PL419907A1 - Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji - Google Patents

Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji

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Publication number
PL419907A1
PL419907A1 PL419907A PL41990716A PL419907A1 PL 419907 A1 PL419907 A1 PL 419907A1 PL 419907 A PL419907 A PL 419907A PL 41990716 A PL41990716 A PL 41990716A PL 419907 A1 PL419907 A1 PL 419907A1
Authority
PL
Poland
Prior art keywords
genetic material
biological sample
reaction chambers
execution
detection
Prior art date
Application number
PL419907A
Other languages
English (en)
Other versions
PL235210B1 (pl
Inventor
Miron TOKARSKI
Henryk Waldemar ROGUSZCZAK
Tadeusz Dobosz
Leszek GOLONKA
Arkadiusz Dąbrowski
Małgorzata MAŁODOBRA-MAZUR
Damian Andrzejewski
Original Assignee
Genomtec Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomtec Spółka Akcyjna filed Critical Genomtec Spółka Akcyjna
Priority to PL419907A priority Critical patent/PL235210B1/pl
Priority to CN201780078465.0A priority patent/CN110088266A/zh
Priority to HUE17002043A priority patent/HUE058240T2/hu
Priority to RS20220414A priority patent/RS63179B1/sr
Priority to JP2019534892A priority patent/JP6961700B2/ja
Priority to CA2989599A priority patent/CA2989599C/en
Priority to BR112019012501-9A priority patent/BR112019012501B1/pt
Priority to EP22155747.3A priority patent/EP4029607A1/en
Priority to HRP20220582TT priority patent/HRP20220582T1/hr
Priority to DK17002043.2T priority patent/DK3338891T3/da
Priority to EP17002043.2A priority patent/EP3338891B8/en
Priority to ES17002043T priority patent/ES2913092T3/es
Priority to LTEP17002043.2T priority patent/LT3338891T/lt
Priority to PCT/PL2017/050065 priority patent/WO2018117882A1/en
Priority to PT170020432T priority patent/PT3338891T/pt
Priority to SI201731139T priority patent/SI3338891T1/sl
Priority to US15/850,733 priority patent/US10781479B2/en
Publication of PL419907A1 publication Critical patent/PL419907A1/pl
Publication of PL235210B1 publication Critical patent/PL235210B1/pl
Priority to US17/002,321 priority patent/US11608521B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B01L2300/1872—Infrared light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Clinical Laboratory Science (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • AIDS & HIV (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Przedmiotem niniejszego zgłoszenia jest sposób detekcji materiału genetycznego w próbce biologicznej, w którym próbkę biologiczną wprowadza się do wkładu reakcyjnego (6), a następnie umieszcza się wkład reakcyjny (6) w urządzeniu sterującym, wprowadza się pobraną próbkę biologiczną do komory izolacji (7), przeprowadza się izolację materiału genetycznego z próbki biologicznej poprzez ogrzewanie komory izolacji (7), przemieszcza się wyizolowany materiał genetyczny do szeregu komór reakcyjnych (8.1, 8.2, 8.3), przeprowadza się amplifikację materiału genetycznego poprzez ogrzewanie komór reakcyjnych (8.1, 8.2, 8.3), przy czym w komorach reakcyjnych (8.1, 8.2, 8.3) znajdują się zliofilizowane odczynniki do amplifikacji materiału genetycznego wraz z zliofilizowanym znacznikiem fluorescencyjnym interkalującym z wykrywanym materiałem genetycznym, a jednocześnie z etapem amplifikacji materiału genetycznego prowadzi się detekcję sygnału ze znaczników fluorescencyjnych.
PL419907A 2016-12-21 2016-12-21 Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji PL235210B1 (pl)

Priority Applications (18)

Application Number Priority Date Filing Date Title
PL419907A PL235210B1 (pl) 2016-12-21 2016-12-21 Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji
DK17002043.2T DK3338891T3 (da) 2016-12-21 2017-12-20 En fremgangsmåde til at detektere genetisk materiale i en biologisk prøve og en indretning til implementering deraf
EP17002043.2A EP3338891B8 (en) 2016-12-21 2017-12-20 A method of detecting genetic material in a biological sample and a device for its implementation
RS20220414A RS63179B1 (sr) 2016-12-21 2017-12-20 Postupak otkrivanja genetskog materijala u biološkom uzorku i uređaj za nјegovu primenu
JP2019534892A JP6961700B2 (ja) 2016-12-21 2017-12-20 生体サンプル中の遺伝物質を検出する方法及びその実施のための装置
CA2989599A CA2989599C (en) 2016-12-21 2017-12-20 A method of detecting genetic material in a biological sample and a device for its implementation
BR112019012501-9A BR112019012501B1 (pt) 2016-12-21 2017-12-20 Um método para detectar material genético em uma amostra biológica e um dispositivo para sua implementação
EP22155747.3A EP4029607A1 (en) 2016-12-21 2017-12-20 A method of detecting genetic material in a biological sample and a device for its implementation
HRP20220582TT HRP20220582T1 (hr) 2016-12-21 2017-12-20 Postupak otkrivanja genetskog materijala u biološkom uzorku i uređaj za njegovu implementaciju
CN201780078465.0A CN110088266A (zh) 2016-12-21 2017-12-20 检测生物样品中的遗传物质的方法及其实施设备
HUE17002043A HUE058240T2 (hu) 2016-12-21 2017-12-20 Eljárás genetikai anyag biológiai mintában való detektálására, és annak megvalósítására szolgáló eszköz
ES17002043T ES2913092T3 (es) 2016-12-21 2017-12-20 Un método para detectar material genético en una muestra biológica y un dispositivo para su implementación
LTEP17002043.2T LT3338891T (lt) 2016-12-21 2017-12-20 Genetinės medžiagos aptikimo biologiniame ėminyje būdas ir prietaisas jam įgyvendinti
PCT/PL2017/050065 WO2018117882A1 (en) 2016-12-21 2017-12-20 A method of detecting genetic material in a biological sample and a device for its implementation
PT170020432T PT3338891T (pt) 2016-12-21 2017-12-20 Um método para detetar material genético numa amostra biológica e um dispositivo para a sua implementação
SI201731139T SI3338891T1 (sl) 2016-12-21 2017-12-20 Metoda zaznavanja genetskega materiala v biološkem vzorcu in naprava za izvajanje omenjene metode
US15/850,733 US10781479B2 (en) 2016-12-21 2017-12-21 Method of detecting genetic material in a biological sample and a device for its implementation
US17/002,321 US11608521B2 (en) 2016-12-21 2020-08-25 Method of detecting genetic material in a biological sample and a device for its implementation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL419907A PL235210B1 (pl) 2016-12-21 2016-12-21 Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji

Publications (2)

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PL419907A1 true PL419907A1 (pl) 2018-07-02
PL235210B1 PL235210B1 (pl) 2020-06-15

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PL419907A PL235210B1 (pl) 2016-12-21 2016-12-21 Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji

Country Status (16)

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US (2) US10781479B2 (pl)
EP (2) EP4029607A1 (pl)
JP (1) JP6961700B2 (pl)
CN (1) CN110088266A (pl)
BR (1) BR112019012501B1 (pl)
CA (1) CA2989599C (pl)
DK (1) DK3338891T3 (pl)
ES (1) ES2913092T3 (pl)
HR (1) HRP20220582T1 (pl)
HU (1) HUE058240T2 (pl)
LT (1) LT3338891T (pl)
PL (1) PL235210B1 (pl)
PT (1) PT3338891T (pl)
RS (1) RS63179B1 (pl)
SI (1) SI3338891T1 (pl)
WO (1) WO2018117882A1 (pl)

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CN115290606A (zh) * 2022-08-22 2022-11-04 凤凰医学诊断科技有限公司 一种检测装置

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US20180187250A1 (en) 2018-07-05
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