PH27439A - Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof - Google Patents

Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof

Info

Publication number
PH27439A
PH27439A PH37784A PH37784A PH27439A PH 27439 A PH27439 A PH 27439A PH 37784 A PH37784 A PH 37784A PH 37784 A PH37784 A PH 37784A PH 27439 A PH27439 A PH 27439A
Authority
PH
Philippines
Prior art keywords
quinolone
sulfinyl
methylthio
methyl
preparation
Prior art date
Application number
PH37784A
Other languages
English (en)
Inventor
Lachlan Maclean
David Lloyd Roberts
Kenneth John Nichol
Albert Ernest Harrison
Kenneth Barron
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of PH27439A publication Critical patent/PH27439A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH37784A 1987-11-18 1988-11-09 Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof PH27439A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process

Publications (1)

Publication Number Publication Date
PH27439A true PH27439A (en) 1993-07-02

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37784A PH27439A (en) 1987-11-18 1988-11-09 Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof

Country Status (28)

Country Link
US (2) US5011931A (xx)
EP (2) EP0317149B1 (xx)
JP (1) JPH02502013A (xx)
KR (1) KR890701563A (xx)
AT (1) ATE69221T1 (xx)
AU (1) AU628305B2 (xx)
BG (1) BG50157A3 (xx)
CS (1) CS274487B2 (xx)
DD (1) DD290188A5 (xx)
DE (1) DE3866086D1 (xx)
ES (1) ES2038310T3 (xx)
FI (1) FI91063C (xx)
GB (1) GB8726950D0 (xx)
GR (1) GR3003378T3 (xx)
HU (1) HU204511B (xx)
IE (1) IE883366L (xx)
IL (1) IL88358A (xx)
MX (1) MX168918B (xx)
NZ (1) NZ227008A (xx)
PH (1) PH27439A (xx)
PL (1) PL157191B1 (xx)
PT (1) PT89024B (xx)
RO (1) RO104615B1 (xx)
SU (1) SU1766255A3 (xx)
TW (1) TW204344B (xx)
WO (1) WO1989004827A1 (xx)
YU (1) YU46989B (xx)
ZA (1) ZA888241B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6649764B2 (en) 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
US4552884A (en) * 1984-01-13 1985-11-12 The Boots Company Plc Method of treating heart disease
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
CS274487B2 (en) 1991-04-11
BG50157A3 (en) 1992-05-15
FI91063B (fi) 1994-01-31
IE883366L (en) 1989-05-18
KR890701563A (ko) 1989-12-21
NZ227008A (en) 1991-10-25
GR3003378T3 (en) 1993-02-17
AU628305B2 (en) 1992-09-17
JPH02502013A (ja) 1990-07-05
AU2616388A (en) 1989-06-14
DD290188A5 (de) 1991-05-23
PT89024A (pt) 1988-12-01
ES2038310T3 (es) 1993-07-16
ATE69221T1 (de) 1991-11-15
PL275880A1 (en) 1989-06-12
FI893405A0 (fi) 1989-07-13
PL157191B1 (pl) 1992-05-29
IL88358A0 (en) 1989-06-30
MX168918B (es) 1993-06-14
GB8726950D0 (en) 1987-12-23
CS748988A2 (en) 1990-09-12
FI893405A (fi) 1989-07-13
EP0343206A1 (en) 1989-11-29
EP0317149B1 (en) 1991-11-06
YU209788A (en) 1990-08-31
US5011931A (en) 1991-04-30
PT89024B (pt) 1993-02-26
IL88358A (en) 1993-02-21
US5079264A (en) 1992-01-07
FI91063C (fi) 1994-05-10
WO1989004827A1 (en) 1989-06-01
HUT53085A (en) 1990-09-28
HU204511B (en) 1992-01-28
RO104615B1 (en) 1992-11-03
TW204344B (xx) 1993-04-21
DE3866086D1 (de) 1991-12-12
EP0317149A1 (en) 1989-05-24
ZA888241B (en) 1989-10-25
SU1766255A3 (ru) 1992-09-30
YU46989B (sh) 1994-09-09

Similar Documents

Publication Publication Date Title
PH27439A (en) Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof
EG19678A (en) Derivatives of propenoic acid useful as fungicides
ES2064356T3 (es) Azaespiranos inmunomoduladores.
IL101012A0 (en) Pyranyl cyanoguanadine derivatives,processes for the preparation thereof and cardioplegic solution containing the same
LU88795I2 (fr) Mycophenolate mofetil ou un sel pharmaceutiquement acceptable de celui-ci
BR8704582A (pt) Processo para preparar derivados de piridinacarboxamida
GR3004139T3 (xx)
KR910000666A (ko) 살리실알데히드 유도체 및 살리실산 유도체 및 이들의 황 유사체, 이들의 제조방법 및 이들을 사용하는 제초방법 및 생물성장 조절방법
HUT49792A (en) Insecticide compositions containing phenyl-pyrimidinone derivatives as active components and process for producing the active components
HUT53886A (en) Fungicide preparations containing propencarboxylic acid derivatives as agents and process for producing the agents
DK240283D0 (da) Beta-carbolin-3-carboxylsyrederivater og fremgangsmade til fremstilling af samme
ATE79626T1 (de) Verfahren zur herstellung von oxazinobenzothiazin-6,6-dioxidderivaten.
FI842533A (fi) Hexahydropyrrolo/2,1-a/isokinolin- derivat.
ATE104270T1 (de) Glutarsaeurederivate und ihre herstellung.
ES2044883T3 (es) Procedimiento para preparar quinoxalinas sustituidas.
DK46884D0 (da) 5-aminomethyl-imidazol-1-yl-1,3-dialkyl-1h-pyrazol-4-yl-aroyl-methanoner,fremgangsmaade til deres fremstilling samt deres anvendelse
PT73948A (en) Process for the preparation of biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof