PL55274B1 - - Google Patents

Info

Publication number

PL55274B1

PL55274B1 PL110825A PL11082565A PL55274B1 PL 55274 B1 PL55274 B1 PL 55274B1 PL 110825 A PL110825 A PL 110825A PL 11082565 A PL11082565 A PL 11082565A PL 55274 B1 PL55274 B1 PL 55274B1

Authority

PL

Poland

Prior art keywords

cobalt

solution

complex

water

aqueous solution

Prior art date

1965-09-11

Links

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• 239000000243 solution Substances 0.000 claims description 33
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
• 239000010941 cobalt Substances 0.000 claims description 16
• 229910017052 cobalt Inorganic materials 0.000 claims description 16
• GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 16
• 239000007864 aqueous solution Substances 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 14
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 13
• 229920002307 Dextran Polymers 0.000 claims description 11
• 239000000047 product Substances 0.000 claims description 8
• 239000000203 mixture Substances 0.000 claims description 7
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
• GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims description 5
• 239000003960 organic solvent Substances 0.000 claims description 5
• 238000001556 precipitation Methods 0.000 claims description 5
• 238000006243 chemical reaction Methods 0.000 claims description 4
• 150000001868 cobalt Chemical class 0.000 claims description 4
• 238000002360 preparation method Methods 0.000 claims description 4
• 150000003839 salts Chemical class 0.000 claims description 4
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
• 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
• 239000007900 aqueous suspension Substances 0.000 claims description 2
• 239000007795 chemical reaction product Substances 0.000 claims description 2
• 238000000502 dialysis Methods 0.000 claims description 2
• 239000012467 final product Substances 0.000 claims description 2
• 150000002500 ions Chemical class 0.000 claims description 2
• 238000002955 isolation Methods 0.000 claims description 2
• 159000000000 sodium salts Chemical class 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 claims description 2
• YSVZGWAJIHWNQK-UHFFFAOYSA-N [3-(hydroxymethyl)-2-bicyclo[2.2.1]heptanyl]methanol Chemical compound C1CC2C(CO)C(CO)C1C2 YSVZGWAJIHWNQK-UHFFFAOYSA-N 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000011541 reaction mixture Substances 0.000 claims 1
• 238000001226 reprecipitation Methods 0.000 claims 1
• 238000005507 spraying Methods 0.000 claims 1
• 239000012153 distilled water Substances 0.000 description 9
• 238000002347 injection Methods 0.000 description 9
• 239000007924 injection Substances 0.000 description 9
• 239000002244 precipitate Substances 0.000 description 8
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 7
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
• 229910052708 sodium Inorganic materials 0.000 description 6
• 239000011734 sodium Substances 0.000 description 6
• 238000003756 stirring Methods 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 238000001816 cooling Methods 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 238000010908 decantation Methods 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 239000001508 potassium citrate Substances 0.000 description 3
• 229960002635 potassium citrate Drugs 0.000 description 3
• QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 3
• 235000011082 potassium citrates Nutrition 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 235000011121 sodium hydroxide Nutrition 0.000 description 3
• 230000001954 sterilising effect Effects 0.000 description 3
• 238000004659 sterilization and disinfection Methods 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000003792 electrolyte Substances 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
• 230000003647 oxidation Effects 0.000 description 2
• 238000007254 oxidation reaction Methods 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• DPEYHNFHDIXMNV-UHFFFAOYSA-N (9-amino-3-bicyclo[3.3.1]nonanyl)-(4-benzyl-5-methyl-1,4-diazepan-1-yl)methanone dihydrochloride Chemical compound Cl.Cl.CC1CCN(CCN1Cc1ccccc1)C(=O)C1CC2CCCC(C1)C2N DPEYHNFHDIXMNV-UHFFFAOYSA-N 0.000 description 1
• 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
• 240000001592 Amaranthus caudatus Species 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 229920000298 Cellophane Polymers 0.000 description 1
• 229910021503 Cobalt(II) hydroxide Inorganic materials 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 235000012735 amaranth Nutrition 0.000 description 1
• 239000004178 amaranth Substances 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 239000002585 base Substances 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 229920001429 chelating resin Polymers 0.000 description 1
• 150000001860 citric acid derivatives Chemical class 0.000 description 1
• 238000005352 clarification Methods 0.000 description 1
• 229910021446 cobalt carbonate Inorganic materials 0.000 description 1
• 150000001869 cobalt compounds Chemical class 0.000 description 1
• ZOTKGJBKKKVBJZ-UHFFFAOYSA-L cobalt(2+);carbonate Chemical compound [Co+2].[O-]C([O-])=O ZOTKGJBKKKVBJZ-UHFFFAOYSA-L 0.000 description 1
• ASKVAEGIVYSGNY-UHFFFAOYSA-L cobalt(ii) hydroxide Chemical compound [OH-].[OH-].[Co+2] ASKVAEGIVYSGNY-UHFFFAOYSA-L 0.000 description 1
• 230000000536 complexating effect Effects 0.000 description 1
• 230000001143 conditioned effect Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 238000010410 dusting Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 238000006266 etherification reaction Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
• 159000000003 magnesium salts Chemical class 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 230000003472 neutralizing effect Effects 0.000 description 1
• 239000007800 oxidant agent Substances 0.000 description 1
• 150000002978 peroxides Chemical class 0.000 description 1
• 230000008092 positive effect Effects 0.000 description 1
• 239000012429 reaction media Substances 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 239000012265 solid product Substances 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 238000001694 spray drying Methods 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1