DK161968C - Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf - Google Patents

Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf

Info

Publication number
DK161968C
DK161968C DK227183A DK227183A DK161968C DK 161968 C DK161968 C DK 161968C DK 227183 A DK227183 A DK 227183A DK 227183 A DK227183 A DK 227183A DK 161968 C DK161968 C DK 161968C
Authority
DK
Denmark
Prior art keywords
pyrazolo
pyrimidines
imidazo
analogue
preparation
Prior art date
Application number
DK227183A
Other languages
Danish (da)
English (en)
Other versions
DK161968B (da
DK227183A (da
DK227183D0 (da
Inventor
Horace A Dewald
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK227183D0 publication Critical patent/DK227183D0/da
Publication of DK227183A publication Critical patent/DK227183A/da
Publication of DK161968B publication Critical patent/DK161968B/da
Application granted granted Critical
Publication of DK161968C publication Critical patent/DK161968C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK227183A 1982-05-24 1983-05-20 Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf DK161968C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/381,484 US4469868A (en) 1982-05-24 1982-05-24 Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US38148482 1982-05-24

Publications (4)

Publication Number Publication Date
DK227183D0 DK227183D0 (da) 1983-05-20
DK227183A DK227183A (da) 1983-11-25
DK161968B DK161968B (da) 1991-09-02
DK161968C true DK161968C (da) 1992-02-03

Family

ID=23505215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK227183A DK161968C (da) 1982-05-24 1983-05-20 Analogifremgangsmaade til fremstilling af imidazo-pyrazolo-pyrimidiner eller farmaceutisk acceptable salte deraf

Country Status (22)

Country Link
US (1) US4469868A (sv)
EP (1) EP0095289B1 (sv)
JP (1) JPS58210087A (sv)
KR (1) KR870000931B1 (sv)
AR (1) AR240941A1 (sv)
AT (1) ATE24510T1 (sv)
AU (1) AU553708B2 (sv)
CA (1) CA1210393A (sv)
DE (1) DE3368635D1 (sv)
DK (1) DK161968C (sv)
ES (4) ES8407051A1 (sv)
FI (1) FI74012C (sv)
GR (1) GR79262B (sv)
HK (1) HK102989A (sv)
HU (1) HU187913B (sv)
IE (1) IE55111B1 (sv)
IL (1) IL68360A0 (sv)
NO (1) NO160444C (sv)
NZ (1) NZ204321A (sv)
PH (1) PH18454A (sv)
PT (1) PT76745B (sv)
ZA (1) ZA832637B (sv)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
EP1814885A4 (en) * 2004-11-23 2009-12-16 Us Therapeutics Inc Reddy NOVEL HETEROCYCLIC BICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME
BRPI0611095B8 (pt) 2005-06-06 2021-05-25 Intracellular Therapies Inc compostos inibidores de pde1, composição farmacêutica compreendendo-os, usos dos mesmos como inibidores de pde1 para o tratamento de doenças relacionadas, tal como doença de parkinson e deficiência cognitiva, e métodos para produção dos ditos compostos
US9006258B2 (en) 2006-12-05 2015-04-14 Intra-Cellular Therapies, Inc. Method of treating female sexual dysfunction with a PDE1 inhibitor
KR20110103949A (ko) 2008-12-06 2011-09-21 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
WO2010132127A1 (en) 2009-05-13 2010-11-18 Intra-Cellular Therapies, Inc. Organic compounds
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
EP2576551A4 (en) 2010-05-31 2014-04-16 Intra Cellular Therapies Inc ORGANIC COMPOUNDS
BR112013026521A2 (pt) * 2011-04-21 2016-12-27 Origenis Gmbh pirazolo[4,3-d]pirimidinas úteis como inibidores de cinase
US9637491B2 (en) 2012-10-19 2017-05-02 Origenis Gmbh Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
US9801882B2 (en) 2013-02-17 2017-10-31 Intra-Cellular Therapies, Inc. Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
ES2836129T3 (es) 2013-03-15 2021-06-24 Intra Cellular Therapies Inc Compuestos orgánicos
JP2016518343A (ja) 2013-03-15 2016-06-23 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
JP6810613B2 (ja) 2014-06-20 2021-01-06 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
ES2745819T3 (es) 2014-08-07 2020-03-03 Intra Cellular Therapies Inc Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1
KR102332957B1 (ko) 2014-09-17 2021-11-29 인트라-셀룰라 써래피스, 인코퍼레이티드. 화합물 및 방법
EP3436083A4 (en) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. NEW COMPOSITIONS AND METHODS
EP3970719A1 (en) 2016-09-12 2022-03-23 Intra-Cellular Therapies, Inc. Pde1 inhibitor for use in a method of treatment or prophylaxis of inflammation and/or an inflammatory disease or disorder
EP3746081A4 (en) 2018-01-31 2021-10-27 Intra-Cellular Therapies, Inc. INNOVATIVE USES

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422807A (de) * 1963-08-16 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung von Imidazo- und Pyrimidochinazolinen
US3313815A (en) * 1964-05-04 1967-04-11 Sterling Drug Inc 8-chloropyrazolo-[1, 5-c]quinazoline derivatives and methods of preparing same
US3309369A (en) * 1966-04-11 1967-03-14 Wander Ag Dr A Imidazo- and pyrimido-quinazolines
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
DE2058501A1 (de) * 1970-11-27 1972-05-31 Bayer Ag Verfahren zur Herstellung von neuen N-verbrueckten bicyclischen Heteroaromaten
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3984556A (en) * 1973-01-19 1976-10-05 Sandoz, Inc. Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure
JPS516993A (en) * 1974-07-05 1976-01-20 Dainippon Pharmaceutical Co Adeninjudotaino seiho
JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
US4250181A (en) * 1977-10-31 1981-02-10 The Upjohn Company Methods of treating psychosis
US4247553A (en) * 1977-10-31 1981-01-27 The Upjohn Company Methods of treating psychosis
US4206123A (en) * 1977-10-31 1980-06-03 Mccall John M Isothiochroman
US4192803A (en) * 1978-09-15 1980-03-11 American Cyanamid Company 5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
CA1141384A (en) * 1978-11-01 1983-02-15 Morton Harfenist Pharmaceutical heterocyclic comounds, preparation, use and intermediates therefor and their preparations
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
HU178523B (en) * 1979-05-18 1982-05-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing new pyrazolo-quinazoline derivatives
US4230707A (en) * 1979-08-27 1980-10-28 Warner-Lambert Company Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
US4396770A (en) * 1982-04-09 1983-08-02 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4415581A (en) * 1982-04-09 1983-11-15 Hoechst-Roussel Pharmaceuticals Inc. 1-[3-6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines to treat psychoses
US4390544A (en) * 1982-04-09 1983-06-28 Hoechst-Roussel Pharmaceuticals Inc. {1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-(2-oxo-1-benzimidazolinyl}p
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
US4409230A (en) * 1982-04-09 1983-10-11 Hoechst-Roussel Pharmaceuticals Inc. Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol

Also Published As

Publication number Publication date
US4469868A (en) 1984-09-04
ES8506019A1 (es) 1985-06-16
KR870000931B1 (ko) 1987-05-11
IL68360A (en) 1986-10-31
GR79262B (sv) 1984-10-22
ES529371A0 (es) 1985-07-01
ES8506004A1 (es) 1985-06-16
KR840004756A (ko) 1984-10-24
AU1342783A (en) 1983-12-01
FI831742A0 (fi) 1983-05-18
EP0095289A3 (en) 1984-09-05
AR240941A1 (es) 1991-03-27
PH18454A (en) 1985-07-18
NZ204321A (en) 1986-06-11
HK102989A (en) 1990-01-05
DK161968B (da) 1991-09-02
JPS58210087A (ja) 1983-12-07
EP0095289B1 (en) 1986-12-30
IL68360A0 (en) 1986-10-31
ES529372A0 (es) 1985-06-16
NO160444B (no) 1989-01-09
DK227183A (da) 1983-11-25
ZA832637B (en) 1984-01-25
DK227183D0 (da) 1983-05-20
ES522617A0 (es) 1984-09-01
ATE24510T1 (de) 1987-01-15
PT76745A (en) 1983-06-01
NO831792L (no) 1983-11-25
DE3368635D1 (en) 1987-02-05
FI74012C (sv) 1987-12-10
HU187913B (en) 1986-03-28
FI831742L (fi) 1983-11-25
ES8506315A1 (es) 1985-07-01
NO160444C (no) 1989-04-19
FI74012B (fi) 1987-08-31
ES529373A0 (es) 1985-06-16
EP0095289A2 (en) 1983-11-30
IE55111B1 (en) 1990-06-06
IE830822L (en) 1983-11-24
ES8407051A1 (es) 1984-09-01
AU553708B2 (en) 1986-07-24
CA1210393A (en) 1986-08-26
AR240941A2 (es) 1991-03-27
PT76745B (en) 1986-04-21
JPH0320395B2 (sv) 1991-03-19

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