AR214649A1 - PROCEDURE FOR PREPARING NEW ACIDS AND ALKYL ESTERS OF 1- (3-MERCAPTOPROPANOIL OR 3-MERCAPTO-2-ALKYL (C1-C7) -PROPANOIL) -L-PROLINE - Google Patents

PROCEDURE FOR PREPARING NEW ACIDS AND ALKYL ESTERS OF 1- (3-MERCAPTOPROPANOIL OR 3-MERCAPTO-2-ALKYL (C1-C7) -PROPANOIL) -L-PROLINE

Info

Publication number
AR214649A1
AR214649A1 AR269794A AR26979477A AR214649A1 AR 214649 A1 AR214649 A1 AR 214649A1 AR 269794 A AR269794 A AR 269794A AR 26979477 A AR26979477 A AR 26979477A AR 214649 A1 AR214649 A1 AR 214649A1
Authority
AR
Argentina
Prior art keywords
alkyl
propanoil
mercaptopropanoil
proline
mercapto
Prior art date
Application number
AR269794A
Other languages
Spanish (es)
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/657,792 external-priority patent/US4046889A/en
Priority claimed from US05/751,851 external-priority patent/US4105776A/en
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of AR214649A1 publication Critical patent/AR214649A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR269794A 1976-02-13 1977-10-31 PROCEDURE FOR PREPARING NEW ACIDS AND ALKYL ESTERS OF 1- (3-MERCAPTOPROPANOIL OR 3-MERCAPTO-2-ALKYL (C1-C7) -PROPANOIL) -L-PROLINE AR214649A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/657,792 US4046889A (en) 1976-02-13 1976-02-13 Azetidine-2-carboxylic acid derivatives
US69843276A 1976-06-21 1976-06-21
US05/751,851 US4105776A (en) 1976-06-21 1976-12-22 Proline derivatives and related compounds

Publications (1)

Publication Number Publication Date
AR214649A1 true AR214649A1 (en) 1979-07-13

Family

ID=27417986

Family Applications (4)

Application Number Title Priority Date Filing Date
AR266525A AR222445A1 (en) 1976-02-13 1977-02-11 PROCEDURE TO PREPARE NEW ACID DERIVATIVES 1- (MERCAPTOALQUIL- (C1-C3) -CARBONIL) -L-PROLINA AND ITS SALTS
AR269793A AR222783A1 (en) 1976-02-13 1977-10-31 PROCEDURE FOR PREPARING NEW DERIVATIVES OF N- (ALCANOYLTIO-ALCANOYL) -PROLINE AND ITS LIMES
AR269794A AR214649A1 (en) 1976-02-13 1977-10-31 PROCEDURE FOR PREPARING NEW ACIDS AND ALKYL ESTERS OF 1- (3-MERCAPTOPROPANOIL OR 3-MERCAPTO-2-ALKYL (C1-C7) -PROPANOIL) -L-PROLINE
AR278014A AR226290A1 (en) 1976-02-13 1979-09-11 PROCEDURE TO PREPARE NUETOALQUIL- (C1-C3) -CARBONIL) -L-PROVOS DERIVED FROM ACID-1- (MERCAPLINA, AND ITS SALTS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AR266525A AR222445A1 (en) 1976-02-13 1977-02-11 PROCEDURE TO PREPARE NEW ACID DERIVATIVES 1- (MERCAPTOALQUIL- (C1-C3) -CARBONIL) -L-PROLINA AND ITS SALTS
AR269793A AR222783A1 (en) 1976-02-13 1977-10-31 PROCEDURE FOR PREPARING NEW DERIVATIVES OF N- (ALCANOYLTIO-ALCANOYL) -PROLINE AND ITS LIMES

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR278014A AR226290A1 (en) 1976-02-13 1979-09-11 PROCEDURE TO PREPARE NUETOALQUIL- (C1-C3) -CARBONIL) -L-PROVOS DERIVED FROM ACID-1- (MERCAPLINA, AND ITS SALTS

Country Status (31)

Country Link
JP (1) JPS604815B2 (en)
AR (4) AR222445A1 (en)
AT (1) AT365569B (en)
AU (1) AU509899B2 (en)
BG (3) BG37074A3 (en)
CA (1) CA1101864A (en)
CH (3) CH622503A5 (en)
DD (1) DD129442B3 (en)
DE (2) DE2703828C2 (en)
DK (1) DK157487C (en)
ES (5) ES455803A1 (en)
FI (1) FI66596C (en)
FR (1) FR2340932A1 (en)
GB (1) GB1576161A (en)
GR (1) GR69811B (en)
HK (1) HK20281A (en)
HU (1) HU181965B (en)
IE (1) IE44707B1 (en)
IL (1) IL51297A (en)
IT (1) IT1062293B (en)
KE (1) KE3136A (en)
MY (2) MY8200075A (en)
NL (1) NL168509C (en)
NO (1) NO146985C (en)
NZ (1) NZ183130A (en)
PH (1) PH12970A (en)
PL (1) PL118161B1 (en)
RO (1) RO69941A (en)
SE (2) SE423812B (en)
SU (1) SU747422A3 (en)
YU (1) YU40664B (en)

Families Citing this family (54)

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US4206122A (en) * 1978-04-14 1980-06-03 E. R. Squibb & Sons, Inc. Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
US4129566A (en) * 1978-02-15 1978-12-12 E. R. Squibb & Sons, Inc. Derivatives of dehydrocyclicimino acids
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
FR2412537A1 (en) * 1977-12-22 1979-07-20 Science Union & Cie NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION
CA1120400A (en) * 1977-12-27 1982-03-23 Zola P. Horovitz Method of treating hypertension and medicaments therefor
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
CA1109475A (en) * 1978-07-27 1981-09-22 Miguel A. Ondetti Thiopropanoylamino acid derivatives
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809121A (en) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw OPTICALLY ACTIVE DERIVATIVES OF MERCAPTO-ISO BUTIC ACID.
NL7809120A (en) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES.
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
GR73585B (en) * 1978-09-11 1984-03-26 Univ Miami
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4198515A (en) * 1978-12-08 1980-04-15 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4410542A (en) 1978-12-30 1983-10-18 Santen Pharmaceutical Co., Ltd. Disulfide compounds
CA1138452A (en) * 1979-01-15 1982-12-28 John Krapcho Carbamate derivatives of mercaptoacyl hydroxy prolines
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4220791A (en) * 1979-03-08 1980-09-02 E. R. Squibb & Sons, Inc. Mercaptoacylpyrazolidinone carboxylic acid derivatives
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
JPS5629403U (en) * 1979-08-13 1981-03-20
DE2937779A1 (en) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
GB2066240A (en) * 1979-12-10 1981-07-08 Squibb & Sons Inc Derivatives of mercaptoacyl amino acids
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
SE431331B (en) * 1980-03-21 1984-01-30 Squibb & Sons Inc NEW THERAPEUTICALLY ACTIVE SULFUR CONTAINING N-ACYLATED DERIVATIVES OF 4-OXO-L-PROLINE
DE3011239A1 (en) * 1980-03-22 1981-10-01 C.H. Boehringer Sohn, 6507 Ingelheim SUBSTITUTED ALKYLTHIOACYLAMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
SE8203245L (en) * 1981-05-27 1982-11-28 Crc Ricerca Chim PROCEDURE FOR ENANTIOSELECTIVE PREPARATION OF N-SUBSTITUTED PROLINE DERIVATIVES
KR860001391B1 (en) * 1984-07-23 1986-09-22 보령제약 주식회사 Process for the preparation of pyrolidines
JPH06740B2 (en) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 Process for producing optically active carboxylic acid amide
HU196369B (en) * 1984-10-18 1988-11-28 Egyt Gyogyszervegyeszeti Gyar New process for producing n-acylized l-prolin derivatives
KR870001570B1 (en) * 1984-12-19 1987-09-04 보령제약 주식회사 Preparing process for pyrolidine derivatives
KR870001569B1 (en) * 1985-02-11 1987-09-04 보령제약 주식회사 Preparing process for pyrolidine derivatives
AT395012B (en) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet METHOD FOR PRODUCING N- (1 (S) | THOXYCARBONYL-3-PHENYL-PROPYL) - (S) -ALANYL- (S) PROLIN AND ITS ACID ADDITION SALTS
JP2863534B2 (en) * 1988-10-24 1999-03-03 マリオン ラボラトリーズ，インコーポレイティド Pharmaceutical composition
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
DE4228455A1 (en) * 1992-08-26 1994-09-15 Beiersdorf Ag Cosmetic and dermatological sunscreen formulations containing thiols and / or thiol derivatives
JPH08506085A (en) * 1992-08-26 1996-07-02 バイヤースドルフ・アクチエンゲゼルシヤフト Use of free-radical scavengers as immunomodulators in cosmetic and dermatological formulations
IT1266570B1 (en) * 1993-07-30 1997-01-09 Zambon Spa DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9704522D0 (en) * 1997-03-05 1997-04-23 Smithkline Beecham Plc Compounds
DE69808017T2 (en) * 1997-10-31 2003-04-30 F. Hoffmann-La Roche Ag, Basel D-proline
EP1421063A1 (en) * 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Disulfide and thiosulfonate ligands and libraries comprising these ligands
CN100361971C (en) * 2005-09-19 2008-01-16 华中师范大学 Double functional group L-proline derivative with adjustable catalytic activity and its prepn
KR101660059B1 (en) 2008-08-22 2016-09-26 박스알타 인코퍼레이티드 Polymeric benzyl carbonate-derivatives
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CA946836A (en) * 1970-03-18 1974-05-07 Miguel A. Ondetti Enzyme inhibitor

Also Published As

Publication number Publication date
DE2703828A1 (en) 1977-08-18
IL51297A (en) 1980-03-31
MY8200075A (en) 1982-12-31
DK59677A (en) 1977-08-14
AR226290A1 (en) 1982-06-30
KE3136A (en) 1981-07-03
AU2134777A (en) 1978-07-20
DK157487C (en) 1990-06-11
IE44707B1 (en) 1982-03-10
IT1062293B (en) 1984-05-23
PL118161B1 (en) 1981-09-30
CA1101864A (en) 1981-05-26
GB1576161A (en) 1980-10-01
CH622503A5 (en) 1981-04-15
DD129442B3 (en) 1990-01-10
ES467050A1 (en) 1978-11-01
IL51297A0 (en) 1977-03-31
FI66596C (en) 1987-03-18
JPS52116457A (en) 1977-09-29
ES455803A1 (en) 1978-06-16
AR222783A1 (en) 1981-06-30
HK20281A (en) 1981-05-22
SE7701561L (en) 1977-09-23
NO146985B (en) 1982-10-04
SE8104660L (en) 1981-08-03
JPS604815B2 (en) 1985-02-06
SU747422A3 (en) 1980-07-23
CH624932A5 (en) 1981-08-31
ATA98977A (en) 1981-06-15
ES467053A1 (en) 1978-11-01
YU33177A (en) 1983-01-21
PH12970A (en) 1979-10-24
RO69941A (en) 1980-05-15
AU509899B2 (en) 1980-05-29
FI770437A (en) 1977-08-14
NZ183130A (en) 1979-08-31
IE44707L (en) 1977-08-13
BG37074A3 (en) 1985-03-15
BG37375A3 (en) 1985-05-15
SE423812B (en) 1982-06-07
AT365569B (en) 1982-01-25
NO770464L (en) 1977-08-16
CH624931A5 (en) 1981-08-31
BG37075A3 (en) 1985-03-15
GR69811B (en) 1982-07-13
FR2340932A1 (en) 1977-09-09
DE2759862C2 (en) 1989-12-07
YU40664B (en) 1986-04-30
AR222445A1 (en) 1981-05-29
DE2703828C2 (en) 1984-06-20
DK157487B (en) 1990-01-15
FR2340932B1 (en) 1981-02-06
ES467051A1 (en) 1978-11-01
PL195965A1 (en) 1978-02-27
FI66596B (en) 1984-07-31
NO146985C (en) 1983-01-12
HU181965B (en) 1983-11-28
MY102705A (en) 1992-09-30
ES467052A1 (en) 1978-11-01
SE426697B (en) 1983-02-07
DD129442A5 (en) 1978-01-18
NL7701457A (en) 1977-08-16
NL168509C (en) 1982-04-16

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