PT1083924E - Peptido-1 do tipo glucagon que melhora a resposta de celulas-beta a glucose em individuos com diminuicao da tolerancia a glucose - Google Patents

Peptido-1 do tipo glucagon que melhora a resposta de celulas-beta a glucose em individuos com diminuicao da tolerancia a glucose

Info

Publication number
PT1083924E
PT1083924E PT99921778T PT99921778T PT1083924E PT 1083924 E PT1083924 E PT 1083924E PT 99921778 T PT99921778 T PT 99921778T PT 99921778 T PT99921778 T PT 99921778T PT 1083924 E PT1083924 E PT 1083924E
Authority
PT
Portugal
Prior art keywords
glucose
diminuation
bell
individuals
cells
Prior art date
Application number
PT99921778T
Other languages
English (en)
Inventor
Burkhard Goke
Maria Byrne
Thomas R Coolidge
Original Assignee
Amylin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22215287&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1083924(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amylin Pharmaceuticals Inc filed Critical Amylin Pharmaceuticals Inc
Publication of PT1083924E publication Critical patent/PT1083924E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT99921778T 1998-06-12 1999-05-07 Peptido-1 do tipo glucagon que melhora a resposta de celulas-beta a glucose em individuos com diminuicao da tolerancia a glucose PT1083924E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8904498P 1998-06-12 1998-06-12

Publications (1)

Publication Number Publication Date
PT1083924E true PT1083924E (pt) 2004-10-29

Family

ID=22215287

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99921778T PT1083924E (pt) 1998-06-12 1999-05-07 Peptido-1 do tipo glucagon que melhora a resposta de celulas-beta a glucose em individuos com diminuicao da tolerancia a glucose

Country Status (30)

Country Link
US (1) US7265087B1 (pt)
EP (2) EP1419783A3 (pt)
JP (1) JP2002517469A (pt)
KR (1) KR20010052800A (pt)
CN (1) CN1209166C (pt)
AP (1) AP2001002027A0 (pt)
AT (1) ATE270897T1 (pt)
AU (2) AU758825B2 (pt)
BG (1) BG64975B1 (pt)
BR (1) BR9911112A (pt)
CA (1) CA2334872C (pt)
CZ (1) CZ294848B6 (pt)
DE (1) DE69918691T2 (pt)
DK (1) DK1083924T3 (pt)
EA (1) EA004538B1 (pt)
ES (1) ES2224659T3 (pt)
GE (1) GEP20033015B (pt)
HU (1) HUP0102193A2 (pt)
ID (1) ID28617A (pt)
IL (2) IL140223A0 (pt)
MX (1) MXPA00012286A (pt)
NO (1) NO20006336L (pt)
NZ (2) NZ508823A (pt)
OA (1) OA11694A (pt)
PL (1) PL195662B1 (pt)
PT (1) PT1083924E (pt)
SK (1) SK19042000A3 (pt)
TR (1) TR200100079T2 (pt)
UA (1) UA69412C2 (pt)
WO (1) WO1999064061A1 (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
US20020025306A1 (en) * 2000-01-07 2002-02-28 Baetge Edward E. Methods of increasing the glucose responsiveness of pancreatic ss-cells
WO2002043709A1 (fr) 2000-12-01 2002-06-06 Takeda Chemical Industries, Ltd. Procede de production d'une preparation contenant une substance bioactive
ES2545090T3 (es) 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US8921311B2 (en) * 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006126688A1 (ja) * 2005-05-27 2006-11-30 Asubio Pharma Co., Ltd. インスリン抵抗性改善剤
RU2390325C2 (ru) 2005-09-14 2010-05-27 Маннкайнд Корпорейшн Способ приготовления лекарственного препарата, основанный на увеличении сродства активных агентов к поверхностям кристаллических микрочастиц
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8288339B2 (en) 2006-04-20 2012-10-16 Amgen Inc. GLP-1 compounds
MX2008014870A (es) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
EP2363112B8 (en) 2006-08-09 2018-11-21 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
RU2413528C2 (ru) 2007-01-18 2011-03-10 Открытое Акционерное Общество "Валента Фармацевтика" Лекарственный препарат для лечения сахарного диабета на основе экзенатида и даларгина, применение и способ лечения
EP2157967B1 (en) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspension formulations of insulinotropic peptides and uses thereof
WO2009040019A2 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
WO2009046850A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Cgrp as a therapeutic agent
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US20120058105A1 (en) * 2008-06-27 2012-03-08 Martin Kean Chong Ng Method of treatment of vascular complications
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2010298733B2 (en) 2009-09-28 2014-10-09 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
WO2014010586A1 (ja) 2012-07-10 2014-01-16 武田薬品工業株式会社 注射用製剤
JP6312262B2 (ja) 2012-07-12 2018-04-18 マンカインド コーポレイション 乾燥粉末薬物送達システム
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
PE20151239A1 (es) 2012-12-21 2015-09-08 Sanofi Sa Derivados de exendina-4 funcionalizada
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／升糖素受體促效劑
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
TW201609795A (zh) 2013-12-13 2016-03-16 賽諾菲公司 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
RU2573933C1 (ru) 2014-08-21 2016-01-27 Дафот Энтерпрайсис Лимитед Пептид для лечения сахарного диабета 2-го типа и его осложнений
CN104267194B (zh) * 2014-09-23 2016-01-13 上海市东方医院 人胰高血糖素样肽-1、抗体及其试剂盒
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
IL307966A (en) 2017-01-03 2023-12-01 Intarcia Therapeutics Inc Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug
KR20210091230A (ko) * 2018-11-12 2021-07-21 톈진 인스티튜트 오브 파마슈티컬 리서치 씨오., 엘티디. 글루카곤 유도 펩티드 및 이의 용도
CN113430154A (zh) * 2021-05-21 2021-09-24 深圳市前海金卓生物技术有限公司 分泌glp-1的蛋白表达系统及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59712555D1 (de) 1996-06-05 2006-04-06 Roche Diagnostics Gmbh Exendin-analoga, verfahren zu deren herstellung und diese enthaltende arzneimittel
US6277819B1 (en) * 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6344180B1 (en) * 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes

Also Published As

Publication number Publication date
AU2003212050A1 (en) 2003-08-14
IL140223A0 (en) 2002-02-10
DE69918691T2 (de) 2005-07-21
TR200100079T2 (tr) 2001-06-21
US7265087B1 (en) 2007-09-04
CN1209166C (zh) 2005-07-06
EA004538B1 (ru) 2004-06-24
EP1083924B1 (en) 2004-07-14
OA11694A (en) 2005-01-12
CA2334872C (en) 2014-08-19
JP2002517469A (ja) 2002-06-18
NO20006336D0 (no) 2000-12-12
UA69412C2 (uk) 2004-09-15
BG105079A (en) 2001-09-28
AP2001002027A0 (en) 2001-03-31
CZ294848B6 (cs) 2005-03-16
PL345212A1 (en) 2001-12-03
CZ20004614A3 (en) 2001-06-13
NZ508823A (en) 2003-10-31
ES2224659T3 (es) 2005-03-01
PL195662B1 (pl) 2007-10-31
EA200100029A1 (ru) 2001-10-22
IL140223A (en) 2010-12-30
EP1419783A2 (en) 2004-05-19
MXPA00012286A (es) 2002-10-17
BR9911112A (pt) 2001-11-27
BG64975B1 (bg) 2006-11-30
KR20010052800A (ko) 2001-06-25
CN1311687A (zh) 2001-09-05
NO20006336L (no) 2001-02-12
SK19042000A3 (sk) 2001-11-06
CA2334872A1 (en) 1999-12-16
AU2003212050B2 (en) 2006-02-16
AU3889999A (en) 1999-12-30
EP1083924A1 (en) 2001-03-21
DE69918691D1 (de) 2004-08-19
WO1999064061A1 (en) 1999-12-16
AU758825B2 (en) 2003-04-03
ID28617A (id) 2001-06-21
EP1419783A3 (en) 2005-01-12
GEP20033015B (en) 2003-07-25
NZ527473A (en) 2005-02-25
ATE270897T1 (de) 2004-07-15
DK1083924T3 (da) 2004-11-22
HUP0102193A2 (hu) 2001-10-28

Similar Documents

Publication Publication Date Title
PT1083924E (pt) Peptido-1 do tipo glucagon que melhora a resposta de celulas-beta a glucose em individuos com diminuicao da tolerancia a glucose
PT998538E (pt) Selante na construcao em bruto resistente a lavagem e de endurecimento a quente
PT941994E (pt) Pirazolopirimidinas e pirazolotriazinas com afinidade para o receptor de 5-ht6
DE69517607D1 (de) Unsichtbare Tintenzusammensetzung das auf Infrarotlicht reagiert
DE69801482D1 (de) Verbesserung an oder in bezug auf thermische auslöseeinheiten
PT890403E (pt) Broca com ranhuras constituidas por partes em helice e partes rectilineas
BR8802532A (pt) Arvore oca com elementos propulsores nela presos por alargamento da mesma
DE69431789D1 (de) Verbesserungen in oder in Bezug auf EEPROMs
DE59810987D1 (de) Karosseriestruktur mit wenigstens einer Querverbindung
DE69739652D1 (de) Verbesserungen in oder sich beziehend auf einer atm-vermittlungsstelle
DE59600318D1 (de) Laminatbauteil mit anderer elastizität in den randzonen
DE69811495D1 (de) Verbesserungen an oder in bezug auf elektrizitätszähler
GB0118267D0 (en) Brassica extracts or sulforaphane in combination with reseratol as antitumor agents
BR9601963A (pt) Conjunto de pinos de sincronizador e conjunto de sincronizador do tipo de pinos de ação dupla
DE69738734D1 (de) Verbesserungen bei oder in Verbindung mit Servern
DE69912148D1 (de) Verbesserungen in oder hinsichtlich von vdsl übertragungssystemen
DE69825182D1 (de) Entlaminierungsresistente verbundglasstrukture
GB2322035B (en) Improvements in and relating to computers
IL131233A0 (en) Melanins with improved ability to inhibit hiv replication
DE69902054D1 (de) Verbesserungen an oder in bezug auf feuerfestprodukte
TW386613U (en) Embedded structure of side board in computer skeleton
MX9205556A (es) Mejoras en composiciones novedosas que comprenden pentafluoroetano y monoclorodifluorometano.
ATE301468T1 (de) Synergistische kombination enthaltend ein interferon und ein nucleosid mit antiflaviviralem und antirhabdoviralem effekt
PT97772A (pt) Mecanismos de seguranca para a composicao e fixacao de paineis em elementos de sustentacao para cartazes de sinalizacao e outras utilizacoes
IT242764Y1 (it) Cavalletto con ali