PL3059239T3 - Związek bicykliczny zawierający siarkę - Google Patents

Związek bicykliczny zawierający siarkę

Info

Publication number
PL3059239T3
PL3059239T3 PL14853825T PL14853825T PL3059239T3 PL 3059239 T3 PL3059239 T3 PL 3059239T3 PL 14853825 T PL14853825 T PL 14853825T PL 14853825 T PL14853825 T PL 14853825T PL 3059239 T3 PL3059239 T3 PL 3059239T3
Authority
PL
Poland
Prior art keywords
compound containing
containing sulfur
bicyclic compound
bicyclic
sulfur
Prior art date
Application number
PL14853825T
Other languages
English (en)
Inventor
Nobuyuki Shiraishi
Hiroaki Hoshii
Wataru Hamaguchi
Eriko Honjo
Tomofumi Takuwa
Yuji Kondo
Takayuki Goto
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of PL3059239T3 publication Critical patent/PL3059239T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL14853825T 2013-10-17 2014-10-17 Związek bicykliczny zawierający siarkę PL3059239T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013216332 2013-10-17
EP14853825.9A EP3059239B1 (en) 2013-10-17 2014-10-17 Sulfur-containing bicyclic compound
PCT/JP2014/077653 WO2015056771A1 (ja) 2013-10-17 2014-10-17 含硫黄二環式化合物

Publications (1)

Publication Number Publication Date
PL3059239T3 true PL3059239T3 (pl) 2018-10-31

Family

ID=52826697

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14853825T PL3059239T3 (pl) 2013-10-17 2014-10-17 Związek bicykliczny zawierający siarkę

Country Status (31)

Country Link
US (2) US9051339B2 (pl)
EP (1) EP3059239B1 (pl)
JP (1) JP6477484B2 (pl)
KR (1) KR102248450B1 (pl)
CN (1) CN105636965B (pl)
AR (1) AR098070A1 (pl)
AU (1) AU2014335304B2 (pl)
BR (1) BR112016008654B8 (pl)
CA (1) CA2927518C (pl)
CY (1) CY1120880T1 (pl)
DK (1) DK3059239T3 (pl)
EA (1) EA029075B1 (pl)
ES (1) ES2685070T3 (pl)
HR (1) HRP20181183T1 (pl)
HU (1) HUE040208T2 (pl)
IL (1) IL244953B (pl)
LT (1) LT3059239T (pl)
MX (1) MX367857B (pl)
MY (1) MY177271A (pl)
NZ (1) NZ719149A (pl)
PH (1) PH12016500625A1 (pl)
PL (1) PL3059239T3 (pl)
PT (1) PT3059239T (pl)
RS (1) RS57532B1 (pl)
SA (1) SA516370956B1 (pl)
SG (1) SG11201602926UA (pl)
SI (1) SI3059239T1 (pl)
SM (1) SMT201800431T1 (pl)
TW (1) TWI648281B (pl)
UA (1) UA116042C2 (pl)
WO (1) WO2015056771A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231058B1 (hu) 2017-03-13 2020-04-28 Richter Gedeon Nyrt. Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok
WO2019155765A1 (ja) 2018-02-06 2019-08-15 株式会社瑞光 伸縮シート及び伸縮シートを用いた使い捨て着用物品、並びにそれらの製造方法
JP7355020B2 (ja) 2018-08-31 2023-10-03 アステラス製薬株式会社 経口投与用医薬組成物
CN112979655A (zh) 2019-12-16 2021-06-18 上海赛默罗生物科技有限公司 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途
TWI907472B (zh) 2020-08-05 2025-12-11 匈牙利商羅特格登公司 具藥理活性之經雜環取代的吡唑并〔1,5-a〕嘧啶衍生物
WO2023028519A2 (en) * 2021-08-27 2023-03-02 Astellas Pharma Global Development, Inc. Methods of treating substance use disorder
JP2025157626A (ja) * 2022-09-01 2025-10-16 アステラス製薬株式会社 6-(4,4-ジメチルシクロヘキシル)-4-[(1,1-ジオキソ-1λ6-チオモルホリン-4-イル)メチル]-2-メチルチエノ[2,3-d]ピリミジンまたはその塩の製造方法
JP2026514915A (ja) * 2023-04-21 2026-05-13 シーザン ハイスーク ファーマシューティカル カンパニー リミテッド Cyp11a1阻害剤及びその用途
CN117263951A (zh) * 2023-09-13 2023-12-22 广东莱佛士制药技术有限公司 6-溴-2-甲基噻吩并[2,3-d]嘧啶-4-甲腈的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001097979A (ja) 1999-07-28 2001-04-10 Takeda Chem Ind Ltd 縮合複素環化合物、その製造法および用途
JP2002308882A (ja) * 2001-02-08 2002-10-23 Yamanouchi Pharmaceut Co Ltd チエノピリミジン誘導体
WO2002062803A1 (en) 2001-02-08 2002-08-15 Yamanouchi Pharmaceutical Co., Ltd. Thienopyrimidine derivative
BRPI0408988A (pt) 2003-03-31 2006-03-28 Predix Pharmaceuticals Holding composto de piperidinilamino-tieno[2,3-d]pirimidina
US7723324B2 (en) * 2003-10-28 2010-05-25 Sepracor, Inc. Imidazo[1,2-A]pyridine anxiolytics
GB0416168D0 (en) 2004-07-20 2004-08-18 Vernalis Cambridge Ltd Pyrmidothiophene compounds
GB0420719D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
ES2324231T3 (es) * 2004-12-17 2009-08-03 F. Hoffmann-La Roche Ag Derivados de tieno-piridina como intensificadores alostericos de gaba-b.
PL2041139T3 (pl) 2006-04-26 2012-05-31 Hoffmann La Roche Związki farmaceutyczne
EP2923734B1 (en) 2009-03-13 2018-01-10 Katholieke Universiteit Leuven, K.U. Leuven R&D Purine analogues and their use as immunosuppressive agents
AU2010289321A1 (en) * 2009-09-04 2012-04-05 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles

Also Published As

Publication number Publication date
EA201690790A1 (ru) 2016-08-31
EP3059239B1 (en) 2018-06-27
CA2927518C (en) 2022-04-12
HUE040208T2 (hu) 2019-02-28
IL244953B (en) 2019-01-31
PT3059239T (pt) 2018-10-09
ES2685070T3 (es) 2018-10-05
SI3059239T1 (en) 2018-08-31
JP6477484B2 (ja) 2019-03-06
EP3059239A1 (en) 2016-08-24
MY177271A (en) 2020-09-10
EA029075B1 (ru) 2018-02-28
DK3059239T3 (en) 2018-08-13
JPWO2015056771A1 (ja) 2017-03-09
US9051339B2 (en) 2015-06-09
US9642852B2 (en) 2017-05-09
CN105636965B (zh) 2017-11-24
BR112016008654B1 (pt) 2022-12-06
MX2016004944A (es) 2016-07-11
US20150231138A1 (en) 2015-08-20
CY1120880T1 (el) 2020-05-29
NZ719149A (en) 2019-09-27
HRP20181183T1 (hr) 2018-10-19
BR112016008654A2 (pl) 2017-08-01
US20150111876A1 (en) 2015-04-23
UA116042C2 (uk) 2018-01-25
PH12016500625B1 (en) 2016-05-23
CA2927518A1 (en) 2015-04-23
LT3059239T (lt) 2018-09-10
KR102248450B1 (ko) 2021-05-06
KR20160071408A (ko) 2016-06-21
RS57532B1 (sr) 2018-10-31
SG11201602926UA (en) 2016-05-30
CN105636965A (zh) 2016-06-01
PH12016500625A1 (en) 2016-05-23
HK1220192A1 (zh) 2017-04-28
EP3059239A4 (en) 2017-04-26
BR112016008654B8 (pt) 2023-02-14
AR098070A1 (es) 2016-04-27
SA516370956B1 (ar) 2019-04-04
IL244953A0 (en) 2016-05-31
AU2014335304B2 (en) 2018-03-01
TW201607951A (zh) 2016-03-01
SMT201800431T1 (it) 2018-09-13
TWI648281B (zh) 2019-01-21
MX367857B (es) 2019-09-09
WO2015056771A1 (ja) 2015-04-23

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