-11-03
US60/245,166 2000-11-03
DKPA200100936 2001-06-18
DKPA200100936 2001-06-18

Publications (2)

Publication Number Publication Date
WO2002034287A2 WO2002034287A2 (en) 2002-05-02
WO2002034287A3 true WO2002034287A3 (en) 2003-01-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2001/000705 WO2002034287A2 (en) 2000-10-27 2001-10-26 Therapeutic vaccine formulations containing chitosan

Country Status (2)

Country Link
AU (1) AU2002210407A1 (en)
WO (1) WO2002034287A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015716A2 (en) 2001-08-13 2003-02-27 Ige Therapeutics, Inc. Immunoglobulin e vaccines and methods of use thereof
JP2005501845A (en) 2001-08-16 2005-01-20 メディカル リサーチ カウンシル Chitin microparticles and their medical uses
CN100333792C (en) 2001-09-28 2007-08-29 南佛罗里达大学 Rsv gene expression vaccine
EP1594547A2 (en) 2003-02-14 2005-11-16 University Of South Florida Research Foundation, Inc. Chitosan-microparticles for ifn gene delivery
US6890913B2 (en) 2003-02-26 2005-05-10 Food Industry Research And Development Institute Chitosans
WO2005072088A2 (en) * 2003-12-11 2005-08-11 Sciperio, Inc. Immunotherapy compositions, method of making and method of use thereof
KR20070057932A (en) * 2004-09-15 2007-06-07 오츠카 세이야쿠 가부시키가이샤 Permucosal composition and method of improving permucosal absorption
FR2893254B1 (en) * 2005-11-14 2007-12-21 Biomerieux Sa COMPOSITION COMPRISING A BIORESORBABLE COLLOIDAL SYNTHETIC VECTOR AND A VIRAL VECTOR AND ITS PROPHYLACTIC, THERAPEUTIC AND DIAGNOSTIC USE.
US20100150960A1 (en) * 2006-09-22 2010-06-17 The United States Of America, As Represented By The Secretary,Department Of Health And Human Servi Compositions and methods for chitosan enhanced immune response
EP2123261A1 (en) 2008-05-20 2009-11-25 Stallergenes S.A. Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance
RU2377305C1 (en) * 2008-11-13 2009-12-27 Всеволод Иванович Киселев Mucosal vaccine for immune therapy of diseases caused by human papilloma viruses, and related therapy (versions)
GB201214007D0 (en) * 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
CN113069537A (en) * 2021-04-29 2021-07-06 江苏欣生元生物科技有限公司 Fusion protein nano vaccine based on RAS (RAS-mediated isothermal amplification) variant neoepitope and preparation method thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0183556A2 (en) * 1984-11-29 1986-06-04 IHARA CHEMICAL INDUSTRY Co., Ltd. Use of chitin- or chitosan-oligomers for the manufacture of a immunopotentiating agent for enhancing the immune response against bacterial and fungal infections and against the growth of tumours
WO1997020576A1 (en) * 1995-12-07 1997-06-12 Danbiosyst Uk Limited Vaccine compositions for intranasal administration comprising chitosan and use thereof
WO2000020027A2 (en) * 1998-10-05 2000-04-13 M & E Biotech A/S Methods for therapeutic vaccination

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0183556A2 (en) * 1984-11-29 1986-06-04 IHARA CHEMICAL INDUSTRY Co., Ltd. Use of chitin- or chitosan-oligomers for the manufacture of a immunopotentiating agent for enhancing the immune response against bacterial and fungal infections and against the growth of tumours
WO1997020576A1 (en) * 1995-12-07 1997-06-12 Danbiosyst Uk Limited Vaccine compositions for intranasal administration comprising chitosan and use thereof
WO2000020027A2 (en) * 1998-10-05 2000-04-13 M & E Biotech A/S Methods for therapeutic vaccination

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NISHIMURA K ET AL: "ADJUVANT ACTIVITY OF CHITIN DERIVATIVES IN MICE AND GUINEA-PIGS", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 3, no. 5, 1 December 1985 (1985-12-01), pages 379 - 384, XP002017432, ISSN: 0264-410X *

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WO2002034287A2 (en) 2002-05-02

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