PL2606068T3 - SKOJARZONE ZASTOSOWANIE PRZECIWCIAŁ SPECYFICZNYCH WZGLĘDEM GAMMA RIIB (CD32B) I CD19, CD20 lub CD40 - Google Patents

SKOJARZONE ZASTOSOWANIE PRZECIWCIAŁ SPECYFICZNYCH WZGLĘDEM GAMMA RIIB (CD32B) I CD19, CD20 lub CD40

Info

Publication number
PL2606068T3
PL2606068T3 PL11760819T PL11760819T PL2606068T3 PL 2606068 T3 PL2606068 T3 PL 2606068T3 PL 11760819 T PL11760819 T PL 11760819T PL 11760819 T PL11760819 T PL 11760819T PL 2606068 T3 PL2606068 T3 PL 2606068T3
Authority
PL
Poland
Prior art keywords
cd32b
specific antibodies
combined use
gamma riib
riib
Prior art date
Application number
PL11760819T
Other languages
English (en)
Inventor
Mark Cragg
Martin Glennie
Ali Roghanian
Stephen Beers
Peter Johnson
Sean Lim
Björn Frendeus
Ingrid Teige
Original Assignee
University Of Southampton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Southampton filed Critical University Of Southampton
Publication of PL2606068T3 publication Critical patent/PL2606068T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
PL11760819T 2010-08-20 2011-08-19 SKOJARZONE ZASTOSOWANIE PRZECIWCIAŁ SPECYFICZNYCH WZGLĘDEM GAMMA RIIB (CD32B) I CD19, CD20 lub CD40 PL2606068T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1013989.7A GB201013989D0 (en) 2010-08-20 2010-08-20 Biological materials and methods of using the same
EP11760819.0A EP2606068B1 (en) 2010-08-20 2011-08-19 COMBINED USE OF FC GAMMA RIIB (CD32B) AND CD19-, CD20- or CD40- SPECIFIC ANTIBODIES
PCT/GB2011/051572 WO2012022985A1 (en) 2010-08-20 2011-08-19 Combined use of fc gamma riib (cd32b) and cd20 - specific antibodies

Publications (1)

Publication Number Publication Date
PL2606068T3 true PL2606068T3 (pl) 2018-03-30

Family

ID=42984443

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11760819T PL2606068T3 (pl) 2010-08-20 2011-08-19 SKOJARZONE ZASTOSOWANIE PRZECIWCIAŁ SPECYFICZNYCH WZGLĘDEM GAMMA RIIB (CD32B) I CD19, CD20 lub CD40

Country Status (17)

Country Link
US (4) US10525129B2 (pl)
EP (2) EP3263602A1 (pl)
JP (2) JP6215704B2 (pl)
KR (1) KR101948609B1 (pl)
CN (7) CN114099669A (pl)
AU (1) AU2011290503B2 (pl)
CA (1) CA2808744C (pl)
DK (1) DK2606068T3 (pl)
ES (1) ES2653685T3 (pl)
GB (1) GB201013989D0 (pl)
HU (1) HUE037478T2 (pl)
NO (1) NO2606068T3 (pl)
PL (1) PL2606068T3 (pl)
PT (1) PT2606068T (pl)
RU (2) RU2769949C2 (pl)
SI (1) SI2606068T1 (pl)
WO (1) WO2012022985A1 (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201013989D0 (en) * 2010-08-20 2010-10-06 Univ Southampton Biological materials and methods of using the same
EP2925351A4 (en) * 2012-11-29 2016-08-24 Bayer Healthcare Llc MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED PROTEIN C (APC)
EP2740805B1 (en) * 2012-12-07 2019-02-20 SuppreMol GmbH Stratification and treatment of patients suffering from idiopathic thrombocytopenic purpura
CA2902432A1 (en) 2013-03-12 2014-10-09 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
EP2833139A1 (en) * 2013-08-01 2015-02-04 SuppreMol GmbH In vitro method for determining the stability of compositions comprising soluble Fc gamma receptor(s)
CN112851769A (zh) 2014-01-27 2021-05-28 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
GB2526139A (en) 2014-05-15 2015-11-18 Biolnvent Internat Ab Medicaments, uses and methods
CN113831416A (zh) 2014-06-11 2021-12-24 分子模板公司 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
KR20170110601A (ko) 2015-02-05 2017-10-11 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 영역을 포함하는 다가 cd20 결합 분자 및 이들의 강화된 조성물
JP6726676B2 (ja) * 2015-03-16 2020-07-22 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト(ゲーエムベーハー)Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) Hbv感染および関連症状を治療するための三重特異的結合分子
MX2017015493A (es) 2015-05-30 2018-02-09 Molecular Templates Inc Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden.
JP2019506844A (ja) 2015-12-18 2019-03-14 ノバルティス アーゲー CD32bを標的とする抗体およびその使用方法
KR102557126B1 (ko) 2016-12-07 2023-07-18 몰레큘러 템플레이츠, 인코퍼레이션. 부위 특이적 접합을 위한 시가 독소 a 서브유닛 작동체 폴리펩타이드, 시가 독소 작동체 스캐폴드, 및 세포-표적화 분자
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
ES2971981T3 (es) 2017-01-25 2024-06-10 Molecular Templates Inc Moléculas de reconocimiento de células que comprenden efectores de la subunidad A de la toxina Shiga desinmunizados y epítopos de células T CD8+
AU2018213418A1 (en) * 2017-01-30 2019-06-20 Ohio State Innovation Foundation Passive antibody dependent cell-mediated activation
CA3054632A1 (en) 2017-03-30 2018-10-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
WO2018229706A1 (en) 2017-06-16 2018-12-20 Novartis Ag Combination therapy for the treatment of cancer
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
EP3700933A1 (en) 2017-10-25 2020-09-02 Novartis AG Antibodies targeting cd32b and methods of use thereof
SG11202005005YA (en) 2017-11-30 2020-06-29 Novartis Ag Bcma-targeting chimeric antigen receptor, and uses thereof
CN110612117B (zh) 2018-04-17 2024-04-12 分子模板公司 包含去免疫化的志贺毒素a亚基支架的her2靶向分子
CN108823211A (zh) * 2018-05-04 2018-11-16 中国医学科学院基础医学研究所 一种cd19核酸适配体及其应用
JP7398396B2 (ja) 2018-06-01 2023-12-14 ノバルティス アーゲー Bcmaに対する結合分子及びその使用
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US12227565B2 (en) 2018-06-20 2025-02-18 Biora Therapeutics, Inc. Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine
CN116726361A (zh) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
US20220259309A1 (en) * 2019-07-17 2022-08-18 Bioinvent International Ab Antibody combinations for treatment of cancer in specific patients
CR20220166A (es) * 2019-10-18 2022-06-15 Genentech Inc Métodos para usar inmunoconjugados anti-cd79b para tratar linfoma difuso de linfocitos b grandes
US11707610B2 (en) 2019-12-13 2023-07-25 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
EP3919077A1 (en) 2020-06-04 2021-12-08 BioInvent International AB Model for prediction of tolerability issues in connection with intravenous administration of therapeutic antibodies
IL298757A (en) 2020-06-04 2023-02-01 Bioinvent Int Ab Improving antibody tolerability associated with intravenous administration
IL302569A (en) 2020-11-06 2023-07-01 Novartis Ag Cd19 binding molecules and uses thereof
TW202336033A (zh) 2022-03-07 2023-09-16 瑞典商生物創新國際有限公司 抗體之新穎組合及用途
US20230399375A1 (en) 2022-04-15 2023-12-14 Kyverna Therapeutics, Inc. Methods and compositions for treating autoimmune disease
WO2023240064A1 (en) 2022-06-08 2023-12-14 Kyverna Therapeutics, Inc. Methods and compositions for treating autoimmune disease

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4880078A (en) 1987-06-29 1989-11-14 Honda Giken Kogyo Kabushiki Kaisha Exhaust muffler
ATE221379T1 (de) 1991-05-01 2002-08-15 Jackson H M Found Military Med Verfahren zur behandlung infektiöser respiratorischer erkrankungen
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
EP0885002B1 (en) 1996-03-04 2011-05-11 The Penn State Research Foundation Materials and methods for enhancing cellular internalization
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
EP0954282B1 (en) 1997-01-16 2005-01-19 Massachusetts Institute Of Technology Preparation of particles for inhalation
AU747231B2 (en) 1998-06-24 2002-05-09 Alkermes, Inc. Large porous particles emitted from an inhaler
EP1229935A1 (en) * 1999-11-08 2002-08-14 Idec Pharmaceuticals Corporation Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy
DK1534335T4 (en) * 2002-08-14 2015-10-05 Macrogenics Inc FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
AU2003265522A1 (en) * 2003-08-18 2005-03-10 Macrogenics, Inc. FCGammaRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
AU2004293184B2 (en) 2003-11-26 2010-12-16 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Substance binding human IgG Fc receptor IIb
JP5367982B2 (ja) 2004-04-16 2013-12-11 マクロジェニクス,インコーポレーテッド FcγRIIB特異的抗体とその利用法
CN101001872A (zh) * 2004-04-16 2007-07-18 宏观基因有限公司 FcγRIIB-特异性抗体及其使用方法
JP2007536932A (ja) * 2004-05-10 2007-12-20 マクロジェニクス,インコーポレーテッド ヒト化FcγRIIB特異的抗体とその利用法
JP2008513351A (ja) * 2004-05-20 2008-05-01 セントメアリーズ ホスピタル エヌエイチエス トラスト アレルギー疾患の処置のためのIgE再標的化機能変更分子(ERFAM)
CA2587766A1 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
CA2590935C (en) 2004-12-15 2014-09-30 Macrogenics, Inc. Fc.gamma.riib-specific antibodies and methods of use thereof
EP1674479A1 (en) * 2004-12-22 2006-06-28 Memorial Sloan-Kettering Cancer Center Modulation of Fc Gamma receptors for optimizing immunotherapy
CA2656224C (en) * 2006-06-26 2018-01-09 Macrogenics, Inc. Combination of fc.gamma.riib antibodies and cd20-specific antibodies and methods of use thereof
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
US20120030144A1 (en) * 2007-11-08 2012-02-02 Pikamab, Inc. Methods for doing business using biomarkers
US8802089B2 (en) 2008-01-03 2014-08-12 Genmab A/S Monoclonal antibodies against CD32B
EP2385953A4 (en) 2009-01-08 2012-06-06 Uab Research Foundation METHOD FOR REGULATING IMMUNO REACTIONS
GB201013989D0 (en) * 2010-08-20 2010-10-06 Univ Southampton Biological materials and methods of using the same
GB2526139A (en) 2014-05-15 2015-11-18 Biolnvent Internat Ab Medicaments, uses and methods

Also Published As

Publication number Publication date
NO2606068T3 (pl) 2018-02-24
KR101948609B1 (ko) 2019-02-15
US20210346498A1 (en) 2021-11-11
ES2653685T3 (es) 2018-02-08
AU2011290503A1 (en) 2013-03-07
CN114099668B (zh) 2025-10-17
RU2017143633A3 (pl) 2021-01-29
CN114099669A (zh) 2022-03-01
EP2606068A1 (en) 2013-06-26
CN114099666A (zh) 2022-03-01
US11623005B2 (en) 2023-04-11
US20130251706A1 (en) 2013-09-26
RU2017143633A (ru) 2019-02-14
CN114099668A (zh) 2022-03-01
CN114099667A (zh) 2022-03-01
US10525129B2 (en) 2020-01-07
CN107670034B (zh) 2021-07-20
CN114099702A (zh) 2022-03-01
CN114099702B (zh) 2024-08-27
JP2016138129A (ja) 2016-08-04
CN114099666B (zh) 2025-05-02
WO2012022985A1 (en) 2012-02-23
RU2769949C2 (ru) 2022-04-11
CN107670034A (zh) 2018-02-09
KR20140005866A (ko) 2014-01-15
EP2606068B1 (en) 2017-09-27
GB201013989D0 (en) 2010-10-06
CA2808744C (en) 2023-03-07
CA2808744A1 (en) 2012-02-23
AU2011290503B2 (en) 2015-09-03
CN114099667B (zh) 2025-10-21
HUE037478T2 (hu) 2018-08-28
EP3263602A1 (en) 2018-01-03
JP2013537547A (ja) 2013-10-03
DK2606068T3 (da) 2017-11-20
RU2013112345A (ru) 2014-09-27
JP6215704B2 (ja) 2017-10-18
SI2606068T1 (en) 2018-01-31
PT2606068T (pt) 2017-12-29
JP6421140B2 (ja) 2018-11-07
US20230381310A1 (en) 2023-11-30
US20200069798A1 (en) 2020-03-05
CN103080131A (zh) 2013-05-01

Similar Documents

Publication Publication Date Title
PT2606068T (pt) Utilização combinada de fc gama riib (cd32b) e anticorpos específicos para cd19, cd20 ou cd40
IL276573A (en) Antibodies against PD–L1 and uses thereof
LTPA2017041I1 (lt) Anti-PD-L1 antikūnai ir jų panaudojimas T ląstelių funkcijos pagerinimui
IL250691B (en) Anti-ox40 antibodies and methods of using them
SI2424896T1 (sl) Protitelesa anti-ceacam1 in postopki za njihovo uporabo
IL237737A0 (en) Human monoclonal antibodies against pd-l1 and methods of use
ZA201304654B (en) Systems and methods to assess cognitive function
EP2599217A4 (en) Gfsk receiver architecture and methodology
EP2539005A4 (en) ORAL PIECE AND METHODS OF USING THE SAME
EP2654549A4 (en) INTEGRATED SYSTEM ARCHITECTURES AND USE PROCESSES
ZA201304153B (en) Anti-pcsk9 antibodies and methods of use
PL2621955T3 (pl) Przeciwciała anty-CEACAM6 i ich zastosowania
IL222514A0 (en) Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
EP2734234A4 (en) ANTI-CXCR4 ANTIBODIES AND METHOD OF USE THEREOF
ZA201401326B (en) Novel anti-cxcr4 antibody and its use for the detection and diagnosis of cancer
IL225389A0 (en) Antibody preparations and methods of use
ZA201300174B (en) Anti-neuropilin antibodies and methods of use
ZA201400500B (en) Use of the antibody i-3859 for the detection and diagnosis of cancer
ZA201205271B (en) Predicting and reducing alloimmunogenicity of protein therapeutics
EP2875347A4 (en) METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF SEPSIS
GB201010942D0 (en) Display of input selection
EP2553151A4 (en) USE OF INDUCED PLURIPOTENTIAL CELLS AND OTHER CELLS FOR SCREENING COMPOSITE LIBRARIES
HK40066736A (zh) FCγRIIB(CD32B)和CD20特异性抗体的组合应用
HK40066736B (zh) FCγRIIB(CD32B)和CD20特异性抗体的组合应用
HK40066733A (zh) FCγRIIB(CD32B)和CD20特异性抗体的组合应用