PL2444395T3 - Podstawiona pochodna izochinoliny - Google Patents
Podstawiona pochodna izochinolinyInfo
- Publication number
- PL2444395T3 PL2444395T3 PL10789260T PL10789260T PL2444395T3 PL 2444395 T3 PL2444395 T3 PL 2444395T3 PL 10789260 T PL10789260 T PL 10789260T PL 10789260 T PL10789260 T PL 10789260T PL 2444395 T3 PL2444395 T3 PL 2444395T3
- Authority
- PL
- Poland
- Prior art keywords
- isoquinoline derivative
- substituted isoquinoline
- substituted
- derivative
- isoquinoline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009146040 | 2009-06-19 | ||
| PCT/JP2010/004101 WO2010146881A1 (ja) | 2009-06-19 | 2010-06-18 | 置換されたイソキノリン誘導体 |
| EP10789260.6A EP2444395B1 (en) | 2009-06-19 | 2010-06-18 | Substituted isoquinoline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2444395T3 true PL2444395T3 (pl) | 2016-06-30 |
Family
ID=43356211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10789260T PL2444395T3 (pl) | 2009-06-19 | 2010-06-18 | Podstawiona pochodna izochinoliny |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8951997B2 (pl) |
| EP (1) | EP2444395B1 (pl) |
| JP (1) | JP4915010B2 (pl) |
| KR (1) | KR101732907B1 (pl) |
| CN (1) | CN102448941B (pl) |
| AU (1) | AU2010261206B2 (pl) |
| BR (1) | BRPI1011683B8 (pl) |
| CA (1) | CA2764124C (pl) |
| CY (1) | CY1117157T1 (pl) |
| DK (1) | DK2444395T3 (pl) |
| EA (1) | EA019523B1 (pl) |
| ES (1) | ES2560603T3 (pl) |
| HR (1) | HRP20160096T1 (pl) |
| HU (1) | HUE028684T2 (pl) |
| MX (1) | MX2011013857A (pl) |
| NZ (1) | NZ596615A (pl) |
| PL (1) | PL2444395T3 (pl) |
| TW (1) | TWI527798B (pl) |
| WO (1) | WO2010146881A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| BR112013015604B1 (pt) | 2010-12-22 | 2021-11-03 | D. Western Therapeutics Institute, Inc | Derivado de isoquinolina-6-sulfonamida, composição farmacêutica compreendendo o mesmo e uso do dito composto para tratar ou prevenir glaucoma, hipertensão ocular ou doença cardiovascular |
| JP2013035802A (ja) * | 2011-08-10 | 2013-02-21 | D Western Therapeutics Institute Inc | 緑内障又は高眼圧症の予防又は治療剤 |
| CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
| EP2990040B1 (en) * | 2013-04-24 | 2019-12-04 | Kyushu University, National University Corporation | Therapeutic agent for eyeground disease |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| CN105906609A (zh) * | 2016-05-19 | 2016-08-31 | 武昌理工学院 | 一种1，4-二氮杂环庚烷衍生物的制备方法 |
| WO2018041122A1 (zh) | 2016-08-31 | 2018-03-08 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
| CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| US9840468B1 (en) | 2016-12-30 | 2017-12-12 | Aerie Pharmaceuticals, Inc. | Methods for the preparation of 6-aminoisoquinoline |
| CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
| CN109134433B (zh) * | 2017-06-16 | 2021-05-25 | 成都先导药物开发股份有限公司 | 一种抑制rock的化合物及其应用 |
| CN108929270B (zh) * | 2018-08-15 | 2021-06-08 | 上海罕道医药科技有限公司 | 一种药物中间体双取代含氮杂环的胺类化合物的合成 |
| US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| TW202031638A (zh) * | 2018-11-01 | 2020-09-01 | 日商Ｄ 西方治療學研究所股份有限公司 | 1，4－二氮雜環辛烷化合物或其鹽 |
| KR20210104730A (ko) | 2018-12-18 | 2021-08-25 | 가부시키가이샤 디. 웨스턴 세라퓨틱스 겡큐쇼 | 이소퀴놀린술포닐클로라이드 산부가염 및 그 제조 방법 |
| WO2022047315A1 (en) * | 2020-08-31 | 2022-03-03 | Viewpoint Therapeutics, Inc. | Compounds and formulations for treating ophthalmic diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456757A (en) | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS5993054A (ja) | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | イソキノリンスルホン酸アミド誘導体 |
| US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| JPH0667926B2 (ja) | 1985-11-12 | 1994-08-31 | 旭化成工業株式会社 | 環状のイソキノリンスルホンアミド誘導体 |
| JPH0215067A (ja) | 1988-07-04 | 1990-01-18 | Hokuriku Seiyaku Co Ltd | イソキノリンスルホンアミド誘導体 |
| US5245034A (en) | 1988-12-26 | 1993-09-14 | Kiroyoshi Hidaka | Compound having vessel smooth muscle relaxation activity |
| US5216150A (en) | 1988-12-26 | 1993-06-01 | Hiroyoshi Hidaka | Derivatives of isoquinoline (and naphthalene) sulfonamides |
| JPH069402A (ja) | 1991-05-15 | 1994-01-18 | Hiroyoshi Hidaka | 抗潰瘍剤 |
| US6153608A (en) | 1996-02-02 | 2000-11-28 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| JP2007523202A (ja) | 2004-02-24 | 2007-08-16 | ビオアクソン・テラプティーク・インコーポレーテッド | ４置換ピペリジン誘導体 |
| US20050272723A1 (en) | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| WO2006115244A1 (ja) | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | ４－ブロモイソキノリン誘導体及びこれを含有する医薬 |
| US20090306053A1 (en) | 2005-04-25 | 2009-12-10 | Hiroyoshi Hidaka | Highly selective rho-kinase inhibitor |
| KR101149954B1 (ko) | 2005-08-30 | 2012-06-01 | 아사히 가세이 파마 가부시키가이샤 | 술폰아미드 화합물 |
| US20080064681A1 (en) * | 2006-09-11 | 2008-03-13 | Hiroyoshi Hidaka | Therapeutic agent for treating glaucoma |
| PT2125744E (pt) | 2006-12-27 | 2011-07-01 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
| JP5405316B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| EP2130828A4 (en) * | 2007-02-28 | 2010-12-29 | Asahi Kasei Pharma Corp | sulfonamide |
-
2010
- 2010-06-18 TW TW099120004A patent/TWI527798B/zh active
- 2010-06-18 WO PCT/JP2010/004101 patent/WO2010146881A1/ja active Application Filing
- 2010-06-18 AU AU2010261206A patent/AU2010261206B2/en active Active
- 2010-06-18 KR KR1020117028931A patent/KR101732907B1/ko active IP Right Grant
- 2010-06-18 HU HUE10789260A patent/HUE028684T2/en unknown
- 2010-06-18 ES ES10789260.6T patent/ES2560603T3/es active Active
- 2010-06-18 EP EP10789260.6A patent/EP2444395B1/en active Active
- 2010-06-18 CA CA2764124A patent/CA2764124C/en active Active
- 2010-06-18 CN CN201080023516.8A patent/CN102448941B/zh active Active
- 2010-06-18 DK DK10789260.6T patent/DK2444395T3/en active
- 2010-06-18 JP JP2011519583A patent/JP4915010B2/ja active Active
- 2010-06-18 BR BRPI1011683A patent/BRPI1011683B8/pt active IP Right Grant
- 2010-06-18 MX MX2011013857A patent/MX2011013857A/es active IP Right Grant
- 2010-06-18 US US13/265,246 patent/US8951997B2/en active Active
- 2010-06-18 EA EA201171328A patent/EA019523B1/ru unknown
- 2010-06-18 PL PL10789260T patent/PL2444395T3/pl unknown
- 2010-06-18 NZ NZ596615A patent/NZ596615A/xx unknown
-
2016
- 2016-01-21 CY CY20161100066T patent/CY1117157T1/el unknown
- 2016-01-28 HR HRP20160096TT patent/HRP20160096T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1011683B8 (pt) | 2021-05-25 |
| EP2444395A4 (en) | 2012-11-28 |
| CA2764124A1 (en) | 2010-12-23 |
| CN102448941A (zh) | 2012-05-09 |
| MX2011013857A (es) | 2012-01-30 |
| BRPI1011683A2 (pt) | 2016-03-22 |
| US20120035159A1 (en) | 2012-02-09 |
| JPWO2010146881A1 (ja) | 2012-12-06 |
| KR20120069609A (ko) | 2012-06-28 |
| HRP20160096T1 (hr) | 2016-02-26 |
| CY1117157T1 (el) | 2017-04-05 |
| AU2010261206B2 (en) | 2015-10-08 |
| JP4915010B2 (ja) | 2012-04-11 |
| WO2010146881A1 (ja) | 2010-12-23 |
| NZ596615A (en) | 2013-07-26 |
| KR101732907B1 (ko) | 2017-05-08 |
| HUE028684T2 (en) | 2016-12-28 |
| EA201171328A1 (ru) | 2012-05-30 |
| BRPI1011683B1 (pt) | 2020-10-20 |
| EA019523B1 (ru) | 2014-04-30 |
| AU2010261206A1 (en) | 2011-12-15 |
| CA2764124C (en) | 2016-12-13 |
| DK2444395T3 (en) | 2016-03-14 |
| ES2560603T3 (es) | 2016-02-22 |
| US8951997B2 (en) | 2015-02-10 |
| EP2444395B1 (en) | 2016-01-06 |
| TWI527798B (zh) | 2016-04-01 |
| CN102448941B (zh) | 2016-04-06 |
| EP2444395A1 (en) | 2012-04-25 |
| TW201100385A (en) | 2011-01-01 |
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