PL195965A1 - METHOD OF MAKING NEW DERIVATIVES OF PROLINES - Google Patents
METHOD OF MAKING NEW DERIVATIVES OF PROLINESInfo
- Publication number
- PL195965A1 PL195965A1 PL19596577A PL19596577A PL195965A1 PL 195965 A1 PL195965 A1 PL 195965A1 PL 19596577 A PL19596577 A PL 19596577A PL 19596577 A PL19596577 A PL 19596577A PL 195965 A1 PL195965 A1 PL 195965A1
- Authority
- PL
- Poland
- Prior art keywords
- formula
- acid
- prolines
- acylation
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
The compounds of formula I are prepared by N-acylation of a compound of formula II' by means of an acid of formula III'. In these formulae, R is a hydroxyl, NH2 or alkoxy group, R1 and R4 are each H or an alkyl, phenyl or phenylalkyl group, R2 is H or an organic substituent, R3 is H or a hydroxyl or alkyl group, m is 1, 2 or 3 and n is 0, 1 or 2. The acid of formula III' can be replaced by a functional derivative of the latter or, when n is 1, by an acrylic acid of formula R4CH=C(R1)-COOH. In the latter case, after the acylation, a thiol or thioacid R2SH is added to the double bond of the acryloyl residue. The compounds of formula I are therapeutically active in the treatment of blood hypertension (high blood pressure). <IMAGE>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/657,792 US4046889A (en) | 1976-02-13 | 1976-02-13 | Azetidine-2-carboxylic acid derivatives |
US69843276A | 1976-06-21 | 1976-06-21 | |
US05/751,851 US4105776A (en) | 1976-06-21 | 1976-12-22 | Proline derivatives and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PL195965A1 true PL195965A1 (en) | 1978-02-27 |
PL118161B1 PL118161B1 (en) | 1981-09-30 |
Family
ID=27417986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1977195965A PL118161B1 (en) | 1976-02-13 | 1977-02-12 | Process for preparing novel derivatives of proline |
Country Status (31)
Country | Link |
---|---|
JP (1) | JPS604815B2 (en) |
AR (4) | AR222445A1 (en) |
AT (1) | AT365569B (en) |
AU (1) | AU509899B2 (en) |
BG (3) | BG37075A3 (en) |
CA (1) | CA1101864A (en) |
CH (3) | CH622503A5 (en) |
DD (1) | DD129442B3 (en) |
DE (2) | DE2703828C2 (en) |
DK (1) | DK157487C (en) |
ES (5) | ES455803A1 (en) |
FI (1) | FI66596C (en) |
FR (1) | FR2340932A1 (en) |
GB (1) | GB1576161A (en) |
GR (1) | GR69811B (en) |
HK (1) | HK20281A (en) |
HU (1) | HU181965B (en) |
IE (1) | IE44707B1 (en) |
IL (1) | IL51297A (en) |
IT (1) | IT1062293B (en) |
KE (1) | KE3136A (en) |
MY (2) | MY8200075A (en) |
NL (1) | NL168509C (en) |
NO (1) | NO146985C (en) |
NZ (1) | NZ183130A (en) |
PH (1) | PH12970A (en) |
PL (1) | PL118161B1 (en) |
RO (1) | RO69941A (en) |
SE (2) | SE423812B (en) |
SU (1) | SU747422A3 (en) |
YU (1) | YU40664B (en) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4206122A (en) * | 1978-04-14 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor |
US4053651A (en) | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
AU518147B2 (en) * | 1976-12-03 | 1981-09-17 | E.R. Squibb & Sons, Inc. | Derivatives of thiazolidine, thiazine and morpholine carboxylic acids |
US4129566A (en) * | 1978-02-15 | 1978-12-12 | E. R. Squibb & Sons, Inc. | Derivatives of dehydrocyclicimino acids |
US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
FR2412537A1 (en) * | 1977-12-22 | 1979-07-20 | Science Union & Cie | NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION |
CA1120400A (en) * | 1977-12-27 | 1982-03-23 | Zola P. Horovitz | Method of treating hypertension and medicaments therefor |
PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
JPS559058A (en) * | 1978-07-06 | 1980-01-22 | Dainippon Pharmaceut Co Ltd | 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative |
CA1109475A (en) * | 1978-07-27 | 1981-09-22 | Miguel A. Ondetti | Thiopropanoylamino acid derivatives |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
NZ190995A (en) * | 1978-09-05 | 1982-03-09 | American Cyanamid Co | Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions |
NL7809120A (en) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES. |
NL7809121A (en) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | OPTICALLY ACTIVE DERIVATIVES OF MERCAPTO-ISO BUTIC ACID. |
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
US4690937A (en) * | 1979-08-14 | 1987-09-01 | University Of Miami | Anti-hypertensive agents |
GR73585B (en) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
JPS5540622A (en) * | 1978-09-14 | 1980-03-22 | Santen Pharmaceut Co Ltd | Hypotensive agent |
US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
US4198515A (en) * | 1978-12-08 | 1980-04-15 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids |
US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
US4410542A (en) | 1978-12-30 | 1983-10-18 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
CA1138452A (en) * | 1979-01-15 | 1982-12-28 | John Krapcho | Carbamate derivatives of mercaptoacyl hydroxy prolines |
US4461896A (en) * | 1979-02-07 | 1984-07-24 | Norwich Eaton Pharmaceuticals, Inc. | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids |
US4220791A (en) * | 1979-03-08 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Mercaptoacylpyrazolidinone carboxylic acid derivatives |
ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
US4234489A (en) * | 1979-06-25 | 1980-11-18 | E. R. Squibb & Sons, Inc. | Pyroglutamic acid derivatives and analogs |
JPS5629403U (en) * | 1979-08-13 | 1981-03-20 | ||
DE2937779A1 (en) * | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
GB2066240A (en) * | 1979-12-10 | 1981-07-08 | Squibb & Sons Inc | Derivatives of mercaptoacyl amino acids |
GB2065643B (en) * | 1979-12-13 | 1983-08-24 | Kanegafuchi Chemical Ind | Optically active n-mercaptoalkanoylamino acids |
JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
GB2070586A (en) * | 1980-03-21 | 1981-09-09 | Squibb & Sons Inc | Derivatives of Proline or Pipecolic Acid |
DE3011239A1 (en) * | 1980-03-22 | 1981-10-01 | C.H. Boehringer Sohn, 6507 Ingelheim | SUBSTITUTED ALKYLTHIOACYLAMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS |
SE8203245L (en) * | 1981-05-27 | 1982-11-28 | Crc Ricerca Chim | PROCEDURE FOR ENANTIOSELECTIVE PREPARATION OF N-SUBSTITUTED PROLINE DERIVATIVES |
KR860001391B1 (en) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | Process for the preparation of pyrolidines |
JPH06740B2 (en) * | 1984-08-16 | 1994-01-05 | 三菱レイヨン株式会社 | Process for producing optically active carboxylic acid amide |
HU196369B (en) * | 1984-10-18 | 1988-11-28 | Egyt Gyogyszervegyeszeti Gyar | New process for producing n-acylized l-prolin derivatives |
KR870001570B1 (en) * | 1984-12-19 | 1987-09-04 | 보령제약 주식회사 | Preparing process for pyrolidine derivatives |
KR870001569B1 (en) * | 1985-02-11 | 1987-09-04 | 보령제약 주식회사 | Preparing process for pyrolidine derivatives |
AT395012B (en) * | 1986-06-27 | 1992-08-25 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING N- (1 (S) | THOXYCARBONYL-3-PHENYL-PROPYL) - (S) -ALANYL- (S) PROLIN AND ITS ACID ADDITION SALTS |
JP2863534B2 (en) * | 1988-10-24 | 1999-03-03 | マリオン ラボラトリーズ,インコーポレイティド | Pharmaceutical composition |
US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
EP0656773B1 (en) * | 1992-08-26 | 1997-04-02 | Beiersdorf Aktiengesellschaft | Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions |
DE4228455A1 (en) * | 1992-08-26 | 1994-09-15 | Beiersdorf Ag | Cosmetic and dermatological sunscreen formulations containing thiols and / or thiol derivatives |
IT1266570B1 (en) * | 1993-07-30 | 1997-01-09 | Zambon Spa | DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES |
US7056935B2 (en) | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
GB9704522D0 (en) * | 1997-03-05 | 1997-04-23 | Smithkline Beecham Plc | Compounds |
ES2182203T3 (en) | 1997-10-31 | 2003-03-01 | Hoffmann La Roche | DERIVATIVES OF D-PROLINA. |
CA2457814A1 (en) * | 2001-08-07 | 2003-02-20 | Sunesis Pharmaceuticals, Inc. | Disulfide and thiosulfonate ligands and libraries comprising these ligands |
CN100361971C (en) * | 2005-09-19 | 2008-01-16 | 华中师范大学 | Double functional group L-proline derivative with adjustable catalytic activity and its prepn |
US8653131B2 (en) | 2008-08-22 | 2014-02-18 | Baxter Healthcare S.A. | Polymeric benzyl carbonate-derivatives |
CN104822266B (en) | 2012-04-27 | 2017-12-05 | 陶氏益农公司 | Pesticidal combination and relative method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA946836A (en) * | 1970-03-18 | 1974-05-07 | Miguel A. Ondetti | Enzyme inhibitor |
-
1977
- 1977-01-14 AU AU21347/77A patent/AU509899B2/en not_active Expired
- 1977-01-19 NZ NZ183130A patent/NZ183130A/en unknown
- 1977-01-20 IL IL51297A patent/IL51297A/en unknown
- 1977-01-21 CA CA270,184A patent/CA1101864A/en not_active Expired
- 1977-01-27 PH PH19390A patent/PH12970A/en unknown
- 1977-01-31 DE DE2703828A patent/DE2703828C2/en not_active Expired
- 1977-01-31 DE DE2759862A patent/DE2759862C2/de not_active Expired
- 1977-02-08 YU YU331/77A patent/YU40664B/en unknown
- 1977-02-08 GR GR52745A patent/GR69811B/el unknown
- 1977-02-09 RO RO7789327A patent/RO69941A/en unknown
- 1977-02-10 ES ES455803A patent/ES455803A1/en not_active Expired
- 1977-02-10 FI FI770437A patent/FI66596C/en not_active IP Right Cessation
- 1977-02-11 NO NO770464A patent/NO146985C/en unknown
- 1977-02-11 BG BG8362894A patent/BG37075A3/en unknown
- 1977-02-11 DD DD77197339A patent/DD129442B3/en unknown
- 1977-02-11 CH CH170377A patent/CH622503A5/en not_active IP Right Cessation
- 1977-02-11 IT IT48008/77A patent/IT1062293B/en active Protection Beyond IP Right Term
- 1977-02-11 BG BG8362893A patent/BG37074A3/en unknown
- 1977-02-11 SU SU772450455A patent/SU747422A3/en active
- 1977-02-11 HU HU77SU939A patent/HU181965B/en unknown
- 1977-02-11 DK DK059677A patent/DK157487C/en active
- 1977-02-11 BG BG7735398A patent/BG37375A3/en unknown
- 1977-02-11 IE IE305/77A patent/IE44707B1/en not_active IP Right Cessation
- 1977-02-11 AR AR266525A patent/AR222445A1/en active
- 1977-02-11 NL NLAANVRAGE7701457,A patent/NL168509C/en not_active IP Right Cessation
- 1977-02-11 SE SE7701561A patent/SE423812B/en not_active IP Right Cessation
- 1977-02-12 PL PL1977195965A patent/PL118161B1/en not_active IP Right Cessation
- 1977-02-12 JP JP52014542A patent/JPS604815B2/en not_active Expired
- 1977-02-13 GB GB4088/77A patent/GB1576161A/en not_active Expired
- 1977-02-14 AT AT0098977A patent/AT365569B/en not_active IP Right Cessation
- 1977-02-14 FR FR7704122A patent/FR2340932A1/en active Granted
- 1977-10-31 AR AR269794A patent/AR214649A1/en active
- 1977-10-31 AR AR269793A patent/AR222783A1/en active
-
1978
- 1978-02-16 ES ES467050A patent/ES467050A1/en not_active Expired
- 1978-02-16 ES ES467053A patent/ES467053A1/en not_active Expired
- 1978-02-16 ES ES467052A patent/ES467052A1/en not_active Expired
- 1978-05-16 ES ES467051A patent/ES467051A1/en not_active Expired
-
1979
- 1979-09-11 AR AR278014A patent/AR226290A1/en active
-
1980
- 1980-02-21 CH CH140980A patent/CH624931A5/fr not_active IP Right Cessation
- 1980-02-21 CH CH141080A patent/CH624932A5/fr not_active IP Right Cessation
-
1981
- 1981-05-14 HK HK202/81A patent/HK20281A/en unknown
- 1981-06-18 KE KE3136A patent/KE3136A/en unknown
- 1981-08-03 SE SE8104660A patent/SE426697B/en not_active IP Right Cessation
-
1982
- 1982-12-30 MY MY75/82A patent/MY8200075A/en unknown
-
1987
- 1987-09-30 MY MYPI87002538A patent/MY102705A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
LAPS | Decisions on the lapse of the protection rights |
Effective date: 20030125 |