WO2005007804A3 - Anthrax conjugate vaccine and antibodies - Google Patents

Anthrax conjugate vaccine and antibodies Download PDF

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Publication number
WO2005007804A3
WO2005007804A3 PCT/US2004/010933 US2004010933W WO2005007804A3 WO 2005007804 A3 WO2005007804 A3 WO 2005007804A3 US 2004010933 W US2004010933 W US 2004010933W WO 2005007804 A3 WO2005007804 A3 WO 2005007804A3
Authority
WO
WIPO (PCT)
Prior art keywords
pga
antibodies
anthrax
conjugate vaccine
present
Prior art date
Application number
PCT/US2004/010933
Other languages
French (fr)
Other versions
WO2005007804A2 (en
Inventor
Julia Y Wang
John Mekalanos
Gi-Eun Rhie
John R Collier
Original Assignee
Harvard College
Brigham & Womens Hospital
Julia Y Wang
John Mekalanos
Gi-Eun Rhie
John R Collier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Brigham & Womens Hospital, Julia Y Wang, John Mekalanos, Gi-Eun Rhie, John R Collier filed Critical Harvard College
Publication of WO2005007804A2 publication Critical patent/WO2005007804A2/en
Publication of WO2005007804A3 publication Critical patent/WO2005007804A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention is directed to immunogenic conjugates comprised of poly-Ϝ-D-glutamic acid (PGA) which has been covalently bound to protective antigen (PA). The invention includes methods for making conjugates, vaccines in which they are present and methods for immunizing individuals in which they are used. Conjugation produces a synergistic effect dramatically increasing the response of animals to both the PGA and PA components of the conjugate. Antibodies to PGA and PA confer protection against bacilli and anthrax toxins.
PCT/US2004/010933 2003-04-10 2004-04-09 Anthrax conjugate vaccine and antibodies WO2005007804A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46140603P 2003-04-10 2003-04-10
US60/461,406 2003-04-10

Publications (2)

Publication Number Publication Date
WO2005007804A2 WO2005007804A2 (en) 2005-01-27
WO2005007804A3 true WO2005007804A3 (en) 2005-09-09

Family

ID=34079009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010933 WO2005007804A2 (en) 2003-04-10 2004-04-09 Anthrax conjugate vaccine and antibodies

Country Status (1)

Country Link
WO (1) WO2005007804A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
US20070148188A1 (en) * 2003-07-30 2007-06-28 Merck & Co., Inc. Anthrax vaccine
US8409590B2 (en) 2004-02-11 2013-04-02 Ligocyte Pharmaceuticals, Inc. Anthrax antigens and methods of use
KR100517114B1 (en) * 2005-02-25 2005-09-27 주식회사 바이오리더스 Composition for adjuvant containing poly-gamma-glutamic acid
US20080206276A1 (en) 2005-07-08 2008-08-28 Michael Otto Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections
US8420607B2 (en) 2006-06-30 2013-04-16 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
EP2044194B1 (en) 2006-06-30 2011-10-05 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
WO2008130381A2 (en) * 2006-10-24 2008-10-30 Wyeth Polyglutamic acid compositions and their use as immunogens
US20140302084A1 (en) * 2011-08-05 2014-10-09 The University Of Chicago Immunogenic protein conjugates and method for making and using the same
CN107986863A (en) * 2017-12-07 2018-05-04 湖南省农业环境生态研究所 A kind of water-soluble fertilizer of blade face resistance control rice Cd uptake and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898033A (en) * 1995-06-07 1999-04-27 Swadesh; Joel K. Antigen-processing cell-targeted conjugates
US20040258699A1 (en) * 2002-02-11 2004-12-23 Bowdish Katherine S. Immunotherapeutics for biodefense

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898033A (en) * 1995-06-07 1999-04-27 Swadesh; Joel K. Antigen-processing cell-targeted conjugates
US20040258699A1 (en) * 2002-02-11 2004-12-23 Bowdish Katherine S. Immunotherapeutics for biodefense

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PEZARD C. ET AL.: "Protective immunity induced by bacilus anthracis toxin-deficient strains, infection and immunity.", vol. 63, no. 4, 1995, pages 1369 - 1372, XP002323449 *
PITTMAN P. ET AL.: "Antrax vaccine: immunogenicity and safety of a dose-reduction", VACCINE., vol. 20, 2002, pages 1412 - 1420, XP004334121 *

Also Published As

Publication number Publication date
WO2005007804A2 (en) 2005-01-27

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