PH27122A - N-pyridinyl-9H-carbazol-9-amines and a process for their preparation - Google Patents
N-pyridinyl-9H-carbazol-9-amines and a process for their preparation Download PDFInfo
- Publication number
- PH27122A PH27122A PH39801A PH39801A PH27122A PH 27122 A PH27122 A PH 27122A PH 39801 A PH39801 A PH 39801A PH 39801 A PH39801 A PH 39801A PH 27122 A PH27122 A PH 27122A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- hydrogen
- pyridinyl
- carbazol
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- CIWUYDQBINQGMR-UHFFFAOYSA-N n-pyridin-2-ylcarbazol-9-amine Chemical class C12=CC=CC=C2C2=CC=CC=C2N1NC1=CC=CC=N1 CIWUYDQBINQGMR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 49
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
- 239000001257 hydrogen Substances 0.000 claims abstract description 17
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 7
- 150000002367 halogens Chemical class 0.000 claims abstract description 7
- 150000002431 hydrogen Chemical group 0.000 claims abstract 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims description 7
- 238000007792 addition Methods 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Chemical group 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003371 toe Anatomy 0.000 claims 1
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- 239000007787 solid Substances 0.000 description 21
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- 239000000243 solution Substances 0.000 description 20
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- 239000000203 mixture Substances 0.000 description 14
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 12
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 11
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- 125000004076 pyridyl group Chemical group 0.000 description 10
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- 239000011780 sodium chloride Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
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- 210000001367 artery Anatomy 0.000 description 2
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- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/289,887 US4868190A (en) | 1988-12-27 | 1988-12-27 | N-pyridinyl-9H-carbazol-9-amines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27122A true PH27122A (en) | 1993-03-16 |
Family
ID=23113557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39801A PH27122A (en) | 1988-12-27 | 1989-12-26 | N-pyridinyl-9H-carbazol-9-amines and a process for their preparation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4868190A (fr) |
| EP (1) | EP0376155B1 (fr) |
| JP (1) | JPH0725749B2 (fr) |
| KR (1) | KR900009596A (fr) |
| AT (1) | ATE79118T1 (fr) |
| AU (1) | AU623205B2 (fr) |
| CA (1) | CA2006529C (fr) |
| DE (1) | DE68902386T2 (fr) |
| DK (1) | DK662189A (fr) |
| ES (1) | ES2044043T3 (fr) |
| FI (1) | FI896243A0 (fr) |
| GR (1) | GR3006140T3 (fr) |
| IE (1) | IE894175L (fr) |
| IL (1) | IL92867A0 (fr) |
| NO (1) | NO895222L (fr) |
| NZ (1) | NZ231943A (fr) |
| PH (1) | PH27122A (fr) |
| PT (1) | PT92696A (fr) |
| ZA (1) | ZA899904B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916135A (en) * | 1989-05-08 | 1990-04-10 | Hoechst Roussel Pharmaceuticals Inc. | N-heteroaryl-4-quinolinamines |
| US5179099A (en) * | 1989-08-02 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Incorporated | 2,3-dihydro-1-(pyridinylamino)-indoles |
| ATE118002T1 (de) * | 1989-08-02 | 1995-02-15 | Hoechst Roussel Pharma | 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. |
| US4994472A (en) * | 1989-08-02 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-(pyridinylamino)-2-pyrrolidinones as pain relievers |
| US4983608A (en) * | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| US5776955A (en) * | 1995-07-27 | 1998-07-07 | Hoechst Marion Roussel, Inc. | Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents |
| CN1184969C (zh) * | 1995-07-27 | 2005-01-19 | 阿温蒂斯药物公司 | 未取代和取代的n－(吡咯－1－基)吡啶胺作为抗惊厥药的用途 |
| ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
| UA74195C2 (uk) * | 2000-07-21 | 2005-11-15 | Орто-Макнейл Фармацевтикал, Інк. | Застосування карбаматної сполуки, призначеної для попередження або лікування невропатичного болю та, асоційованих з головним болем, кластерного болю і мігрені |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7181M (fr) * | 1966-11-16 | 1969-08-11 | ||
| EP0073849A1 (fr) * | 1981-09-03 | 1983-03-16 | Schering Corporation | Phényltétrahydro-1,2,3,4 carbazoles, leur préparation et compositions pharmaceutiques les contenant |
| US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
| US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
| ATE115143T1 (de) * | 1987-04-24 | 1994-12-15 | Hoechst Roussel Pharma | N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel. |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4916135A (en) * | 1989-05-08 | 1990-04-10 | Hoechst Roussel Pharmaceuticals Inc. | N-heteroaryl-4-quinolinamines |
| ATE118002T1 (de) * | 1989-08-02 | 1995-02-15 | Hoechst Roussel Pharma | 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
-
1988
- 1988-12-27 US US07/289,887 patent/US4868190A/en not_active Expired - Lifetime
-
1989
- 1989-12-21 EP EP89123612A patent/EP0376155B1/fr not_active Expired - Lifetime
- 1989-12-21 NZ NZ231943A patent/NZ231943A/en unknown
- 1989-12-21 IE IE894175A patent/IE894175L/xx unknown
- 1989-12-21 AT AT89123612T patent/ATE79118T1/de not_active IP Right Cessation
- 1989-12-21 DE DE8989123612T patent/DE68902386T2/de not_active Expired - Fee Related
- 1989-12-21 ES ES89123612T patent/ES2044043T3/es not_active Expired - Lifetime
- 1989-12-22 AU AU47203/89A patent/AU623205B2/en not_active Ceased
- 1989-12-22 PT PT92696A patent/PT92696A/pt unknown
- 1989-12-22 FI FI896243A patent/FI896243A0/fi not_active Application Discontinuation
- 1989-12-22 NO NO89895222A patent/NO895222L/no unknown
- 1989-12-22 DK DK662189A patent/DK662189A/da not_active Application Discontinuation
- 1989-12-22 CA CA002006529A patent/CA2006529C/fr not_active Expired - Fee Related
- 1989-12-25 IL IL92867A patent/IL92867A0/xx unknown
- 1989-12-26 JP JP1335256A patent/JPH0725749B2/ja not_active Expired - Fee Related
- 1989-12-26 KR KR1019890019472A patent/KR900009596A/ko not_active Application Discontinuation
- 1989-12-26 PH PH39801A patent/PH27122A/en unknown
- 1989-12-27 ZA ZA899904A patent/ZA899904B/xx unknown
-
1992
- 1992-11-04 GR GR920402184T patent/GR3006140T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO895222L (no) | 1990-06-28 |
| DK662189D0 (da) | 1989-12-22 |
| FI896243A0 (fi) | 1989-12-22 |
| EP0376155A1 (fr) | 1990-07-04 |
| CA2006529A1 (fr) | 1990-06-27 |
| ZA899904B (en) | 1991-02-27 |
| US4868190A (en) | 1989-09-19 |
| AU623205B2 (en) | 1992-05-07 |
| CA2006529C (fr) | 1999-08-10 |
| KR900009596A (ko) | 1990-07-05 |
| DE68902386T2 (de) | 1993-02-11 |
| EP0376155B1 (fr) | 1992-08-05 |
| IE894175L (en) | 1990-06-27 |
| JPH0725749B2 (ja) | 1995-03-22 |
| JPH02247173A (ja) | 1990-10-02 |
| IL92867A0 (en) | 1990-09-17 |
| ATE79118T1 (de) | 1992-08-15 |
| ES2044043T3 (es) | 1994-01-01 |
| DE68902386D1 (de) | 1992-09-10 |
| NZ231943A (en) | 1992-06-25 |
| DK662189A (da) | 1990-06-28 |
| AU4720389A (en) | 1990-07-05 |
| GR3006140T3 (fr) | 1993-06-21 |
| NO895222D0 (no) | 1989-12-22 |
| PT92696A (pt) | 1990-06-29 |
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