PL2804858T3 - Związki - inhibitory metaloenzymu - Google Patents
Związki - inhibitory metaloenzymuInfo
- Publication number
- PL2804858T3 PL2804858T3 PL13738427T PL13738427T PL2804858T3 PL 2804858 T3 PL2804858 T3 PL 2804858T3 PL 13738427 T PL13738427 T PL 13738427T PL 13738427 T PL13738427 T PL 13738427T PL 2804858 T3 PL2804858 T3 PL 2804858T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitor compounds
- metalloenzyme inhibitor
- metalloenzyme
- compounds
- inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940125956 metalloenzyme inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261589076P | 2012-01-20 | 2012-01-20 | |
| EP13738427.7A EP2804858B1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
| PCT/US2013/022313 WO2013109998A1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2804858T3 true PL2804858T3 (pl) | 2020-06-29 |
Family
ID=48799718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13738427T PL2804858T3 (pl) | 2012-01-20 | 2013-01-18 | Związki - inhibitory metaloenzymu |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10221160B2 (ref) |
| EP (1) | EP2804858B1 (ref) |
| JP (1) | JP6189865B2 (ref) |
| KR (1) | KR102061137B1 (ref) |
| CN (1) | CN104136427B (ref) |
| AU (2) | AU2013209516A1 (ref) |
| BR (1) | BR112014017751B1 (ref) |
| CA (1) | CA2861339C (ref) |
| DK (1) | DK2804858T3 (ref) |
| EA (1) | EA026209B1 (ref) |
| ES (1) | ES2774267T3 (ref) |
| IN (1) | IN2014DN06792A (ref) |
| PL (1) | PL2804858T3 (ref) |
| WO (1) | WO2013109998A1 (ref) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8809378B2 (en) * | 2011-06-19 | 2014-08-19 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EA026209B1 (ru) * | 2012-01-20 | 2017-03-31 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| US10077250B2 (en) * | 2014-03-19 | 2018-09-18 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119748A4 (en) | 2014-03-19 | 2017-08-30 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CN109678791B (zh) | 2014-03-19 | 2022-07-01 | 美国陶氏益农公司 | 1-(2,4-二氟苯)-2,2-二氟-2-(5-取代吡啶-2-基)乙酮及制备方法 |
| US10000465B2 (en) | 2014-03-19 | 2018-06-19 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP6613391B2 (ja) | 2014-03-19 | 2019-12-04 | ブイピーエス‐３，インコーポレイテッド | ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程 |
| EP3119754A4 (en) * | 2014-03-19 | 2017-12-13 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119749A4 (en) * | 2014-03-19 | 2017-12-13 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119746A4 (en) * | 2014-03-19 | 2017-08-16 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| US9981943B2 (en) * | 2014-03-19 | 2018-05-29 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP6509897B2 (ja) * | 2014-03-19 | 2019-05-08 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 抗真菌化合物の調製方法 |
| PL3271347T3 (pl) * | 2015-03-19 | 2022-11-21 | Mycovia Pharmaceuticals, Inc. | Związki przeciwgrzybicze i sposoby wytwarzania |
| EP3349753A4 (en) | 2015-09-18 | 2019-01-23 | VPS-3, Inc. | FUNGICIDE COMPOUNDS AND METHOD OF PREPARING THEREOF |
| WO2017117393A1 (en) | 2015-12-30 | 2017-07-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EP3842442B1 (en) | 2016-12-22 | 2023-11-01 | Precision Pharmaceuticals, Inc. | Compositions and methods for inhibiting arginase activity |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| CN109810049B (zh) * | 2018-11-30 | 2021-01-15 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
| TW202140445A (zh) * | 2020-01-17 | 2021-11-01 | 大陸商上海森輝醫藥有限公司 | 四氮唑類化合物的可藥用鹽及其結晶形式、製備方法和用途 |
| CN116528855B (zh) * | 2020-10-16 | 2026-03-13 | 米拉洛克斯有限责任公司 | 用于治疗癌症、阿尔茨海默病、血色沉着病和其它病症的金属酶抑制剂 |
| WO2026006142A1 (en) * | 2024-06-24 | 2026-01-02 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization |
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| GB8304282D0 (en) * | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| GB8305377D0 (en) | 1983-02-25 | 1983-03-30 | Pfizer Ltd | Antifungal agents |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| AU4327585A (en) | 1984-06-21 | 1986-01-02 | Imperial Chemical Industries Plc | Antifungal azole compounds |
| GB8415889D0 (en) | 1984-06-21 | 1984-07-25 | Ici Plc | Antifungal azole compounds |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
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| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
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| US5358939A (en) | 1992-06-25 | 1994-10-25 | Rohm And Haas Company | Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| MY115814A (en) | 1995-06-16 | 2003-09-30 | Bayer Ip Gmbh | Crop protection compositions |
| GB9512961D0 (en) | 1995-06-26 | 1995-08-30 | Pfizer Ltd | Antifungal agents |
| GB9602080D0 (en) * | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| JP2000344744A (ja) * | 1999-06-04 | 2000-12-12 | Ss Pharmaceut Co Ltd | アセトフェノン誘導体およびその製法 |
| US6362172B2 (en) | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US8215955B2 (en) | 2006-10-18 | 2012-07-10 | Bnl Biotech Co., Ltd. | Endodontic instrument for root canal filling and heating tip adapted to the same |
| WO2008064311A2 (en) | 2006-11-21 | 2008-05-29 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
| US8221057B2 (en) | 2008-06-25 | 2012-07-17 | General Electric Company | Method, system and controller for establishing a wheel space temperature alarm in a turbomachine |
| EA201100437A1 (ru) | 2008-09-03 | 2011-10-31 | Байер Кропсайенс Аг | Применение композиций фунгицидных соединений для контроля некоторых ржавчинных грибов |
| CA2785898C (en) * | 2009-12-31 | 2018-07-03 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| AU2011242562B2 (en) * | 2010-04-24 | 2016-10-13 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| CA2816088A1 (en) * | 2010-10-28 | 2012-05-03 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| KR20180039185A (ko) * | 2010-11-13 | 2018-04-17 | 이노크린 파마슈티컬즈, 인크. | 금속효소 억제제 화합물 |
| EA201390876A1 (ru) * | 2010-12-13 | 2013-12-30 | Вайамет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| US8809378B2 (en) * | 2011-06-19 | 2014-08-19 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| CN105884743B (zh) * | 2011-06-19 | 2019-08-06 | 威尔金制药(Nc)有限公司 | 金属酶抑制剂化合物 |
| EA201490052A1 (ru) * | 2011-06-23 | 2014-04-30 | Вайамет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| AU2012300275A1 (en) * | 2011-08-30 | 2014-03-06 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EP3351541A1 (en) * | 2011-12-11 | 2018-07-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| EA026209B1 (ru) * | 2012-01-20 | 2017-03-31 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| BR112014017799A8 (pt) | 2012-01-20 | 2017-07-11 | Viamet Pharmaceuticals Inc | Compostos inibidores de metaloenzima |
| AU2014209107B2 (en) * | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| JP6386035B2 (ja) * | 2013-06-12 | 2018-09-05 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 金属酵素阻害剤化合物 |
| CN106231901A (zh) * | 2014-04-15 | 2016-12-14 | 美国陶氏益农公司 | 作为杀真菌剂的金属酶抑制剂化合物 |
| KR20160145640A (ko) * | 2014-04-15 | 2016-12-20 | 다우 아그로사이언시즈 엘엘씨 | 살진균제로서의 금속효소 억제제 화합물 |
| EP3562487B1 (en) * | 2016-12-29 | 2023-11-29 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
-
2013
- 2013-01-18 EA EA201491385A patent/EA026209B1/ru unknown
- 2013-01-18 EP EP13738427.7A patent/EP2804858B1/en active Active
- 2013-01-18 JP JP2014553491A patent/JP6189865B2/ja active Active
- 2013-01-18 CN CN201380010231.4A patent/CN104136427B/zh active Active
- 2013-01-18 ES ES13738427T patent/ES2774267T3/es active Active
- 2013-01-18 WO PCT/US2013/022313 patent/WO2013109998A1/en not_active Ceased
- 2013-01-18 IN IN6792DEN2014 patent/IN2014DN06792A/en unknown
- 2013-01-18 DK DK13738427.7T patent/DK2804858T3/da active
- 2013-01-18 AU AU2013209516A patent/AU2013209516A1/en not_active Abandoned
- 2013-01-18 BR BR112014017751-1A patent/BR112014017751B1/pt active IP Right Grant
- 2013-01-18 US US14/373,314 patent/US10221160B2/en active Active
- 2013-01-18 KR KR1020147023020A patent/KR102061137B1/ko active Active
- 2013-01-18 PL PL13738427T patent/PL2804858T3/pl unknown
- 2013-01-18 CA CA2861339A patent/CA2861339C/en active Active
-
2017
- 2017-09-20 AU AU2017232080A patent/AU2017232080B2/en active Active
-
2019
- 2019-01-28 US US16/259,096 patent/US10526312B2/en active Active
-
2020
- 2020-01-06 US US16/735,094 patent/US11247981B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017232080B2 (en) | 2019-02-14 |
| CN104136427B (zh) | 2017-03-01 |
| KR20140116939A (ko) | 2014-10-06 |
| US10221160B2 (en) | 2019-03-05 |
| US20200247779A1 (en) | 2020-08-06 |
| JP2015504095A (ja) | 2015-02-05 |
| IN2014DN06792A (ref) | 2015-05-22 |
| CA2861339C (en) | 2020-08-25 |
| KR102061137B1 (ko) | 2019-12-31 |
| US20150004666A1 (en) | 2015-01-01 |
| CN104136427A (zh) | 2014-11-05 |
| BR112014017751A8 (pt) | 2021-03-09 |
| DK2804858T3 (da) | 2020-03-16 |
| US11247981B2 (en) | 2022-02-15 |
| US10526312B2 (en) | 2020-01-07 |
| US20190169159A1 (en) | 2019-06-06 |
| EA201491385A1 (ru) | 2015-02-27 |
| CA2861339A1 (en) | 2013-07-25 |
| EP2804858A4 (en) | 2015-07-29 |
| BR112014017751B1 (pt) | 2021-12-07 |
| EA026209B1 (ru) | 2017-03-31 |
| EP2804858B1 (en) | 2019-12-25 |
| AU2013209516A1 (en) | 2014-08-28 |
| EP2804858A1 (en) | 2014-11-26 |
| AU2017232080A1 (en) | 2017-10-12 |
| JP6189865B2 (ja) | 2017-08-30 |
| WO2013109998A1 (en) | 2013-07-25 |
| ES2774267T3 (es) | 2020-07-20 |
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