PL33751B1 - The method of producing compounds of the rhenium cyclopentane polyhydrophenan series, containing oxygen in the C ring or groups containing oxygen - Google Patents

The method of producing compounds of the rhenium cyclopentane polyhydrophenan series, containing oxygen in the C ring or groups containing oxygen Download PDF

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Publication number
PL33751B1
PL33751B1 PL33751A PL3375143A PL33751B1 PL 33751 B1 PL33751 B1 PL 33751B1 PL 33751 A PL33751 A PL 33751A PL 3375143 A PL3375143 A PL 3375143A PL 33751 B1 PL33751 B1 PL 33751B1
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PL
Poland
Prior art keywords
double bond
containing oxygen
series
agents
cyclopentane
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Application number
PL33751A
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Polish (pl)
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Publication date
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Publication of PL33751B1 publication Critical patent/PL33751B1/en

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Próbka najczystszego naturalnego octanu de- jhydrokortykosteronu topi sie w tych samych warunkach w temperaturze 177 — 179*0, z produktem syntetycznym nie wykazuje obni¬ zenia temperatury topnienia i wykazuje te sa¬ ma skrecalnosc. wlasciwa.Przez zmydlenie metanolowym roztworem kwasu solnego* albo wodnometanolowym roztwo¬ rem dwuweglanu potasowego otrzymuje sle wolny dehydrokortykosteron o temperaturze topnienia 174 — 180óC, Zwiazek ten mozn?\ nastepnie w znany sposób przeprowadzic w do¬ wolne estry, ^np. propionian, palmitynian, ben¬ zoesan, bursztynian, maslany, fosforany albo weglany. PLA sample of the purest natural dehydrocorticosterone acetate melts under the same conditions at a temperature of 177-179 ° 0, with the synthetic product it does not show a decrease in melting point and shows the same crunchiness. By saponification with methanolic hydrochloric acid solution or with aqueous methanolic potassium bicarbonate solution, a free dehydrocorticosterone is obtained with a melting point of 174-180 ° C. This compound can then be converted into any esters in a known manner, e.g. propionate, palmitate, benzoate, succinate, butyrate, phosphate or carbonate. PL

Claims (1)

Zastrzezenia patentowePatent claims 1. Sposób wytwarzania zwiazków szeregu cy- klcrpentanowielohydrofenantrenowego, zawie¬ rajacych w pierscieniu C tlen albo grupy za¬ wierajace tlen,. znamienny tym, ze zwiazki tego szeregu wykazujace' w rcjzeniu podwój¬ ne wiazanie przy atomie wegla 11, traktuje sie srodkami, które sa zdolne* przy zniesie¬ niu tego podwójnego wiazania do wytwa¬ rzania produktów przylaczenia, w których co najmniej jedna z wartosciowosci, bioracych pierwotnie udzial w wiazaniu podwójnym, zostaje wysycona tlenem, po czym na po¬ wstale produkty dziala sie ewentualnie srod¬ kami utleniajacymi albo redukujacymi lub takimi srodkami, które powoduja izomery¬ zacje ugrupowania tlenkowego na postac ketonowa. , l. Sposób wedlug zastrz. i, znamienny tym, ze jako materialy wyjsciowe stostfje sie — 13 —zwiazki szeregu cyklopentanowielohydrofe - nantrenowego, które w polozeniu 11, 12 za¬ wieraja padwójne wiazanie. 3 Sposób wedlug zastrz. 1 i 2, znamienny tym, ze jako srodki zdolne do zniesienia podwój¬ nego wiazania z wytworzeniem produktów przylaczenia, w których co najmniej jedna z wartosciowosci, bioracych pierwotnie udzial w wiazaniu podwójnym, zostaje wysycon* tlenem, stosuje sie kwasy podchlorowcowe, ich sole, etery lub estry albo takie mate¬ rialy, które w obecnosci wody odszczepiaja kwas podchlorowcowy- 4, Sposób wedlug zastrz. 1 — 3, znamienny tym, ze otrzymane produkty traktuje sie na¬ stepnie srodkami zmydlajacymi, estryfikuja¬ cymi, chlorowcujacymi albo odszczepiajacy- mi kwasy, uzytymi pojedynczo albo w kom¬ binacji i w dowolnej kolejnosci. N. V,Organon Zastepcy: Inz. W. Romer i Mgr J. Schoeppingk rzecznicy patentowi P. O. Z. G./13 Oddz- w B-stoku — 150 zam. 156/2015—5.lX-49—T 1-10055-23.XII-50 PL1. A method for producing compounds of the cyclopentane polyhydrophenanthrene series which contain oxygen in the C-ring or groups containing oxygen. characterized in that the compounds of this series showing a double bond at the carbon atom 11 are treated with agents which are capable of abolishing this double bond to produce addition products in which at least one of the values, initially involved in the double bond, is saturated with oxygen and the products are then treated with oxidizing or reducing agents or with agents which cause the isomerization of the oxide moiety into ketone form. , l. The method according to claims and, characterized in that the starting materials are compounds of the cyclopentane-polyhydrophein-nanthrene series which at position 11, 12 contain a double bond. 3 The method according to claim 1 and 2, characterized in that hypochlorous acids, their salts are used as agents capable of abolishing the double bond with the formation of addition products in which at least one of the values initially involved in the double bond is saturated with oxygen, ethers or esters or such materials which, in the presence of water, split off hypochlorous acid-4. A process as claimed in any one of claims 1 to 3, characterized in that the products obtained are then treated with saponifiers, esterifiers, halogenating agents or acid cleavers, used individually or in combination and in any order. N. V, Organon Deputies: Inz. W. Romer and Mgr J. Schoeppingk patent attorneys P. O. Z. G./13 B-stok office - 150 registered 156 / 2015—5.lX-49 — T 1-10055-23.XII-50 PL
PL33751A 1943-04-20 The method of producing compounds of the rhenium cyclopentane polyhydrophenan series, containing oxygen in the C ring or groups containing oxygen PL33751B1 (en)

Publications (1)

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PL33751B1 true PL33751B1 (en) 1949-08-31

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