PH20208A - Method of treating cardiac disorders with n-(aryloxyalkyl)-n'-(aminoalkyl)ureas - Google Patents

Method of treating cardiac disorders with n-(aryloxyalkyl)-n'-(aminoalkyl)ureas

Info

Publication number
PH20208A
PH20208A PH27277A PH27277A PH20208A PH 20208 A PH20208 A PH 20208A PH 27277 A PH27277 A PH 27277A PH 27277 A PH27277 A PH 27277A PH 20208 A PH20208 A PH 20208A
Authority
PH
Philippines
Prior art keywords
aryloxyalkyl
ureas
aminoalkyl
treating cardiac
cardiac disorders
Prior art date
Application number
PH27277A
Other languages
English (en)
Inventor
James Robert Shanklin Jr
Christopher Peter Johnson Iii
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of PH20208A publication Critical patent/PH20208A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH27277A 1981-05-20 1982-05-12 Method of treating cardiac disorders with n-(aryloxyalkyl)-n'-(aminoalkyl)ureas PH20208A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26551081A 1981-05-20 1981-05-20

Publications (1)

Publication Number Publication Date
PH20208A true PH20208A (en) 1986-10-20

Family

ID=23010745

Family Applications (1)

Application Number Title Priority Date Filing Date
PH27277A PH20208A (en) 1981-05-20 1982-05-12 Method of treating cardiac disorders with n-(aryloxyalkyl)-n'-(aminoalkyl)ureas

Country Status (22)

Country Link
EP (1) EP0066987B1 (en:Method)
JP (1) JPS57197215A (en:Method)
KR (1) KR890001999B1 (en:Method)
AU (1) AU544977B2 (en:Method)
CA (1) CA1190228A (en:Method)
DE (1) DE3272856D1 (en:Method)
DK (1) DK228582A (en:Method)
EG (1) EG15911A (en:Method)
ES (3) ES512337A0 (en:Method)
FI (1) FI76552C (en:Method)
GR (1) GR76408B (en:Method)
HK (1) HK86187A (en:Method)
HU (1) HU187706B (en:Method)
IE (1) IE53319B1 (en:Method)
IL (1) IL65556A (en:Method)
IN (1) IN156479B (en:Method)
NO (1) NO153295C (en:Method)
NZ (1) NZ200668A (en:Method)
PH (1) PH20208A (en:Method)
PT (1) PT74931B (en:Method)
SG (1) SG48887G (en:Method)
ZA (1) ZA823213B (en:Method)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486344A (en) * 1983-03-28 1984-12-04 Miles Laboratories, Inc. Urea-linked immunogens, antibodies, and preparative method
JPS61126065A (ja) * 1984-11-26 1986-06-13 Mitsui Petrochem Ind Ltd 置換フエノキシ尿素、その製造法およびそれを有効成分として含有する除草剤
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
JP2826826B2 (ja) * 1988-04-11 1998-11-18 日本ケミファ株式会社 アルキレンジアミン誘導体
AU2031692A (en) * 1991-07-22 1993-01-28 Zyma S.A. Arylalkylamine derivatives
US8106221B2 (en) 2007-06-20 2012-01-31 Vitae Pharmaceuticals, Inc. Renin inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2344934A (en) * 1943-02-12 1944-03-21 American Cyanamid Co Quaternary nitrogen condensation products of methylol urea ethers
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas

Also Published As

Publication number Publication date
DE3272856D1 (de) 1986-10-02
IN156479B (en:Method) 1985-08-10
HK86187A (en) 1987-11-27
FI76552C (fi) 1988-11-10
GR76408B (en:Method) 1984-08-10
ES8303307A1 (es) 1983-02-01
ZA823213B (en) 1983-03-30
ES512335A0 (es) 1983-02-01
ES8303308A1 (es) 1983-02-01
DK228582A (da) 1982-11-21
AU544977B2 (en) 1985-06-27
JPS57197215A (en) 1982-12-03
IL65556A (en) 1985-07-31
FI821775A0 (fi) 1982-05-19
PT74931A (en) 1982-06-01
NO153295C (no) 1986-02-19
KR830010058A (ko) 1983-12-24
CA1190228A (en) 1985-07-09
HU187706B (en) 1986-02-28
IE821192L (en) 1982-11-20
NO153295B (no) 1985-11-11
KR890001999B1 (ko) 1989-06-07
AU8388282A (en) 1982-11-25
EG15911A (en) 1986-09-30
PT74931B (en) 1983-12-23
FI76552B (fi) 1988-07-29
EP0066987B1 (en) 1986-08-27
IL65556A0 (en) 1982-07-30
NZ200668A (en) 1985-11-08
ES512337A0 (es) 1983-02-01
NO821669L (no) 1982-11-22
ES512338A0 (es) 1983-02-01
SG48887G (en) 1987-07-24
EP0066987A3 (en) 1983-09-14
EP0066987A2 (en) 1982-12-15
ES8303306A1 (es) 1983-02-01
IE53319B1 (en) 1988-10-12

Similar Documents

Publication Publication Date Title
PH23928A (en) N'-(2'-aminophenyl)benzamide derivatives and method of use thereof
PH20866A (en) N-((4,6-dimethoxypyrimidin-2-yl)aminocarbonyl)-3-trifluoromethylpyridine-2-sulfonamide or salts thereof, herbicidal composition and method of use thereof
ES532475A0 (es) Procedimiento para la produccion de n-(5-nitropirimidinil)-n'-sulfonilureas
GB2157178B (en) Apparatus for treating disorders of cardiac rhythm
ZA837747B (en) Substituted n-phenyl-n'-benzoyl ureas and their use as insectecides and acaricides
JPS5726605A (en) Emulsion type stable composition of n-(3,4-dichlorophenyl)-n'-methoxy-n-methylurea and 2,6-dinitro-n,n-dipropyl-4-trifluoromethyl aniline
NZ189349A (en) N-phenyl-n'-(2-chloro-6-fluorobenzoyl) ureas and athropodicidal compositions
PH20208A (en) Method of treating cardiac disorders with n-(aryloxyalkyl)-n'-(aminoalkyl)ureas
GR870518B (en) Herbicide compositions based on biscarbamate and method of herbicide treatment using said compositions
IL51513A0 (en) N-(4-benzyloxyphenyl)-n'-methyl-n'-methoxyurea
NZ196859A (en) N-(3-or 4-ethynylphenyl)-n'-benzoylureas
DE3473443D1 (en) New amino derivatives of 2- (n-(2,2,5,5-tetramethyl-3-pyrrolin-or pyrrolidine-3-carbonyl))
ES526276A0 (es) Procedimiento de preparacion de nuevas n-(5-aminometil 2-oxazolin 2-il)-n'-fenilureas
PH23473A (en) N-(arylthioalkyl)-n'-(aminoalkyl) ureas
ZA823212B (en) N-(arylthioalkyl)-n'-(aminoalkyl)
IT8349153A0 (it) Procedimento per l'ingrassaggio dicuoio e pelliccia
KE3663A (en) N-(arylthioalkyl)-n'-(aminoalkyl)ureas
SU1593569A3 (ru) Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
KE3735A (en) N-(aryloxyalkyl)-n'-(amino-alkyl)ureas
PH22450A (en) Agent for treating parkinson's disease or parkinsonism
BG32762A1 (en) Method for obtaining on of n- (4- isopropylphenil)- n', n'- dimethylcarbamide
DE3476538D1 (en) N-benzoyl-n'-alkoxyphenyl ureas and their use in combating insects and acaridae
ZA838700B (en) N-(5-amino-methyl-2-oxazolin-2-yl)-n'-phenylureas,the method for their preparation and their application in therapy
ZA866223B (en) N-(2,6-difluorobenzoyl)-n'-3,5-dichloro-4-(3,3,3-trifluoro-2-chloroprop-1-en-1-yl)phenil-urea having insecticide activity
BG40728A1 (en) 2- (substituted- 1- (1'- (s)- phenylethyl) pyrolidenes and method for their manufacture