PL4218797T3 - Stabilizowane płynne i liofilizowane preparaty adamts13 - Google Patents

Stabilizowane płynne i liofilizowane preparaty adamts13

Info

Publication number
PL4218797T3
PL4218797T3 PL23172759.5T PL23172759T PL4218797T3 PL 4218797 T3 PL4218797 T3 PL 4218797T3 PL 23172759 T PL23172759 T PL 23172759T PL 4218797 T3 PL4218797 T3 PL 4218797T3
Authority
PL
Poland
Prior art keywords
adamts13
stabilized liquid
lyophilized preparations
lyophilized
preparations
Prior art date
Application number
PL23172759.5T
Other languages
English (en)
Polish (pl)
Inventor
H. Peter Matthiessen
Peter Turecek
Hans-Peter Schwarz
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of PL4218797T3 publication Critical patent/PL4218797T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL23172759.5T 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13 PL4218797T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21

Publications (1)

Publication Number Publication Date
PL4218797T3 true PL4218797T3 (pl) 2025-02-10

Family

ID=43598388

Family Applications (4)

Application Number Title Priority Date Filing Date
PL23172759.5T PL4218797T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL10759786.6T PL2480198T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL20211228.0T PL3834841T3 (pl) 2009-09-21 2010-09-21 Stabilizowane ciekłe i liofilizowane preparaty adamts13
PL15203085T PL3167897T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL10759786.6T PL2480198T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL20211228.0T PL3834841T3 (pl) 2009-09-21 2010-09-21 Stabilizowane ciekłe i liofilizowane preparaty adamts13
PL15203085T PL3167897T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13

Country Status (21)

Country Link
US (9) US8623352B2 (enFirst)
EP (5) EP3167897B1 (enFirst)
JP (2) JP5819303B2 (enFirst)
KR (6) KR20210054598A (enFirst)
CN (2) CN102573792B (enFirst)
AU (1) AU2010295299B2 (enFirst)
BR (1) BR112012006283B1 (enFirst)
CA (1) CA2774556A1 (enFirst)
DK (4) DK4218797T5 (enFirst)
EA (1) EA024267B1 (enFirst)
ES (4) ES2865250T3 (enFirst)
FI (2) FI3834841T3 (enFirst)
FR (1) FR24C1049I2 (enFirst)
HR (1) HRP20160295T1 (enFirst)
HU (1) HUE028688T2 (enFirst)
IN (1) IN2012DN02645A (enFirst)
MX (3) MX339205B (enFirst)
NZ (1) NZ598839A (enFirst)
PL (4) PL4218797T3 (enFirst)
PT (2) PT3834841T (enFirst)
WO (1) WO2011035335A2 (enFirst)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415114B2 (en) 2008-12-05 2013-04-09 Baxter International Inc. Methods of measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof
ES2865250T3 (es) 2009-09-21 2021-10-15 Takeda Pharmaceuticals Co Formulaciones de ADAMTS13 líquidas y liofilizadas estabilizadas
US8835387B2 (en) * 2012-02-16 2014-09-16 Atyr Pharma, Inc. Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
CN103566362B (zh) * 2012-07-21 2015-07-29 复旦大学 重组adamts13在制备脑出血药物中的用途
CA2890848C (en) 2012-11-09 2020-11-17 Puget Sound Blood Center Protein stabilizing factors apolipoprotein a-1 or high density lipoprotein
WO2014145050A1 (en) 2013-03-15 2014-09-18 Atyr Pharma, Inc. Histidyl-trna synthetase-fc conjugates
AU2013203062C1 (en) * 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
EP4285930A3 (en) * 2014-06-26 2024-02-28 Amgen Inc. Protein formulations
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
JP7002727B2 (ja) * 2016-01-08 2022-02-15 Kmバイオロジクス株式会社 Adamts13を主成分とする診断薬および医薬品
MX2019001255A (es) 2016-08-04 2019-05-20 Baxalta Inc Uso de una desintegrina y metaloproteinasa con motivo tipo 1 de trombospondina, miembro-13 (adamts13) para tratar, mejorar y/o prevenir crisis vaso-oclusiva en enfermedad de celulas falciformes, lesion pulmonar aguda y/o sindrome de insuficiencia respiratoria aguda.
EP3534922B1 (en) 2016-11-04 2024-04-17 Takeda Pharmaceutical Company Limited Adeno-associated virus formulations
US11767520B2 (en) 2017-04-20 2023-09-26 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
JP7263312B2 (ja) * 2017-07-25 2023-04-24 ジエンス ヘンルイ メデイシンカンパニー リミテッド Il-15タンパク質複合体医薬組成物およびその使用
KR20210032984A (ko) * 2018-07-11 2021-03-25 박스알타 인코퍼레이티드 Aav 조성물
WO2021067668A1 (en) 2019-10-04 2021-04-08 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
EP4127158A2 (en) 2020-04-02 2023-02-08 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
WO2021234458A1 (en) 2020-05-22 2021-11-25 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
IL300596A (en) * 2020-08-13 2023-04-01 Hadasit Medical Res Services & Development Limited Mutants of disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (adamts-13), preparations and their uses in therapeutic methods
IL315475A (en) 2022-03-08 2024-11-01 Equashield Medical Ltd A position for transferring liquids in a robotic system for preparing medicines
WO2024151093A1 (ko) * 2023-01-11 2024-07-18 주식회사 녹십자 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
EP1154796B1 (en) 1999-02-22 2007-06-20 University of Connecticut Novel albumin-free factor viii formulations
JP2001227510A (ja) 2000-02-15 2001-08-24 Tomoe Tech Res Co 複作動型の空気式アクチュエータ
JP3783507B2 (ja) 2000-02-16 2006-06-07 日本精工株式会社 トロイダル型無段変速機用ディスクの加工方法
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
JP2003284570A (ja) 2001-04-25 2003-10-07 Chemo Sero Therapeut Res Inst フォンビルブラント因子(vWF)切断酵素
WO2003016492A2 (en) 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
ITPR20010055A1 (it) 2001-08-31 2003-03-03 Vetroarredo Spa Procedimento e impianto per la realizzazione di mattoni in vetro.
KR100472006B1 (ko) 2002-10-09 2005-03-10 동부아남반도체 주식회사 모스 트랜지스터 제조 방법
EP1642128B1 (en) * 2003-07-07 2016-11-16 University Of North Carolina At Chapel Hill Method and system for detection of von willebrand factor (vwf) multimers
GB0404693D0 (en) * 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
EP1902141B1 (en) * 2005-06-17 2012-02-08 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
JP4880997B2 (ja) * 2005-12-28 2012-02-22 アルフレッサファーマ株式会社 Adamts13の安定化方法
CN101360820A (zh) 2006-01-04 2009-02-04 巴克斯特国际公司 无寡肽的细胞培养基
ES2865250T3 (es) * 2009-09-21 2021-10-15 Takeda Pharmaceuticals Co Formulaciones de ADAMTS13 líquidas y liofilizadas estabilizadas
US8823352B2 (en) 2011-07-11 2014-09-02 Linear Technology Corporation Switching power supply having separate AC and DC current sensing paths

Also Published As

Publication number Publication date
EP3834841A1 (en) 2021-06-16
KR20250008986A (ko) 2025-01-16
DK3834841T3 (da) 2023-06-06
EP4218797A1 (en) 2023-08-02
EP2480198B1 (en) 2016-03-09
PL3167897T3 (pl) 2021-09-27
AU2010295299B2 (en) 2015-12-24
CN104224705A (zh) 2014-12-24
PT3834841T (pt) 2023-06-19
IN2012DN02645A (enFirst) 2015-09-11
AU2010295299A1 (en) 2012-04-12
DK4218797T5 (da) 2025-07-21
US10238720B2 (en) 2019-03-26
KR101891646B1 (ko) 2018-08-27
EP3167897A1 (en) 2017-05-17
US8623352B2 (en) 2014-01-07
MX2019000547A (es) 2020-11-12
FR24C1049I2 (fr) 2025-12-12
MX339205B (es) 2016-05-16
EA024267B1 (ru) 2016-09-30
EA201200519A1 (ru) 2012-09-28
EP3834841B1 (en) 2023-05-17
FI4218797T3 (fi) 2024-12-07
PL2480198T3 (pl) 2016-09-30
HRP20160295T1 (hr) 2016-05-20
CN102573792B (zh) 2014-10-15
EP2480198B9 (en) 2016-11-23
US20160375111A1 (en) 2016-12-29
KR20220139456A (ko) 2022-10-14
ES2579906T3 (es) 2016-08-17
KR20120099646A (ko) 2012-09-11
CA2774556A1 (en) 2011-03-24
WO2011035335A3 (en) 2011-12-01
MX2012003414A (es) 2012-06-19
US20200376098A1 (en) 2020-12-03
DK2480198T3 (en) 2016-03-29
US20180207245A1 (en) 2018-07-26
EP4467160A2 (en) 2024-11-27
FI3834841T3 (fi) 2023-06-05
BR112012006283B1 (pt) 2022-03-15
US12178861B2 (en) 2024-12-31
US20110229455A1 (en) 2011-09-22
FR24C1049I1 (fr) 2025-01-17
EP4467160A3 (en) 2025-01-15
BR112012006283A2 (pt) 2016-05-31
ES3001509T3 (en) 2025-03-05
JP5819303B2 (ja) 2015-11-24
NZ598839A (en) 2014-03-28
US10758599B2 (en) 2020-09-01
ES2948612T3 (es) 2023-09-14
KR20210054598A (ko) 2021-05-13
HK1173968A1 (zh) 2013-05-31
EP4218797B9 (en) 2025-04-30
KR20190137954A (ko) 2019-12-11
US20250099559A1 (en) 2025-03-27
JP2013505270A (ja) 2013-02-14
PT4218797T (pt) 2024-12-09
MX362382B (es) 2019-01-14
EP3167897B1 (en) 2021-01-27
DK4218797T3 (da) 2024-12-09
JP2015063556A (ja) 2015-04-09
WO2011035335A2 (en) 2011-03-24
US9351935B2 (en) 2016-05-31
CN102573792A (zh) 2012-07-11
US20230130866A1 (en) 2023-04-27
US9572778B2 (en) 2017-02-21
EP2480198A2 (en) 2012-08-01
US20170112906A1 (en) 2017-04-27
ES2865250T3 (es) 2021-10-15
CN104224705B (zh) 2018-02-02
EP4218797B1 (en) 2024-09-11
DK3167897T3 (da) 2021-04-19
US11564979B2 (en) 2023-01-31
US20190247475A1 (en) 2019-08-15
KR20180095738A (ko) 2018-08-27
HUE028688T2 (en) 2017-01-30
US20140178357A1 (en) 2014-06-26
US9937244B2 (en) 2018-04-10
PL3834841T3 (pl) 2023-07-24

Similar Documents

Publication Publication Date Title
PL3167897T3 (pl) Stabilizowane płynne i liofilizowane preparaty adamts13
SG10201503540QA (en) Integrated sample preparation systems and stabilized enzyme mixtures
IL243932A0 (en) Certain chemical entities, compositions and methods
IL211158B (en) Solid core microcapsular compositions and uses thereof
HRP20160579T1 (hr) Spoj indola i njegova farmaceutska upotreba
HUE062860T2 (hu) Magas koncentrációjú gyógyszerészeti készítmények
HRP20160737T1 (hr) Anti-her3-protutijela i njihove uporabe
EP2258831A4 (en) MUTANT YEAST AND YEAST EXTRACT
IL250259A0 (en) Compositions comprising ursolic acid and derivatives thereof and uses thereof
FI20106349L (fi) Anturi ja anturijärjestelmä
HRP20150926T4 (hr) Pripravci u krutom stanju
BRPI0914155A2 (pt) preparações de xampu
EE01079U1 (et) Territooriumi ja selle perimeetri j„lgimise ssteem
EP2515946A4 (en) NANOCONJUGATES AND COMPOSITIONS OF NANOCONJUGATES
IL225607A0 (en) Heteroaryls and uses thereof
BRPI0914152A2 (pt) preparações de xampu
BRPI1008270A2 (pt) aparelho e sistema
DK2260994T3 (da) Formsystem samt anvendelse deraf
HUE036183T2 (hu) JC Vírus antitestekre vonatkozó assay
BRPI1008887A2 (pt) peptídeos de foxm1 e vacinas contendo os mesmo
IL213598A0 (en) Enema preparations and their use
FR2963612B1 (fr) Element en treillis et grue
IT1401531B1 (it) Sistema utilizzabile in due modalita'
PT2408913T (pt) Péptidos neil3 e vacinas que incluem os mesmos
IT1401910B1 (it) Composizione fotoattiva stabilizzata e suo utilizzo