PL3119783T3 - Inhibitory kinazy 1 oddziałującej z adaptorem, kompozycje je zawierające i sposoby ich zastosowania - Google Patents

Inhibitory kinazy 1 oddziałującej z adaptorem, kompozycje je zawierające i sposoby ich zastosowania

Info

Publication number
PL3119783T3
PL3119783T3 PL15712026T PL15712026T PL3119783T3 PL 3119783 T3 PL3119783 T3 PL 3119783T3 PL 15712026 T PL15712026 T PL 15712026T PL 15712026 T PL15712026 T PL 15712026T PL 3119783 T3 PL3119783 T3 PL 3119783T3
Authority
PL
Poland
Prior art keywords
inhibitors
compositions
methods
associated kinase
adapter associated
Prior art date
Application number
PL15712026T
Other languages
English (en)
Polish (pl)
Inventor
Yingzhi Bi
Godwin KUMI
Original Assignee
Lexicon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals, Inc. filed Critical Lexicon Pharmaceuticals, Inc.
Publication of PL3119783T3 publication Critical patent/PL3119783T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL15712026T 2014-03-17 2015-03-16 Inhibitory kinazy 1 oddziałującej z adaptorem, kompozycje je zawierające i sposoby ich zastosowania PL3119783T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953976P 2014-03-17 2014-03-17
EP15712026.2A EP3119783B1 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use
PCT/US2015/020696 WO2015142714A1 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

Publications (1)

Publication Number Publication Date
PL3119783T3 true PL3119783T3 (pl) 2021-01-11

Family

ID=52727478

Family Applications (2)

Application Number Title Priority Date Filing Date
PL15712026T PL3119783T3 (pl) 2014-03-17 2015-03-16 Inhibitory kinazy 1 oddziałującej z adaptorem, kompozycje je zawierające i sposoby ich zastosowania
PL20177604T PL3719021T3 (pl) 2014-03-17 2015-03-16 Inhibitory kinazy 1 związanej z adapterem, kompozycje je zawierające, oraz sposoby ich zastosowania

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20177604T PL3719021T3 (pl) 2014-03-17 2015-03-16 Inhibitory kinazy 1 związanej z adapterem, kompozycje je zawierające, oraz sposoby ich zastosowania

Country Status (14)

Country Link
US (1) US9682982B2 (enExample)
EP (2) EP3119783B1 (enExample)
JP (1) JP6553081B2 (enExample)
CN (1) CN106103447B (enExample)
AR (1) AR099766A1 (enExample)
AU (1) AU2015231672B2 (enExample)
CA (1) CA2941870C (enExample)
DK (2) DK3119783T3 (enExample)
ES (2) ES2911388T3 (enExample)
HU (1) HUE050975T2 (enExample)
PL (2) PL3119783T3 (enExample)
PT (2) PT3719021T (enExample)
TW (1) TW201620911A (enExample)
WO (1) WO2015142714A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302649B (zh) * 2012-03-09 2017-06-23 莱西肯医药有限公司 基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
JP6473146B2 (ja) 2013-10-11 2019-02-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ピロロトリアジンキナーゼ阻害剤
CN109369576B (zh) * 2018-09-19 2020-11-27 上海凌凯医药科技有限公司 一种合成3-甲基氧杂环丁烷-3-(4-硝基苯基)碳酸酯的方法
US11730723B2 (en) 2020-04-21 2023-08-22 Lexicon Pharmaceuticals, Inc. Compounds and methods for treating viral infections
CN115427045A (zh) * 2020-04-21 2022-12-02 莱西肯医药有限公司 用于治疗cov-229e或cov-oc43冠状病毒感染的4-(3-(吡啶-3-基)吡唑并[1，5-a]嘧啶-5-基)哌嗪
WO2023196584A2 (en) * 2022-04-08 2023-10-12 New York University Endocytosis inhibitors and their use for pain treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
WO2010118207A1 (en) * 2009-04-09 2010-10-14 Schering Corporation Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
WO2011087999A1 (en) * 2010-01-14 2011-07-21 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
HUE036040T2 (hu) * 2012-03-09 2018-06-28 Lexicon Pharmaceuticals Inc Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére
CN104302649B (zh) 2012-03-09 2017-06-23 莱西肯医药有限公司 基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
US8969565B2 (en) * 2012-03-09 2015-03-03 Lexicon Pharmaceuticals, Inc. Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use

Also Published As

Publication number Publication date
CN106103447B (zh) 2019-07-16
EP3119783B1 (en) 2020-06-24
JP6553081B2 (ja) 2019-07-31
AU2015231672A1 (en) 2016-09-15
EP3719021B1 (en) 2022-03-09
DK3719021T3 (da) 2022-06-13
HUE050975T2 (hu) 2021-01-28
HK1226065A1 (zh) 2017-09-22
PT3119783T (pt) 2020-09-24
EP3719021A1 (en) 2020-10-07
ES2821441T3 (es) 2021-04-26
PT3719021T (pt) 2022-04-08
US9682982B2 (en) 2017-06-20
US20160039824A1 (en) 2016-02-11
CA2941870A1 (en) 2015-09-24
TW201620911A (zh) 2016-06-16
DK3119783T3 (da) 2020-09-28
JP2017507980A (ja) 2017-03-23
CA2941870C (en) 2022-07-19
CN106103447A (zh) 2016-11-09
EP3119783A1 (en) 2017-01-25
AU2015231672B2 (en) 2019-06-20
ES2911388T3 (es) 2022-05-19
WO2015142714A1 (en) 2015-09-24
PL3719021T3 (pl) 2022-06-20
AR099766A1 (es) 2016-08-17

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