PL444846A1 - Sposób otrzymywania czwartorzędowych soli amoniowych z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem salicylanowym - Google Patents
Sposób otrzymywania czwartorzędowych soli amoniowych z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem salicylanowymInfo
- Publication number
- PL444846A1 PL444846A1 PL444846A PL44484623A PL444846A1 PL 444846 A1 PL444846 A1 PL 444846A1 PL 444846 A PL444846 A PL 444846A PL 44484623 A PL44484623 A PL 44484623A PL 444846 A1 PL444846 A1 PL 444846A1
- Authority
- PL
- Poland
- Prior art keywords
- sub
- carbamoyl
- solvent
- quaternary ammonium
- ammonium salts
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001768 cations Chemical class 0.000 title abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 title abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000007979 citrate buffer Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 159000000011 group IA salts Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 239000012451 post-reaction mixture Substances 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania czwartorzędowych soli amoniowych zbudowanych z kationu 3-karbamoilo-1-alkilopirydyniowego i anionu kwasu salicylowego, o wzorze ogólnym 1, w którym R oznacza nierozgałęziony podstawnik alkilowy z wiązaniami nasyconymi zawierający od 2 do 14 atomów węgla. W sposobie tym bromek N-alkilonikotynamidu o wzorze ogólnym 2, w którym R oznacza nierozgałęziony podstawnik alkilowy z wiązaniami nasyconymi zawierający od 2 do 14 atomów węgla, rozpuszcza się w rozpuszczalniku z grupy: metanol lub etanol. Następnie do uzyskanego roztworu dodaje bufor cytrynianowy, a po osiągnięciu wartości pH w zakresie od 4 do 6,5 wprowadza się sól alkaliczną kwasu salicylowego w stosunku molowym 1:1 do 1:1,1, korzystnie 1:1,05, w temperaturze od 30 do 50°C, korzystnie 35°C. Po czym produkt izoluje się poprzez schłodzenie mieszaniny poreakcyjnej do temperatury poniżej 5°C, korzystnie 2°C i odsączenie soli nieorganicznej, a następnie usunięcie rozpuszczalników organicznych z przesączu, przemycie uzyskanego produktu mieszaniną acetonu i wybranego rozpuszczalnika (z grupy: metanol etanol), odsączenie zanieczyszczeń, usunięcie rozpuszczalnika z przesączu na wyparce próżniowej. Finalnie produkt reakcji suszy się w suszarce próżniowej, w temperaturze 70°C przez 48 godzin i przechowuje nad P<sub>4</sub>O<sub>10</sub>.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL444846A PL444846A1 (pl) | 2023-05-10 | 2023-05-10 | Sposób otrzymywania czwartorzędowych soli amoniowych z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem salicylanowym |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL444846A PL444846A1 (pl) | 2023-05-10 | 2023-05-10 | Sposób otrzymywania czwartorzędowych soli amoniowych z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem salicylanowym |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL444846A1 true PL444846A1 (pl) | 2024-03-11 |
Family
ID=90195151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL444846A PL444846A1 (pl) | 2023-05-10 | 2023-05-10 | Sposób otrzymywania czwartorzędowych soli amoniowych z kationem 3-karbamoilo-1-alkilopirydyniowym i anionem salicylanowym |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL444846A1 (pl) |
-
2023
- 2023-05-10 PL PL444846A patent/PL444846A1/pl unknown
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