PL2066339T3 - Kompozycje i sposoby zwiększania odpowiedzi immunologicznych - Google Patents
Kompozycje i sposoby zwiększania odpowiedzi immunologicznychInfo
- Publication number
- PL2066339T3 PL2066339T3 PL07842706T PL07842706T PL2066339T3 PL 2066339 T3 PL2066339 T3 PL 2066339T3 PL 07842706 T PL07842706 T PL 07842706T PL 07842706 T PL07842706 T PL 07842706T PL 2066339 T3 PL2066339 T3 PL 2066339T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- methods
- immune responses
- enhancing immune
- enhancing
- Prior art date
Links
- 230000002708 enhancing effect Effects 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6006—Cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82598306P | 2006-09-18 | 2006-09-18 | |
| EP07842706.9A EP2066339B1 (en) | 2006-09-18 | 2007-09-18 | Compositions and methods of enhancing immune responses |
| PCT/US2007/078785 WO2008036675A2 (en) | 2006-09-18 | 2007-09-18 | Compositions and methods of enhancing immune responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2066339T3 true PL2066339T3 (pl) | 2015-02-27 |
Family
ID=39201208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07842706T PL2066339T3 (pl) | 2006-09-18 | 2007-09-18 | Kompozycje i sposoby zwiększania odpowiedzi immunologicznych |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8604178B2 (pl) |
| EP (3) | EP2857038B1 (pl) |
| KR (1) | KR101460551B1 (pl) |
| CN (1) | CN101522210B (pl) |
| DK (1) | DK2066339T3 (pl) |
| ES (1) | ES2520026T3 (pl) |
| MY (2) | MY183797A (pl) |
| PL (1) | PL2066339T3 (pl) |
| PT (1) | PT2066339E (pl) |
| WO (1) | WO2008036675A2 (pl) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1229045A1 (en) * | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| EP2857038B1 (en) * | 2006-09-18 | 2019-04-10 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| CA2704457A1 (en) | 2007-10-30 | 2009-05-07 | Walter Bottje | Compositions and methods of enhancing immune responses to flagellated bacterium |
| PT2214701T (pt) | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
| US8974788B2 (en) | 2009-08-14 | 2015-03-10 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| WO2011091255A1 (en) * | 2010-01-21 | 2011-07-28 | The Board Of Trustees Of The University Of Arkansas | Vaccine vectors and methods of enhancing immune responses |
| CA2800830C (en) | 2010-06-09 | 2020-09-08 | The Board Of Trustees Of The University Of Arkansas | Vaccine and methods to reduce campylobacter infection |
| US20190263888A1 (en) | 2010-10-19 | 2019-08-29 | Op-T Llc | Therapeutic peptides and methods for treating autoimmune related disease |
| WO2012054745A1 (en) | 2010-10-20 | 2012-04-26 | New York Blood Center, Inc. | Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection |
| KR101360112B1 (ko) | 2011-05-30 | 2014-02-06 | 건국대학교 산학협력단 | 공기전파가 가능한 신규한 h9n2형 저병원성 조류인플루엔자 바이러스 균주 및 그로부터 유래된 백신 |
| DE102012006546B4 (de) | 2012-04-02 | 2018-02-08 | Trw Automotive Electronics & Components Gmbh | Kapazitiver Sensor, Verfahren zum Auslesen eines kapazitiven Sensorfeldes und Verfahren zur Herstellung eines kapazitiven Sensorfeldes |
| EP3639851A1 (en) * | 2012-09-04 | 2020-04-22 | Bavarian Nordic A/S | Methods and compositions for enhancing vaccine immune responses |
| ES2758759T3 (es) | 2013-02-14 | 2020-05-06 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a eimeria o limitar la infección por eimeria |
| CN105142653B (zh) | 2013-03-15 | 2019-11-15 | 阿肯色大学评议会 | 增强对肠病原体免疫应答的组合物和方法 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7467027B2 (ja) | 2016-05-03 | 2024-04-15 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 免疫刺激性ポリペプチドおよび抗原性ポリペプチドを含む酵母ワクチンベクター並びにそれを使用する方法 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108373507A (zh) * | 2018-01-18 | 2018-08-07 | 复旦大学 | 一种重组亚单位禽流感疫苗Sef4M2e |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US11793854B2 (en) | 2019-03-21 | 2023-10-24 | Op-T Llc | Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction |
| WO2021011437A1 (en) | 2019-07-12 | 2021-01-21 | Op-T Llc | Peptides and methods for treating diseases |
| EP4135742A2 (en) | 2020-04-17 | 2023-02-22 | Op-T Llc | Bioactive peptides and methods of use thereof |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2023076820A1 (en) * | 2021-10-26 | 2023-05-04 | Navicure Biopharmaceuticals Limited | Immunogenic fusion proteins against coronavirus |
| CN114854654B (zh) * | 2022-04-06 | 2023-12-15 | 青岛易邦生物工程有限公司 | 一种肠炎沙门氏菌活疫苗 |
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| TWI382843B (zh) | 2004-10-07 | 2013-01-21 | Argos Therapeutics Inc | 成熟樹突細胞組合物及培養彼等之方法 |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| BRPI0519705A2 (pt) * | 2004-12-21 | 2009-03-10 | Vaxinnate Corp | composiÇÕes, proteÍnas de fusço e mÉtodos de estimular uma resposta imune em um indivÍduo |
| WO2006105972A1 (en) * | 2005-04-07 | 2006-10-12 | Universite Libre De Bruxelles | Transgenic organism expressing cd40l and uses thereof |
| US20060286074A1 (en) | 2005-05-31 | 2006-12-21 | Yucheng Tang | Methods for immunotherapy of cancer |
| RS51402B (sr) | 2005-10-07 | 2011-02-28 | Proyecto De Biomedicina Cima, S.L. | Imunostimulatorne kombinacije za profilaksu i lečenje hepatitisa c |
| JP2009514536A (ja) | 2005-11-07 | 2009-04-09 | シドニー キンメル キャンサー センター | Cd40リガンド融合蛋白質ワクチン |
| WO2007054658A1 (en) | 2005-11-14 | 2007-05-18 | King's College London | Control of immune responses |
| WO2007103048A2 (en) | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| EP2857038B1 (en) * | 2006-09-18 | 2019-04-10 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses |
| WO2008109825A2 (en) | 2007-03-08 | 2008-09-12 | Mayo Foundation For Medical Education And Research | Inducing immune-mediated tumor cell death |
| CA2704457A1 (en) * | 2007-10-30 | 2009-05-07 | Walter Bottje | Compositions and methods of enhancing immune responses to flagellated bacterium |
| PT2214701T (pt) * | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
| AU2012334962B2 (en) | 2011-11-11 | 2017-02-16 | Chr. Hansen A/S | Lactic acid bacteria and their use as dietary supplementals for poultry |
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2007
- 2007-09-18 EP EP14173324.6A patent/EP2857038B1/en not_active Not-in-force
- 2007-09-18 MY MYPI2013002516A patent/MY183797A/en unknown
- 2007-09-18 MY MYPI20091090A patent/MY188753A/en unknown
- 2007-09-18 KR KR1020097007854A patent/KR101460551B1/ko not_active Expired - Fee Related
- 2007-09-18 WO PCT/US2007/078785 patent/WO2008036675A2/en not_active Ceased
- 2007-09-18 PT PT78427069T patent/PT2066339E/pt unknown
- 2007-09-18 ES ES07842706.9T patent/ES2520026T3/es active Active
- 2007-09-18 EP EP07842706.9A patent/EP2066339B1/en not_active Not-in-force
- 2007-09-18 DK DK07842706.9T patent/DK2066339T3/da active
- 2007-09-18 PL PL07842706T patent/PL2066339T3/pl unknown
- 2007-09-18 EP EP12165985.8A patent/EP2517723B1/en active Active
- 2007-09-18 CN CN200780037288.8A patent/CN101522210B/zh not_active Expired - Fee Related
- 2007-09-18 US US12/441,851 patent/US8604178B2/en active Active
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2013
- 2013-12-09 US US14/100,957 patent/US9226957B2/en not_active Expired - Fee Related
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2015
- 2015-12-16 US US14/971,704 patent/US10004798B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MY188753A (en) | 2021-12-29 |
| US20140093534A1 (en) | 2014-04-03 |
| EP2857038B1 (en) | 2019-04-10 |
| DK2066339T3 (da) | 2014-11-03 |
| US20160114025A1 (en) | 2016-04-28 |
| WO2008036675A8 (en) | 2009-08-06 |
| EP2517723A1 (en) | 2012-10-31 |
| EP2066339A4 (en) | 2010-02-03 |
| PT2066339E (pt) | 2014-10-31 |
| MY183797A (en) | 2021-03-16 |
| EP2857038A3 (en) | 2015-07-08 |
| KR20090075824A (ko) | 2009-07-09 |
| WO2008036675A2 (en) | 2008-03-27 |
| EP2517723B1 (en) | 2019-11-06 |
| KR101460551B1 (ko) | 2014-11-18 |
| CN101522210B (zh) | 2017-03-22 |
| EP2066339A2 (en) | 2009-06-10 |
| WO2008036675A3 (en) | 2008-12-04 |
| US9226957B2 (en) | 2016-01-05 |
| US8604178B2 (en) | 2013-12-10 |
| CN101522210A (zh) | 2009-09-02 |
| EP2857038A2 (en) | 2015-04-08 |
| ES2520026T3 (es) | 2014-11-11 |
| US10004798B2 (en) | 2018-06-26 |
| EP2066339B1 (en) | 2014-08-13 |
| US20110027309A1 (en) | 2011-02-03 |
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