PL4153597T3 - Związki hamujące kinazę zależną od cykliny do leczenia zaburzeń medycznych - Google Patents

Związki hamujące kinazę zależną od cykliny do leczenia zaburzeń medycznych

Info

Publication number
PL4153597T3
PL4153597T3 PL21807941.6T PL21807941T PL4153597T3 PL 4153597 T3 PL4153597 T3 PL 4153597T3 PL 21807941 T PL21807941 T PL 21807941T PL 4153597 T3 PL4153597 T3 PL 4153597T3
Authority
PL
Poland
Prior art keywords
cyclin
treatment
dependent kinase
inhibiting compounds
medical disorders
Prior art date
Application number
PL21807941.6T
Other languages
English (en)
Inventor
Jay Copeland Strum
Original Assignee
Pharmacosmos Holding A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacosmos Holding A/S filed Critical Pharmacosmos Holding A/S
Publication of PL4153597T3 publication Critical patent/PL4153597T3/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL21807941.6T 2020-05-19 2021-05-18 Związki hamujące kinazę zależną od cykliny do leczenia zaburzeń medycznych PL4153597T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063027113P 2020-05-19 2020-05-19
US202063085672P 2020-09-30 2020-09-30
PCT/US2021/032976 WO2021236650A1 (en) 2020-05-19 2021-05-18 Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders

Publications (1)

Publication Number Publication Date
PL4153597T3 true PL4153597T3 (pl) 2026-01-26

Family

ID=78707529

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21807941.6T PL4153597T3 (pl) 2020-05-19 2021-05-18 Związki hamujące kinazę zależną od cykliny do leczenia zaburzeń medycznych

Country Status (15)

Country Link
US (3) US11643416B2 (pl)
EP (2) EP4153597B1 (pl)
JP (1) JP2023528257A (pl)
KR (1) KR20230012547A (pl)
CN (2) CN120865218A (pl)
AU (1) AU2021273744A1 (pl)
CA (1) CA3173678A1 (pl)
ES (1) ES3048084T3 (pl)
HR (1) HRP20251397T1 (pl)
IL (2) IL298294B1 (pl)
MX (2) MX2022014573A (pl)
PL (1) PL4153597T3 (pl)
TW (1) TW202208372A (pl)
WO (1) WO2021236650A1 (pl)
ZA (1) ZA202212019B (pl)

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Publication number Priority date Publication date Assignee Title
PL4153597T3 (pl) * 2020-05-19 2026-01-26 Pharmacosmos Holding A/S Związki hamujące kinazę zależną od cykliny do leczenia zaburzeń medycznych
TW202309030A (zh) 2021-05-07 2023-03-01 美商凱麥拉醫療公司 Cdk2降解劑及其用途
WO2023116884A1 (en) * 2021-12-24 2023-06-29 Qilu Regor Therapeutics Inc. Cdk2 inhibitors and use thereof
KR20250067120A (ko) * 2022-06-20 2025-05-14 인사이클릭스 바이오, 엘엘씨 의학적 치료를 위한 시클린-의존성 키나제 2 억제제
KR20250121114A (ko) 2022-12-16 2025-08-11 아스트라제네카 아베 2,6,9-삼치환된 퓨린
CN121358484A (zh) * 2023-04-18 2026-01-16 因西克利克斯生物有限责任公司 用于施用inx-315的有利的人类剂量方案
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

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CN115698014A (zh) 2023-02-03
EP4153597C0 (en) 2025-09-10
MX2022014573A (es) 2022-12-15
US12312360B2 (en) 2025-05-27
EP4153597B1 (en) 2025-09-10
MX2025014135A (es) 2026-01-07
HRP20251397T1 (hr) 2026-01-02
US20240150369A1 (en) 2024-05-09
ES3048084T3 (en) 2025-12-09
EP4153597A1 (en) 2023-03-29
CN115698014B (zh) 2025-07-29
IL298294B1 (en) 2025-11-01
IL298294A (en) 2023-01-01
EP4652997A2 (en) 2025-11-26
CN120865218A (zh) 2025-10-31
IL323777A (en) 2025-12-01
WO2021236650A1 (en) 2021-11-25
US20220306644A1 (en) 2022-09-29
US11643416B2 (en) 2023-05-09
JP2023528257A (ja) 2023-07-04
EP4153597A4 (en) 2024-05-15
TW202208372A (zh) 2022-03-01
ZA202212019B (en) 2025-03-26
US20250270226A1 (en) 2025-08-28
CA3173678A1 (en) 2021-11-25
AU2021273744A1 (en) 2022-12-08
KR20230012547A (ko) 2023-01-26

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