PL2054406T3 - Nukleozydy do hamowania lub zmniejszania powstawania oporności w przypadku leczenia cytostatykami - Google Patents

Nukleozydy do hamowania lub zmniejszania powstawania oporności w przypadku leczenia cytostatykami

Info

Publication number
PL2054406T3
PL2054406T3 PL07786668T PL07786668T PL2054406T3 PL 2054406 T3 PL2054406 T3 PL 2054406T3 PL 07786668 T PL07786668 T PL 07786668T PL 07786668 T PL07786668 T PL 07786668T PL 2054406 T3 PL2054406 T3 PL 2054406T3
Authority
PL
Poland
Prior art keywords
nucleosides
suppressing
development
resistance
reducing
Prior art date
Application number
PL07786668T
Other languages
English (en)
Inventor
Rudolf Fahrig
Dieter Lohmann
Andreas Rolfs
Henrik Dieks
Janek Teubner
Jörg-Christian Heinrich
Original Assignee
Resprotect Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resprotect Gmbh filed Critical Resprotect Gmbh
Publication of PL2054406T3 publication Critical patent/PL2054406T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL07786668T 2006-08-11 2007-08-13 Nukleozydy do hamowania lub zmniejszania powstawania oporności w przypadku leczenia cytostatykami PL2054406T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006037786A DE102006037786A1 (de) 2006-08-11 2006-08-11 Nukleoside, diese enthaltendes Arzneimittel und deren Verwendung
PCT/EP2007/007147 WO2008017515A1 (de) 2006-08-11 2007-08-13 Nukleoside zur unterdrückung oder reduzierung der resistenzbildung bei der zytostatika-behandlung
EP07786668.9A EP2054406B1 (de) 2006-08-11 2007-08-13 Nukleoside zur unterdrückung oder reduzierung der resistenzbildung bei der zytostatika-behandlung

Publications (1)

Publication Number Publication Date
PL2054406T3 true PL2054406T3 (pl) 2016-04-29

Family

ID=38537796

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07786668T PL2054406T3 (pl) 2006-08-11 2007-08-13 Nukleozydy do hamowania lub zmniejszania powstawania oporności w przypadku leczenia cytostatykami

Country Status (16)

Country Link
US (1) US8492537B2 (pl)
EP (1) EP2054406B1 (pl)
JP (1) JP5461989B2 (pl)
KR (1) KR101113029B1 (pl)
CN (1) CN101522666B (pl)
AU (1) AU2007283729B2 (pl)
BR (1) BRPI0716425A2 (pl)
CA (1) CA2660636C (pl)
DE (1) DE102006037786A1 (pl)
DK (1) DK2054406T3 (pl)
ES (1) ES2553404T3 (pl)
HU (1) HUE028077T2 (pl)
MX (1) MX2009001433A (pl)
PL (1) PL2054406T3 (pl)
PT (1) PT2054406E (pl)
WO (1) WO2008017515A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2785395A1 (en) * 2009-12-23 2011-06-30 Board Of Regents Of The University Of Nebraska Targeted radiolabeled compounds and their use for the treatment and diagnosis of cancer
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP3074411A2 (en) 2013-11-27 2016-10-05 Idenix Pharmaceuticals LLC Nucleotides for the treatment of liver cancer
CN107540718B (zh) * 2017-10-26 2020-01-31 天津立博美华基因科技有限责任公司 1-（2-脱氧-β-D-呋喃核糖基）-5-碘-2-嘧啶酮的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8100177A (nl) * 1981-01-15 1982-08-02 Stichting Rega V Z W 3'-amino- of -azidoderivaten van e-5-(2-halogeenvinyl)-2'-deoxyuridine.
HU183567B (en) 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0097039A1 (en) 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
EP0104857A1 (en) 1982-09-28 1984-04-04 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
DD251984A5 (de) * 1985-09-17 1987-12-02 The Wellcome Foundation Limited,Gb Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon
US5010176A (en) 1988-11-10 1991-04-23 Eli Lilly And Company Antibody-drug conjugates
GB8912972D0 (en) 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
DD288827A5 (de) * 1989-11-07 1991-04-11 Adw Zi F. Molekularbiologie,De Verfahren zur herstellung von 5-vinyl-analoga des 2',3'-diedesoxy-3'-fluoruridins
DE19545892A1 (de) * 1995-12-08 1997-06-12 Fraunhofer Ges Forschung Verwendung von (E)-5-(2-Bromovinyl-)-2'-deoxyuridine (BVDU) zur Resistenzbildung bei der Zytostatikabehandlung und Arzneimittel, enthaltend BVDU
DK0806956T3 (da) 1995-02-01 2003-01-06 Resprotect Gmbh Anvendelse af 5-substituerede nucleosider til hæmning af resistensdannelse ved cytostatikabehandling
JP2001518931A (ja) 1997-03-24 2001-10-16 イーライ・リリー・アンド・カンパニー ジフルオロヌクレオシドホスホン酸とその誘導体
ES2172303T3 (es) * 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
PT1411954E (pt) * 2000-10-18 2011-03-16 Pharmasset Inc Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal
US20020147175A1 (en) 2000-11-16 2002-10-10 Shepard H. Michael Synergistic ECTA compositions
DE10108851A1 (de) * 2001-02-23 2002-09-12 Resprotect Gmbh Verwendung von 5'-substituierten Nukleosiden und/oder deren Prodrugs zur resistenzfreien Therapie von Infektionskrankheiten
DE10313035A1 (de) * 2003-03-24 2004-10-07 Resprotect Gmbh Methode zur Verstärkung der apoptotischen Wirkung von Zytostatika ohne Erhöhung toxischer Nebenwirkungen
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
EP1674104A1 (en) * 2004-12-24 2006-06-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Uridine derivatives as antiviral drugs against a flaviviridae, especially HCV

Also Published As

Publication number Publication date
DK2054406T3 (en) 2015-11-30
ES2553404T3 (es) 2015-12-09
MX2009001433A (es) 2009-04-09
CA2660636C (en) 2015-10-06
KR20090040905A (ko) 2009-04-27
JP5461989B2 (ja) 2014-04-02
HUE028077T2 (en) 2016-11-28
DE102006037786A1 (de) 2008-03-20
US20100227834A1 (en) 2010-09-09
AU2007283729A1 (en) 2008-02-14
EP2054406B1 (de) 2015-10-07
CN101522666A (zh) 2009-09-02
BRPI0716425A2 (pt) 2013-12-03
US8492537B2 (en) 2013-07-23
CA2660636A1 (en) 2008-02-14
CN101522666B (zh) 2014-01-22
PT2054406E (pt) 2015-11-30
JP2010500307A (ja) 2010-01-07
WO2008017515A1 (de) 2008-02-14
KR101113029B1 (ko) 2012-06-05
AU2007283729B2 (en) 2011-09-01
EP2054406A1 (de) 2009-05-06

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