PH31394A - Certain Ä,2,5-thiadiazol-4-ylÜ-1-azabicyclo Ä3,2,1Üoctane derivaives and their pharmaceutical uses. - Google Patents

Certain Ä,2,5-thiadiazol-4-ylÜ-1-azabicyclo Ä3,2,1Üoctane derivaives and their pharmaceutical uses.

Info

Publication number
PH31394A
PH31394A PH47880A PH47880A PH31394A PH 31394 A PH31394 A PH 31394A PH 47880 A PH47880 A PH 47880A PH 47880 A PH47880 A PH 47880A PH 31394 A PH31394 A PH 31394A
Authority
PH
Philippines
Prior art keywords
ylü
1üoctane
derivaives
thiadiazol
azabicyclo
Prior art date
Application number
PH47880A
Other languages
English (en)
Inventor
Sauerberg Per
Preben H Plesen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PH31394A publication Critical patent/PH31394A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PH47880A 1993-03-05 1994-03-04 Certain Ä,2,5-thiadiazol-4-ylÜ-1-azabicyclo Ä3,2,1Üoctane derivaives and their pharmaceutical uses. PH31394A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/026,943 US5418240A (en) 1990-08-21 1993-03-05 Heterocyclic compounds and their preparation and use

Publications (1)

Publication Number Publication Date
PH31394A true PH31394A (en) 1998-10-29

Family

ID=21834696

Family Applications (1)

Application Number Title Priority Date Filing Date
PH47880A PH31394A (en) 1993-03-05 1994-03-04 Certain Ä,2,5-thiadiazol-4-ylÜ-1-azabicyclo Ä3,2,1Üoctane derivaives and their pharmaceutical uses.

Country Status (21)

Country Link
US (1) US5418240A (xx)
EP (1) EP0687266B1 (xx)
JP (1) JP3411923B2 (xx)
KR (1) KR100344329B1 (xx)
CN (1) CN1046722C (xx)
AT (1) ATE173257T1 (xx)
AU (1) AU694415B2 (xx)
CZ (1) CZ290639B6 (xx)
DE (1) DE69414554T2 (xx)
DK (1) DK0687266T3 (xx)
ES (1) ES2126099T3 (xx)
FI (1) FI954130A (xx)
HU (1) HUT72443A (xx)
IL (1) IL108865A (xx)
NO (1) NO312676B1 (xx)
NZ (1) NZ262372A (xx)
PH (1) PH31394A (xx)
SK (1) SK281005B6 (xx)
TW (1) TW350846B (xx)
WO (1) WO1994020496A1 (xx)
ZA (1) ZA941542B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
CZ42796A3 (en) * 1993-08-19 1996-12-11 Novo Nordisk As The use of thiazole and oxazole compounds for preparing a pharmaceutical preparation and the pharmaceutical preparation for treating schizophrenia or schizophrenic diseases
US6281232B1 (en) 1993-08-19 2001-08-28 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US6265419B1 (en) * 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5821371A (en) * 1994-10-24 1998-10-13 Eli Lilly And Comany Heterocyclic compounds and their preparation and use
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
EP0871627A1 (en) * 1995-09-22 1998-10-21 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
BR9610960A (pt) * 1995-10-13 1999-03-02 Neurosearch As Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso
EP0874828A4 (en) * 1995-12-06 1999-09-01 Lilly Co Eli PAIN TREATMENT COMPOSITIONS
KR19990071976A (ko) * 1995-12-07 1999-09-27 피터 지. 스트링거 통증 치료용 조성물
JP2000502716A (ja) * 1996-01-04 2000-03-07 ノボ ノルディスク アクティーゼルスカブ 高コレステロール血症及び関連する疾患を治療する方法
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
AU2991397A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
CA2252563A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO1998046226A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Method for treating schizophrenia
EP1007041A4 (en) * 1997-04-11 2001-03-07 Lilly Co Eli COMPOSITION FOR TREATING PAIN
US6015813A (en) * 1997-04-22 2000-01-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
ATE299504T1 (de) * 1997-04-22 2005-07-15 Novo Nordisk As Heterozyklische verbindungen, ihre herstellung und ihre anwendung
WO1998054151A1 (en) * 1997-05-29 1998-12-03 Eli Lilly And Company Process for preparing heterocyclic compounds
CA2291157A1 (en) * 1997-05-29 1998-12-03 Eli Lilly And Company Process for preparing heterocyclic compounds
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US20050131051A1 (en) * 2000-08-21 2005-06-16 Shaomeng Wang 2-3-disubstituted quinuclidiness as modulators of monoamine transporters and theraperutic and diagnostic methods based thereon
EP2296471A4 (en) 2008-05-15 2012-03-14 Univ Toledo MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
CZ290639B6 (cs) 2002-09-11
JP3411923B2 (ja) 2003-06-03
IL108865A0 (en) 1994-06-24
JPH08507499A (ja) 1996-08-13
ES2126099T3 (es) 1999-03-16
SK281005B6 (sk) 2000-10-09
DK0687266T3 (da) 1999-07-26
DE69414554T2 (de) 1999-06-17
DE69414554D1 (de) 1998-12-17
AU6202794A (en) 1994-09-26
HUT72443A (en) 1996-04-29
WO1994020496A1 (en) 1994-09-15
NO312676B1 (no) 2002-06-17
ZA941542B (en) 1995-09-04
CN1121349A (zh) 1996-04-24
HU9502588D0 (en) 1995-11-28
NO953491L (no) 1995-09-05
KR100344329B1 (ko) 2002-11-30
NO953491D0 (no) 1995-09-05
SK110195A3 (en) 1996-10-02
CZ225195A3 (en) 1996-04-17
IL108865A (en) 2000-07-16
AU694415B2 (en) 1998-07-23
FI954130A0 (fi) 1995-09-04
CN1046722C (zh) 1999-11-24
FI954130A (fi) 1995-10-27
NZ262372A (en) 1997-07-27
US5418240A (en) 1995-05-23
EP0687266B1 (en) 1998-11-11
EP0687266A1 (en) 1995-12-20
TW350846B (en) 1999-01-21
KR960701049A (ko) 1996-02-24
ATE173257T1 (de) 1998-11-15

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