PL3368152T3 - Leczenie ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodności oparte na obrazowaniu rm - Google Patents

Leczenie ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodności oparte na obrazowaniu rm

Info

Publication number
PL3368152T3
PL3368152T3 PL16795424T PL16795424T PL3368152T3 PL 3368152 T3 PL3368152 T3 PL 3368152T3 PL 16795424 T PL16795424 T PL 16795424T PL 16795424 T PL16795424 T PL 16795424T PL 3368152 T3 PL3368152 T3 PL 3368152T3
Authority
PL
Poland
Prior art keywords
mri
optimization
conductivity measurements
electrode positions
ttfield
Prior art date
Application number
PL16795424T
Other languages
English (en)
Inventor
Cornelia WENGER
Pedro Michael Cavaleiro MIRANDA
Noa URMAN
Eilon KIRSON
Yoram Wasserman
Yoram Palti
Zeev Bomzon
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of PL3368152T3 publication Critical patent/PL3368152T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36025External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053Measuring electrical impedance or conductance of a portion of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531Measuring skin impedance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064Evaluating the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0456Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0476Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/08Arrangements or circuits for monitoring, protecting, controlling or indicating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002Cancer treatment, e.g. tumour
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/3603Control systems
    • A61N1/36031Control systems using physiological parameters for adjustment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/002D [Two Dimensional] image generation
    • G06T11/003Reconstruction from projections, e.g. tomography
    • G06T11/005Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/002D [Two Dimensional] image generation
    • G06T11/003Reconstruction from projections, e.g. tomography
    • G06T11/008Specific post-processing after tomographic reconstruction, e.g. voxelisation, metal artifact correction
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16ZINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00Subject matter not provided for in other main groups of this subclass
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10088Magnetic resonance imaging [MRI]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30016Brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Psychiatry (AREA)
  • Social Psychology (AREA)
  • Oncology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Physiology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Electrotherapy Devices (AREA)
  • Cold Cathode And The Manufacture (AREA)
PL16795424T 2015-10-28 2016-10-28 Leczenie ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodności oparte na obrazowaniu rm PL3368152T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562247314P 2015-10-28 2015-10-28
US201662294372P 2016-02-12 2016-02-12
EP16795424.7A EP3368152B1 (en) 2015-10-28 2016-10-28 Ttfield treatment with optimization of electrode positions on the head based on mri-based conductivity measurements
PCT/IB2016/056495 WO2017072706A1 (en) 2015-10-28 2016-10-28 Ttfield treatment with optimization of electrode positions on the head based on mri-based conductivity measurements

Publications (1)

Publication Number Publication Date
PL3368152T3 true PL3368152T3 (pl) 2021-08-30

Family

ID=57321363

Family Applications (2)

Application Number Title Priority Date Filing Date
PL21155810.1T PL3838338T3 (pl) 2015-10-28 2016-10-28 Leczenie polem ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodnictwa oparte na rezonansie magnetycznym
PL16795424T PL3368152T3 (pl) 2015-10-28 2016-10-28 Leczenie ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodności oparte na obrazowaniu rm

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL21155810.1T PL3838338T3 (pl) 2015-10-28 2016-10-28 Leczenie polem ttfield z optymalizacją pozycji elektrod na głowie w oparciu o pomiary przewodnictwa oparte na rezonansie magnetycznym

Country Status (13)

Country Link
US (3) US10188851B2 (pl)
EP (2) EP3368152B1 (pl)
JP (5) JP7183045B2 (pl)
KR (3) KR102312079B1 (pl)
CN (2) CN108348761B (pl)
CA (1) CA3003370A1 (pl)
DK (2) DK3368152T3 (pl)
ES (2) ES2860714T3 (pl)
FI (1) FI3838338T3 (pl)
HU (2) HUE054032T2 (pl)
PL (2) PL3838338T3 (pl)
PT (1) PT3368152T (pl)
WO (1) WO2017072706A1 (pl)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9851426B2 (en) * 2012-05-04 2017-12-26 The Regents Of The University Of Michigan Error analysis and correction of MRI ADC measurements for gradient nonlinearity
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
WO2016134474A1 (en) * 2015-02-25 2016-09-01 London Health Sciences Centre Research Inc. Automated segmentation of histological sections for vasculature quantification
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US10441776B2 (en) 2016-06-30 2019-10-15 Novocure Gmbh Arrays for longitudinal delivery of TTFields to a body
US11446487B2 (en) 2016-09-23 2022-09-20 Beth Israel Deaconess Medical Center, Inc. System and methods for cancer treatment using alternating electric fields
AU2017377003B2 (en) 2016-12-13 2022-05-19 Novocure Gmbh Treating patients with TTFields with the electrode positions optimized using deformable templates
US11573221B2 (en) 2017-01-19 2023-02-07 Novocure Gmbh System for viewing cell cultures under a microscope whilst applying TTFields
CA3056694C (en) * 2017-05-18 2022-01-18 Brainlab Ag Determining a clinical target volume
KR101950815B1 (ko) * 2017-08-25 2019-02-21 뉴로핏 주식회사 패치 가이드 방법 및 프로그램
US11986319B2 (en) 2017-08-25 2024-05-21 NEUROPHET Inc. Patch guide method and program
KR101995900B1 (ko) * 2017-09-11 2019-07-04 뉴로핏 주식회사 3차원 뇌지도 생성 방법 및 프로그램
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
WO2019133997A1 (en) 2017-12-31 2019-07-04 Neuroenhancement Lab, LLC System and method for neuroenhancement to enhance emotional response
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
EP3773726B1 (en) 2018-04-09 2024-06-05 Novocure GmbH Treating tumors with ttfields and an aurora kinase inhibitor
CA3096429C (en) * 2018-04-10 2023-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
KR102104961B1 (ko) * 2018-07-03 2020-04-27 고려대학교산학협력단 최적화 알고리즘을 이용한 전기장 암치료장치
WO2020009306A1 (ko) * 2018-07-03 2020-01-09 고려대학교 산학협력단 최적화 알고리즘을 이용한 전기장 암치료장치 및 방법
AU2019299533B2 (en) 2018-07-03 2023-03-09 Novocure Gmbh Using alternating electric fields to increase cell membrane permeability
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
AU2019301956B2 (en) 2018-07-10 2023-04-13 Novocure Gmbh Inhibiting viral infection using alternating electric fields
CN112423836A (zh) * 2018-07-17 2021-02-26 迪格尼提健康公司 利用交变电场产生治疗癌症的系统和方法
WO2020016840A1 (en) * 2018-07-18 2020-01-23 Novocure Gmbh Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)
WO2020039390A1 (en) 2018-08-23 2020-02-27 Carsten Hagemann Using alternating electric fields to increase permeability of the blood brain barrier
US11623085B2 (en) * 2018-08-29 2023-04-11 Regents Of The University Of Minnesota Devices and methods for treatment of tumors using electromagnetic signal
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
CN112770806A (zh) 2018-09-07 2021-05-07 诺沃库勒有限责任公司 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖
EP3849410A4 (en) 2018-09-14 2022-11-02 Neuroenhancement Lab, LLC SLEEP ENHANCEMENT SYSTEM AND METHOD
EP3863512A1 (en) 2018-10-09 2021-08-18 Koninklijke Philips N.V. Automatic eeg sensor registration
JP7284886B2 (ja) 2018-10-15 2023-06-01 ノボキュア ゲーエムベーハー 脳全体にわたる高均一性での腫瘍治療電場(tt電場)の発生
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達
CA3110448C (en) 2018-11-19 2023-12-19 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
WO2020110050A1 (en) 2018-11-29 2020-06-04 Novocure Gmbh Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
US11141585B2 (en) * 2018-12-28 2021-10-12 Palo Alto Research Center Incorporated Non-invasive neural interface
JP7246486B2 (ja) * 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場(ttfields)を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
CN109864733A (zh) * 2019-01-16 2019-06-11 漫迪医疗仪器(上海)有限公司 心脑异常的检测方法、系统、介质及设备
KR102185662B1 (ko) * 2019-01-31 2020-12-02 뉴로핏 주식회사 10-20 시스템 기반의 위치 정보 제공 방법
US11554262B2 (en) 2019-02-26 2023-01-17 Novocure Gmbh Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells
US11471676B2 (en) 2019-02-27 2022-10-18 Novocure Gmbh Delivering tumor treating fields (TTFields) using implantable transducer arrays
EP3946322B1 (en) 2019-03-29 2023-09-20 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
EP3924039B1 (en) 2019-04-17 2023-11-22 Novocure GmbH Uploading data from an isolated system without compromising isolation
EP3958954B1 (en) 2019-04-22 2024-04-24 Boston Scientific Scimed Inc. Electrical stimulation devices for cancer treatment
US11420049B2 (en) 2019-04-22 2022-08-23 Boston Scientific Scimed, Inc. Systems for administering electrical stimulation to treat cancer
JP7476231B2 (ja) 2019-04-23 2024-04-30 ボストン サイエンティフィック サイムド,インコーポレイテッド 温熱療法又は熱モニタと共に行われる電気刺激
WO2020219517A2 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
US11850422B2 (en) 2019-04-23 2023-12-26 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer
US11620789B2 (en) 2019-05-03 2023-04-04 Novocure Gmbh Methods, systems, and apparatuses for managing transducer array placement
WO2020236956A1 (en) * 2019-05-20 2020-11-26 Neuroelectrics Corporation Systems and methods for treating tumors using targeted neurostimulation
CN110119586B (zh) * 2019-05-21 2023-02-28 中煤科工集团西安研究院有限公司 轴向电导率各向异性瞬变电磁三分量三维fdtd正演方法
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
KR20210003333A (ko) * 2019-07-01 2021-01-12 고려대학교 산학협력단 피부에 인가되는 분산 전류를 이용한 전기장 기반 암 치료장치
WO2021019403A1 (en) 2019-07-31 2021-02-04 Yoram Wasserman Applying tumor treating fields (ttfields) via electrodes embedded into skull implants
JP2022545794A (ja) * 2019-08-30 2022-10-31 ノボキュア ゲーエムベーハー 頸部への腫瘍治療電界(TTFields)の印加
US11445960B2 (en) * 2019-10-09 2022-09-20 Trustees Of Boston University Electrography system employing layered electrodes for improved spatial resolution
US11534601B2 (en) 2019-11-08 2022-12-27 Novocure Gmbh Perforated hydrogel configurations and methods of production and use thereof
WO2021111186A1 (en) 2019-12-02 2021-06-10 Novocure Gmbh Methods and apparatuses for optimizing transducer array placement
DK4074367T3 (da) 2019-12-31 2023-05-22 Novocure Gmbh Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer
CN114830248A (zh) 2019-12-31 2022-07-29 诺沃库勒有限责任公司 用于电场分布的快速近似的方法、系统和装置
JP2023508584A (ja) 2019-12-31 2023-03-02 ノボキュア ゲーエムベーハー 画像セグメンテーションのための方法、システム、および装置
US20230147250A1 (en) 2019-12-31 2023-05-11 Novocure Gmbh Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy
WO2021136964A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh Methods, systems, and apparatuses for associating dielectric properties with a patient model
EP4074368A1 (en) 2019-12-31 2022-10-19 Novocure GmbH High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
US20210196967A1 (en) 2019-12-31 2021-07-01 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
WO2021150877A1 (en) 2020-01-22 2021-07-29 Novocure Gmbh Assemblies containing two conductive gel compositions and methods of production and use thereof
WO2021173509A1 (en) 2020-02-24 2021-09-02 Boston Scientific Scimed, Inc. Systems and methods for treatment of pancreatic cancer
US20210299439A1 (en) * 2020-03-31 2021-09-30 Novocure Gmb Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields
CN111420271A (zh) * 2020-04-02 2020-07-17 河北普尼医疗科技有限公司 一种基于头部肿瘤治疗的电极贴片定位方法
TW202200232A (zh) 2020-05-06 2022-01-01 瑞士商諾沃庫勒有限責任公司 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法
KR102464313B1 (ko) 2020-05-18 2022-11-08 주식회사 필드큐어 전기장 암 치료 시스템을 위한 품질 보증 장치 및 방법
EP4168108A1 (en) 2020-06-19 2023-04-26 The Methodist Hospital dba Houston Methodist Hospital Method and apparatus for oncomagnetic treatment
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
KR102490645B1 (ko) * 2020-07-16 2023-01-25 고려대학교 산학협력단 흡수에너지 기반 전기장 암치료 계획 시스템 및 방법
KR102385708B1 (ko) * 2020-07-20 2022-04-13 경희대학교 산학협력단 알츠하이머병 진단을 위한 인공지능 기반의 전도도 영상 복원 장치 및 방법
KR102458768B1 (ko) * 2020-09-29 2022-10-26 고려대학교 산학협력단 체내 온도 제어 및 흡수에너지 기반 종양치료 전기장 최적화 방법 및 시스템, 및 이를 포함하는 전기장 시스템 구동 방법 및 시스템
US20220096829A1 (en) * 2020-09-30 2022-03-31 Novocure Gmbh Method and apparatus for delivering tumor treating fields to a torso, and method for determining locations for transducers to deliver tumor treating fields
US20220096853A1 (en) * 2020-09-30 2022-03-31 Novocure Gmbh Methods and systems for transducer array placement and skin surface condition avoidance
TWI827889B (zh) * 2020-10-16 2024-01-01 瑞士商諾沃庫勒有限責任公司 用於管理傳感器陣列佈置的方法和設備以及相關的非暫態的電腦可讀取的媒體
TWI805954B (zh) * 2020-10-16 2023-06-21 瑞士商諾沃庫勒有限責任公司 經由嵌入顱骨植入物中之電極來應用腫瘤治療電場(TTFields)
US20220148171A1 (en) * 2020-11-06 2022-05-12 Novocure Gmbh Methods and apparatuses for determining transducer locations to generate tumor treating fields
CN116782980A (zh) 2020-12-21 2023-09-19 诺沃库勒有限责任公司 复合电极的优化
US11869151B2 (en) 2021-01-26 2024-01-09 Beth Israel Deaconess Medical Center Systems and methods for finite element analysis of tumor treating fields
JP2024514045A (ja) 2021-03-12 2024-03-28 ノボキュア ゲーエムベーハー 電極アレイ、ならびにその製造および使用方法
WO2022195542A2 (en) 2021-03-18 2022-09-22 Novocure Gmbh Constructing a 3d phantom with liquid hydrogel
EP4284489A1 (en) * 2021-03-31 2023-12-06 Novocure Gmbh Impedance tomography using electrodes of a tumor treating fields (ttfields) system
EP4320631A1 (en) * 2021-04-04 2024-02-14 Dignity Health Systems and methods for machine-learning guided treatment planning and monitoring of electric field therapy implants
CN113101517B (zh) * 2021-04-15 2022-02-01 中国医学科学院北京协和医院 植入式电极装置及其制备方法
EP4344413A1 (en) 2021-07-21 2024-04-03 Novocure GmbH Conductive pad generating tumor treating field and methods of production and use thereof
EP4376939A1 (en) 2021-09-14 2024-06-05 Novocure GmbH Temperature independent method and system for applying ttfields
US20230102915A1 (en) 2021-09-30 2023-03-30 Novocure Gmbh Method and system for applying tumor treating fields interfacing with hair follicles
WO2023084340A1 (en) * 2021-11-12 2023-05-19 Novocure Gmbh Adjusting tumor treating fields simulation and treatment using molecular imaging
WO2023095111A1 (en) 2021-11-29 2023-06-01 Novocure Gmbh Methods of reducing ciliogenesis with alternating electric fields
US20230173265A1 (en) 2021-12-10 2023-06-08 Novocure Gmbh Garment providing a biasing force on a transducer array
WO2023168033A1 (en) * 2022-03-03 2023-09-07 Medtronic, Inc. Electric field therapy via implantable electrodes
WO2023242741A1 (en) 2022-06-13 2023-12-21 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
WO2023248139A1 (en) 2022-06-20 2023-12-28 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors
US20230407282A1 (en) 2022-06-21 2023-12-21 Novocure Gmbh Systems and methods for treating conditions and diseases using alternating electric fields and crispr-cas system
US20240001133A1 (en) * 2022-06-30 2024-01-04 Novocure Gmbh Tumor treating field transducers with protective border, and apparatuses and methods for active detection of improper transducer configuration
WO2024052877A1 (en) 2022-09-08 2024-03-14 Novocure Gmbh Constructing a 3d phantom with a matrix material having conductive particles dispersed therein
US20240103041A1 (en) 2022-09-27 2024-03-28 Novocure Gmbh Ingestible implantable device to measure internal ttfield intensity
CA3180284A1 (en) 2022-09-29 2024-03-29 Novocure Gmbh Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment
WO2024069501A1 (en) 2022-09-29 2024-04-04 Novocure Gmbh System and method for maintaining ttfields during battery changes
WO2024069531A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for treating cancer using alternating electric fields and apoptotic cancer cell vaccination
US20240110174A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for treating cancer using alternating electric fields and dendritic cells
US20240123228A1 (en) 2022-09-30 2024-04-18 Novocure Gmbh Single wire temperature measurement solution for a ttfield application system and methods of production and use thereof
US20240108699A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for reducing electrosensation and/or skin irritation
CN116542115B (zh) * 2023-07-06 2023-10-20 湖南安泰康成生物科技有限公司 生物体目标区域电场强度模的确定方法、装置及电子设备
CN117954050A (zh) * 2024-03-25 2024-04-30 湖南安泰康成生物科技有限公司 电极片贴敷方案确定方法及装置、设备及存储介质

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5568816A (en) 1990-09-07 1996-10-29 Sam Technology, Inc. EEG deblurring method and system for improved spatial detail
JPH09173315A (ja) * 1995-12-26 1997-07-08 Hitachi Medical Corp 磁気共鳴イメージング方法
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
CA2400526C (en) 2000-02-17 2013-04-23 Yoram Palti Method and apparatus for destroying dividing cells
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
JP2007517571A (ja) * 2004-01-14 2007-07-05 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ リアルタイムの磁場マッピングを用いる磁気共鳴撮像方法及び装置
WO2005081842A2 (en) * 2004-02-20 2005-09-09 University Of Florida Research Foundation, Inc. System for delivering conformal radiation therapy while simultaneously imaging soft tissue
JP4750784B2 (ja) 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
US8180601B2 (en) * 2006-03-09 2012-05-15 The Cleveland Clinic Foundation Systems and methods for determining volume of activation for deep brain stimulation
US7346382B2 (en) * 2004-07-07 2008-03-18 The Cleveland Clinic Foundation Brain stimulation models, systems, devices, and methods
EP2364747B1 (en) 2004-12-07 2018-01-24 Novocure Limited Electrodes for applying an electric field in-vivo over an extended period of time
CN101124011B (zh) 2004-12-27 2011-08-31 斯坦顿有限公司 利用电场从不同方向治疗肿瘤等
CA2611398C (en) 2005-06-08 2018-09-11 Standen Ltd. Treating cancer with electric fields that are guided to desired locations within a body
US9307925B2 (en) 2005-06-16 2016-04-12 Aaken Laboratories Methods and systems for generating electrical property maps of biological structures
US20070043268A1 (en) 2005-06-16 2007-02-22 Russell Michael J Guided Electrical Transcranial Stimulation (GETS) Technique
DK1933937T3 (en) 2005-10-03 2015-04-07 Novocure Ltd OPTIMIZATION OF THE CHARACTERISTICS OF AN ELECTRIC FIELD FOR ENHANCING FIELD EFFECT ON proliferating cells
US20100113959A1 (en) 2006-03-07 2010-05-06 Beth Israel Deaconess Medical Center, Inc. Transcranial magnetic stimulation (tms) methods and apparatus
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
WO2009044289A1 (en) 2007-03-06 2009-04-09 Novocure Ltd. Treating cancer using electromagnetic fields in combination with photodynamic therapy
CN101820947A (zh) 2007-08-14 2010-09-01 诺沃库勒有限公司 用电场治疗寄生物
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
EP2419171B1 (en) 2009-04-13 2017-11-01 Research Foundation Of The City University Of New York Neurocranial electrostimulation models
WO2012052543A1 (en) * 2010-10-22 2012-04-26 Herlev Hospital A method for treating a tissue region with an electric field
US9265557B2 (en) 2011-01-31 2016-02-23 Medtronic Ablation Frontiers Llc Multi frequency and multi polarity complex impedance measurements to assess ablation lesions
WO2014025353A1 (en) * 2012-08-09 2014-02-13 Northeastern University Electric field encephalography: electric field based brain signal detection and monitoring
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
CN104096316B (zh) * 2014-07-21 2015-11-18 中国医学科学院生物医学工程研究所 一种用于脑深部经颅磁刺激的h型线圈优化方法
CN104063565A (zh) * 2014-07-21 2014-09-24 中国医学科学院生物医学工程研究所 一种用于深部磁刺激研究的真实人体头部有限元模型
CN104123416A (zh) * 2014-07-21 2014-10-29 中国医学科学院生物医学工程研究所 一种模拟真实人体颅脑电特性分布的有限元仿真模型
US20190117963A1 (en) 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US10441776B2 (en) 2016-06-30 2019-10-15 Novocure Gmbh Arrays for longitudinal delivery of TTFields to a body
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
BR112019003199A2 (pt) 2016-08-18 2019-06-18 Novocure Ltd medição de temperatura em array para entrega do tt fields
AU2017377003B2 (en) 2016-12-13 2022-05-19 Novocure Gmbh Treating patients with TTFields with the electrode positions optimized using deformable templates
US11573221B2 (en) 2017-01-19 2023-02-07 Novocure Gmbh System for viewing cell cultures under a microscope whilst applying TTFields
EP3773726B1 (en) 2018-04-09 2024-06-05 Novocure GmbH Treating tumors with ttfields and an aurora kinase inhibitor
CA3096429C (en) 2018-04-10 2023-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
AU2019299533B2 (en) 2018-07-03 2023-03-09 Novocure Gmbh Using alternating electric fields to increase cell membrane permeability
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
WO2020016840A1 (en) 2018-07-18 2020-01-23 Novocure Gmbh Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)
WO2020039390A1 (en) 2018-08-23 2020-02-27 Carsten Hagemann Using alternating electric fields to increase permeability of the blood brain barrier
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
CN112770806A (zh) 2018-09-07 2021-05-07 诺沃库勒有限责任公司 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖
US20200108031A1 (en) 2018-10-05 2020-04-09 Novocure Gmbh Treating Tumors Using TTFields Combined with ABT-751
WO2020086753A1 (en) 2018-10-23 2020-04-30 The Board Of Trustees Of The Leland Stanford Junior University Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界(例えばTTField)の送達
US20200146586A1 (en) 2018-11-14 2020-05-14 Novocure Gmbh Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images
CA3110448C (en) 2018-11-19 2023-12-19 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
WO2020110050A1 (en) 2018-11-29 2020-06-04 Novocure Gmbh Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
JP7246486B2 (ja) 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場(ttfields)を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
US20200269041A1 (en) 2019-02-22 2020-08-27 Novocure Gmbh Treating Gastric Cancer Using TTFields Combined with XELOX, FOLFOX or the Individual Constituents Thereof
US11554262B2 (en) 2019-02-26 2023-01-17 Novocure Gmbh Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells
US11471676B2 (en) 2019-02-27 2022-10-18 Novocure Gmbh Delivering tumor treating fields (TTFields) using implantable transducer arrays
EP3946322B1 (en) 2019-03-29 2023-09-20 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
EP3924039B1 (en) 2019-04-17 2023-11-22 Novocure GmbH Uploading data from an isolated system without compromising isolation

Also Published As

Publication number Publication date
US11013909B2 (en) 2021-05-25
DK3838338T3 (da) 2023-07-24
HUE054032T2 (hu) 2021-08-30
WO2017072706A1 (en) 2017-05-04
JP2021074585A (ja) 2021-05-20
JP2019500179A (ja) 2019-01-10
JP7301112B2 (ja) 2023-06-30
KR20210016482A (ko) 2021-02-15
JP7311572B2 (ja) 2023-07-19
KR20200079349A (ko) 2020-07-02
US20210187277A1 (en) 2021-06-24
JP7183045B2 (ja) 2022-12-05
US20170120041A1 (en) 2017-05-04
HUE062370T2 (hu) 2023-10-28
EP3838338A1 (en) 2021-06-23
ES2953093T3 (es) 2023-11-08
PT3368152T (pt) 2021-04-01
JP7383679B2 (ja) 2023-11-20
DK3368152T3 (da) 2021-04-12
KR20180072811A (ko) 2018-06-29
CN108348761A (zh) 2018-07-31
JP2022020713A (ja) 2022-02-01
CN113332601A (zh) 2021-09-03
CA3003370A1 (en) 2017-05-04
EP3368152B1 (en) 2021-03-10
PL3838338T3 (pl) 2023-10-30
ES2860714T3 (es) 2021-10-05
CN108348761B (zh) 2022-07-05
JP7301080B2 (ja) 2023-06-30
KR102278628B1 (ko) 2021-07-19
FI3838338T3 (fi) 2023-07-27
EP3838338B1 (en) 2023-05-24
JP2022020785A (ja) 2022-02-01
EP3368152A1 (en) 2018-09-05
US11642514B2 (en) 2023-05-09
JP2022017424A (ja) 2022-01-25
US20190117956A1 (en) 2019-04-25
KR102312079B1 (ko) 2021-10-13
US10188851B2 (en) 2019-01-29

Similar Documents

Publication Publication Date Title
HUE062370T2 (hu) TTFIELD (tumorkezelõ mezõk) kezelés elektróda helyzetének optimalizálására a fejnél MRI alapú vezetõképességi mérések alapján
PL3242509T3 (pl) Pomiary mobilności
DK3422981T3 (da) Elektrokirurgisk instrument med flere behandlingsmodaliteter
DK2892246T3 (da) Hovedtelefoner med passage over hovedet
DK3034453T3 (da) Udstyr med sideskifter
EP2967400A4 (en) MULTI-CHANNEL HEART MEASUREMENTS
IL252547A0 (en) Treatment of multiple sclerosis using laquinimod
IL238600A0 (en) Catheter electrode with multiple thermocouples
EP2967403A4 (en) MULTICANAL CARDIAC MEASUREMENTS
IL247434B (en) Ablation current measurement
PL2886155T3 (pl) Biomedyczna elektroda
HK1254709A1 (zh) 導電尖端導管
PT3353336T (pt) Elétrodo
HK1218254A1 (zh) 用拉喹莫德治療多發性硬化症
GB201602448D0 (en) Mamr head with inclined mamr head body
SG2014001960A (en) Probe head
HK1249866A1 (zh) 用他塞利昔布進行治療的方法
PL3282988T3 (pl) Igła do odnerwiania z użyciem fal radiowych
GB2539645B (en) Voltage monitor
ZA201607682B (en) Radiofrequency probes with retractable multi-tined electrodes
GB2518258B (en) Electrosurgical electrode
PL3383851T3 (pl) Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej
PL3156564T3 (pl) Trzpień sprzęgający o nastawnej długości
PT3353335T (pt) Elétrodo
GB201503329D0 (en) Current sensor with balls