GB569083A - Process for the manufacture of pantothenic acid and the salts thereof - Google Patents
Process for the manufacture of pantothenic acid and the salts thereofInfo
- Publication number
- GB569083A GB569083A GB10636/43A GB1063643A GB569083A GB 569083 A GB569083 A GB 569083A GB 10636/43 A GB10636/43 A GB 10636/43A GB 1063643 A GB1063643 A GB 1063643A GB 569083 A GB569083 A GB 569083A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- hydroxypropyl
- amide
- dimethyl
- diacetoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Pantothenic acid is produced by the oxidation of d(+) - a g - dihydroxy - b b - dimethyl - butyric acid-(31-hydroxypropyl)-amide or the corresponding a g -diacetoxy compound, using as the oxidizing agent a permanganate such as potassium permanganate or barium permanganate at a temperature not substantially exceeding room temperature in dilute weakly acid solution. In examples: d(+)-a g -dihydroxy-b b -dimethylbutyric acid-(31-hydroxypropyl)-amide is added to aqueous sulphuric acid and to the solution so formed a solution of barium permanganate is run in slowly, the temperature being maintained at 15-20 DEG C. The pantothenic acid is purified and crystallised in the form of its cinchonidine salt; (2) d(+) - a g - diacetoxy - b b - dimethyl - butyric acid-(31-hydroxypropyl)-amide is dissolved in aqueous sulphuric acid and treated as in example (1). The d(+)-a : g -dihydroxy-b b -dimethyl-butyric acid-(3-hydroxypropyl)-amide which is used as the starting material may be prepared by the process described in Specification 568,355, and the d(+)-a : g -diacetoxy-b b -dimethyl - butyric acid - (31 - hydroxypropyl) - amide is obtained by the condensation of d(+)-diacetoxy-dimethyl-butyric acid chloride with g -hydroxy-propylamine in the presence of acetic acid ethyl ester.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH569083X | 1942-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB569083A true GB569083A (en) | 1945-05-03 |
Family
ID=4520796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10636/43A Expired GB569083A (en) | 1942-07-17 | 1943-06-30 | Process for the manufacture of pantothenic acid and the salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB569083A (en) |
-
1943
- 1943-06-30 GB GB10636/43A patent/GB569083A/en not_active Expired
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