PL4036244T3 - Enzymatyczny sposób wytwarzania kwasu (2s)-2-[(4r)-2-oxo-4-propylo-pirolidyn-1-ylo]masłowego i jego przemiana w briwaracetam - Google Patents
Enzymatyczny sposób wytwarzania kwasu (2s)-2-[(4r)-2-oxo-4-propylo-pirolidyn-1-ylo]masłowego i jego przemiana w briwaracetamInfo
- Publication number
- PL4036244T3 PL4036244T3 PL21159958.4T PL21159958T PL4036244T3 PL 4036244 T3 PL4036244 T3 PL 4036244T3 PL 21159958 T PL21159958 T PL 21159958T PL 4036244 T3 PL4036244 T3 PL 4036244T3
- Authority
- PL
- Poland
- Prior art keywords
- brivaracetam
- pyrrolidin
- oxo
- propyl
- conversion
- Prior art date
Links
- LTDAHGXWZNKFNP-BDAKNGLRSA-N (2s)-2-[(4r)-2-oxo-4-propylpyrrolidin-1-yl]butanoic acid Chemical compound CCC[C@H]1CN([C@@H](CC)C(O)=O)C(=O)C1 LTDAHGXWZNKFNP-BDAKNGLRSA-N 0.000 title 1
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 title 1
- 229960002161 brivaracetam Drugs 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202141004400 | 2021-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4036244T3 true PL4036244T3 (pl) | 2024-03-11 |
Family
ID=74844839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21159958.4T PL4036244T3 (pl) | 2021-02-01 | 2021-03-01 | Enzymatyczny sposób wytwarzania kwasu (2s)-2-[(4r)-2-oxo-4-propylo-pirolidyn-1-ylo]masłowego i jego przemiana w briwaracetam |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11400074B1 (pl) |
| EP (1) | EP4036244B1 (pl) |
| JP (1) | JP7280984B2 (pl) |
| KR (1) | KR102791352B1 (pl) |
| ES (1) | ES2969331T3 (pl) |
| FI (1) | FI4036244T3 (pl) |
| PL (1) | PL4036244T3 (pl) |
| SI (1) | SI4036244T1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115851866A (zh) * | 2022-12-22 | 2023-03-28 | 浙江普洛家园药业有限公司 | 一种布瓦西坦及其中间体的制备方法 |
| WO2026040943A1 (zh) * | 2024-08-19 | 2026-02-26 | 浙江华海药业股份有限公司 | 一种酶催化制备α-手性羧酸或α-手性酯的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060252134A1 (en) | 1999-10-29 | 2006-11-09 | Novus International, Inc. | Enantioselective oligomerization of alpha-hydroxy carboxylic acids and alpha-amino acids |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| AU2003247201A1 (en) | 2003-07-25 | 2005-02-14 | Posco | Method of preparation of optically active alcohols |
| CN101263113B (zh) | 2005-09-15 | 2012-06-13 | Ucb医药有限公司 | 4-取代的-吡咯烷-2-酮及其用途 |
| US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| WO2009009117A2 (en) * | 2007-07-11 | 2009-01-15 | Bioverdant, Inc. | Chemoenzymatic processes for preparation of levetiracetam |
| CN101284811B (zh) | 2008-06-11 | 2010-06-16 | 常州恩滋生物科技有限公司 | 阿巴卡韦的手性碳环中间体的合成方法 |
| WO2016075082A1 (en) * | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| JP6872500B2 (ja) | 2015-05-25 | 2021-05-19 | エステベ・キミカ・ソシエダッド・アノニマＥｓｔｅｖｅ Ｑｕｉｍｉｃａ， Ｓ．Ａ． | ブリバラセタムを製造する方法 |
| WO2018042393A1 (en) | 2016-09-05 | 2018-03-08 | Micro Labs Limited | Novel process for the preparation of brivaracetam |
| WO2019087172A1 (en) * | 2017-12-19 | 2019-05-09 | Glenmark Pharmaceuticals Limited | Process for preparation of brivaracetam |
| CN108101824B (zh) | 2018-02-13 | 2020-04-03 | 扬州奥锐特药业有限公司 | 一种高手性纯度内酰胺中间体及布瓦西坦的制备方法 |
-
2021
- 2021-02-24 US US17/183,436 patent/US11400074B1/en active Active
- 2021-03-01 EP EP21159958.4A patent/EP4036244B1/en active Active
- 2021-03-01 FI FIEP21159958.4T patent/FI4036244T3/fi active
- 2021-03-01 PL PL21159958.4T patent/PL4036244T3/pl unknown
- 2021-03-01 ES ES21159958T patent/ES2969331T3/es active Active
- 2021-03-01 SI SI202130095T patent/SI4036244T1/sl unknown
-
2022
- 2022-01-14 JP JP2022004669A patent/JP7280984B2/ja active Active
- 2022-01-28 KR KR1020220013738A patent/KR102791352B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11400074B1 (en) | 2022-08-02 |
| JP7280984B2 (ja) | 2023-05-24 |
| KR20220111209A (ko) | 2022-08-09 |
| SI4036244T1 (sl) | 2024-03-29 |
| US20220241242A1 (en) | 2022-08-04 |
| EP4036244A1 (en) | 2022-08-03 |
| ES2969331T3 (es) | 2024-05-17 |
| KR102791352B1 (ko) | 2025-04-03 |
| EP4036244B1 (en) | 2023-10-11 |
| JP2022117945A (ja) | 2022-08-12 |
| FI4036244T3 (fi) | 2023-12-18 |
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