PL3484471T3 - Sposób wytwarzania polimorficznej postaci a 3-[5-amino-4-(3- cyjanobenzoilo)-pirazol-1-ilo]-n-cyklopropylo-4- metylo-benzamidu - Google Patents

Sposób wytwarzania polimorficznej postaci a 3-[5-amino-4-(3- cyjanobenzoilo)-pirazol-1-ilo]-n-cyklopropylo-4- metylo-benzamidu

Info

Publication number
PL3484471T3
PL3484471T3 PL17742278T PL17742278T PL3484471T3 PL 3484471 T3 PL3484471 T3 PL 3484471T3 PL 17742278 T PL17742278 T PL 17742278T PL 17742278 T PL17742278 T PL 17742278T PL 3484471 T3 PL3484471 T3 PL 3484471T3
Authority
PL
Poland
Prior art keywords
cyanobenzoyl
methylbenzamide
pyrazol
cyclopropyl
amino
Prior art date
Application number
PL17742278T
Other languages
English (en)
Inventor
Osama SULEIMAN
Lucia Romero PEREZ
Cornelius Stephan HARLACHER
Stewart Jones
Original Assignee
Mereo Biopharma 1 Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 1 Limited filed Critical Mereo Biopharma 1 Limited
Publication of PL3484471T3 publication Critical patent/PL3484471T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL17742278T 2016-07-14 2017-07-13 Sposób wytwarzania polimorficznej postaci a 3-[5-amino-4-(3- cyjanobenzoilo)-pirazol-1-ilo]-n-cyklopropylo-4- metylo-benzamidu PL3484471T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1612240.0A GB201612240D0 (en) 2016-07-14 2016-07-14 Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide
PCT/GB2017/052056 WO2018011579A1 (en) 2016-07-14 2017-07-13 Method for producing a polymorphic form of 3-[5-amino-4-(3- cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide
EP17742278.9A EP3484471B1 (en) 2016-07-14 2017-07-13 Method for producing a polymorphic form of 3-[5-amino-4-(3- cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

Publications (1)

Publication Number Publication Date
PL3484471T3 true PL3484471T3 (pl) 2021-09-20

Family

ID=56890600

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17742278T PL3484471T3 (pl) 2016-07-14 2017-07-13 Sposób wytwarzania polimorficznej postaci a 3-[5-amino-4-(3- cyjanobenzoilo)-pirazol-1-ilo]-n-cyklopropylo-4- metylo-benzamidu

Country Status (18)

Country Link
US (2) US10934260B2 (pl)
EP (1) EP3484471B1 (pl)
JP (1) JP7094021B2 (pl)
KR (1) KR102460529B1 (pl)
CN (1) CN109414429B (pl)
AU (1) AU2017294643B2 (pl)
BR (1) BR112019000460A2 (pl)
CA (1) CA3030622A1 (pl)
DK (1) DK3484471T3 (pl)
ES (1) ES2874661T3 (pl)
GB (1) GB201612240D0 (pl)
HU (1) HUE054539T2 (pl)
IL (1) IL263908B (pl)
MX (1) MX2019000385A (pl)
PL (1) PL3484471T3 (pl)
PT (1) PT3484471T (pl)
SG (1) SG11201811515WA (pl)
WO (1) WO2018011579A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201612240D0 (en) * 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3590586B2 (ja) 1998-05-05 2004-11-17 エフ.ホフマン−ラ ロシュ アーゲー P−38mapキナーゼインヒビターとしてのピラゾール誘導体
PT2298743E (pt) 2003-06-26 2012-12-04 Novartis Ag Inibidores de p38 quinase a base de heterociclo de 5 elementos
MA37455B1 (fr) * 2012-03-20 2017-03-31 Novartis Ag Utilisation d'un dérivé de pyrazole dans le traitement d'exacerbations aigues d'une maladie pulmonaire obstructive chronique
MX2018010782A (es) 2016-03-08 2019-01-10 Mereo Biopharma 1 Ltd Regimen de dosificacion para el tratamiento de exacerbaciones agudas de enfermedad pulmonar obstructiva cronica.
RU2709509C1 (ru) 2016-03-08 2019-12-18 Мерео Байофарма 1 Лимитед Режим дозирования для лечения острых обострений воспалительных состояний
GB201612240D0 (en) * 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

Also Published As

Publication number Publication date
IL263908B (en) 2022-07-01
CA3030622A1 (en) 2018-01-18
GB201612240D0 (en) 2016-08-31
CN109414429B (zh) 2021-09-14
US11434204B2 (en) 2022-09-06
RU2019103880A3 (pl) 2020-09-29
US20210206726A1 (en) 2021-07-08
KR102460529B1 (ko) 2022-10-31
EP3484471A1 (en) 2019-05-22
JP2019520420A (ja) 2019-07-18
EP3484471B1 (en) 2021-05-05
HUE054539T2 (hu) 2021-09-28
US10934260B2 (en) 2021-03-02
AU2017294643B2 (en) 2021-02-25
RU2019103880A (ru) 2020-08-14
IL263908A (en) 2019-01-31
US20190352269A1 (en) 2019-11-21
KR20190028432A (ko) 2019-03-18
ES2874661T3 (es) 2021-11-05
SG11201811515WA (en) 2019-01-30
PT3484471T (pt) 2021-06-02
JP7094021B2 (ja) 2022-07-01
DK3484471T3 (da) 2021-05-31
MX2019000385A (es) 2019-05-23
AU2017294643A1 (en) 2019-01-17
WO2018011579A1 (en) 2018-01-18
BR112019000460A2 (pt) 2019-04-24
CN109414429A (zh) 2019-03-01

Similar Documents

Publication Publication Date Title
HUE054565T2 (hu) Eljárás csõ elõállítására
ZA201600520B (en) A method of producing higher alcohols
PL3760815T3 (pl) Sposób wytwarzania podczęści wieży
GB2542365B (en) A method of controlling a vehicle take-off from rest
GB201505620D0 (en) Specification for method of abandoning a well
GB201715584D0 (en) Method of controlling a well
GB2572706B (en) A method for production of thymoquinone
GB2548108B (en) Method of controlling a vehicle
PL3277882T3 (pl) Sposób wytwarzania wypełniacza
SI3141335T1 (sl) Postopek za izdelavo sestavnega dela z jedrnim odsekom, ki sestoji iz jekla
GB201702541D0 (en) A method of forming a component
GB201620962D0 (en) A method of abandoning a well
PT3262905T (pt) Método de calibração de um distribuidor
PT3497225T (pt) Método de produção de ácido láctico
GB2552815B (en) Method of manufacturing a tubular member
IL263908A (en) Method for preparing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide
PL3075869T3 (pl) Sposób wytwarzania stopów żelazo - krzem - glin
IL263900B (en) Method for preparing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide
PL3383615T3 (pl) Sposób formowania części
IL271713B (en) A method for creating a flat matrix
PL3081623T3 (pl) Sposób wytwarzania składników na bazie oleju
GB201410324D0 (en) Method of making a confectionery product
ZA201607831B (en) Method of manufacturing a sausage
TWI562979B (en) Method of manufacturing nitrone compounds
PL3530434T3 (pl) Sposób dodatkowego osłaniania kształtki rurowej