PL3221332T3 - Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr - Google Patents

Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Info

Publication number
PL3221332T3
PL3221332T3 PL15800910T PL15800910T PL3221332T3 PL 3221332 T3 PL3221332 T3 PL 3221332T3 PL 15800910 T PL15800910 T PL 15800910T PL 15800910 T PL15800910 T PL 15800910T PL 3221332 T3 PL3221332 T3 PL 3221332T3
Authority
PL
Poland
Prior art keywords
steroids
intermediates
beta
hydroxy
alkyl
Prior art date
Application number
PL15800910T
Other languages
English (en)
Polish (pl)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Nathan Bartlett
Montserrat Shelbourne
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of PL3221332T3 publication Critical patent/PL3221332T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL15800910T 2014-11-19 2015-11-19 Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr PL3221332T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
EP15800910.0A EP3221332B1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
PL3221332T3 true PL3221332T3 (pl) 2019-10-31

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15800910T PL3221332T3 (pl) 2014-11-19 2015-11-19 Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Country Status (14)

Country Link
US (1) US10131688B2 (cg-RX-API-DMAC7.html)
EP (1) EP3221332B1 (cg-RX-API-DMAC7.html)
JP (1) JP6724004B2 (cg-RX-API-DMAC7.html)
KR (1) KR102526632B1 (cg-RX-API-DMAC7.html)
CN (1) CN107108687B (cg-RX-API-DMAC7.html)
CA (1) CA2968301C (cg-RX-API-DMAC7.html)
DK (1) DK3221332T3 (cg-RX-API-DMAC7.html)
EA (1) EA033445B1 (cg-RX-API-DMAC7.html)
ES (1) ES2733643T3 (cg-RX-API-DMAC7.html)
HK (1) HK1244285B (cg-RX-API-DMAC7.html)
MX (1) MX375864B (cg-RX-API-DMAC7.html)
PL (1) PL3221332T3 (cg-RX-API-DMAC7.html)
TW (1) TWI686400B (cg-RX-API-DMAC7.html)
WO (1) WO2016079518A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170327531A1 (en) 2014-11-19 2017-11-16 NZP UK Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
CN107108688B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇
CN107207559B (zh) 2014-11-19 2019-10-25 Nzp英国有限公司 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇
KR20180095070A (ko) * 2015-12-22 2018-08-24 인터셉트 파마슈티컬즈, 인크. 오베티콜산의 다형성 결정질 형태들
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
CN106279331B (zh) * 2016-07-27 2019-06-14 宋火良 胆酸类肝病治疗药物
EP3431486A1 (en) * 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
CN113135970B (zh) * 2020-01-20 2024-11-22 成都贝诺科成生物科技有限公司 一种具有抗芽孢活性的化合物及其药用组合物

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624748A (en) 1950-09-09 1953-01-06 Upjohn Co Bisnorchola-4, 6-dien-3-one-22-al
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
JPH07505915A (ja) 1992-04-14 1995-06-29 コーネル　リサーチ　ファウンデーション、インコーポレーテッド 樹枝状巨大分子およびその製造法
WO1994019366A1 (en) 1993-02-26 1994-09-01 Magainin Pharmaceuticals Inc. Chemical synthesis of squalamine
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
DE60205891T2 (de) 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. Steroide als agonisten für fxr
US20090062256A1 (en) 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
WO2003040211A2 (en) 2001-11-07 2003-05-15 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP2007210888A (ja) * 2006-01-12 2007-08-23 Mitsubishi Chemicals Corp ステロイド化合物の製造方法
CA2642220A1 (en) 2006-02-14 2007-08-23 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
EP2040713B1 (en) 2006-06-27 2014-06-18 Intercept Pharmaceuticals Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions
CN101679476B (zh) 2007-01-19 2014-05-07 英特塞普特医药品公司 23取代的胆汁酸作为tgr5调节剂及其使用方法
AU2009276507B2 (en) * 2008-07-30 2015-11-19 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
CN102325784B (zh) 2008-11-19 2014-11-19 英特塞普特医药品公司 G蛋白偶联受体5(tgr5)调节剂及其使用方法
EP3150620B1 (en) * 2008-11-19 2020-01-08 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
CN102482315A (zh) 2009-07-29 2012-05-30 芝加哥大学 肝x受体激动剂
CN104781272A (zh) 2012-06-19 2015-07-15 英特塞普特医药品公司 奥贝胆酸的制备、用途和固体形式
US9777038B2 (en) 2012-10-26 2017-10-03 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
AU2013352288B2 (en) * 2012-11-28 2017-11-23 Intercept Pharmaceuticals, Inc. Treatment of pulmonary disease
US20140206657A1 (en) 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
EA030152B1 (ru) 2013-05-14 2018-06-29 Интерсепт Фармасьютикалз, Инк 11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторов
CN105392780A (zh) 2013-05-24 2016-03-09 雀巢产品技术援助有限公司 用于预测肠易激综合征诊断的途径特异性测定
US10166246B2 (en) 2014-05-27 2019-01-01 City Of Hope TGR5 agonist complexes for treating diabetes and cancer
ES2938874T3 (es) 2014-05-29 2023-04-17 Bar Pharmaceuticals S R L Derivados de colano para su uso en el tratamiento y/o prevención de enfermedades mediadas por FXR y TGR5/GPBAR1
CA2966885A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
CN107108688B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇
CN107207559B (zh) 2014-11-19 2019-10-25 Nzp英国有限公司 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
US20170327531A1 (en) 2014-11-19 2017-11-16 NZP UK Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
WO2016086134A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
US10519191B2 (en) 2014-11-26 2019-12-31 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
CN106279328A (zh) 2015-05-20 2017-01-04 重庆药友制药有限责任公司 一种制备6α-烷基鹅去氧胆酸的方法
TW201700447A (zh) 2015-06-19 2017-01-01 英特賽普醫藥品公司 Tgr5調控劑及其用法
CN106397522A (zh) 2015-07-31 2017-02-15 中国人民解放军军事医学科学院毒物药物研究所 3,7‑二（叔丁基二甲基硅基氧基）‑6‑烯‑5β‑胆烷‑24‑酸甲酯
CN106478759A (zh) 2015-08-31 2017-03-08 陕西合成药业股份有限公司 奥贝胆酸衍生物及其制备方法和用途
CN106478756A (zh) 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 Oca-e单晶及其制备方法和用途
CN106518946A (zh) 2015-09-10 2017-03-22 上海迪诺医药科技有限公司 磺酰脲衍生物、其药物组合物及应用

Also Published As

Publication number Publication date
TWI686400B (zh) 2020-03-01
JP2017538691A (ja) 2017-12-28
EA201790881A1 (ru) 2017-11-30
EP3221332B1 (en) 2019-04-24
CN107108687B (zh) 2019-10-29
MX375864B (es) 2025-03-07
CN107108687A (zh) 2017-08-29
WO2016079518A1 (en) 2016-05-26
DK3221332T3 (da) 2019-07-29
HK1244285B (en) 2020-06-05
JP6724004B2 (ja) 2020-07-15
CA2968301C (en) 2023-05-16
ES2733643T3 (es) 2019-12-02
TW201629081A (zh) 2016-08-16
CA2968301A1 (en) 2016-05-26
US10131688B2 (en) 2018-11-20
EP3221332A1 (en) 2017-09-27
MX2017006564A (es) 2018-01-26
KR102526632B1 (ko) 2023-04-27
KR20170099895A (ko) 2017-09-01
US20170320907A1 (en) 2017-11-09
EA201790881A8 (ru) 2019-07-31
EA033445B1 (ru) 2019-10-31

Similar Documents

Publication Publication Date Title
PL3221332T3 (pl) Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr
PT3221331T (pt) Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediários para a produção de moduladores de fxr esteroidais
EP3230441A4 (en) Compositions and methods for the production of scaav
PL3221333T3 (pl) Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr
EP3119401A4 (en) Cenicriviroc for the treatment of fibrosis
IL250984A0 (en) Process for preparing 3-(3-chloro-1h-pyrazol-1-yl)pyridine
ZA201700243B (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
IL250628A0 (en) Process for preparing 3-(3-chloro-h1-pyrazol-1-yl)pyridine
PL3201253T3 (pl) Sposób wytwarzania poliestrów
IL249988A0 (en) Process for preparing 3-(3-chloro-h1-pyrazol-1-yl)pyridine
ZA201700168B (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3166931A4 (en) An improved process for the preparation of enzalutamide
SG11201606307PA (en) A process for the preparation of a feedstock for a hydroprocessing unit
GB201704946D0 (en) Method for obfuscating the display of text
IL248267A0 (en) A process for preparing converted cycloserines
IL285700A (en) 21- Hydroxylation of steroids
EP3227298A4 (en) Process for the preparation of baricitinib and an intermediate thereof
EP3182981A4 (en) Process for the production of isomaltooligosaccharides
IL247443B (en) Process for the preparation of 5-fluorotryptophol
EP3174878A4 (en) A process for the preparation of palbociclib
EP3152691A4 (en) Refining of material definitions for designed parts
HUE071989T2 (hu) Új intermedierek 11-metilén-szteroidok elõállítására
IL237572A0 (en) Process and intermediates for the preparation of dastinib
PT3102565T (pt) Processos para a preparação de intermediários de raltegravir
SG11201703783TA (en) Process for the production of aromatics from biomass