PL2146719T3 - Sposób wytwarzania galantaminy - Google Patents

Sposób wytwarzania galantaminy

Info

Publication number
PL2146719T3
PL2146719T3 PL08727257T PL08727257T PL2146719T3 PL 2146719 T3 PL2146719 T3 PL 2146719T3 PL 08727257 T PL08727257 T PL 08727257T PL 08727257 T PL08727257 T PL 08727257T PL 2146719 T3 PL2146719 T3 PL 2146719T3
Authority
PL
Poland
Prior art keywords
galantamine
making
making galantamine
Prior art date
Application number
PL08727257T
Other languages
English (en)
Polish (pl)
Inventor
Lunghu Wang
Yung Fa Chen
Julian Paul Henschke
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of PL2146719T3 publication Critical patent/PL2146719T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
PL08727257T 2007-04-12 2008-04-02 Sposób wytwarzania galantaminy PL2146719T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92319107P 2007-04-12 2007-04-12
EP08727257.1A EP2146719B1 (en) 2007-04-12 2008-04-02 Process for making galantamine
PCT/US2008/004303 WO2008127560A1 (en) 2007-04-12 2008-04-02 Process for making galantamine

Publications (1)

Publication Number Publication Date
PL2146719T3 true PL2146719T3 (pl) 2013-12-31

Family

ID=39854337

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08727257T PL2146719T3 (pl) 2007-04-12 2008-04-02 Sposób wytwarzania galantaminy

Country Status (14)

Country Link
US (1) US7985879B2 (es)
EP (1) EP2146719B1 (es)
JP (1) JP5441883B2 (es)
KR (1) KR101172044B1 (es)
CN (1) CN101674835B (es)
AR (1) AR066054A1 (es)
AU (1) AU2008239730B2 (es)
CA (1) CA2683098C (es)
ES (1) ES2432405T3 (es)
NZ (1) NZ580271A (es)
PL (1) PL2146719T3 (es)
SI (1) SI2146719T1 (es)
TW (1) TWI343909B (es)
WO (1) WO2008127560A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532149B (zh) * 2011-12-14 2015-05-13 南开大学 加兰他敏和力可拉敏的不对称合成方法
CN113292420A (zh) * 2021-05-27 2021-08-24 神隆医药（常熟）有限公司 加兰他敏中间体原料2-溴-5-羟基-4-甲氧基苯甲酸回收方法
CN113683491A (zh) * 2021-09-01 2021-11-23 王传良 一种4-(2-溴乙基)苯酚的制备方法
CN113620821A (zh) * 2021-09-01 2021-11-09 广汉市派瑞林科技有限责任公司 一种大麦芽碱盐酸盐的制备方法
CN113683522A (zh) * 2021-09-01 2021-11-23 广汉市派瑞林科技有限责任公司 一种n-甲基酪胺盐酸盐的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8514679D0 (en) * 1985-06-11 1985-07-10 Beecham Group Plc Compounds
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
EP0787115B1 (de) 1994-10-21 2000-01-05 Sanochemia Pharmazeutika AG VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS
GB9506843D0 (en) 1995-04-03 1995-05-24 Chiroscience Ltd Oxidative process and products thereof
CA2540248C (en) * 2003-09-26 2010-12-07 Scinopharm Taiwan, Ltd. Resolution of a narwedine amide derivative
US20060009640A1 (en) * 2004-07-08 2006-01-12 Bolugoddu Vijaya B Preparation of (-)-galantamine hydrobromide
JP2007039466A (ja) * 2004-11-29 2007-02-15 Japan Tobacco Inc 窒素含有縮合環化合物及びその用途
WO2006072818A2 (en) * 2005-01-04 2006-07-13 Emcure Pharmaceuticals Limited Process for preparation of galanthamine
ATE459627T1 (de) * 2005-05-03 2010-03-15 Medichem Sa Synthesen und herstellungen von narwedin und verwandten neuen verbindungen

Also Published As

Publication number Publication date
EP2146719A4 (en) 2012-07-04
TW200902483A (en) 2009-01-16
US20080255347A1 (en) 2008-10-16
KR101172044B1 (ko) 2012-08-08
ES2432405T3 (es) 2013-12-03
JP2010523658A (ja) 2010-07-15
CN101674835B (zh) 2013-12-11
NZ580271A (en) 2011-03-31
JP5441883B2 (ja) 2014-03-12
CA2683098C (en) 2014-03-18
AR066054A1 (es) 2009-07-22
CA2683098A1 (en) 2008-10-23
TWI343909B (en) 2011-06-21
US7985879B2 (en) 2011-07-26
KR20100015748A (ko) 2010-02-12
AU2008239730B2 (en) 2011-10-06
AU2008239730A1 (en) 2008-10-23
SI2146719T1 (sl) 2013-10-30
EP2146719B1 (en) 2013-08-14
CN101674835A (zh) 2010-03-17
EP2146719A1 (en) 2010-01-27
WO2008127560A1 (en) 2008-10-23

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