PL2185691T3 - Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych - Google Patents
Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczychInfo
- Publication number
- PL2185691T3 PL2185691T3 PL08837420T PL08837420T PL2185691T3 PL 2185691 T3 PL2185691 T3 PL 2185691T3 PL 08837420 T PL08837420 T PL 08837420T PL 08837420 T PL08837420 T PL 08837420T PL 2185691 T3 PL2185691 T3 PL 2185691T3
- Authority
- PL
- Poland
- Prior art keywords
- stem cell
- pluripotent stem
- cell differentiation
- feeder cells
- human feeder
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/22—Coculture with; Conditioned medium produced by pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95293707P | 2007-07-31 | 2007-07-31 | |
EP08837420.2A EP2185691B1 (en) | 2007-07-31 | 2008-07-31 | Pluripotent stem cell differentiation by using human feeder cells |
PCT/US2008/071775 WO2009048675A1 (en) | 2007-07-31 | 2008-07-31 | Pluripotent stem cell differentiation by using human feeder cells |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2185691T3 true PL2185691T3 (pl) | 2018-08-31 |
Family
ID=40193704
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12182658T PL2584034T3 (pl) | 2007-07-31 | 2008-07-31 | Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych |
PL08837420T PL2185691T3 (pl) | 2007-07-31 | 2008-07-31 | Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12182658T PL2584034T3 (pl) | 2007-07-31 | 2008-07-31 | Różnicowanie pluripotencjalnych komórek macierzystych poprzez zastosowanie ludzkich komórek odżywczych |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP2584034B8 (pl) |
JP (2) | JP6087043B2 (pl) |
KR (1) | KR101592180B1 (pl) |
CN (1) | CN102317443B (pl) |
BR (1) | BRPI0815052A2 (pl) |
CA (1) | CA2694956C (pl) |
ES (2) | ES2648128T3 (pl) |
PL (2) | PL2584034T3 (pl) |
RU (1) | RU2010107181A (pl) |
WO (1) | WO2009048675A1 (pl) |
ZA (1) | ZA201001436B (pl) |
Families Citing this family (48)
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CN102389344B (zh) | 2006-02-07 | 2015-12-16 | 脊柱赛特有限公司 | 采用机械应变使人皮肤成纤维细胞发生软骨形成分化的方法 |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
CN105886459A (zh) | 2008-02-21 | 2016-08-24 | 詹森生物科技公司 | 用于细胞粘附、培养和分离的方法、表面改性培养板和组合物 |
CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
JP2012507289A (ja) | 2008-10-31 | 2012-03-29 | ヤンセン バイオテツク,インコーポレーテツド | ヒト胚性幹細胞の膵内分泌系への分化 |
MX2011005288A (es) | 2008-11-20 | 2011-06-01 | Centocor Ortho Biotech Inc | Celulas madre pluripotentes en microportadores. |
CN102257132B (zh) | 2008-11-20 | 2014-09-03 | 森托科尔奥索生物科技公司 | 用于在平面基底上进行细胞附着和培养的方法和组合物 |
JP6219568B2 (ja) | 2009-07-20 | 2017-10-25 | ヤンセン バイオテツク,インコーポレーテツド | ヒト胚性幹細胞の分化 |
BR112012017761A2 (pt) * | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
US9969981B2 (en) | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
MX351515B (es) | 2010-05-12 | 2017-10-17 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
ES2658146T3 (es) | 2010-08-31 | 2018-03-08 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
BR112013004616A2 (pt) | 2010-08-31 | 2016-07-05 | Janssen Biotech Inc | diferenciação das células tronco embrionárias humanas |
RU2599420C2 (ru) | 2010-08-31 | 2016-10-10 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
CN102732479B (zh) * | 2011-03-31 | 2014-08-27 | 北京大学 | 胸腺上皮前体细胞的制备方法及其专用培养基 |
WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
CN108014339A (zh) * | 2011-11-09 | 2018-05-11 | 脊核细胞有限责任公司 | 用于治疗椎间盘退变性疾病的成纤维细胞 |
KR102090751B1 (ko) | 2011-12-22 | 2020-03-19 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화 |
MX357280B (es) * | 2012-02-14 | 2018-07-03 | Univ Washington State | Método sin alimentadoras para cultivo de células madre espermatogonias de bovino y porcino. |
WO2013134378A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
EP2857500B1 (en) * | 2012-05-25 | 2018-01-31 | Saitama Medical University | Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter |
DK3450542T3 (da) | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
CN104903440B (zh) | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
EP2913396B1 (en) * | 2012-10-29 | 2018-08-29 | Saitama Medical University | Method of manufacturing differentiated pluripotent stem cell |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
SG11201505112SA (en) | 2012-12-31 | 2015-07-30 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
RU2018116647A (ru) | 2012-12-31 | 2018-10-24 | Янссен Байотек, Инк. | Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки |
CN105705634A (zh) | 2012-12-31 | 2016-06-22 | 詹森生物科技公司 | 用于分化成胰腺内分泌细胞的人多能细胞的悬浮和群集 |
JP2014161257A (ja) * | 2013-02-22 | 2014-09-08 | Univ Of Tokyo | 多能性幹細胞から膵ランゲルハンス島を製造する方法 |
WO2014189127A1 (ja) | 2013-05-24 | 2014-11-27 | 学校法人埼玉医科大学 | 新規ペプチド及びその用途 |
WO2014204806A2 (en) | 2013-06-19 | 2014-12-24 | Spinalcyte, Llc | Adipose cells for chondrocyte applications |
WO2015004762A1 (ja) * | 2013-07-10 | 2015-01-15 | 株式会社日立製作所 | 細胞培養方法、装置、及び細胞シート |
US9796962B2 (en) | 2013-08-07 | 2017-10-24 | Kyoto University | Method for generating pancreatic hormone-producing cells |
WO2015112120A1 (en) * | 2014-01-21 | 2015-07-30 | Empire Technology Development Llc | Methods and devices for high throughput screening of conditions affecting stem cell differentiation |
RU2694311C2 (ru) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках |
CN107530375A (zh) * | 2015-05-11 | 2018-01-02 | 南加利福尼亚大学阿尔弗雷德·E·曼恩生物医学工程研究所 | 胰腺基质祖细胞 |
CN107779433A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 便捷的刺激nk细胞增殖和分化的饲养层制备方法 |
KR102095346B1 (ko) * | 2018-11-16 | 2020-03-31 | 고려대학교 산학협력단 | 삼차원 공배양을 통한 신생혈관능이 증가된 이식용 지방줄기세포 시트 및 이의 제조방법 |
WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
CN114173837A (zh) | 2019-05-31 | 2022-03-11 | W.L.戈尔及同仁股份有限公司 | 生物相容性膜复合材料 |
CA3139585C (en) | 2019-05-31 | 2024-01-23 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
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JP7284516B2 (ja) | 2020-12-14 | 2023-05-31 | 合同会社オフィス・ゼロ | プログラム作成支援システム及びその方法並びにそのプログラム |
CN114891734A (zh) * | 2022-06-02 | 2022-08-12 | 四川农业大学 | 一种永生化的牦牛瘤胃成纤维细胞系及其构建和应用 |
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US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
WO2005065354A2 (en) | 2003-12-31 | 2005-07-21 | The Burnham Institute | Defined media for pluripotent stem cell culture |
AU2005221079B2 (en) | 2004-03-10 | 2010-07-22 | Regents Of The University Of California | Compositions and methods for growth of embryonic stem cells |
JP5687816B2 (ja) * | 2004-07-09 | 2015-03-25 | ヴィアサイト,インコーポレイテッド | 胚体内胚葉を分化させるための因子を同定する方法 |
PL1860950T3 (pl) | 2005-03-04 | 2017-09-29 | Lifescan, Inc. | Dojrzałe komórki podścieliska pochodzenia trzustkowego |
WO2006126574A1 (ja) * | 2005-05-24 | 2006-11-30 | Kumamoto University | Es細胞の分化誘導方法 |
GB2444686B (en) | 2005-09-12 | 2010-08-25 | Es Cell Int Pte Ltd | Differentiation of pluripotent stem cells using p38 MAPK inhibitors or prostaglandins |
WO2007082963A1 (es) * | 2006-01-18 | 2007-07-26 | Fundación Instituto Valenciano De Infertilidad | Líneas de células madre embrionarias humanas y métodos para usar las mismas |
JP6110048B2 (ja) * | 2006-03-02 | 2017-04-05 | ヴィアサイト,インコーポレイテッド | 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 |
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2008
- 2008-07-31 WO PCT/US2008/071775 patent/WO2009048675A1/en active Application Filing
- 2008-07-31 ES ES12182658.0T patent/ES2648128T3/es active Active
- 2008-07-31 RU RU2010107181/10A patent/RU2010107181A/ru unknown
- 2008-07-31 CN CN200880108821.XA patent/CN102317443B/zh not_active Expired - Fee Related
- 2008-07-31 KR KR1020107004456A patent/KR101592180B1/ko active IP Right Grant
- 2008-07-31 JP JP2010520192A patent/JP6087043B2/ja not_active Expired - Fee Related
- 2008-07-31 BR BRPI0815052-4A2A patent/BRPI0815052A2/pt not_active IP Right Cessation
- 2008-07-31 CA CA2694956A patent/CA2694956C/en not_active Expired - Fee Related
- 2008-07-31 EP EP12182658.0A patent/EP2584034B8/en not_active Not-in-force
- 2008-07-31 EP EP08837420.2A patent/EP2185691B1/en not_active Not-in-force
- 2008-07-31 ES ES08837420.2T patent/ES2665434T3/es active Active
- 2008-07-31 PL PL12182658T patent/PL2584034T3/pl unknown
- 2008-07-31 PL PL08837420T patent/PL2185691T3/pl unknown
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2010
- 2010-02-26 ZA ZA2010/01436A patent/ZA201001436B/en unknown
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2016
- 2016-07-15 JP JP2016140191A patent/JP6453277B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2584034B8 (en) | 2017-12-06 |
ES2648128T3 (es) | 2017-12-28 |
BRPI0815052A2 (pt) | 2014-10-21 |
KR20100061455A (ko) | 2010-06-07 |
RU2010107181A (ru) | 2011-09-20 |
CN102317443B (zh) | 2018-09-14 |
KR101592180B1 (ko) | 2016-02-05 |
JP6087043B2 (ja) | 2017-03-01 |
CA2694956C (en) | 2017-12-19 |
WO2009048675A1 (en) | 2009-04-16 |
CA2694956A1 (en) | 2009-04-16 |
CN102317443A (zh) | 2012-01-11 |
JP6453277B2 (ja) | 2019-01-16 |
ZA201001436B (en) | 2011-06-29 |
JP2010535035A (ja) | 2010-11-18 |
EP2185691B1 (en) | 2018-03-14 |
EP2185691A1 (en) | 2010-05-19 |
EP2584034B1 (en) | 2017-10-25 |
EP2584034A1 (en) | 2013-04-24 |
PL2584034T3 (pl) | 2018-03-30 |
ES2665434T3 (es) | 2018-04-25 |
JP2016208984A (ja) | 2016-12-15 |
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