PT1288208E - Processo para preparacao de compostos de 2 - (4 - alquil - 1 - piperazinil) - benzaldeido e - benzilidenilo por substituicao necleofilica aromatica de 2 - fluorobenzaldeido com 4 - alquil - 1 - piperazina em agua como solvente - Google Patents

Processo para preparacao de compostos de 2 - (4 - alquil - 1 - piperazinil) - benzaldeido e - benzilidenilo por substituicao necleofilica aromatica de 2 - fluorobenzaldeido com 4 - alquil - 1 - piperazina em agua como solvente

Info

Publication number
PT1288208E
PT1288208E PT02255713T PT02255713T PT1288208E PT 1288208 E PT1288208 E PT 1288208E PT 02255713 T PT02255713 T PT 02255713T PT 02255713 T PT02255713 T PT 02255713T PT 1288208 E PT1288208 E PT 1288208E
Authority
PT
Portugal
Prior art keywords
fluorobenzaldeide
benzaldeide
alpho
benzylidenyl
necleophilic
Prior art date
Application number
PT02255713T
Other languages
English (en)
Inventor
Rainville Joseph Philip
Sinay Terry Gene Jr
Walinsky Stanley Walter
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PT1288208E publication Critical patent/PT1288208E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT02255713T 2001-08-30 2002-08-15 Processo para preparacao de compostos de 2 - (4 - alquil - 1 - piperazinil) - benzaldeido e - benzilidenilo por substituicao necleofilica aromatica de 2 - fluorobenzaldeido com 4 - alquil - 1 - piperazina em agua como solvente PT1288208E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31601001P 2001-08-30 2001-08-30

Publications (1)

Publication Number Publication Date
PT1288208E true PT1288208E (pt) 2006-09-29

Family

ID=23227067

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02255713T PT1288208E (pt) 2001-08-30 2002-08-15 Processo para preparacao de compostos de 2 - (4 - alquil - 1 - piperazinil) - benzaldeido e - benzilidenilo por substituicao necleofilica aromatica de 2 - fluorobenzaldeido com 4 - alquil - 1 - piperazina em agua como solvente

Country Status (24)

Country Link
US (1) US6608195B2 (pt)
EP (1) EP1288208B1 (pt)
JP (1) JP3902751B2 (pt)
KR (1) KR100503518B1 (pt)
CN (1) CN1172920C (pt)
AR (1) AR036373A1 (pt)
AT (1) ATE332897T1 (pt)
AU (1) AU2002300770B2 (pt)
BR (1) BR0203426A (pt)
CA (1) CA2399970A1 (pt)
CY (1) CY1106126T1 (pt)
DE (1) DE60213043T2 (pt)
DK (1) DK1288208T3 (pt)
ES (1) ES2266416T3 (pt)
HK (1) HK1051190A1 (pt)
HU (1) HUP0202907A3 (pt)
IL (1) IL151430A0 (pt)
MX (1) MXPA02008538A (pt)
PL (1) PL355799A1 (pt)
PT (1) PT1288208E (pt)
RU (1) RU2222533C1 (pt)
TW (1) TWI234563B (pt)
YU (1) YU62302A (pt)
ZA (1) ZA200206888B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
WO2005113526A2 (en) * 2004-05-21 2005-12-01 Pfizer Products Inc. Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]-thiomorpholin-3-one
CN111269585B (zh) * 2020-03-11 2021-10-08 苏州根岸生物科技有限责任公司 一种荧光染料及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA56185C2 (uk) * 1996-09-30 2003-05-15 Пфайзер Інк. Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування
US6248888B1 (en) * 1997-11-14 2001-06-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of terazosin hydrochloride dihydrate
TW426667B (en) 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists

Also Published As

Publication number Publication date
EP1288208B1 (en) 2006-07-12
HU0202907D0 (pt) 2002-10-28
DE60213043D1 (de) 2006-08-24
AU2002300770B2 (en) 2007-06-07
HUP0202907A2 (hu) 2003-06-28
US20030087914A1 (en) 2003-05-08
CN1403448A (zh) 2003-03-19
CY1106126T1 (el) 2011-06-08
ZA200206888B (en) 2004-03-01
JP3902751B2 (ja) 2007-04-11
KR20030019190A (ko) 2003-03-06
US6608195B2 (en) 2003-08-19
RU2222533C1 (ru) 2004-01-27
HK1051190A1 (en) 2003-07-25
RU2002123289A (ru) 2004-03-10
PL355799A1 (en) 2003-03-10
EP1288208A1 (en) 2003-03-05
HUP0202907A3 (en) 2004-06-28
DK1288208T3 (da) 2006-10-16
DE60213043T2 (de) 2007-01-04
JP2003096060A (ja) 2003-04-03
KR100503518B1 (ko) 2005-07-25
MXPA02008538A (es) 2003-03-05
ES2266416T3 (es) 2007-03-01
CN1172920C (zh) 2004-10-27
YU62302A (sh) 2005-03-15
ATE332897T1 (de) 2006-08-15
TWI234563B (en) 2005-06-21
CA2399970A1 (en) 2003-02-28
BR0203426A (pt) 2003-05-13
AR036373A1 (es) 2004-09-01
IL151430A0 (en) 2003-04-10

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