PL3226888T3 - Podawanie selektywnego transsygnałowego inhibitora IL-6 - Google Patents
Podawanie selektywnego transsygnałowego inhibitora IL-6Info
- Publication number
- PL3226888T3 PL3226888T3 PL15832692T PL15832692T PL3226888T3 PL 3226888 T3 PL3226888 T3 PL 3226888T3 PL 15832692 T PL15832692 T PL 15832692T PL 15832692 T PL15832692 T PL 15832692T PL 3226888 T3 PL3226888 T3 PL 3226888T3
- Authority
- PL
- Poland
- Prior art keywords
- trans
- administration
- selective
- signalling inhibitor
- signalling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086054P | 2014-12-01 | 2014-12-01 | |
| PCT/IB2015/002459 WO2016087941A1 (en) | 2014-12-01 | 2015-12-01 | Administration of a selective il-6-trans-signalling inhibitor |
| EP15832692.6A EP3226888B1 (en) | 2014-12-01 | 2015-12-01 | Administration of a selective il-6-trans-signalling inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3226888T3 true PL3226888T3 (pl) | 2021-11-02 |
Family
ID=55305021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15832692T PL3226888T3 (pl) | 2014-12-01 | 2015-12-01 | Podawanie selektywnego transsygnałowego inhibitora IL-6 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11198721B2 (pl) |
| EP (2) | EP3912636A1 (pl) |
| JP (1) | JP6775513B2 (pl) |
| KR (1) | KR20170135819A (pl) |
| CN (1) | CN107223132A (pl) |
| CA (1) | CA2969301A1 (pl) |
| DK (1) | DK3226888T3 (pl) |
| ES (1) | ES2875351T3 (pl) |
| HR (1) | HRP20210737T1 (pl) |
| HU (1) | HUE054742T2 (pl) |
| LT (1) | LT3226888T (pl) |
| MA (2) | MA54761A (pl) |
| MD (1) | MD3226888T2 (pl) |
| MX (1) | MX2017007067A (pl) |
| PL (1) | PL3226888T3 (pl) |
| PT (1) | PT3226888T (pl) |
| RS (1) | RS61947B1 (pl) |
| SI (1) | SI3226888T1 (pl) |
| WO (1) | WO2016087941A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41116A (fr) | 2014-12-01 | 2017-10-10 | Ferring Bv | Compositions d'inhibiteur de trans-signalisation par l'il-6 sélectif |
| WO2021250069A1 (en) * | 2020-06-10 | 2021-12-16 | Christian-Albrechts-Universität Zu Kiel | Pharmaceutical compound for the treatment of atherosclerotic cardiovascular disease |
| TW202242142A (zh) | 2020-12-22 | 2022-11-01 | 荷蘭商菲林公司 | 預測炎性腸病患者的響應之血液基因表現生物標誌物 |
| WO2024011946A1 (en) * | 2022-07-12 | 2024-01-18 | I-Mab Biopharma (Hangzhou) Co., Ltd | Polypeptide dimers for the treatment of systemic sclerosis |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| AU5670194A (en) | 1992-11-20 | 1994-06-22 | Enzon, Inc. | Linker for linked fusion polypeptides |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| DE19941897B4 (de) | 1999-09-02 | 2006-06-14 | GSF - Forschungszentrum für Umwelt und Gesundheit GmbH | IL-6 Rezeptor-Protein, Beta-Kette (gp130) des IL-6 Rezeptor-Proteins, für diese Proteine kodierende DNA, davon abgeleitete RNA, Peptid mit den Aminosäuren 771-811 dieser Beta-Kette oder Teilen davon und deren Verwendungen |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| ATE382636T1 (de) | 2000-04-21 | 2008-01-15 | Conaris Res Inst Ag | Fusionsproteine, die zwei lösliche gp130 moleküle enthalten |
| CN101045166A (zh) | 2001-05-21 | 2007-10-03 | 耐科塔医药公司 | 化学修饰胰岛素的肺部给药 |
| JP2005511005A (ja) | 2001-07-18 | 2005-04-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 糖タンパク質ｖｉ融合タンパク質 |
| AU2002356511A1 (en) | 2001-07-30 | 2003-04-01 | Immunex Corporation | T. reesei phytase enyzmes, polynucleides encoding the enzymes, vectors and host cells thereof, and methods of using |
| JP2004182638A (ja) | 2002-12-03 | 2004-07-02 | Yakult Honsha Co Ltd | 炎症性疾患又は悪性腫瘍の予防治療剤 |
| EP1491554A1 (en) | 2003-06-23 | 2004-12-29 | CONARIS research institute AG | PEGylated soluble gp130-dimers useful as a medicament |
| DK1630232T3 (da) | 2004-08-27 | 2008-10-20 | Conaris Res Inst Ag | Optimerede nukleotidsekvenser kodende for sgp130 |
| EP1801121A1 (en) | 2005-12-23 | 2007-06-27 | CONARIS research institute AG | Soluble gp130 molecule variants useful as a medicament |
| ES2382164T3 (es) * | 2005-12-30 | 2012-06-05 | Merck Patent Gmbh | Anticuerpos anti-IL-6 que impiden la unión de la IL-6 en complejo con el IL-6R( ) a la GP130 |
| DE602006016765D1 (de) | 2006-06-30 | 2010-10-21 | Conaris Res Inst Ag | Verbesserte sgp 130Fc Dimere |
| EP2050759A1 (en) * | 2007-10-19 | 2009-04-22 | CONARIS research institute AG | Soluble gp 130 muteins with improved binding activity |
| AU2012204241A1 (en) | 2011-01-06 | 2013-06-06 | The Johns Hopkins University | Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells |
| MA41116A (fr) | 2014-12-01 | 2017-10-10 | Ferring Bv | Compositions d'inhibiteur de trans-signalisation par l'il-6 sélectif |
-
2015
- 2015-12-01 SI SI201531602T patent/SI3226888T1/sl unknown
- 2015-12-01 MX MX2017007067A patent/MX2017007067A/es unknown
- 2015-12-01 RS RS20210709A patent/RS61947B1/sr unknown
- 2015-12-01 CA CA2969301A patent/CA2969301A1/en active Pending
- 2015-12-01 JP JP2017547084A patent/JP6775513B2/ja active Active
- 2015-12-01 WO PCT/IB2015/002459 patent/WO2016087941A1/en active Application Filing
- 2015-12-01 KR KR1020177018155A patent/KR20170135819A/ko not_active IP Right Cessation
- 2015-12-01 MA MA054761A patent/MA54761A/fr unknown
- 2015-12-01 EP EP21162245.1A patent/EP3912636A1/en active Pending
- 2015-12-01 MD MDE20170156T patent/MD3226888T2/ro unknown
- 2015-12-01 PT PT158326926T patent/PT3226888T/pt unknown
- 2015-12-01 EP EP15832692.6A patent/EP3226888B1/en active Active
- 2015-12-01 LT LTEP15832692.6T patent/LT3226888T/lt unknown
- 2015-12-01 PL PL15832692T patent/PL3226888T3/pl unknown
- 2015-12-01 CN CN201580075096.0A patent/CN107223132A/zh active Pending
- 2015-12-01 DK DK15832692.6T patent/DK3226888T3/da active
- 2015-12-01 HU HUE15832692A patent/HUE054742T2/hu unknown
- 2015-12-01 ES ES15832692T patent/ES2875351T3/es active Active
- 2015-12-01 US US15/532,092 patent/US11198721B2/en active Active
- 2015-12-01 MA MA41114A patent/MA41114B1/fr unknown
-
2021
- 2021-05-11 HR HRP20210737TT patent/HRP20210737T1/hr unknown
- 2021-11-09 US US17/522,320 patent/US20220135652A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2875351T3 (es) | 2021-11-10 |
| WO2016087941A1 (en) | 2016-06-09 |
| EP3226888B1 (en) | 2021-04-21 |
| KR20170135819A (ko) | 2017-12-08 |
| EP3912636A1 (en) | 2021-11-24 |
| RS61947B1 (sr) | 2021-07-30 |
| HUE054742T2 (hu) | 2021-09-28 |
| LT3226888T (lt) | 2021-05-25 |
| MD3226888T2 (ro) | 2021-08-31 |
| EP3226888A1 (en) | 2017-10-11 |
| MA41114B1 (fr) | 2021-06-30 |
| HRP20210737T1 (hr) | 2021-06-11 |
| CA2969301A1 (en) | 2016-06-09 |
| US11198721B2 (en) | 2021-12-14 |
| JP6775513B2 (ja) | 2020-10-28 |
| JP2017537155A (ja) | 2017-12-14 |
| US20220135652A1 (en) | 2022-05-05 |
| MA54761A (fr) | 2021-11-24 |
| MX2017007067A (es) | 2018-04-30 |
| DK3226888T3 (da) | 2021-07-12 |
| US20170320932A1 (en) | 2017-11-09 |
| PT3226888T (pt) | 2021-06-02 |
| CN107223132A (zh) | 2017-09-29 |
| SI3226888T1 (sl) | 2021-08-31 |
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