PH27439A - Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof - Google Patents
Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereofInfo
- Publication number
- PH27439A PH27439A PH37784A PH37784A PH27439A PH 27439 A PH27439 A PH 27439A PH 37784 A PH37784 A PH 37784A PH 37784 A PH37784 A PH 37784A PH 27439 A PH27439 A PH 27439A
- Authority
- PH
- Philippines
- Prior art keywords
- quinolone
- sulfinyl
- methylthio
- methyl
- preparation
- Prior art date
Links
- CVDODZNMQPRAGV-UHFFFAOYSA-N 1,3-dimethylquinoline-4-thione Chemical compound C1=CC=C2C(=S)C(C)=CN(C)C2=C1 CVDODZNMQPRAGV-UHFFFAOYSA-N 0.000 title 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 title 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Preparation (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878726950A GB8726950D0 (en) | 1987-11-18 | 1987-11-18 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27439A true PH27439A (en) | 1993-07-02 |
Family
ID=10627131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH37784A PH27439A (en) | 1987-11-18 | 1988-11-09 | Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5011931A (pl) |
| EP (2) | EP0343206A1 (pl) |
| JP (1) | JPH02502013A (pl) |
| KR (1) | KR890701563A (pl) |
| AT (1) | ATE69221T1 (pl) |
| AU (1) | AU628305B2 (pl) |
| BG (1) | BG50157A3 (pl) |
| CS (1) | CS274487B2 (pl) |
| DD (1) | DD290188A5 (pl) |
| DE (1) | DE3866086D1 (pl) |
| ES (1) | ES2038310T3 (pl) |
| FI (1) | FI91063C (pl) |
| GB (1) | GB8726950D0 (pl) |
| GR (1) | GR3003378T3 (pl) |
| HU (1) | HU204511B (pl) |
| IE (1) | IE883366L (pl) |
| IL (1) | IL88358A (pl) |
| MX (1) | MX168918B (pl) |
| NZ (1) | NZ227008A (pl) |
| PH (1) | PH27439A (pl) |
| PL (1) | PL157191B1 (pl) |
| PT (1) | PT89024B (pl) |
| RO (1) | RO104615B1 (pl) |
| SU (1) | SU1766255A3 (pl) |
| TW (1) | TW204344B (pl) |
| WO (1) | WO1989004827A1 (pl) |
| YU (1) | YU46989B (pl) |
| ZA (1) | ZA888241B (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
| US6194433B1 (en) | 1998-10-05 | 2001-02-27 | Neal R. Cutler | Sexual dysfunction in females |
| US6132753A (en) * | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
| US6110489A (en) * | 1998-05-01 | 2000-08-29 | Cutler; Neal R. | Use of quinolines and quinolones to treat male erectile dysfunction |
| US6132757A (en) * | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
| US6426084B1 (en) | 2000-06-19 | 2002-07-30 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
| US6303135B1 (en) | 1999-07-08 | 2001-10-16 | Neal R. Cutler | Use of quinolines and quinolones to treat male erectile dysfunction |
| US6307050B1 (en) * | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
| US6562838B2 (en) * | 2001-01-26 | 2003-05-13 | R. T. Alamo Ventures I, L.L.C. | Treatment of cardiovascular disease with quinolinone enantiomers |
| US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
| US6458804B1 (en) | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
| US6596871B2 (en) | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US6573382B2 (en) | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US6660864B2 (en) | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US6531603B1 (en) | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US6657061B2 (en) | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US6649764B2 (en) | 2001-10-25 | 2003-11-18 | R. T. Alamo Ventures I, Llc | Stereospecific enrichment of heterocyclic enantiomers |
| US6730790B2 (en) * | 2002-03-01 | 2004-05-04 | R.T. Alamo Ventures I. Llc | Chlorinated heterocyclic compounds and methods of synthesis |
| US7041677B2 (en) * | 2002-03-01 | 2006-05-09 | R.T. Alamo Ventures I, Llc | Use of monochloroflosequinan in the treatment of sexual dysfunction |
| CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920699A (en) * | 1974-04-26 | 1975-11-18 | Warner Lambert Co | Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby |
| US4192873A (en) * | 1976-11-25 | 1980-03-11 | Ciba-Geigy Corporation | Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
| NZ193167A (en) * | 1979-03-27 | 1984-08-24 | Boots Co Plc | Quinoline derivatives and pharmaceutical compositions |
| IE51542B1 (en) * | 1980-09-26 | 1987-01-07 | Boots Co Ltd | Therapeutic agents |
| FR2532939A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
| DE3578374D1 (de) * | 1984-01-13 | 1990-08-02 | Boots Co Ltd | Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen. |
| FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
| GB8515209D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
| GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
| GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
-
1987
- 1987-11-18 GB GB878726950A patent/GB8726950D0/en active Pending
-
1988
- 1988-11-03 ZA ZA888241A patent/ZA888241B/xx unknown
- 1988-11-07 KR KR1019890701326A patent/KR890701563A/ko not_active Ceased
- 1988-11-07 JP JP63508842A patent/JPH02502013A/ja active Pending
- 1988-11-07 ES ES198888310463T patent/ES2038310T3/es not_active Expired - Lifetime
- 1988-11-07 HU HU886294A patent/HU204511B/hu not_active IP Right Cessation
- 1988-11-07 US US07/378,216 patent/US5011931A/en not_active Expired - Fee Related
- 1988-11-07 EP EP88909581A patent/EP0343206A1/en active Pending
- 1988-11-07 DE DE8888310463T patent/DE3866086D1/de not_active Expired - Fee Related
- 1988-11-07 EP EP88310463A patent/EP0317149B1/en not_active Expired - Lifetime
- 1988-11-07 WO PCT/GB1988/000952 patent/WO1989004827A1/en not_active Ceased
- 1988-11-07 AU AU26163/88A patent/AU628305B2/en not_active Ceased
- 1988-11-07 AT AT88310463T patent/ATE69221T1/de not_active IP Right Cessation
- 1988-11-07 RO RO140740A patent/RO104615B1/ro unknown
- 1988-11-09 IE IE883366A patent/IE883366L/xx unknown
- 1988-11-09 PH PH37784A patent/PH27439A/en unknown
- 1988-11-10 IL IL88358A patent/IL88358A/xx unknown
- 1988-11-10 MX MX013748A patent/MX168918B/es unknown
- 1988-11-11 YU YU209788A patent/YU46989B/sh unknown
- 1988-11-11 TW TW077107879A patent/TW204344B/zh active
- 1988-11-15 CS CS748988A patent/CS274487B2/cs unknown
- 1988-11-16 DD DD88321853A patent/DD290188A5/de not_active IP Right Cessation
- 1988-11-17 PT PT89024A patent/PT89024B/pt not_active IP Right Cessation
- 1988-11-18 PL PL1988275880A patent/PL157191B1/pl unknown
- 1988-11-18 NZ NZ227008A patent/NZ227008A/en unknown
-
1989
- 1989-05-17 SU SU894614311A patent/SU1766255A3/ru active
- 1989-07-13 FI FI893405A patent/FI91063C/fi not_active IP Right Cessation
- 1989-07-17 BG BG089219A patent/BG50157A3/xx unknown
-
1991
- 1991-03-01 US US07/663,085 patent/US5079264A/en not_active Expired - Fee Related
- 1991-12-18 GR GR91402063T patent/GR3003378T3/el unknown
Also Published As
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