PL90625B1 - Pyridoquinoline derivatives[gb1308787a] - Google Patents

Pyridoquinoline derivatives[gb1308787a] Download PDF

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Publication number
PL90625B1
PL90625B1 PL1971178228A PL17822871A PL90625B1 PL 90625 B1 PL90625 B1 PL 90625B1 PL 1971178228 A PL1971178228 A PL 1971178228A PL 17822871 A PL17822871 A PL 17822871A PL 90625 B1 PL90625 B1 PL 90625B1
Authority
PL
Poland
Prior art keywords
carbon atoms
ring
pattern
alkyl
radical
Prior art date
Application number
PL1971178228A
Other languages
English (en)
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of PL90625B1 publication Critical patent/PL90625B1/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

  1. Zastrzezenia patentowe 1. Sposób wytwarzania nowych estrów pirydochinolinowych o wzorze ogólnym 1, w którym pierscien benzenowy A oznacza grupe o wzorze ogólnym 2, 3, 4 lub 5, przy czym we wzorach tych a oznacza miejsce skondensowania z pierscieniem pirydynowym we wzorze 1, R1, oznacza atom wodoru lub rodnik metylowy, R2 oznacza rodnik aIkoksyIowy o 1—6 atomach wegla, a pierscien benzenowy B ewentualnie posiada nie wiecej niz dwa podstawniki, takie jak rodniki alkilowe o 1-8 atomach wegla, cykloalkilowe o nie wiecej niz 6 atomach wegla, alkoksylowe o 1 —6 atomach wegla, trójfluorometylowe, fenolowe lub fenoksylowe, atomy chlorowca lub grupy o wzorze —NR3 R4, w którym R3 oznacza rodnik alkilowy o 1—6 atomach wegla, a R4 oznacza rodnik alkilowy o 1-6 atomach wegla, lub fenyIowy, lub grupy -NR3R4 oznaczaja rodniki heterocykliczne o nie wiecej niz 7 czlonach w pierscieniu zawierajacym atom azotu jako -heteroatom, lub w przypadku gdy pierscien benzenowy A we wzorze 1 oznacza grupe o wzorze 2 lub 4, pierscien benzenowy B ewentualnie zawiera rodnik alkilenowy o 3-5 atomach wegla, przy czym jezeli R1 oznacza rodnik metylowy wówczas zwiazki o wzorze ogólnym 1 stanowia pochodne 1,7-fenantroliny posiadajace jako podstawnik rodnik alkilowy o 1—5 atomach4 90 625 wegla, aIkoksyIowy o 1 —4 atomach wegla, fenoRsylowy, piperydynowy lub morfolinowy, kazdy w pozycji!)- lub 6- pierscienia, lub rodniki metylowe w pozycji 5- i 6- lub w pozycji 5- rodnik fenylowy a w pozycji 6- rodnik metoksyIowy lub rodniki alkilenowe o,3-5 atomach wegla w pozycjach 5- i 6- oraz nietoksyczne, farmakologicz¬ nie dozwolone sole, z wyjatkiem estrów dwualkilowych, o 1-6 atomach wegla w alkilu, 2,8-dwukarboksy 4,10- dwuhydroksy-1,7-fenantroliny I 4J9-dwuhydroksy-2,7-dwumetoksykarbonylo plrydo(2,3-g)chlnoliny i ich nieto¬ ksycznych, farmakologicznie dozwolonych soli, z n a m I e n n y tym, ie poddaje sie estryfikacji odpowiedni kwas dwukarboksylowy lub transestryfikacji odpowiedni ester.
  2. 2. Sposób wedlug zastrz. 1,znamienny tym, ze kwas dwukarboksylowy estryfikuje sie alkaffclem o wzorze ogólnym R2 H, w którym R2 ma znaczenie podane w zastrz. 1, i odpowiednim kwasem nieorganicznym.90 625 OH R2CO- all A WZÓR \ 2 COR WZÓR 2 COR' WZÓR 4 WZÓR 690 625 WZÓR 8 COR COR WZÓR 10 NH NH, WZÓR 11 WZÓR 12 Prac. Poligraf. UP PRL naklad 120+18 Cena 10 zl PL
PL1971178228A 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a] PL90625B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4715170 1970-10-05

Publications (1)

Publication Number Publication Date
PL90625B1 true PL90625B1 (en) 1977-01-31

Family

ID=10443928

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1971178228A PL90625B1 (en) 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a]
PL1971178226A PL90724B1 (en) 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a]
PL1971178227A PL90626B1 (en) 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a]

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL1971178226A PL90724B1 (en) 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a]
PL1971178227A PL90626B1 (en) 1970-10-05 1971-09-16 Pyridoquinoline derivatives[gb1308787a]

Country Status (9)

Country Link
AT (2) AT313911B (pl)
CS (2) CS177817B2 (pl)
CY (1) CY846A (pl)
GB (1) GB1308787A (pl)
HK (1) HK37776A (pl)
MY (1) MY7600126A (pl)
PL (3) PL90625B1 (pl)
SU (2) SU462335A3 (pl)
ZA (1) ZA716109B (pl)

Also Published As

Publication number Publication date
GB1308787A (en) 1973-03-07
PL90724B1 (en) 1977-01-31
AT313287B (de) 1974-02-11
HK37776A (en) 1976-06-25
AT313911B (de) 1974-02-15
CS177817B2 (pl) 1977-08-31
PL90626B1 (en) 1977-01-31
ZA716109B (en) 1972-05-31
SU540567A3 (ru) 1976-12-25
CS177842B2 (pl) 1977-08-31
CY846A (en) 1976-09-10
SU462335A3 (ru) 1975-02-28
MY7600126A (en) 1976-12-31

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