PL364230A1 - Benzimidazole compounds for modulating ige and inhibiting cellular proliferation - Google Patents
Benzimidazole compounds for modulating ige and inhibiting cellular proliferationInfo
- Publication number
- PL364230A1 PL364230A1 PL02364230A PL36423002A PL364230A1 PL 364230 A1 PL364230 A1 PL 364230A1 PL 02364230 A PL02364230 A PL 02364230A PL 36423002 A PL36423002 A PL 36423002A PL 364230 A1 PL364230 A1 PL 364230A1
- Authority
- PL
- Poland
- Prior art keywords
- cellular proliferation
- benzimidazole compounds
- inhibiting cellular
- modulating ige
- ige
- Prior art date
Links
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27526001P | 2001-03-12 | 2001-03-12 | |
| US10/090,044 US6759425B2 (en) | 1999-10-21 | 2002-02-27 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| PCT/US2002/006801 WO2002072090A1 (en) | 2001-03-12 | 2002-02-28 | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL364230A1 true PL364230A1 (en) | 2004-12-13 |
Family
ID=34115140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL02364230A PL364230A1 (en) | 2001-03-12 | 2002-02-28 | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7282518B2 (https=) |
| EP (1) | EP1368028B1 (https=) |
| JP (1) | JP2004528304A (https=) |
| CN (1) | CN1496257A (https=) |
| AR (1) | AR034023A1 (https=) |
| AT (1) | ATE369853T1 (https=) |
| BR (1) | BR0208010A (https=) |
| CA (1) | CA2441177A1 (https=) |
| CZ (1) | CZ20032691A3 (https=) |
| DE (1) | DE60221804T2 (https=) |
| DK (1) | DK1368028T3 (https=) |
| ES (1) | ES2291455T3 (https=) |
| HU (1) | HUP0303460A3 (https=) |
| MX (1) | MXJL03000027A (https=) |
| NZ (1) | NZ528835A (https=) |
| PL (1) | PL364230A1 (https=) |
| PT (1) | PT1368028E (https=) |
| RU (1) | RU2003127367A (https=) |
| WO (1) | WO2002072090A1 (https=) |
| ZA (1) | ZA200307916B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| US6919366B2 (en) * | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| BR0208010A (pt) * | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| JP4658473B2 (ja) | 2001-07-27 | 2011-03-23 | キュリス，インコーポレイテッド | ヘッジホッグシグナル伝達経路メディエーター、それに関連した組成物及び利用 |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| EP1388535A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated arylcycloalkylamines and their use as pharmaceuticals |
| AU2003270426A1 (en) * | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| WO2004041280A1 (en) * | 2002-11-02 | 2004-05-21 | Kyung-Lim Lee | Composition for preventing secretion of immunoglobulin e-dependent histamine releasing factor |
| JP4726235B2 (ja) | 2003-04-17 | 2011-07-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 癌の処置のためのチェックポイントキナーゼｃｄｓ１（ｃｈｋ２）インヒビターとしての２−フェニル−ベンズイミダゾールおよび２−フェニル−イミダゾ−‘４，５！−ピリジン誘導体 |
| EP1651198A2 (en) * | 2003-08-08 | 2006-05-03 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| US7485658B2 (en) * | 2003-08-21 | 2009-02-03 | Osi Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors |
| EP1664032B1 (en) | 2003-08-21 | 2008-11-05 | OSI Pharmaceuticals, Inc. | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors |
| EP1824832B1 (en) * | 2004-06-30 | 2011-04-27 | Janssen Pharmaceutica NV | Aryl-substituted benzimidazole and imidazopyridine ethers as anti-cancer agents |
| UA92180C2 (en) * | 2005-09-06 | 2010-10-11 | Смиткляйн Бичам Корпорейшн | Benzimidazole thiophene compounds as plk inhibitors |
| JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体 |
| US8334290B2 (en) | 2005-10-31 | 2012-12-18 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| EP1960382A1 (en) * | 2005-11-03 | 2008-08-27 | ChemBridge Research Laboratories, Inc. | Heterocyclic compounds as tyrosine kinase modulators |
| GB0606774D0 (en) * | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| AR063311A1 (es) | 2006-10-18 | 2009-01-21 | Novartis Ag | Compuestos organicos |
| MX2009011208A (es) * | 2007-04-19 | 2009-10-30 | Novartis Ag | Derivados de acido nicotinico como moduladores del receptor de glutamato metabotropico-5. |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| WO2009112445A1 (en) * | 2008-03-10 | 2009-09-17 | Novartis Ag | Method of increasing cellular phosphatidyl choline by dgat1 inhibition |
| CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
| CN104208701A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有抗真菌药物的复方吸入制剂 |
| ES2973850T3 (es) * | 2016-09-20 | 2024-06-24 | Centre Leon Berard | Derivados del benzoimidazol como agentes anticancerígenos |
| EP3810117A4 (en) * | 2018-06-01 | 2022-03-02 | Merck Sharp & Dohme Corp. | NEW [3.3.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| WO1986006739A1 (en) | 1985-05-03 | 1986-11-20 | The Foxboro Company | Distillation cut point control |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| US5206257A (en) | 1987-03-05 | 1993-04-27 | May & Baker Limited | Pesticidal method using 2-phenylimidazole derivatives |
| JP2630432B2 (ja) | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
| AU629536B2 (en) | 1988-02-02 | 1992-10-08 | Schering Biotech Corporation | Method of reducing immunoglobulin e responses |
| JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| IT1232252B (it) | 1989-02-22 | 1992-01-28 | Rotta Research Lab | Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione |
| FR2643903A1 (fr) | 1989-03-03 | 1990-09-07 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux |
| EP0415886A3 (en) | 1989-08-30 | 1991-10-23 | Ciba-Geigy Ag | Aza compounds |
| FR2658511B1 (fr) | 1990-02-16 | 1992-06-19 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| AU8225991A (en) | 1990-07-31 | 1992-03-02 | Teikoku Hormone Mfg. Co., Ltd. | 2-phenylindole derivative |
| DE69113162T2 (de) | 1990-08-02 | 1996-03-14 | Hoffmann La Roche | Antiallergische Mischung. |
| US5633377A (en) | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
| JPH06263993A (ja) | 1991-01-21 | 1994-09-20 | Konica Corp | アゾメチン系染料、インドアニリン系染料及びインドフェノール系染料の製造法 |
| IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| JP3634861B2 (ja) | 1992-06-15 | 2005-03-30 | セルテック リミテッド | 選択的ホスホジエステラーゼｉｖ阻害剤としての三置換フェニル誘導体 |
| US5322847A (en) | 1992-11-05 | 1994-06-21 | Pfizer Inc. | Azabenzimidazoles in the treatment of asthma, arthritis and related diseases |
| NZ270985A (en) | 1994-04-29 | 1997-06-24 | Lilly Co Eli | Substituted benzimidazole derivatives; medicaments and preparation of medicaments |
| US5643893A (en) | 1994-06-22 | 1997-07-01 | Macronex, Inc. | N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines |
| DE4426625A1 (de) | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| US5496826A (en) | 1994-09-02 | 1996-03-05 | Bristol-Myers Squibb Company | Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides |
| US5821258A (en) * | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
| DE19503160A1 (de) | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
| IL123147A (en) | 1995-08-02 | 2004-02-19 | Univ Newcastle Ventures Ltd | Benzamide imidazole - 4 carboxamide and their use |
| US6387938B1 (en) | 1996-07-05 | 2002-05-14 | Mochida Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| TW467902B (en) | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| US6153631A (en) | 1996-10-23 | 2000-11-28 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| WO1998017267A1 (en) | 1996-10-23 | 1998-04-30 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| CA2232467A1 (en) | 1997-03-20 | 1998-09-20 | Richard A. Glennon | Imidazoles with serotonin receptor binding activity |
| US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| DE69816992T2 (de) | 1997-06-10 | 2004-07-22 | Glaxo Group Ltd., Greenford | Benzimidazolderivate |
| GB9718833D0 (en) | 1997-09-04 | 1997-11-12 | Merck Sharp & Dohme | Therapeutic agents |
| NZ503432A (en) | 1997-09-26 | 2002-11-26 | Zentaris Gmbh | Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function |
| US6100282A (en) | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
| US6303645B1 (en) | 1998-05-22 | 2001-10-16 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6919366B2 (en) | 1998-05-22 | 2005-07-19 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of IgE |
| US6369091B1 (en) | 1998-05-22 | 2002-04-09 | Avanir Pharmaceuticals | Benzimidazole analogs as down-regulators of IgE |
| US6911462B2 (en) | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| RU2236220C2 (ru) * | 1998-05-22 | 2004-09-20 | Аванир Фармасьютикэлз | Аналоги бензимидазола в качестве понижающих регуляторов ige |
| JP2000095767A (ja) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| NZ510760A (en) | 1998-10-23 | 2003-08-29 | F | Bicyclic nitrogen heterocycles |
| DE59911249D1 (de) * | 1998-11-03 | 2005-01-13 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| DK1131301T3 (da) | 1998-11-17 | 2006-01-09 | Abbott Gmbh & Co Kg | 2-phenylbenzimidazoler og 2-phenylindoler, fremstilling af anvendelse heraf |
| CA2352554C (en) | 1998-11-27 | 2006-10-10 | Basf Aktiengesellschaft | Substituted benzimidazoles and their use as parp inhibitors |
| DE19918211A1 (de) | 1999-04-22 | 2000-10-26 | Basf Ag | Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung |
| DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| DE19939463A1 (de) | 1999-08-20 | 2001-02-22 | Boehringer Ingelheim Pharma | Aminocarbonyl-substituierte Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6759425B2 (en) | 1999-10-21 | 2004-07-06 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| US6242461B1 (en) | 2000-01-25 | 2001-06-05 | Pfizer Inc. | Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
| US6777442B2 (en) | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
| BR0208010A (pt) * | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
| BRPI0208075B8 (pt) | 2001-03-12 | 2021-05-25 | Janssen Pharmaceutica Nv | processo para a preparação de compostos de imidazol |
| TW200304820A (en) | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
| CN1826111A (zh) | 2003-04-10 | 2006-08-30 | 阿文尼尔药品公司 | 用于治疗变应性和过增生性疾病的咪唑衍生物 |
| EP1651198A2 (en) | 2003-08-08 | 2006-05-03 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
-
2002
- 2002-02-28 BR BR0208010-9A patent/BR0208010A/pt not_active IP Right Cessation
- 2002-02-28 AT AT02715052T patent/ATE369853T1/de not_active IP Right Cessation
- 2002-02-28 EP EP02715052A patent/EP1368028B1/en not_active Expired - Lifetime
- 2002-02-28 NZ NZ528835A patent/NZ528835A/en unknown
- 2002-02-28 MX MXJL03000027A patent/MXJL03000027A/es not_active Application Discontinuation
- 2002-02-28 ES ES02715052T patent/ES2291455T3/es not_active Expired - Lifetime
- 2002-02-28 PT PT02715052T patent/PT1368028E/pt unknown
- 2002-02-28 PL PL02364230A patent/PL364230A1/xx unknown
- 2002-02-28 CA CA002441177A patent/CA2441177A1/en not_active Abandoned
- 2002-02-28 CN CNA028064860A patent/CN1496257A/zh active Pending
- 2002-02-28 DK DK02715052T patent/DK1368028T3/da active
- 2002-02-28 CZ CZ20032691A patent/CZ20032691A3/cs unknown
- 2002-02-28 JP JP2002571049A patent/JP2004528304A/ja active Pending
- 2002-02-28 WO PCT/US2002/006801 patent/WO2002072090A1/en not_active Ceased
- 2002-02-28 DE DE60221804T patent/DE60221804T2/de not_active Expired - Fee Related
- 2002-02-28 HU HU0303460A patent/HUP0303460A3/hu unknown
- 2002-02-28 RU RU2003127367/15A patent/RU2003127367A/ru not_active Application Discontinuation
- 2002-03-11 AR ARP020100869A patent/AR034023A1/es unknown
-
2003
- 2003-10-10 ZA ZA200307916A patent/ZA200307916B/en unknown
-
2004
- 2004-03-05 US US10/795,006 patent/US7282518B2/en not_active Expired - Fee Related
-
2007
- 2007-04-27 US US11/741,702 patent/US20070202133A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE369853T1 (de) | 2007-09-15 |
| HUP0303460A3 (en) | 2004-07-28 |
| JP2004528304A (ja) | 2004-09-16 |
| US20070202133A1 (en) | 2007-08-30 |
| CN1496257A (zh) | 2004-05-12 |
| US20040214821A1 (en) | 2004-10-28 |
| RU2003127367A (ru) | 2005-03-20 |
| CZ20032691A3 (en) | 2004-04-14 |
| PT1368028E (pt) | 2007-11-26 |
| ES2291455T3 (es) | 2008-03-01 |
| CA2441177A1 (en) | 2002-09-19 |
| BR0208010A (pt) | 2004-12-21 |
| EP1368028B1 (en) | 2007-08-15 |
| DK1368028T3 (da) | 2007-12-27 |
| DE60221804D1 (de) | 2007-09-27 |
| US7282518B2 (en) | 2007-10-16 |
| ZA200307916B (en) | 2004-09-03 |
| AR034023A1 (es) | 2004-01-21 |
| HUP0303460A2 (hu) | 2004-03-01 |
| EP1368028A1 (en) | 2003-12-10 |
| DE60221804T2 (de) | 2008-05-15 |
| WO2002072090A1 (en) | 2002-09-19 |
| NZ528835A (en) | 2005-05-27 |
| MXJL03000027A (es) | 2004-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL364230A1 (en) | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation | |
| EP1546157A4 (en) | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELL PROLIFERATION | |
| EP1537079A4 (en) | PHENYL-INDOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELL PROLIFERATION | |
| PL370909A1 (en) | Cis-imidazolines as mdm2 inhibitors | |
| EP1237624A4 (en) | DEVICE FOR INHIBITING CELL PROLIFERATION | |
| IL164687A0 (en) | Cellular libraries and methods for the preparationthereof | |
| HUP0302650A3 (en) | Fumaric and derivatives as nf-kappab inhibitors | |
| EP1426399A4 (en) | HIGHLY MOLECULAR COMPOUNDS AND ORGANIC LUMINESCENT DEVICES | |
| EP1465287A4 (en) | ANTENNA AND APPARATUS COMPRISING SAID ANTENNA | |
| EP1543009A4 (en) | Pyrrolotriazine KINASE INHIBITORS | |
| PL369855A1 (en) | 4-arylquinazolines and use thereof as nhe-3 inhibitors | |
| EP1576173A4 (en) | MODULATORS OF CELL PROLIFERATION | |
| GB0202437D0 (en) | Cellular mosfet devices and their manufacture | |
| PL363391A1 (en) | Phthalayinone-piperidino-derivatives as pde4 inhibitors | |
| GB2412372B (en) | Pyrazine-based tubulin inhibitors | |
| AU2003301036A8 (en) | Systems and methods for wireless telecommunications | |
| GB0221513D0 (en) | Novel compounds and processes | |
| GB0221438D0 (en) | Processes and compounds | |
| AU2002364612A8 (en) | Methods and materials for modulating enac-beta | |
| IL157730A0 (en) | Benzimidazole compounds for modulating ige and inhibiting cellular prolifration | |
| GB2389272B (en) | SIM Configuration | |
| HK1076279A (en) | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation | |
| HK1076280A (en) | Phenyl-aza-benzimidazole compounds for modulating ige and inhibiting cellular proliferation | |
| AU2003286729A8 (en) | Modulation of cellular proliferation | |
| GB0222035D0 (en) | Histological assessment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |