PH18454A - Alkylimidazo 1,2-c pyrazolo 3,4-e pyrimidines as antipsychotic agents - Google Patents

Alkylimidazo 1,2-c pyrazolo 3,4-e pyrimidines as antipsychotic agents

Info

Publication number
PH18454A
PH18454A PH28929A PH28929A PH18454A PH 18454 A PH18454 A PH 18454A PH 28929 A PH28929 A PH 28929A PH 28929 A PH28929 A PH 28929A PH 18454 A PH18454 A PH 18454A
Authority
PH
Philippines
Prior art keywords
alkylimidazo
pyrazolo
pyrimidines
antipsychotic agents
antipsychotic
Prior art date
Application number
PH28929A
Other languages
English (en)
Inventor
Horace A Dewald
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PH18454A publication Critical patent/PH18454A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PH28929A 1982-05-24 1983-05-18 Alkylimidazo 1,2-c pyrazolo 3,4-e pyrimidines as antipsychotic agents PH18454A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/381,484 US4469868A (en) 1982-05-24 1982-05-24 Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines

Publications (1)

Publication Number Publication Date
PH18454A true PH18454A (en) 1985-07-18

Family

ID=23505215

Family Applications (1)

Application Number Title Priority Date Filing Date
PH28929A PH18454A (en) 1982-05-24 1983-05-18 Alkylimidazo 1,2-c pyrazolo 3,4-e pyrimidines as antipsychotic agents

Country Status (22)

Country Link
US (1) US4469868A (sv)
EP (1) EP0095289B1 (sv)
JP (1) JPS58210087A (sv)
KR (1) KR870000931B1 (sv)
AR (1) AR240941A1 (sv)
AT (1) ATE24510T1 (sv)
AU (1) AU553708B2 (sv)
CA (1) CA1210393A (sv)
DE (1) DE3368635D1 (sv)
DK (1) DK161968C (sv)
ES (4) ES522617A0 (sv)
FI (1) FI74012C (sv)
GR (1) GR79262B (sv)
HK (1) HK102989A (sv)
HU (1) HU187913B (sv)
IE (1) IE55111B1 (sv)
IL (1) IL68360A0 (sv)
NO (1) NO160444C (sv)
NZ (1) NZ204321A (sv)
PH (1) PH18454A (sv)
PT (1) PT76745B (sv)
ZA (1) ZA832637B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
EP1814885A4 (en) * 2004-11-23 2009-12-16 Us Therapeutics Inc Reddy NOVEL HETEROCYCLIC BICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME
EP1888534B1 (en) 2005-06-06 2017-07-26 Intra-Cellular Therapies, Inc. Organic compounds
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
ES2551133T3 (es) 2008-12-06 2015-11-16 Intra-Cellular Therapies, Inc. Compuestos de 4,5,7,8-tetrahidro-4-oxo-2H-imidazo[1,2-a]pirrolo[3,4-e]pirimidina como inhibidores de PDE1
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
US9763948B2 (en) 2010-05-31 2017-09-19 Intra-Cellular Therapies, Inc. PDE1 inhibitory compounds and methods
WO2012143144A1 (en) * 2011-04-21 2012-10-26 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
US9637491B2 (en) 2012-10-19 2017-05-02 Origenis Gmbh Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
WO2014127331A1 (en) 2013-02-17 2014-08-21 Intra-Cellular Therapies, Inc. Novel uses
US9545406B2 (en) 2013-03-15 2017-01-17 Intra-Cellular Therapies, Inc. Method of treating a CNS injury with a PDE1 inhibitor
EP2970279B1 (en) 2013-03-15 2020-09-16 Intra-Cellular Therapies, Inc. Organic compounds
ES2732442T3 (es) 2014-06-20 2019-11-22 Intra Cellular Therapies Inc Compuestos orgánicos
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
EP3177627B1 (en) 2014-08-07 2019-07-24 Intra-Cellular Therapies, Inc. Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-one derivatives with pde1 inhibiting activity
ES2857567T3 (es) 2014-09-17 2021-09-29 Intra Cellular Therapies Inc Derivados de 7,8-dihidro-[2h]-imidazo-[1,2-a]pirazolo[4,3-e]pirimidin-4(5h)-ona como inhibidores de fosfodiesterasa 1 (PDE1) para tratar enfermedades, trastornos o lesiones del sistema nervioso central (SNC)
JP2019510039A (ja) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規組成物および方法
EP3509589B1 (en) 2016-09-12 2021-11-17 Intra-Cellular Therapies, Inc. Novel uses
US11839614B2 (en) 2018-01-31 2023-12-12 Intra-Cellular Therapies, Inc. Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422807A (de) * 1963-08-16 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung von Imidazo- und Pyrimidochinazolinen
US3313815A (en) * 1964-05-04 1967-04-11 Sterling Drug Inc 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same
US3309369A (en) * 1966-04-11 1967-03-14 Wander Ag Dr A Imidazo- and pyrimido-quinazolines
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
DE2058501A1 (de) * 1970-11-27 1972-05-31 Bayer Ag Verfahren zur Herstellung von neuen N-verbrueckten bicyclischen Heteroaromaten
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3984556A (en) * 1973-01-19 1976-10-05 Sandoz, Inc. Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure
JPS516993A (en) * 1974-07-05 1976-01-20 Dainippon Pharmaceutical Co Adeninjudotaino seiho
JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
US4250181A (en) * 1977-10-31 1981-02-10 The Upjohn Company Methods of treating psychosis
US4247553A (en) * 1977-10-31 1981-01-27 The Upjohn Company Methods of treating psychosis
US4206123A (en) * 1977-10-31 1980-06-03 Mccall John M Isothiochroman
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
EP0012208B1 (en) * 1978-11-01 1983-01-26 The Wellcome Foundation Limited 9-(3-(3,5-cis-dimethylpiperazino)propyl)-carbazole, its preparation and pharmaceutical compositions containing it
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
HU178523B (en) * 1979-05-18 1982-05-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing new pyrazolo-quinazoline derivatives
US4230707A (en) * 1979-08-27 1980-10-28 Warner-Lambert Company Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4415581A (en) * 1982-04-09 1983-11-15 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines to treat psychoses
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
US4409230A (en) * 1982-04-09 1983-10-11 Hoechst-Roussel Pharmaceuticals Inc. Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof
US4390544A (en) * 1982-04-09 1983-06-28 Hoechst-Roussel Pharmaceuticals Inc. {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol

Also Published As

Publication number Publication date
PT76745B (en) 1986-04-21
CA1210393A (en) 1986-08-26
EP0095289B1 (en) 1986-12-30
HU187913B (en) 1986-03-28
GR79262B (sv) 1984-10-22
ES8407051A1 (es) 1984-09-01
ES529373A0 (es) 1985-06-16
IL68360A (en) 1986-10-31
ES8506019A1 (es) 1985-06-16
AR240941A2 (es) 1991-03-27
HK102989A (en) 1990-01-05
ES529371A0 (es) 1985-07-01
NO160444B (no) 1989-01-09
PT76745A (en) 1983-06-01
IE55111B1 (en) 1990-06-06
NZ204321A (en) 1986-06-11
JPH0320395B2 (sv) 1991-03-19
NO160444C (no) 1989-04-19
ES8506004A1 (es) 1985-06-16
IE830822L (en) 1983-11-24
EP0095289A2 (en) 1983-11-30
JPS58210087A (ja) 1983-12-07
ES8506315A1 (es) 1985-07-01
ES522617A0 (es) 1984-09-01
FI74012B (fi) 1987-08-31
FI831742A0 (fi) 1983-05-18
AR240941A1 (es) 1991-03-27
KR840004756A (ko) 1984-10-24
US4469868A (en) 1984-09-04
DK227183A (da) 1983-11-25
ES529372A0 (es) 1985-06-16
DE3368635D1 (en) 1987-02-05
ZA832637B (en) 1984-01-25
DK161968B (da) 1991-09-02
DK161968C (da) 1992-02-03
FI74012C (sv) 1987-12-10
EP0095289A3 (en) 1984-09-05
KR870000931B1 (ko) 1987-05-11
DK227183D0 (da) 1983-05-20
AU1342783A (en) 1983-12-01
IL68360A0 (en) 1986-10-31
AU553708B2 (en) 1986-07-24
FI831742L (fi) 1983-11-25
ATE24510T1 (de) 1987-01-15
NO831792L (no) 1983-11-25

Similar Documents

Publication Publication Date Title
PH18454A (en) Alkylimidazo 1,2-c pyrazolo 3,4-e pyrimidines as antipsychotic agents
IL60330A0 (en) Substituted pyrazolo(1,5-a)pyrimidines
PH22107A (en) 3-pyrazolo(1,5-a)pyrdinium cephem compounds
GB8322993D0 (en) Imidazo 1,2-a pyrimidines
GB2050353B (en) Substituted pyrido(1,2-a) pyrimidines
EP0094080A3 (en) Pyrido(2,1-b)quinazoline derivatives
GB8330735D0 (en) Pyrimidin-4-one derivatives
GB2114129B (en) Substituted 1,3,4-thiadiazolo(3,2-a) pyrimidines and process for their preparation
IL56746A0 (en) Substituted 2,3-dihydroimidazo (1,2-c)pyrimidines anti-virl agents
ZA835684B (en) Imidazo(1,2-a)pyrimidines
GB2138418B (en) Novel s-triazole(1,5-a)pyrimidine derivatives
GB2131021B (en) Antipsychotic benzoxazines
GB8306905D0 (en) Substituted 1h-pyrazolo(1,5-a)pyrimidines
PH22448A (en) Substituted carboxy-thiazolo/3,2-a/pyrimidine derivatives
GB8530144D0 (en) Imidazo(1,5-a)heterocyclic compounds
EP0086389A3 (en) Aminopyrazole compounds
GB2080290B (en) Indolo (2',3',3,4)pyrido(2,1-b) quinazolin-5-ones
ZA803591B (en) Substituted pyrazolo(1,5-a)pyrimidines
GB2131018B (en) Azepino (1 2-a) pyrimidine derivatives
IE820681L (en) IMIDAZO £1,2-a| PYRIMIDINE DERIVATIVES
GB8303089D0 (en) Substituted 1h-pyrazolo 1,5-a pyrimidines
GB8303612D0 (en) Imidazo 1,2-a pyrimidines
IE830215L (en) SUBSTITUTED 1,3,4-THIADIAZOLO£3,2-a| PYRIMIDINES
IE840033L (en) HETEROCYCLE-FUSED PYRAZOLO £3,4-d| PYRIDIN-3-ONE
GB2078224B (en) The preparation of indolo(2'3';3'4)-pyrido-(2,1-b)quinazolin-5-ones