PL90625B1 - Pyridoquinoline derivatives[gb1308787a] - Google Patents
Pyridoquinoline derivatives[gb1308787a] Download PDFInfo
- Publication number
- PL90625B1 PL90625B1 PL1971178228A PL17822871A PL90625B1 PL 90625 B1 PL90625 B1 PL 90625B1 PL 1971178228 A PL1971178228 A PL 1971178228A PL 17822871 A PL17822871 A PL 17822871A PL 90625 B1 PL90625 B1 PL 90625B1
- Authority
- PL
- Poland
- Prior art keywords
- carbon atoms
- ring
- pattern
- alkyl
- radical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
- Zastrzezenia patentowe 1. Sposób wytwarzania nowych estrów pirydochinolinowych o wzorze ogólnym 1, w którym pierscien benzenowy A oznacza grupe o wzorze ogólnym 2, 3, 4 lub 5, przy czym we wzorach tych a oznacza miejsce skondensowania z pierscieniem pirydynowym we wzorze 1, R1, oznacza atom wodoru lub rodnik metylowy, R2 oznacza rodnik aIkoksyIowy o 1—6 atomach wegla, a pierscien benzenowy B ewentualnie posiada nie wiecej niz dwa podstawniki, takie jak rodniki alkilowe o 1-8 atomach wegla, cykloalkilowe o nie wiecej niz 6 atomach wegla, alkoksylowe o 1 —6 atomach wegla, trójfluorometylowe, fenolowe lub fenoksylowe, atomy chlorowca lub grupy o wzorze —NR3 R4, w którym R3 oznacza rodnik alkilowy o 1—6 atomach wegla, a R4 oznacza rodnik alkilowy o 1-6 atomach wegla, lub fenyIowy, lub grupy -NR3R4 oznaczaja rodniki heterocykliczne o nie wiecej niz 7 czlonach w pierscieniu zawierajacym atom azotu jako -heteroatom, lub w przypadku gdy pierscien benzenowy A we wzorze 1 oznacza grupe o wzorze 2 lub 4, pierscien benzenowy B ewentualnie zawiera rodnik alkilenowy o 3-5 atomach wegla, przy czym jezeli R1 oznacza rodnik metylowy wówczas zwiazki o wzorze ogólnym 1 stanowia pochodne 1,7-fenantroliny posiadajace jako podstawnik rodnik alkilowy o 1—5 atomach4 90 625 wegla, aIkoksyIowy o 1 —4 atomach wegla, fenoRsylowy, piperydynowy lub morfolinowy, kazdy w pozycji!)- lub 6- pierscienia, lub rodniki metylowe w pozycji 5- i 6- lub w pozycji 5- rodnik fenylowy a w pozycji 6- rodnik metoksyIowy lub rodniki alkilenowe o,3-5 atomach wegla w pozycjach 5- i 6- oraz nietoksyczne, farmakologicz¬ nie dozwolone sole, z wyjatkiem estrów dwualkilowych, o 1-6 atomach wegla w alkilu, 2,8-dwukarboksy 4,10- dwuhydroksy-1,7-fenantroliny I 4J9-dwuhydroksy-2,7-dwumetoksykarbonylo plrydo(2,3-g)chlnoliny i ich nieto¬ ksycznych, farmakologicznie dozwolonych soli, z n a m I e n n y tym, ie poddaje sie estryfikacji odpowiedni kwas dwukarboksylowy lub transestryfikacji odpowiedni ester.
- 2. Sposób wedlug zastrz. 1,znamienny tym, ze kwas dwukarboksylowy estryfikuje sie alkaffclem o wzorze ogólnym R2 H, w którym R2 ma znaczenie podane w zastrz. 1, i odpowiednim kwasem nieorganicznym.90 625 OH R2CO- all A WZÓR \ 2 COR WZÓR 2 COR' WZÓR 4 WZÓR 690 625 WZÓR 8 COR COR WZÓR 10 NH NH, WZÓR 11 WZÓR 12 Prac. Poligraf. UP PRL naklad 120+18 Cena 10 zl PL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4715170 | 1970-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL90625B1 true PL90625B1 (en) | 1977-01-31 |
Family
ID=10443928
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1971178228A PL90625B1 (en) | 1970-10-05 | 1971-09-16 | Pyridoquinoline derivatives[gb1308787a] |
PL1971178226A PL90724B1 (en) | 1970-10-05 | 1971-09-16 | Pyridoquinoline derivatives[gb1308787a] |
PL1971178227A PL90626B1 (en) | 1970-10-05 | 1971-09-16 | Pyridoquinoline derivatives[gb1308787a] |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1971178226A PL90724B1 (en) | 1970-10-05 | 1971-09-16 | Pyridoquinoline derivatives[gb1308787a] |
PL1971178227A PL90626B1 (en) | 1970-10-05 | 1971-09-16 | Pyridoquinoline derivatives[gb1308787a] |
Country Status (9)
Country | Link |
---|---|
AT (2) | AT313911B (pl) |
CS (2) | CS177817B2 (pl) |
CY (1) | CY846A (pl) |
GB (1) | GB1308787A (pl) |
HK (1) | HK37776A (pl) |
MY (1) | MY7600126A (pl) |
PL (3) | PL90625B1 (pl) |
SU (2) | SU462335A3 (pl) |
ZA (1) | ZA716109B (pl) |
-
1970
- 1970-10-05 GB GB4715170A patent/GB1308787A/en not_active Expired
-
1971
- 1971-09-07 CY CY846A patent/CY846A/xx unknown
- 1971-09-13 ZA ZA716109A patent/ZA716109B/xx unknown
- 1971-09-16 PL PL1971178228A patent/PL90625B1/pl unknown
- 1971-09-16 PL PL1971178226A patent/PL90724B1/pl unknown
- 1971-09-16 PL PL1971178227A patent/PL90626B1/pl unknown
- 1971-10-04 SU SU1702652A patent/SU462335A3/ru active
- 1971-10-05 AT AT00003/73A patent/AT313911B/de not_active IP Right Cessation
- 1971-10-05 AT AT858471A patent/AT313287B/de active
- 1971-10-05 CS CS7026A patent/CS177817B2/cs unknown
- 1971-10-05 CS CS8803A patent/CS177842B2/cs unknown
-
1973
- 1973-02-19 SU SU1885766A patent/SU540567A3/ru active
-
1976
- 1976-06-17 HK HK377/76*UA patent/HK37776A/xx unknown
- 1976-12-30 MY MY126/76A patent/MY7600126A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
GB1308787A (en) | 1973-03-07 |
PL90724B1 (en) | 1977-01-31 |
AT313287B (de) | 1974-02-11 |
HK37776A (en) | 1976-06-25 |
AT313911B (de) | 1974-02-15 |
CS177817B2 (pl) | 1977-08-31 |
PL90626B1 (en) | 1977-01-31 |
ZA716109B (en) | 1972-05-31 |
SU540567A3 (ru) | 1976-12-25 |
CS177842B2 (pl) | 1977-08-31 |
CY846A (en) | 1976-09-10 |
SU462335A3 (ru) | 1975-02-28 |
MY7600126A (en) | 1976-12-31 |
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